IUPHAR Guide to IMMUNOPHARMACOLOGY poster. Presented at the BSI Congress 2017, Brighton, UK (6th December 2017) and at Pharmacology 2017, London, UK (13th December 2017.
A Wellcome Trust-funded project to extend the Guide to PHARMACOLOGY (www.guidetopharmacology.org) to include data on key immunological data types and associate these to drugs and drug targets. Presented at the ELIXIR-UK All-Hand Meeting, Edinburgh, Nov 2017.
Updated poster following beta v3 release. In preparation for Pharmacology Futures, Edinburgh Immunology Symposium and Word Congress of Pharmacology (Kyoto)
The GtoImmuPdb Portal aims to provide a unique access point for immunological data within the Guide to Pharmacology (GtoPdb) database. It will contain expert-curated immunological information on protein targets and ligands tagged as immunologically relevant. The portal will assist in identifying potential drug targets and experimental molecules for testing, and will link targets and ligands to immunological processes, cell types, and related diseases. A beta version of GtoImmuPdb is scheduled for release in Spring 2017.
Flash poster presentation slide of IUPHAR Guide to PHARMACOLOGY. As presented by Dr. Simon Harding at BPS Pharmacology 2016 @BritPharmSoc @GuidetoPHARM
Poster on GtoImmuPdb presented at European Congress of Immunology (Amsterdam, Sep 2018). Overview of the main data types and features included in this extension to the IUPHAR/BPS Guide to PHARMACOLOGY
1) Researchers have created a new online resource called the IUPHAR/MMV Guide to Malaria Pharmacology (GtoMPdb) to curate information on antimalarial compounds and their molecular targets in Plasmodium.
2) The database currently contains 25 Plasmodium molecular targets and 57 antimalarial ligands that were manually curated from scientific literature.
3) A new customized online portal provides open access to the antimalarial data and allows browsing by parasite lifecycle stage, target species, and other features to help malaria research.
Bioinformatics: Building the cornerstones of Sequence Homology and its use fo...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
A Wellcome Trust-funded project to extend the Guide to PHARMACOLOGY (www.guidetopharmacology.org) to include data on key immunological data types and associate these to drugs and drug targets. Presented at the ELIXIR-UK All-Hand Meeting, Edinburgh, Nov 2017.
Updated poster following beta v3 release. In preparation for Pharmacology Futures, Edinburgh Immunology Symposium and Word Congress of Pharmacology (Kyoto)
The GtoImmuPdb Portal aims to provide a unique access point for immunological data within the Guide to Pharmacology (GtoPdb) database. It will contain expert-curated immunological information on protein targets and ligands tagged as immunologically relevant. The portal will assist in identifying potential drug targets and experimental molecules for testing, and will link targets and ligands to immunological processes, cell types, and related diseases. A beta version of GtoImmuPdb is scheduled for release in Spring 2017.
Flash poster presentation slide of IUPHAR Guide to PHARMACOLOGY. As presented by Dr. Simon Harding at BPS Pharmacology 2016 @BritPharmSoc @GuidetoPHARM
Poster on GtoImmuPdb presented at European Congress of Immunology (Amsterdam, Sep 2018). Overview of the main data types and features included in this extension to the IUPHAR/BPS Guide to PHARMACOLOGY
1) Researchers have created a new online resource called the IUPHAR/MMV Guide to Malaria Pharmacology (GtoMPdb) to curate information on antimalarial compounds and their molecular targets in Plasmodium.
2) The database currently contains 25 Plasmodium molecular targets and 57 antimalarial ligands that were manually curated from scientific literature.
3) A new customized online portal provides open access to the antimalarial data and allows browsing by parasite lifecycle stage, target species, and other features to help malaria research.
Bioinformatics: Building the cornerstones of Sequence Homology and its use fo...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
How can Whole Genome Sequencing information be used to address data requireme...OECD Environment
This document discusses the potential use of whole genome sequencing data to address regulatory requirements for approval of microorganisms as active ingredients in plant protection products in the EU. It analyzes how genome sequencing could be used for species assignment, relationship to pathogens, distinction between Bacillus strains, production of metabolites, antibiotic resistance, genetic stability, risk assessment, and unequivocal identification of strains. While noting some potential benefits, it also describes limitations and problems with relying solely on genome sequencing data. It concludes that genome sequencing can be useful to exclude some issues but should not be a standard requirement, and that only reports on analyses—not the genome sequences themselves—should be included in dossiers.
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Progress report 2016: GMI proficiency testing: Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
Presentation from the ECDC expert consultation on Whole Genome Sequencing organised by the European Centre of Disease Prevention and Control - Stockholm, 19 November 2015
This document discusses the use of bioinformatics tools to analyze gene expression data and detect tumors and mutations in tissues. It summarizes the PhyloMap technique, which integrates principal coordinate analysis, vector quantization, and phylogenetic tree construction to provide improved visualization of large genomic data sets. PhyloMap allows researchers to better analyze and predict evolutionary relationships among influenza A virus genes. The document concludes that PhyloMap is an efficient algorithm for analyzing phylogenetic relationships in large genomic data compared to other techniques.
The Global Micorbial Identifier (GMI) initiative - and its working groupsExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
The GMI initiative - and its working groups. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
Activities in development of bioinformatics pipelines for characterisation of...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
Sharing of germplasm data sets, at the TDWG 2006 conferenceDag Endresen
Data exchange for germplasm data sets with PyWrapper/BioCASE. TDWG 2006 conference, 16th October 2006, St. Louis. Dag Endresen, Johan Bäckman, Helmut Knupffer, Samy Gaiji.
Whole Genome Sequencing (WGS) for surveillance of foodborne infections in Den...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Applications of WGS for surveillance of foodborne infections in Denmark; benefits and potential drawbacks on performance and cost. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
US Perspective on use of bioinformatics in microbial pesticide regulation - O...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
Pine Biotech - a company that merges big -omics data analysis with clinical care and precision applications for Real World Evidence: research & development of new targets and therapeutics, stratified clinical trials, and development of biomarkers for early detection and companion diagnostics. We want to improve patient outcomes and provide tools for researchers and clinicians to have an impact on healthcare.
ASHG 2015 - Redundant Annotations in Tertiary AnalysisJames Warren
After obtaining genetic variants from next generation sequencing data, a precursory step in tertiary analysis is to annotate each variant with available relevant information. There is no standardized compendium for this purpose; researchers instead are required to compile data from a motley of annotation tools and public datasets. These sources for annotation are independently maintained, and accordingly there is limited concordance between their reported contents. The choice of annotation datasets thus has a direct and significant impact on the results of the analysis.
IRIDA's Genomic epidemiology application ontology for data standardization, integration and sharing. Presented at IMMEM XI in Estoril, Portugal, March 11 2016.
dkNET Webinar: "The Microphysiology Systems Database (MPS-Db): A Platform For...dkNET
This document discusses harnessing quantitative systems pharmacology to deliver personalized medicine through the Microphysiology Systems Database (MPS-Db). The MPS-Db is presented as a solution for aggregating, analyzing, sharing, and modeling in vitro data from microphysiology systems (MPS) to accelerate drug development and implementation of personalized medicine approaches. Key features and capabilities of the MPS-Db are described, including supporting various model types, integrating with other databases, and performing data analysis, reproducibility evaluation, and computational modeling. Commercial and non-profit versions are discussed.
This document discusses regeneration abilities in vertebrates and invertebrates and their relationship to pharmacological research and cancer regulation. It notes that regeneration capacity varies between phyla and species, with invertebrates and some vertebrates like newts and zebrafish able to regenerate limbs and organs. In contrast, regeneration abilities are more limited in mammals like humans as they age. The aim is to take an evolutionary approach to understand similarities and differences in regeneration processes and how this relates to developing cancer therapies and regenerative medicine.
Find out about collaboration and partnership opportunities with the Wellcome Sanger Institute that aims to create exceptional healthcare opportunities for everyone from extraordinary science.
Overview of the commonly used sequencing platforms, bioinformatic search tool...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
AgriVectors: A Data and Systems Resource for Arthropod Vectors of Plant DiseasesSurya Saha
Arthropod vectors of pathogens cause enormous economic losses and are a fundamental challenge for sustainable increases in food production, yet agricultural pathosystems remain an underserved area of research. To more effectively fight plant diseases, data pertaining to a disease system needs to be consolidated, made searchable and amenable to data mining. The AgriVectors platform is an open access and comprehensive resource for growers, researchers and industry working on plant pathogens and pathosystems spread by arthropod vectors. The portal connects established public repositories with pathosystem-specific data repositories. The AgriVectors system will provide tools to enable technologies such as RNAi, CRISPR, screening bioassays, etc. to leverage current and emerging knowledge across disciplines. It will also include private and unpublished data, using passwords and secure protocols for restricted access. The portal will be based on the Citrusgreening.org (https://citrusgreening.org/) community resource that was developed as a model for systems biology of tritrophic disease complexes. Citrusgreening.org provides omics and biology resources for the Huanglongbing pathosystem. In addition, it includes a biochemical pathway database for each organism in this disease complex, and an expression atlas with proteomics and RNAseq data from psyllids (http://pen.citrusgreening.org) and citrus (http://cen.citrusgreening.org) across multiple infection states. The AgriVectors portal will extend this model beyond gene-centric omics data to the broader Pathosystem-wide information, with integrated pest management, behavioral, plant health, soil health and climate data to incorporate rapid phenotyping information from research trials, building a foundation for more effectively identifying solutions to combat plant diseases.
The document describes a computational platform called the Bina Annotation Platform that efficiently integrates and annotates genetic variants from sequencing data. It leverages big data technologies like Hadoop and NoSQL databases to annotate variants from over 20 databases and allow real-time user interaction. Examples show it can filter millions of variants down to a few potentially causative ones for rare diseases. Future work will support additional analysis types and custom data integration.
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an expert-driven, open database of pharmacological targets and the substances that act on them. It contains information on over 1,800 drug targets and 1,100 related proteins. The database is curated by 500 experts and provides detailed pharmacological data as well as overviews of key properties and ligands. Specialized extensions of GtoPdb include guides to immunopharmacology and malaria pharmacology that connect their fields to drug discovery. The database is continuously updated with new targets, ligands, features and access methods.
This document discusses bioinformatics and its applications in vaccine discovery. It begins with an introduction to bioinformatics, describing it as an interdisciplinary field that develops tools to analyze biological data using computer science, mathematics, and statistics. It then discusses the objectives and need for bioinformatics, as well as important bioinformatics databases. Next, it provides an overview of the concept of bioinformatics and how it has expanded from analyzing sequence data to include modeling and other areas. Finally, it details the impact of bioinformatics on vaccine discovery through approaches like reverse vaccinology, immunoinformatics, and structural vaccinology that use bioinformatics to select antigens and design new generation vaccines.
How can Whole Genome Sequencing information be used to address data requireme...OECD Environment
This document discusses the potential use of whole genome sequencing data to address regulatory requirements for approval of microorganisms as active ingredients in plant protection products in the EU. It analyzes how genome sequencing could be used for species assignment, relationship to pathogens, distinction between Bacillus strains, production of metabolites, antibiotic resistance, genetic stability, risk assessment, and unequivocal identification of strains. While noting some potential benefits, it also describes limitations and problems with relying solely on genome sequencing data. It concludes that genome sequencing can be useful to exclude some issues but should not be a standard requirement, and that only reports on analyses—not the genome sequences themselves—should be included in dossiers.
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Progress report 2016: GMI proficiency testing: Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
Presentation from the ECDC expert consultation on Whole Genome Sequencing organised by the European Centre of Disease Prevention and Control - Stockholm, 19 November 2015
This document discusses the use of bioinformatics tools to analyze gene expression data and detect tumors and mutations in tissues. It summarizes the PhyloMap technique, which integrates principal coordinate analysis, vector quantization, and phylogenetic tree construction to provide improved visualization of large genomic data sets. PhyloMap allows researchers to better analyze and predict evolutionary relationships among influenza A virus genes. The document concludes that PhyloMap is an efficient algorithm for analyzing phylogenetic relationships in large genomic data compared to other techniques.
The Global Micorbial Identifier (GMI) initiative - and its working groupsExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
The GMI initiative - and its working groups. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
Activities in development of bioinformatics pipelines for characterisation of...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
Sharing of germplasm data sets, at the TDWG 2006 conferenceDag Endresen
Data exchange for germplasm data sets with PyWrapper/BioCASE. TDWG 2006 conference, 16th October 2006, St. Louis. Dag Endresen, Johan Bäckman, Helmut Knupffer, Samy Gaiji.
Whole Genome Sequencing (WGS) for surveillance of foodborne infections in Den...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Applications of WGS for surveillance of foodborne infections in Denmark; benefits and potential drawbacks on performance and cost. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management -23-25 May 2016, Rome, Italy.
US Perspective on use of bioinformatics in microbial pesticide regulation - O...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
Pine Biotech - a company that merges big -omics data analysis with clinical care and precision applications for Real World Evidence: research & development of new targets and therapeutics, stratified clinical trials, and development of biomarkers for early detection and companion diagnostics. We want to improve patient outcomes and provide tools for researchers and clinicians to have an impact on healthcare.
ASHG 2015 - Redundant Annotations in Tertiary AnalysisJames Warren
After obtaining genetic variants from next generation sequencing data, a precursory step in tertiary analysis is to annotate each variant with available relevant information. There is no standardized compendium for this purpose; researchers instead are required to compile data from a motley of annotation tools and public datasets. These sources for annotation are independently maintained, and accordingly there is limited concordance between their reported contents. The choice of annotation datasets thus has a direct and significant impact on the results of the analysis.
IRIDA's Genomic epidemiology application ontology for data standardization, integration and sharing. Presented at IMMEM XI in Estoril, Portugal, March 11 2016.
dkNET Webinar: "The Microphysiology Systems Database (MPS-Db): A Platform For...dkNET
This document discusses harnessing quantitative systems pharmacology to deliver personalized medicine through the Microphysiology Systems Database (MPS-Db). The MPS-Db is presented as a solution for aggregating, analyzing, sharing, and modeling in vitro data from microphysiology systems (MPS) to accelerate drug development and implementation of personalized medicine approaches. Key features and capabilities of the MPS-Db are described, including supporting various model types, integrating with other databases, and performing data analysis, reproducibility evaluation, and computational modeling. Commercial and non-profit versions are discussed.
This document discusses regeneration abilities in vertebrates and invertebrates and their relationship to pharmacological research and cancer regulation. It notes that regeneration capacity varies between phyla and species, with invertebrates and some vertebrates like newts and zebrafish able to regenerate limbs and organs. In contrast, regeneration abilities are more limited in mammals like humans as they age. The aim is to take an evolutionary approach to understand similarities and differences in regeneration processes and how this relates to developing cancer therapies and regenerative medicine.
Find out about collaboration and partnership opportunities with the Wellcome Sanger Institute that aims to create exceptional healthcare opportunities for everyone from extraordinary science.
Overview of the commonly used sequencing platforms, bioinformatic search tool...OECD Environment
24 June 2019: This OECD seminar presented and discussed the potential use of genome sequence, bioinformatic tools and databases in a regulatory decision process for microbial pesticides.
AgriVectors: A Data and Systems Resource for Arthropod Vectors of Plant DiseasesSurya Saha
Arthropod vectors of pathogens cause enormous economic losses and are a fundamental challenge for sustainable increases in food production, yet agricultural pathosystems remain an underserved area of research. To more effectively fight plant diseases, data pertaining to a disease system needs to be consolidated, made searchable and amenable to data mining. The AgriVectors platform is an open access and comprehensive resource for growers, researchers and industry working on plant pathogens and pathosystems spread by arthropod vectors. The portal connects established public repositories with pathosystem-specific data repositories. The AgriVectors system will provide tools to enable technologies such as RNAi, CRISPR, screening bioassays, etc. to leverage current and emerging knowledge across disciplines. It will also include private and unpublished data, using passwords and secure protocols for restricted access. The portal will be based on the Citrusgreening.org (https://citrusgreening.org/) community resource that was developed as a model for systems biology of tritrophic disease complexes. Citrusgreening.org provides omics and biology resources for the Huanglongbing pathosystem. In addition, it includes a biochemical pathway database for each organism in this disease complex, and an expression atlas with proteomics and RNAseq data from psyllids (http://pen.citrusgreening.org) and citrus (http://cen.citrusgreening.org) across multiple infection states. The AgriVectors portal will extend this model beyond gene-centric omics data to the broader Pathosystem-wide information, with integrated pest management, behavioral, plant health, soil health and climate data to incorporate rapid phenotyping information from research trials, building a foundation for more effectively identifying solutions to combat plant diseases.
The document describes a computational platform called the Bina Annotation Platform that efficiently integrates and annotates genetic variants from sequencing data. It leverages big data technologies like Hadoop and NoSQL databases to annotate variants from over 20 databases and allow real-time user interaction. Examples show it can filter millions of variants down to a few potentially causative ones for rare diseases. Future work will support additional analysis types and custom data integration.
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an expert-driven, open database of pharmacological targets and the substances that act on them. It contains information on over 1,800 drug targets and 1,100 related proteins. The database is curated by 500 experts and provides detailed pharmacological data as well as overviews of key properties and ligands. Specialized extensions of GtoPdb include guides to immunopharmacology and malaria pharmacology that connect their fields to drug discovery. The database is continuously updated with new targets, ligands, features and access methods.
This document discusses bioinformatics and its applications in vaccine discovery. It begins with an introduction to bioinformatics, describing it as an interdisciplinary field that develops tools to analyze biological data using computer science, mathematics, and statistics. It then discusses the objectives and need for bioinformatics, as well as important bioinformatics databases. Next, it provides an overview of the concept of bioinformatics and how it has expanded from analyzing sequence data to include modeling and other areas. Finally, it details the impact of bioinformatics on vaccine discovery through approaches like reverse vaccinology, immunoinformatics, and structural vaccinology that use bioinformatics to select antigens and design new generation vaccines.
Bioinformatics in the Clinical Pipeline: Contribution in Genomic Medicineiosrjce
This document discusses the role of bioinformatics in clinical medicine and genomic drug development. It begins by outlining how bioinformatics tools like databases and high-throughput sequencing have generated large amounts of biological and medical data that can be used to better understand diseases at the molecular level. This data is increasingly being stored in electronic medical records to facilitate research. The document then discusses how bioinformatics approaches like computational modeling can speed up the drug development process and reduce costs. It also notes that next-generation sequencing is becoming a useful clinical diagnostic tool. Finally, it concludes that while challenges remain, bioinformatics tools hold promise for improving healthcare by enabling more personalized genomic medicine.
Poster presented at the Elixir All-Hands Meeting in Lisbon, June 2019. Gives a broad summary of Guide to Pharmacology activities in the last year. Emphasising new tools and our extension into malaria pharmacology.
This document provides an overview of the International Union of Basic and Clinical Pharmacology Guide to Pharmacology (GtoPdb) database. It describes the database contents including over 1,700 drug targets and 9,400 ligands. The database is curated by 500 experts and provides target and ligand information for researchers. Specialized versions of the database have also been created for immunopharmacology and malaria research.
As an interdisciplinary field of science, bioinformatics combines biology, computer science, information engineering, mathematics and statistics to analyze and interpret the biological data.
In silico 360 Analysis for Drug DevelopmentChris Southan
Introduction:
Consequent to a memorandum of understanding between the Karolinska Institutet and the International Union of Basic and Clinical Pharmacology (IUPHAR) in 2018 a report on academic drug development, including guidelines (ADEV) has been drafted [1]. As part of this exercise, we conceived a triage for comprehensive informatics profiling around the compound, target, disease axis. We have termed this “in slico 360” (INS360) the aim of which was to support ADEV teams since they may lack either internal expertise or external support to do this on their own. Indeed, some past SciLifeLab Drug Discovery and Development Platform projects had been halted because of overlooked competitive impingements or insufficient target validation evidence.
Methods
We assessed the current database landscape, mostly public but including commercial, for potential utility for INS360. We were guided primarily by content coverage, usability, and reputation. We also explored some open property prediction resources for assay interference and toxicological inferences.
Results:
As a first-stop-shop, we selected the IUPHAR/BPS Guide to PHARMACOLOGY with ~900 ligand-target relationships captured via expert curation of journal papers Moving up in scale we evaluated ChEMBL at 1.8 million compounds with 1.1 million assay descriptions and 7,000 targets. With yet another jump we could search the patent corpus with 18 million extracted compounds in SureChEMBL. We explored PubChem that integrates these three with over 500 other sources linked to 96 million compounds, BioAssay results and connectivity into the NCBI Entrez system. The final jump in scale for document-to-chemistry navigation was represented by SciFinder with 155 million structures. On the target side, 360-exploration has the need to encompass literature, structure, genetic variation, splicing, interactions, and disease pathways. From their UniProt links, both GtoPdb and ChEMBL provide these entry points. Navigating genetic association data in support of target validation was enabled by the OpenTargets portal and the GWAS Catalog. We also fount servers that could produce prediction scores from chemical structures for a range of features important for de-risking development.
Conclusion:
This work scoped out initial resource choices for the INS360. We propose that not only ADEV operations but essentially any pharmacology research team has much to gain from this approach and many potential pitfalls can consequently be avoided when approaching key checkpoints, such as preparing a publication. However, support may be needed for both institutions and teams to get the best out of these complex and feature-rich databases.
[1] Southan C, (2019) Towards Academic Drug Development Guidelines, ChemRxiv pre-print no. 8869574
Bioinformatics is an interdisciplinary field involving biology, computer science, mathematics and statistics. It addresses large-scale biological problems from a computational perspective. Common problems include modeling biological processes at the molecular level and making inferences from collected data. A bioinformatics solution typically involves collecting statistics from biological data, building a computational model, solving a computational problem, and testing the algorithm. Bioinformatics plays a role in areas like structural genomics, functional genomics and nutritional genomics. It is used for applications such as transcriptome analysis, drug discovery, cheminformatics analysis, and more. It is an important tool in fields like molecular medicine, gene therapy, microbial genome applications, antibiotic resistance, and evolutionary studies. Biological databases are important for organizing
IMMUNOINFORMATICS , MICROARRAY and Machine Learning - All about Immunology, I...Mekhla Diwan
It contains the information about Immuno informatics, immune cell development, Immunological database management and tools used for immuno informatics, all about Microarray and DNA MIcroArray experiment, Micro Array Data Classificationa and Machine learning Overview.
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an open, expert-driven database that contains information on over 1,700 pharmacological targets and the substances that act on them. The database provides overviews and detailed information on targets that is manually curated from literature and reviewed by experts. It aims to cover human drug targets and potential future therapeutic targets. New features of the database include search tools to find targets and ligands, information on diseases associated with targets and ligands, organization of ligand families, and comparison of ligand activity across species. The database content is available to download in various formats and its interoperability has been increased through developing an RDF version and submitting data to other sources
This 3-day event is the meeting place for international and domestic scientists to share case studies and project updates, showcase new techniques and form collaborations that pave the way towards the future of China’s biopharmaceutical industry.
Drug-to-protein mappings in the Guide to PHARMACOLOGY: Utility as a target va...Guide to PHARMACOLOGY
The Guide to Pharmacology database (GtoPdb) provides expertly curated information on drug-protein interactions and targets of approved and investigational drugs. It currently includes data on interactions between over 1400 protein targets and 7700 ligands derived from over 5000 literature references. The database covers major target classes and provides a useful resource for target validation and drug discovery. Future plans include regular updates with new target and drug data as well as potential specialty sub-portals within the database.
This document provides information about the 6th International Conference on Biotechnology, Bioinformatics, Bio Medical Sciences and Stem Cell Applications held on October 21-22, 2016 in Hong Kong. It includes the conference proceedings, venue information, and several abstracts from studies presented at the conference on topics such as heart rate variability in females with dysmenorrhea, prediction of epitopes for programmed cell death receptor 1, modulation of encapsulated macrophage behavior in hydrogels, experiences of mothers using infant formula milk in Hong Kong, exploring family-centered care for children with HIV/AIDS in Nigeria, factors influencing travel decisions of medical tourists, perceptions of nursing as a career for males, and health issues faced by the urban poor in Nigerian
Exploiting Edinburgh's Guide to PHARMACOLOGY database as a source of protein ...Chris Southan
Presented by Jamie Davies at the SULSA Synthetic Biology Meeting, Edinburgh, 10 June 2014
http://www.eventbrite.co.uk/e/sulsa-synthetic-biology-meeting-registration-11251454403?aff=eorg
Abstract: Synthetic creation of new biological systems typically incorporates pathways and signaling modules from known protein building blocks. Testing the models underpinning the synthetic engineering thus needs the experimental manipulation of individual proteins, for example, ablating a specific enzyme activity via RNAi, SNP mutation, or knockout. However, the option of small-molecule inhibition as the system perturbation has the advantages of 1) rapid onset 2) dose-response 3) analog testing for structure-activity relationships, 4) exploring mixtures for combinatorial effects 5) pulsing and reversal by wash-out. 6) accurate measurements of added substances and 7) a vast precedent of published results in natural systems from medicinal chemistry, pharmacology, and chemical biology. For the synthetic biologists the GToPdb1 can thus be considered as compendium of the latter. It encompasses an interaction matrix between ~4000 small molecules and ~1000 human proteins with a focus on drugs, clinical candidates, research compounds and peptide ligands These not only have ~ 10,000 mapped binding constants but also the spectrum of documented modulation extends across enzymes, receptors, channels and transporters. It thus becomes an increasingly plausible option to choose a “Lego protein” from GToPdb as a synthetic system component that can have experimentally useable activity probes available from chemical vendors. Even if it does not currently have a suitable target-probe pair, as knowledge base (and expertise resource via the curation team who populate it) GToPdb is an ideal starting point from which to walk out to wider chemogenomic spaces. For example, while an approved drug and its target might seem a logical choice, analogs from the lead series or different chemotypes from which the drug was optimized, or even failed in development, can have superior probe-like properties for in vitro experiments (e.g. be more potent, specific and soluble). The GToPdb facilitates access to such compound data via curated papers and patents.
References
1. Pawson AJ, Sharman JL, Benson HE, Faccenda E, Alexander SP, Buneman OP, Davenport AP, McGrath JC, Peters JA, Southan C, Spedding M, Yu W, Harmar AJ; NC-IUPHAR. The IUPHAR/BPS Guide to PHARMACOLOGY: an expert-driven knowledgebase of drug targets and their ligands. Nucleic Acids Res. 2014 Jan 1;42(1)
Quantifying the content of biomedical semantic resources as a core for drug d...Syed Muhammad Ali Hasnain
The biomedical research community is providing large-scale data sources to enable knowledge discovery from the data alone, or from novel scientific experiments in combination with the existing knowledge.
Increasingly semantic Web technologies are being developed and used including ontologies, triple stores and combinations thereof.
The amount of data is constantly increasing as well as the complexity of data.
Since the data sources are publicly available, the amount of content can be derived giving an overview on the accessible content but also on the state of the data representation in comparison to the existing content.
For a better understanding of the existing data resources, i.e.\ judgments on the distribution of data triples across concepts, data types and primary providers, we have performed a comprehensive analysis which delivers an overview on the accessible content for semantic Web solutions.
It can be derived that the information related to genes, proteins and chemical entities form the center, whereas the content related to diseases and pathways forms a smaller portion.
Further data relates to dietary content and specific questions such as cancer prevention and toxicological effects of drugs.
Bioinformatics tools for epitope prediction.pdfShabnam Naaz
This document provides an overview of bioinformatics tools for predicting T cell epitopes that can be used in vaccine development. It discusses how epitope-based vaccines designed using recombinant DNA technologies can target specific epitopes rather than whole pathogens. It also reviews several online tools and databases that use machine learning methods like artificial neural networks to predict binding of potential epitopes to MHC Class I and Class II molecules for a variety of alleles. These tools analyze pathogen genomes to facilitate the in silico selection of epitopes that could elicit protective immune responses and be incorporated into epitope-based vaccine designs.
26 ASBMB TODAY FEBRUARY 2021Discovering an old DoGs’ neMargaritoWhitt221
26 ASBMB TODAY FEBRUARY 2021
Discovering an old DoGs’
new trick
Heterotrimeric G proteins regulate
a variety of signaling pathways that
control cell development and influ-
ence cell morphology via actin/cyto-
skeleton remodeling. There are four
main families of G proteins: Gi/Go,
Gq, Gs and G12/13. Researchers long
have thought that Gs, unlike its family
members, is coupled specifically and
exclusively to adenylyl cyclases.
In a new study published in the
Journal of Biological Chemistry,
Alejandro Castillo–Kauil of the
Center for Research and Advanced
Studies of the National Polytechnic
Institute and collaborators challenge
this dogmatic view by identifying a
new Gs target. Using biochemical,
molecular biological and chemo-
genetic approaches, the researchers
demonstrated that the Gαs subfamily
of G proteins can regulate the activity
of Rho GTPases such as Rho guanine
nucleotide exchange factor, or Rho-
GEF. The interaction identified by the
group activates the small G protein
Cdc42 by Gs-coupled GPCRs, stimu-
lating a rearrangement of the cyto-
skeleton and inducing formation of
fingerlike protrusions called filopodia.
These results provide new insight
into G protein activity and define a
new role for RhoGEF coupling in G
protein function.
DOI: 10.1074/jbc.AC120.015204
A pathogen’s proteins target
mitochondria
The tick-borne pathogen Coxiella
burnetii causes Q fever, or query fever,
a rare flulike disease that can spread
to humans who inhale dust particles
contaminated by infected farm or
CONTINUED FROM PAGE 25
Noninvasive tool provides oral cancer prognosis
Oral squamous cell carcinoma, which affects about 34,000 people
in the U.S. each year, is found in the cells lining the lips and mouth.
Metastasis to the lymph nodes is a sign of disease progression and may
be accompanied by changes in proteolytic activity. During proteolysis,
enzymes cut up proteins into short fragments called peptides. Recent
work suggests that characterizing the sequence and abundance of these
molecules — a method dubbed peptidomics — might provide new in-
sight on cancer biology and in the clinic. In a recent paper in the journal
Molecular & Cellular Proteomics, Leandro Xavier Neves of the Brazil-
ian Biosciences National Laboratory and a team of Brazilian clinicians
and scientists describe their analysis of oral squamous cell carcinoma
patient saliva using peptidomics.
After extracting peptides from saliva samples, the research team ana-
lyzed and compared the peptide content in samples from patients with
and without metastasis to the lymph nodes. They found more than 1,000
uniquely expressed peptides in each group and an additional 1,628 pep-
tides expressed by both groups. A series of statistical analyses identified
77 peptides of particular interest; all of these peptides are overexpressed
in samples from patients with lymph node metastasis, which supports the
hypothesis that proteolytic activity increases ...
This document discusses bioinformatics, including its goals and applications. Bioinformatics is defined as applying information technology to store, organize, and analyze vast amounts of biological data, such as sequences and structures of proteins and nucleic acids. It merges biology, mathematics, statistics, computer science, and information technology. Bioinformatics helps analyze gene and protein expression, compare genomic data, and simulate DNA, RNA, and proteins. It has applications in molecular medicine, drug development, microbial genomics, crop improvement, and more. Common bioinformatics tools include BLAST for comparing biological sequences.
A radiology report serves as an intermediary between a radiologist and referring clinician for suggesting
appropriate treatment to the patients, aimed at better healthcare management. It is essentially a tool
that assists radiologists in conveying their input to the patients and clinicians regarding positive or negative findings on a case. The objective of this paper is to discuss and propose Radiology Information & Reporting System (RIRS), highlight challenges governing its implementation and suggest way forwards
towards its effective implementation across the public sector tertiary care institutions of Pakistan. In the end, it is concluded that the proposed RIRS would potentially offer enormous benefits in terms of cost
savings, reporting accuracy, faster processing and operational efficiency as opposed to the conventionally available manual radiology reporting procedures and systems.
Presentation by Dr. Elena Faccenda on the IUPHAR/BPS Guide to Immunopharmacology at the 39° Congresso Nazionale della Società Italiana di Farmacologia in Florence, Nov 2019
This document discusses the IUPHAR/BPS Guide to Pharmacology database and related resources. It provides open access information on pharmacological targets and the substances that act on them. It includes over 1,700 human drug targets, 9,700 ligands including 1,300 approved drugs. Related databases include the Guide to Immunopharmacology and Guide to Malaria Pharmacology. The databases are regularly updated and include links to other resources to enable interoperability.
The document provides an overview and progress report on database activities from April 2018 - March 2019. Key points include:
- Publications in peer-reviewed journals on the database and new immunopharmacology guide.
- Engagement through conferences, social media, and interactions with users seeking to improve the database.
- Ongoing development of the database interface and content, including expansion to new therapeutic areas.
- Statistics on usage, file downloads, and web service calls that show increasing interaction over time.
Dr. Simon D. Harding of the University of Edinburgh created a knowledge-base that connects immunology and pharmacology. The knowledge-base links immunological targets and ligands to cell types and diseases. It is part of the IUPHAR/BPS Guide to Pharmacology, an open database of drug targets and ligands including approved drugs. A new search tool allows searching of pharmacological information. Dr. Harding also aims to curate data on antimalarial compounds and their molecular targets in Plasmodium through the IUPHAR/MMV Guide to Malaria Pharmacology.
The document summarizes recent updates to the IUPHAR/BPS Guide to PHARMACOLOGY database. It describes new features including expanded target coverage with over 1,700 drug targets and 1,100 related proteins. A new Pharmacology Search Tool allows users to upload protein lists and find associated ligands. The database also now connects immunopharmacology by associating targets with immune processes, cell types, and diseases. Additionally, the guide describes collaborations to include antimalarial compound data and develop an IUPHAR/MMV Guide to Malaria Pharmacology.
The document provides an overview and status report of the Core Guide to PHARMACOLOGY (GtoPdb) database. It discusses recent publications from the team, compliance with new GDPR privacy regulations, website access statistics showing increased usage, new website features, and priorities for further development such as expanding disease and content coverage.
The document provides a status report on the Guide to Immunopharmacology database (GtoImmuPdb). It discusses developments including the addition of disease data, graphical browsing of cell type data, and process data. The database is in beta version 3 and undergoing user testing. Over 500 targets and 1,000 ligands have been curated from the literature. On the curation side, efforts are focused on expanding the literature collection and annotating new targets and ligands. The database is preparing for its official launch in October 2018.
The IUPHAR/BPS Guide to PHARAMCOLOGY in 2018: new features and updatesGuide to PHARMACOLOGY
2018 update poster for the IUPHAR/BPS Guide to PHARMACOLOGY. Giving details of new features and updates. To be presented at Pharmacology Futures, Edinburgh, May 2018; ELIXIR-All Hands, Berlin, June 2018 and World Congress of Pharmacology, Kyoto, Japan, July 2018
IUPHAR/BPS Guide to PHARMACOLOGY in 2017: new features and updatesGuide to PHARMACOLOGY
This document summarizes updates to the IUPHAR/BPS Guide to PHARMACOLOGY database. It provides expert curated data on human drug targets and ligands. Recent additions include new target families, ligands, and links to immunopharmacology data. New features include download options, search tools, and organization of ligand families. The database is maintained by an international team and network of scientists and provides a resource for pharmacology education and research.
These slides will be presented at the Pharmacology 2017 meeting in London during the following session:
Abstract Number: OB073
Abstract Title: Capturing new BIA 10-2474 molecular data in the IUPHAR/BPS Guide to PHARMACOLOGY
Date: Wednesday, December 13, 2017, 11:30 AM
Oral Session: Oral Communications: Mixed Tracks
This comprehensive slide deck is provided for use by those who are teaching and presenting on the IUPHAR/BPS Guide to PHARMACOLOGY. Includes:
- Overview of NC-IUPHAR
- Background to GtoPdb
- Screenshots of the website and search tools
- Recent content expansions
- Other features and initiatives including the Guide to IMMUNOPHARMACOLOGY
This slide set updates the previous set from 2014/15 available at https://www.slideshare.net/GuidetoPHARM/iupharbps-guide-to-pharmacology-generic-slideset
Navigating links between structures and papers:
PubMed-to-PubChem connectivity between the IUPHAR/BPS Guide to PHARMACOLOGY and British Journal of Pharmacology
A poster presented at Pharmacology 2017, London, December 2017
A general poster about the IUPHAR/BPS Guide to PHARMACOLOGY, updated for 2017. This works well used as a handout or pinned on departmental noticeboards.
This document describes updates to the Guide to PHARMACOLOGY (GtoPdb) database in 2017, including new features such as:
1) Organization of drug targets into families and subclasses for easier browsing, and organization of ligands into related families and groups.
2) Ability to visualize ligand binding affinities across species through activity graphs.
3) SynPHARM database for finding ligand binding sequences that can be engineered into synthetic proteins.
4) Expanded content with over 1,700 drug targets, 9,000 ligands, and options to search or download data in various formats.
(First slide is recording of webinar). IUPHAR Web Resources, Simplifying Complexity for Medicine and Education. WDS Webinar#11 held on 28th February 2017.
IUPHAR (International Union of Basic and Clinical Pharmacology) has developed and is developing a series of web-based services for the Pharmacological Sciences, for education, and for drug discovery. These services enable the simplification and dissemination of highly complex datasets, via expert committees linked to ontologically-correct databases (e.g., the drug and receptor sites expressed by the human genome). This has also allowed IUPHAR—in connection with the main national pharmacological societies, particularly the British Pharmacological Society—to raise funds for curators and meetings. This simple model is open-ended and is being expanded to, for example, immunological targets and experimental protocols, and to educational projects.
Speakers: Michael Spedding, Adam Pawson, Steve Alexander, Joanna Sharman, Simon Harding, Jamie Davies, John Szarek and Lynn LeCount
Poster titled "The imperative of small, high quality data for underpinning big data: the IUPHAR/BPS Guide to PHARMACOLOGY". Presented by Dr. Christopher Southan, at the British Society of Pharmacology, Institute for Translational Medicine & Therapeutics (ITMAT) Meeting, Edinburgh, March 2017, ‘Big Data & the Development of New Medicines’.
إتصل على هذا الرقم اذا اردت الحصول على "حبوب الاجهاض الامارات" توصيلنا مجاني رقم الواتساب 00971547952044:
00971547952044. حبوب الإجهاض في دبي | أبوظبي | الشارقة | السطوة | سعر سايتوتك Cytotec يتميز دواء Cytotec (سايتوتك) بفعاليته في إجهاض الحمل. يمكن الحصول على حبوب الاجهاض الامارات بسهولة من خلال خدمات التوصيل السريع والدفع عند الاستلام. تُستخدم حبوب سايتوتك بشكل شائع لإنهاء الحمل غير المرغوب فيه. حبوب الاجهاض الامارات هي الخيار الأمثل لمن يبحث عن طريقة آمنة وفعالة للإجهاض المنزلي.
تتوفر حبوب الاجهاض الامارات بأسعار تنافسية، ويمكنك الحصول على خصم كبير عند الشراء الآن. حبوب الاجهاض الامارات معروفة بقدرتها الفعالة على إنهاء الحمل في الشهر الأول أو الثاني. إذا كنت تبحث عن حبوب لتنزيل الحمل في الشهر الثاني أو الأول، فإن حبوب الاجهاض الامارات هي الخيار المثالي.
دواء سايتوتك يحتوي على المادة الفعالة ميزوبروستول، التي تُستخدم لإجهاض الحمل والتخلص من النزيف ما بعد الولادة. يمكنك الآن الحصول على حبوب سايتوتك للبيع في دبي وأبوظبي والشارقة من خلال الاتصال برقم 00971547952044. نسعى لتقديم أفضل الخدمات في مجال حبوب الاجهاض الامارات، مع توفير حبوب سايتوتك الأصلية بأفضل الأسعار.
إذا كنت في دبي، أبوظبي، الشارقة أو العين، يمكنك الحصول على حبوب الاجهاض الامارات بسهولة وأمان. نحن نضمن لك وصول الحبوب الأصلية بسرية تامة مع خيار الدفع عند الاستلام. حبوب الاجهاض الامارات هي الحل الفعال لإنهاء الحمل غير المرغوب فيه بطريقة آمنة.
تبحث العديد من النساء في الإمارات العربية المتحدة عن حبوب الاجهاض الامارات كبديل للعمليات الجراحية التي تتطلب وقتاً طويلاً وتكلفة عالية. بفضل حبوب الاجهاض الامارات، يمكنك الآن إنهاء الحمل بسلام وأمان في منزلك. نحن نوفر حبوب الاجهاض الامارات الأصلية من إنتاج شركة فايزر، مما يضمن لك الحصول على منتج فعال وآمن.
إذا كنت تبحث عن حبوب الاجهاض الامارات في العين، دبي، أو أبوظبي، يمكنك التواصل معنا عبر الواتس آب أو الاتصال على رقم 00971547952044 للحصول على التفاصيل حول كيفية الشراء والتوصيل. حبوب الاجهاض الامارات متوفرة بأسعار تنافسية، مع تقديم خصومات كبيرة عند الشراء بالجملة.
حبوب الاجهاض الامارات هي الخيار الأمثل لمن تبحث عن وسيلة آمنة وسريعة لإنهاء الحمل غير المرغوب فيه. تواصل معنا اليوم للحصول على حبوب الاجهاض الامارات الأصلية وتجنب أي مشاكل أو مضاعفات صحية.
في النهاية، لا تقلق بشأن الحبوب المقلدة أو الخطرة، فنحن نوفر لك حبوب الاجهاض الامارات الأصلية بأفضل الأسعار وخدمة التوصيل السريع والآمن. اتصل بنا الآن على 00971547952044 لتأكيد طلبك والحصول على حبوب الاجهاض الامارات التي تحتاجها. نحن هنا لمساعدتك وتقديم الدعم اللازم لضمان حصولك على الحل المناسب لمشكلتك.
JAMES WEBB STUDY THE MASSIVE BLACK HOLE SEEDSSérgio Sacani
The pathway(s) to seeding the massive black holes (MBHs) that exist at the heart of galaxies in the present and distant Universe remains an unsolved problem. Here we categorise, describe and quantitatively discuss the formation pathways of both light and heavy seeds. We emphasise that the most recent computational models suggest that rather than a bimodal-like mass spectrum between light and heavy seeds with light at one end and heavy at the other that instead a continuum exists. Light seeds being more ubiquitous and the heavier seeds becoming less and less abundant due the rarer environmental conditions required for their formation. We therefore examine the different mechanisms that give rise to different seed mass spectrums. We show how and why the mechanisms that produce the heaviest seeds are also among the rarest events in the Universe and are hence extremely unlikely to be the seeds for the vast majority of the MBH population. We quantify, within the limits of the current large uncertainties in the seeding processes, the expected number densities of the seed mass spectrum. We argue that light seeds must be at least 103 to 105 times more numerous than heavy seeds to explain the MBH population as a whole. Based on our current understanding of the seed population this makes heavy seeds (Mseed > 103 M⊙) a significantly more likely pathway given that heavy seeds have an abundance pattern than is close to and likely in excess of 10−4 compared to light seeds. Finally, we examine the current state-of-the-art in numerical calculations and recent observations and plot a path forward for near-future advances in both domains.
Mechanics:- Simple and Compound PendulumPravinHudge1
a compound pendulum is a physical system with a more complex structure than a simple pendulum, incorporating its mass distribution and dimensions into its oscillatory motion around a fixed axis. Understanding its dynamics involves principles of rotational mechanics and the interplay between gravitational potential energy and kinetic energy. Compound pendulums are used in various scientific and engineering applications, such as seismology for measuring earthquakes, in clocks to maintain accurate timekeeping, and in mechanical systems to study oscillatory motion dynamics.
Order : Trombidiformes (Acarina) Class : Arachnida
Mites normally feed on the undersurface of the leaves but the symptoms are more easily seen on the uppersurface.
Tetranychids produce blotching (Spots) on the leaf-surface.
Tarsonemids and Eriophyids produce distortion (twist), puckering (Folds) or stunting (Short) of leaves.
Eriophyids produce distinct galls or blisters (fluid-filled sac in the outer layer)
SAP Unveils Generative AI Innovations at Annual Sapphire ConferenceCGB SOLUTIONS
At its annual SAP Sapphire conference, SAP introduced groundbreaking generative AI advancements and strategic partnerships, underscoring its commitment to revolutionizing business operations in the AI era. By integrating Business AI throughout its enterprise cloud portfolio, which supports the world's most critical processes, SAP is fostering a new wave of business insight and creativity.
Discovery of Merging Twin Quasars at z=6.05Sérgio Sacani
We report the discovery of two quasars at a redshift of z = 6.05 in the process of merging. They were
serendipitously discovered from the deep multiband imaging data collected by the Hyper Suprime-Cam (HSC)
Subaru Strategic Program survey. The quasars, HSC J121503.42−014858.7 (C1) and HSC J121503.55−014859.3
(C2), both have luminous (>1043 erg s−1
) Lyα emission with a clear broad component (full width at half
maximum >1000 km s−1
). The rest-frame ultraviolet (UV) absolute magnitudes are M1450 = − 23.106 ± 0.017
(C1) and −22.662 ± 0.024 (C2). Our crude estimates of the black hole masses provide log 8.1 0. ( ) M M BH = 3
in both sources. The two quasars are separated by 12 kpc in projected proper distance, bridged by a structure in the
rest-UV light suggesting that they are undergoing a merger. This pair is one of the most distant merging quasars
reported to date, providing crucial insight into galaxy and black hole build-up in the hierarchical structure
formation scenario. A companion paper will present the gas and dust properties captured by Atacama Large
Millimeter/submillimeter Array observations, which provide additional evidence for and detailed measurements of
the merger, and also demonstrate that the two sources are not gravitationally lensed images of a single quasar.
Unified Astronomy Thesaurus concepts: Double quasars (406); Quasars (1319); Reionization (1383); High-redshift
galaxies (734); Active galactic nuclei (16); Galaxy mergers (608); Supermassive black holes (1663)
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...Sérgio Sacani
Wereport the study of a huge optical intraday flare on 2021 November 12 at 2 a.m. UT in the blazar OJ287. In the binary black hole model, it is associated with an impact of the secondary black hole on the accretion disk of the primary. Our multifrequency observing campaign was set up to search for such a signature of the impact based on a prediction made 8 yr earlier. The first I-band results of the flare have already been reported by Kishore et al. (2024). Here we combine these data with our monitoring in the R-band. There is a big change in the R–I spectral index by 1.0 ±0.1 between the normal background and the flare, suggesting a new component of radiation. The polarization variation during the rise of the flare suggests the same. The limits on the source size place it most reasonably in the jet of the secondary BH. We then ask why we have not seen this phenomenon before. We show that OJ287 was never before observed with sufficient sensitivity on the night when the flare should have happened according to the binary model. We also study the probability that this flare is just an oversized example of intraday variability using the Krakow data set of intense monitoring between 2015 and 2023. We find that the occurrence of a flare of this size and rapidity is unlikely. In machine-readable Tables 1 and 2, we give the full orbit-linked historical light curve of OJ287 as well as the dense monitoring sample of Krakow.
The Limited Role of the Streaming Instability during Moon and Exomoon FormationSérgio Sacani
It is generally accepted that the Moon accreted from the disk formed by an impact between the proto-Earth and
impactor, but its details are highly debated. Some models suggest that a Mars-sized impactor formed a silicate
melt-rich (vapor-poor) disk around Earth, whereas other models suggest that a highly energetic impact produced a
silicate vapor-rich disk. Such a vapor-rich disk, however, may not be suitable for the Moon formation, because
moonlets, building blocks of the Moon, of 100 m–100 km in radius may experience strong gas drag and fall onto
Earth on a short timescale, failing to grow further. This problem may be avoided if large moonlets (?100 km)
form very quickly by streaming instability, which is a process to concentrate particles enough to cause gravitational
collapse and rapid formation of planetesimals or moonlets. Here, we investigate the effect of the streaming
instability in the Moon-forming disk for the first time and find that this instability can quickly form ∼100 km-sized
moonlets. However, these moonlets are not large enough to avoid strong drag, and they still fall onto Earth quickly.
This suggests that the vapor-rich disks may not form the large Moon, and therefore the models that produce vaporpoor disks are supported. This result is applicable to general impact-induced moon-forming disks, supporting the
previous suggestion that small planets (<1.6 R⊕) are good candidates to host large moons because their impactinduced disks would likely be vapor-poor. We find a limited role of streaming instability in satellite formation in an
impact-induced disk, whereas it plays a key role during planet formation.
Unified Astronomy Thesaurus concepts: Earth-moon system (436)
BIRDS DIVERSITY OF SOOTEA BISWANATH ASSAM.ppt.pptxgoluk9330
Ahota Beel, nestled in Sootea Biswanath Assam , is celebrated for its extraordinary diversity of bird species. This wetland sanctuary supports a myriad of avian residents and migrants alike. Visitors can admire the elegant flights of migratory species such as the Northern Pintail and Eurasian Wigeon, alongside resident birds including the Asian Openbill and Pheasant-tailed Jacana. With its tranquil scenery and varied habitats, Ahota Beel offers a perfect haven for birdwatchers to appreciate and study the vibrant birdlife that thrives in this natural refuge.
Signatures of wave erosion in Titan’s coastsSérgio Sacani
The shorelines of Titan’s hydrocarbon seas trace flooded erosional landforms such as river valleys; however, it isunclear whether coastal erosion has subsequently altered these shorelines. Spacecraft observations and theo-retical models suggest that wind may cause waves to form on Titan’s seas, potentially driving coastal erosion,but the observational evidence of waves is indirect, and the processes affecting shoreline evolution on Titanremain unknown. No widely accepted framework exists for using shoreline morphology to quantitatively dis-cern coastal erosion mechanisms, even on Earth, where the dominant mechanisms are known. We combinelandscape evolution models with measurements of shoreline shape on Earth to characterize how differentcoastal erosion mechanisms affect shoreline morphology. Applying this framework to Titan, we find that theshorelines of Titan’s seas are most consistent with flooded landscapes that subsequently have been eroded bywaves, rather than a uniform erosional process or no coastal erosion, particularly if wave growth saturates atfetch lengths of tens of kilometers.
1. Thank you to the BSI for supporting this poster:
GtoImmuPdb Portal
Aims
●
A unique access-point to
immunological data in
GtoPdb
●
An expert-curated
database containing
immunological
information
●
Develop new pages and
extend search mechanism
for immunological data
●
Assist in the identification
of novel therapeutic
targets
●
Assist in identifying
small-molecules for
experimental
investigation
S. D. Harding1
, E. Faccenda1
, S. Ireland1
, A. J. Pawson1
, J. L. Sharman1
, C. Southan1
, S. P. Alexander2
,
S. Anderton3
, C. Bryant4
, A. P. Davenport5
, C. Doerig6
, D. Fabbro7
, F. Levi-Schaffer8
, M. Spedding9
, J. A. Davies1
1Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UNITED KINGDOM, 2Life Sciences, University of Nottingham, Nottingham, UNITED KINGDOM,3MRC Centre for Inflammation Research, QMRI, University
of Edinburgh, Edinburgh, UNITED KINGDOM, 4
Veterinary Medicine, University of Cambridge, Cambridge, UNITED KINGDOM,5
Clinical Pharmacology Unit, University of Cambridge, Cambridge, UNITED KINGDOM, 6
Department of Microbiology, Monash
University, Clayton, AUSTRALIA, 7PIQUR Therapeutics AG, Basel, SWITZERLAND, 8School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, ISRAEL, 9Spedding Research Solutions SARL, Le Vesinet, FRANCE.
Introduction
Background
Immune/inflammatory/infection responses and disorders are a major focus of
pharmacological R&D. Chronic diseases, aspects of ageing and progress of infection all
have, or depend strongly on, an immune, or inflammatory, component. Being able to
modulate these more effectively with better drugs would be immensely valuable.
Development of these drugs will benefit from improved data exchange between the
immunology expert and pharmacology expert communities.
What is the Guide to IMMUNOPHARMACOLOGY
Our Wellcome Trust-funded project to produce the IUPHAR Guide to
IMMUNOPHARMACOLOGY (GtoImmuPdb) addresses this need by providing a new
portal to the existing IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb), that is both
'immunologist-friendly' for pharmacological information and 'pharmacologist-friendly'
for accessing immunological agents and targets. GtoImmuPdb will be a freely-available,
regularly updated and richly annotated resource. Curated by expert NC-IUPHAR*
sub-committees, including additional contributors with expertise in immunity,
inflammation and kinase biology.
GtoImmuPdb Data
The GtoP database has been enriched by tagging targets & ligands of
immunological relevance and by linking these to immunological processes, cell
types and relevant diseases.
Beta-version v2.0 available at:
www.guidetoimmunopharmacology.org
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an open access
resource providing overviews of key properties, background reading and
selective ligands of a wide range of biological targets.
The searchable database provides
quantitative information on drug
targets and the prescription medicines
and experimental drugs that act on
them. For ligands, data on approved
status, clinical use and mechanism of
action are included.
References
* International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug
Classification
1. Harding SD, et al. (2018) The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to
encompass the new Guide to IMMUNOPHARMACOLOGY. Nucl. Acids Res. PMID: 29149325
2. Cell Ontology, http://obofoundry.org/ontology/cl.html ontology.org
3. Gene Ontology Consortium, http://geneontology.org
Human targets in GtoPdb, 2017.5 release
Ligand classes in GtoPdb, 2017.5 release
The 2017.5 release (August 2017)
of the database contains over
15,200 curated interactions across
1,684 human targets and 8,978
ligands. More specifically, the
database contains 1,431 human
targets that have quantitative
interactions to a ligand.
Immuno Process and Cell Type Data
GtoImmuPdb presents a set of top-level immunological process and cell type
categories against which targets in the database can be annotated and which
form the basis of organising, navigating and searching for immunological
process and cell type associations.
Subsets of these ontologies are mapped to each top-level category. This then
forms the basis of searches which will detect any cell type or process
associations annotated with those terms (or their children).
Target detailed view pages
display process and cell
type associations
Including detailed curator
comments and links to
external references
As of 9 Oct 2017 the development GtoImmuPdb held 455 protein targets
and 816 ligands tagged as being of immunological relevance.
GtoImmuPdb uses both
Cell Ontology1
and Gene
Ontology2
terms as
controlled vocabularies
against which to
annotate. Displaying GtoImmuPdb data in detailed view of BTK
Immuno Cell Types
B cells
Dendritic cells
Granulocytes
Innate lymphoid cells
Macrophages & monocytes
Mast cells
Natural killer cells
Other T cells
T cells
Stromal cells
Immuno Processes
Antigen presentation
Barrier integrity
B cell (activation)
Cellular signalling
Chemotaxis & migration
Cytokine production & signalling
Immune regulation
Immune system development
Inflammation
T cell (activation)
Tissue repair
Targets Ligands
Cell types Processes
Disease
Target family pages use a toggle
to switch between GtoPdb &
GtoImmuPdb views
Ligand lists highlight
immuno relevant ligands
with new icons.
Here showing inhibitors
of BTK
IUPHAR Guide to
IMMUNOPHARMACOLOGY