26 ASBMB TODAY FEBRUARY 2021
Discovering an old DoGs’
new trick
Heterotrimeric G proteins regulate
a variety of signaling pathways that
control cell development and influ-
ence cell morphology via actin/cyto-
skeleton remodeling. There are four
main families of G proteins: Gi/Go,
Gq, Gs and G12/13. Researchers long
have thought that Gs, unlike its family
members, is coupled specifically and
exclusively to adenylyl cyclases.
In a new study published in the
Journal of Biological Chemistry,
Alejandro Castillo–Kauil of the
Center for Research and Advanced
Studies of the National Polytechnic
Institute and collaborators challenge
this dogmatic view by identifying a
new Gs target. Using biochemical,
molecular biological and chemo-
genetic approaches, the researchers
demonstrated that the Gαs subfamily
of G proteins can regulate the activity
of Rho GTPases such as Rho guanine
nucleotide exchange factor, or Rho-
GEF. The interaction identified by the
group activates the small G protein
Cdc42 by Gs-coupled GPCRs, stimu-
lating a rearrangement of the cyto-
skeleton and inducing formation of
fingerlike protrusions called filopodia.
These results provide new insight
into G protein activity and define a
new role for RhoGEF coupling in G
protein function.
DOI: 10.1074/jbc.AC120.015204
A pathogen’s proteins target
mitochondria
The tick-borne pathogen Coxiella
burnetii causes Q fever, or query fever,
a rare flulike disease that can spread
to humans who inhale dust particles
contaminated by infected farm or
CONTINUED FROM PAGE 25
Noninvasive tool provides oral cancer prognosis
Oral squamous cell carcinoma, which affects about 34,000 people
in the U.S. each year, is found in the cells lining the lips and mouth.
Metastasis to the lymph nodes is a sign of disease progression and may
be accompanied by changes in proteolytic activity. During proteolysis,
enzymes cut up proteins into short fragments called peptides. Recent
work suggests that characterizing the sequence and abundance of these
molecules — a method dubbed peptidomics — might provide new in-
sight on cancer biology and in the clinic. In a recent paper in the journal
Molecular & Cellular Proteomics, Leandro Xavier Neves of the Brazil-
ian Biosciences National Laboratory and a team of Brazilian clinicians
and scientists describe their analysis of oral squamous cell carcinoma
patient saliva using peptidomics.
After extracting peptides from saliva samples, the research team ana-
lyzed and compared the peptide content in samples from patients with
and without metastasis to the lymph nodes. They found more than 1,000
uniquely expressed peptides in each group and an additional 1,628 pep-
tides expressed by both groups. A series of statistical analyses identified
77 peptides of particular interest; all of these peptides are overexpressed
in samples from patients with lymph node metastasis, which supports the
hypothesis that proteolytic activity increases ...
Environmental Factor - July 2014_ Intramural papers of the month
The document summarizes 5 research papers from the National Institute of Environmental Health Sciences (NIEHS). It describes the key findings and conclusions from each paper which include: 1) NIEHS developed a 7-step framework for systematic reviews to address environmental health questions. 2) A study found that polymerase beta can complement aprataxin function during DNA repair. 3) Retinoic acid-related orphan receptor gamma regulates hepatic glucose metabolism and insulin sensitivity. 4) The INO80 complex maintains embryonic stem cell pluripotency and regulates blastocyst development. 5) A study characterized structural changes in HIV reverse transcriptase formation providing insights for new therapeutics.
1. The document discusses recent discoveries about genetic variations between human genomes and structural variants that can disrupt genes.
2. It describes how identifying these exact genetic sequences of variations can help researchers narrow their searches for disease-causing mutations and develop new treatment possibilities.
3. The continued investigation of protein coding in genes is important for developing new and effective medications, as well as methods for disease prevention and health promotion.
This document provides a summary of Douglas Ivey's expertise and qualifications. Ivey has extensive experience in molecular discovery, genetics, and biochemistry. He has a Ph.D. in Microbiology and Molecular Genetics and has worked on projects involving drug screening, vaccine development, and identifying genetic mutations and proteins in various organisms. Ivey has strong technical skills and is well-suited for leading high-value research projects.
Advances in cell biology: contribution to drug modern design
This document discusses how advances in cell biology have contributed to modern drug design. It outlines how understanding cell structures and functions through areas like proteomics, genomics, and studies of proteins, membranes, and nucleic acids has provided insights for identifying new drug targets. Characterizing proteins of interest like G protein-coupled receptors and enzymes has allowed designing drugs that interact with specific targets linked to various diseases.
The document discusses two studies related to protein synthesis and cancer. The first study developed a new method to selectively silence genes encoding proteins to determine their function in tumor cells. The second study identified the protein components responsible for inserting membrane proteins, resolving a mechanism that was previously unknown. Understanding protein functions and interactions is important for gaining insights into the origins of cancer and developing prevention and treatment strategies.
This document provides an overview of proteomics. It discusses the goals of proteomics including global protein analysis, expression, function, and biomarker discovery. It covers different types of proteomics like expression, structural, and functional proteomics. Methods for protein measurement like mass spectrometry and 2D gel electrophoresis are described. The document discusses clinical applications of proteomics in areas like cancer, infectious diseases, CNS disorders and cardiovascular disease. It also touches on challenges like target discovery and costs, as well as future perspectives and conclusions on the potential of proteomics.
This document discusses genetic polymorphisms and summarizes several research articles. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes a study that used a cross-species strategy to identify genes involved in Alzheimer's disease by comparing human and fly genomes. Another section summarizes findings from a study linking certain genes to membranous nephritis. Specifically, it discusses the association between this disease and the PLA2R receptor gene. The document concludes by discussing the medical utility of these findings, such as enabling early diagnosis and treatment.
This document discusses genetic polymorphisms and summarizes several articles on related topics. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes findings from articles on using cross-species strategies to study human disease like Alzheimer's, identifying genes linked to membranous nephritis and autoantibodies, and discusses the medical utility of early diagnosis and improved treatment from genetic studies.
This document discusses how normalization methods for gene expression measurements that assume equal cellular RNA content across experimental conditions can mask differences in total RNA yield per cell. The authors demonstrate that total RNA yield from Chinese Hamster Ovary (CHO) cells varies between experimental treatments and cell lines expressing recombinant proteins. They apply a normalization method using synthetic spike-in RNA standards added proportionally to cell number, which reveals differences in cellular RNA content and allows detection of global transcriptional amplification or repression. They use this method to assess gene expression in CHO cell lines of different sizes treated with cell cycle or mTOR inhibitors, or subjected to high osmolarity conditions. They find that a cell cycle inhibitor increases cell size and transcriptional amplification, an mTOR inhibitor causes
This document provides information about the 6th International Conference on Healthcare, Nursing and Disease Management that was held from October 21-22, 2016 in Hong Kong. It includes the conference proceedings, venue information, and 4 abstracts from presentations on various health-related topics such as heart rate variability in females with dysmenorrhea, modulation of encapsulated macrophage behavior in hydrogels, experiences of mothers using infant formula milk in Hong Kong, exploring family-centered care for children living with HIV/AIDS in Nigeria, and conceptualizing the destination image in travel decision making of international patients.
Environmental Factor - July 2014_ Intramural papers of the monthXunhai 郑训海
The document summarizes 5 research papers from the National Institute of Environmental Health Sciences (NIEHS). It describes the key findings and conclusions from each paper which include: 1) NIEHS developed a 7-step framework for systematic reviews to address environmental health questions. 2) A study found that polymerase beta can complement aprataxin function during DNA repair. 3) Retinoic acid-related orphan receptor gamma regulates hepatic glucose metabolism and insulin sensitivity. 4) The INO80 complex maintains embryonic stem cell pluripotency and regulates blastocyst development. 5) A study characterized structural changes in HIV reverse transcriptase formation providing insights for new therapeutics.
1. The document discusses recent discoveries about genetic variations between human genomes and structural variants that can disrupt genes.
2. It describes how identifying these exact genetic sequences of variations can help researchers narrow their searches for disease-causing mutations and develop new treatment possibilities.
3. The continued investigation of protein coding in genes is important for developing new and effective medications, as well as methods for disease prevention and health promotion.
This document provides a summary of Douglas Ivey's expertise and qualifications. Ivey has extensive experience in molecular discovery, genetics, and biochemistry. He has a Ph.D. in Microbiology and Molecular Genetics and has worked on projects involving drug screening, vaccine development, and identifying genetic mutations and proteins in various organisms. Ivey has strong technical skills and is well-suited for leading high-value research projects.
Advances in cell biology: contribution to drug modern designEsayas Ayele
This document discusses how advances in cell biology have contributed to modern drug design. It outlines how understanding cell structures and functions through areas like proteomics, genomics, and studies of proteins, membranes, and nucleic acids has provided insights for identifying new drug targets. Characterizing proteins of interest like G protein-coupled receptors and enzymes has allowed designing drugs that interact with specific targets linked to various diseases.
The document discusses two studies related to protein synthesis and cancer. The first study developed a new method to selectively silence genes encoding proteins to determine their function in tumor cells. The second study identified the protein components responsible for inserting membrane proteins, resolving a mechanism that was previously unknown. Understanding protein functions and interactions is important for gaining insights into the origins of cancer and developing prevention and treatment strategies.
This document provides an overview of proteomics. It discusses the goals of proteomics including global protein analysis, expression, function, and biomarker discovery. It covers different types of proteomics like expression, structural, and functional proteomics. Methods for protein measurement like mass spectrometry and 2D gel electrophoresis are described. The document discusses clinical applications of proteomics in areas like cancer, infectious diseases, CNS disorders and cardiovascular disease. It also touches on challenges like target discovery and costs, as well as future perspectives and conclusions on the potential of proteomics.
This document discusses genetic polymorphisms and summarizes several research articles. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes a study that used a cross-species strategy to identify genes involved in Alzheimer's disease by comparing human and fly genomes. Another section summarizes findings from a study linking certain genes to membranous nephritis. Specifically, it discusses the association between this disease and the PLA2R receptor gene. The document concludes by discussing the medical utility of these findings, such as enabling early diagnosis and treatment.
This document discusses genetic polymorphisms and summarizes several articles on related topics. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes findings from articles on using cross-species strategies to study human disease like Alzheimer's, identifying genes linked to membranous nephritis and autoantibodies, and discusses the medical utility of early diagnosis and improved treatment from genetic studies.
This document discusses genetic polymorphisms and summarizes several research studies. It begins by defining genetic polymorphisms as variations in regulatory DNA. It then summarizes three key points:
1) A study that used a cross-species strategy to identify 6 causal genes for Alzheimer's disease by studying interactions between human genes and neurotoxicity in the fly model.
2) Research confirming the association between a genetic variant in the PLA2R gene and membranous nephropathy through genome-wide association studies and previous Asian studies.
3) The potential medical benefits of these discoveries such as earlier diagnosis, improved treatment, and further genetic research.
This document discusses genetic engineering of humans through various methods such as germline genetic modification and somatic genetic modification. It notes both the promising applications for improving health through gene therapy but also the ethical concerns regarding enhancing traits and the possibility of genetic inequality. Specific examples discussed include using CRISPR to genetically modify human embryos to potentially treat disease as well as concerns about "designer babies". The document examines issues around testing for non-disease traits, gene doping in athletes, and the potential benefits and risks of human gene editing technologies.
“I think the biggest innovations of the 21st century will be at the intersection of biology and technology. A new era is beginning.” — Steve Jobs
While analyzing the effects of radio frequency heating on hypothermia in the year 1941, Canadian electrical engineer John Hopps read that if the heart stops beating due to an acute drop in temperature, it could successfully be brought back to life artificially using mechanical or electrical stimulation.
Key achievements in cancer research at Cold Spring Harbor Laboratory: May 201...cshlnews
May is National Cancer Research Month. In recognition, here's a glimpse of key achievements in cancer research over the last 12 months (May 2010 - May 2011) at Cold Spring Harbor Laboratory, which has been an NCI-designated Cancer Center since 1987.
This document describes the development and validation of a new LC/MS/MS method for quantifying four gangliosides (GM2, GM3, GD2, and GD3) in human plasma. Gangliosides are glycosphingolipids that play important roles in neurological function and disease. The method uses protein precipitation for sample extraction, UPLC separation, and MS/MS detection in MRM mode for high sensitivity and specificity. Product ion mass spectra were obtained for the gangliosides to select optimal MRM transitions for quantification. The method was validated for extraction recovery, calibration linearity, precision, and accuracy. This sensitive assay can be used to monitor ganglioside levels in plasma from normal and
This document summarizes a study that identified genes in the extracellular matrix that regulate the susceptibility of cultured cells to prion infection. The study compared gene expression in prion-susceptible and resistant cell lines. They identified 9 genes, including fibronectin 1 and integrin α8, that were upregulated in resistant cells. Knockdown of these genes increased susceptibility by altering the extracellular matrix structure and deposition of prion proteins. The results suggest the extracellular matrix plays a key role in controlling prion infection by influencing how prion proteins interact and convert forms.
1) Researchers have discovered a new genetic test using mitochondrial genes that can more accurately predict cancer recurrence than current methods. The test analyzes over 400 mitochondrial genes and certain genes were found to predict recurrence up to 5 times higher.
2) Genetics provides an understanding of the biological composition of humans and pathological processes. It involves studying gene mapping, inheritance of diseases, and molecular mechanisms of how genes cause disorders. This knowledge aids in diagnosis and treatment.
3) A study used genome editing to block a gene, OCT4, that is important for early human embryo development. This revealed the gene is necessary for proper formation of the blastocyst. Understanding key genes needed for embryo development could improve IVF treatments and shed
Pharmacogenomics is the study of how genes affect individual responses to drugs. It combines pharmacology and genomics to develop safe and effective personalized medications and dosages based on a person's genetic makeup. The goal is to improve treatment outcomes by predicting drug effectiveness and reducing adverse reactions. Challenges include implementing genetic tests in clinical practice and addressing cost, ethical and legal issues. Future applications include developing tailored drugs for many diseases and faster, more targeted clinical trials through biomarkers.
Similar to 26 ASBMB TODAY FEBRUARY 2021Discovering an old DoGs’ ne (20)
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Your supervisor, Sophia, Ballot Online director of information technology, has tasked you with creating a presentation that will convince the executives that using cloud-based computing to accommodate Ballot Online future growth rather than trying to expand the current infrastructure will help the company do business faster and at lower cost while conserving IT resources.
Question:
Create a high-level proposal for a compliance program for Ballot Online that enables the organization and its employees to conduct itself in a manner that is in compliance with legal and regulatory requirements.
The proposal will be one to two pages in length and should take the form of a high-level outline or flowchart showing the different components and relationships among the components.
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Please add references
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Your selected IEP. (Rudy)
Descriptions of appropriate instructional and assessment accommodations for the exceptional student based on their needs as described in the IEP.
You will need to list and describe the appropriate assessment tools and accommodations.
You will also need to describe how the lesson can be modified for other learners with varying reading deficiencies.
Rudy IEP
Current Grade: 2
Present Levels of Educational Performance
• Ruby is in good health with no known physical performance issues, and she socializes well with her peers.
• Ruby performs at grade level in all subjects except reading.
• Ruby can identify all letters of the alphabet and knows the sound of most consonants and short vowels.
• Her sight vocabulary is approximately 65 to 70 words, and she reads on the primer level.
• Ruby can spell most words in a first-grade textbook, but has difficulty with words in the second-grade textbook.
Annual Goals
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Person Responsible: Resource Teacher
2. By the end of the school year, Ruby will increase her sight word vocabulary to 150 words.
Person Responsible: Resource Teacher
3. By the end of the school year, Ruby will read and spell at least 75% of the second-grade spelling words.
Person Responsible: Second-Grade Teacher
Amount of Participation in General Education
• Ruby will participate in all second-grade classes and activities except for reading.
Special Education and Related Services
• Ruby will receive individualized and/or small-group instruction in reading from the Resource Teacher for 30 minutes each day.
.
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Contains unread posts
(Clipart from MS Office)
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In this chapter, Collins begins the process of identifying and further developing from the research those unique factors and variables that differentiated the good and great companies. One of the most significant differences, he asserts, is the quality and nature of leadership in the firm. Collins initially told the research team to downplay the role of top executives in the good-to-great process. It became obvious that there was something different that these leaders did. Collins went on to identify "Level 5 leadership" as a common characteristic of the great companies assessed in the study. By further studying the behaviors and attitudes of so-called Level 5 leaders, Collins found that many of those classified in this group displayed an unusual mix of intense determination and profound humility. Characteristics used to describe these leaders included words like quiet, humble, modest, gracious, and understated. Yet there was also the stoic resolve and an unwavering determination evident. They were low-key executives, rarely appearing in the media, who demonstrated a relentless drive for results. These leaders often had a long-term personal sense of investment in the company and its success, often cultivated through a career-spanning climb up the company’s ranks. The personal ego and individual financial gain were not as important as the long-term benefit of the team and the company. As such, Collins warned of the liability involved in employing a bigger-than-life charismatic leader —personalities often brought in from outside the company or organization by a board seeking a high profile figure. The data suggested that a celebrity CEO brought in to turn around a flailing firm was usually not conducive to fostering the transition from
Good to Great
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Why is this important?
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1200 words.
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name of organization;
introduction of DMP;
need of such program;
benefits of the program;
potential challenges (may include potential problems that may incur without such program);
justification of the important aspects of employee behavior and the relationship to employee motivation;
one inclusion of a motivation theory;
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Young consumers’ insights on brand equity
Effects of brand loyalty, brand awareness, and brand image
1
CONTENTS
INTRODUCTION
LITERATURE REVIEW
METHODOLOGY
2
- Data set development
- Customer expectation
--Brand recognition
--The quality of the brand is guaranteed
- Advantage of Brand effect
-- Increase market share
--Increase of competitive advantage
Research Background
- Data set development
- Customer expectation
--Brand recognition
--The quality of the brand is guaranteed
- Advantage of Brand effect
-- Increase market share
--Increase of competitive advantage
Research Background
3
Research problem
-Limited research
-Different research perspectives
-The impact factor of brand equity
Research objectives
The purpose of this study is to measure the relationship between brand loyalty, brand awareness and brand image and brand equity of young consumers.
Aaker (1991) Model theory was incorporated into the relevant research system
Identify the relationship between brand equity and brand loyalty, brand awareness and brand image
The research scope of brand effect has been expanded
Provide guidance for enterprises to design effective strategies
Significant of study
Contribution
Scope of study
Master students are the main research objects, and the research scope is to investigate Chinese master students.
THEORETICAL FRAMEWORK
The conclusion of this paper is based on the principle of Aaker (1991) model.
It can be said that customers' attitude towards brands has an important impact on brand assets (Choi, Parsa, Sigala, & Putrevu, 2009).
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LITERATURE REVIEW
Brand loyalty
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Brand awareness
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LITERATURE REVIEW
Brand image
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Reference
Darley, J.M. & Latané, B. (1968). Bystander interview in emergencies: Diffusion of responsibility. Journal of Personality and Social Psychology, 8(4), 377-383.
To Prepare:
Review the following:
Scenario: Culture, Psychology, and Community
Imagine an international organization has approached you to help resolve an inter-group conflict. You are an authority in cross-cultural psychology and have been asked to serve as a consultant based on a recent violent conflict involving a refugee community in your town and a local community organization. In the days, weeks, and months leading up to the violent conflict, there were incidents of discrimination and debates regarding the different views and practices people held about work, family, schools, and religious practice. Among the controversies has been the role of women’s participation in political, educational, and community groups.
(6 pages excluding title page and reference page)
:
Part 1: Developing an Understanding
(2 pages)
Based on the scenario, explain how you can help integrate the two diverse communities so that there is increased understanding and appreciation of each group by the other group. (
Note
: Make sure to include in your explanation the different views and practices of cultural groups as well as the role of women.)
Based on your knowledge of culture and psychology, provide three possible suggestions/solutions that will help the community as a whole. In your suggestions make sure to include an explanation regarding group think and individualism vs. collectivism.
Part 2: Socio-Emotional, Cognitive, and Behavioral Aspects
(2 pages)
Based on your explanations in Part 1, how do your suggestions/solutions impact the socio-emotional, cognitive, and behavior aspects of the scenario and why?
Part 3: Gender, Cultural Values and Dimensions, and Group Dynamics
(2 pages)
Explain the impact of gender, cultural values and dimensions, and group dynamics in the scenario.
Further explain any implications that may arise from when working between and within groups.
Support your Assignment by citing all resources in APA
Learning Resources
Required Readings
Ahmed, R., & Gielen, U. (2017). Women in Egypt. In C. M. Brown, U. P. Gielen, J. L. Gibbons, & J. Kuriansky (Eds.), Women's evolving lives: Global and psychosocial perspectives (pp. 91–116). New York, NY: Springer.
Credit Line: Women's Evolving Lives: Global and Psychosocial Perspectives, by Brown, C.; Gielen, U.; Gibbons, J.; Kuriansky, J. (eds). Copyright 2017 by Springer International Publishing. Reprinted by permission of Springer International Publishing via the Copyright Clearance .
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The student will conduct a history and assessment of a head, ear, or eye problem provided by their instructor or from their own experience. They will document their findings, identify any actual or potential risks, and submit a Word document with this information to an assignment drop box. The assignment is due based on the course calendar dates.
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Management
Richard L. Daft
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Cover Pagecover
Title Pagei
HEOA-1HEOA-1
Copyright Pageii
Dedication Pageiii
About the Authorv
Brief Contentsvii
Contentsvix
Prefacexv
Chapter 1: Leading Edge Management2
Chapter 2: The Evolution of Management Thinking38
Chapter 3: The Environment and Corporate Culture74
Chapter 4: Managing in a Global Environment110
Chapter 5: Managing Ethics and Social Responsibility144
Chapter 6: Managing Start-Ups and New Ventures180
Chapter 7: Planning and Goal Setting216
Chapter 8: Strategy Formulation and Execution248
Chapter 9: Managerial Decision Making284
Chapter 10: Designing Organization Structure324
Chapter 11: Managing Innovation and Change370
Chapter 12: Managing Human Talent406
Chapter 13: Managing Diversity and Inclusion446
Chapter 14: Understanding Individual Behavior484
Chapter 15: Leadership528
Chapter 16: Motivating Employees570
Chapter 17: Managing Communication608
Chapter 18: Leading Teams648
Chapter 19: Managing Quality and Performance688
Appendix: Operations Management and E-Commerce721
Name Index741
Company Index756
Subject Index761
Open/Close Margin
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Quality tools, methods paper
In the assigned textbook (chapter 15 p. 269), the authors present a table describing how the used the model for improvement, PDSA, and lean six sigma as a tool to develop their organization’s plan for improvement.
Studying the situation in your organization, present a suggested improvement plan (present a table similar to the one in p.269 + two pages explanation) utilizing one or more of the models discussed in the class (see chapter 2).
Grading rubric:
1. Quality of the table: at last, one of the quality models/tools should be applied correctly
2. Adequate explanation is given to support and explain the table
3. General organization of the assignment. Correct grammar and spelling are used
Note:
Suggested improvement plan is:
Decreased number of urinary catheter infections.
.
You will act as a critic for some of the main subjects covered i.docxMargaritoWhitt221
You will act as a critic for some of the main subjects covered in the humanities. You will conduct a series of short, evaluative critiques of film, philosophy, literature, music, and myth. You will respond to five different prompts, and each response should include an analysis of the topics using terminology unique to that subject area and should include an evaluation as to why the topic stands the test of time. The five prompts are as follows:
1:
Choose a film and offer an analysis of why it is an important film, and discuss it in terms of film as art. Your response should be more than a summary of the film.
2:
Imagine you had known Plato and Aristotle and you had a conversation about how we
fall in love
. Provide an overview of how Plato would explain falling in love, and then provide an overview of how Aristotle might explain falling in love.
3:
Compare and contrast the two poems below:
LOVE’S INCONSISTENCY
I find no peace, and all my war is done;
I fear and hope, I burn and freeze likewise
I fly above the wind, yet cannot rise;
And nought I have, yet all the world I seize on;
That looseth, nor locketh, holdeth me in prison, And holds me not, yet can I ’scape no wise;
Nor lets me live, nor die, at my devise,
And yet of death it giveth none occasion.
Without eyes I see, and without tongue I plain;
I wish to perish, yet I ask for health;
I love another, and yet I hate myself;
I feed in sorrow, and laugh in all my pain;
Lo, thus displeaseth me both death and life,
And my delight is causer of my grief.
Petrarch
After great pain a formal feeling comes—
The nerves sit ceremonious like tombs;
The stiff Heart questions—was it He that bore?
And yesterday—or centuries before?
The feet mechanical go round
A wooden way
Of ground or air or ought
Regardless grown,
A quartz contentment like a stone.
This is the hour of lead
Remembered if outlived
As freezing persons recollect
The snow—
First chill, then stupor, then
The letting go
Emily Dickinson
4:
Compare and contrast these two pieces of music: see files attached below
Beethoven’s Violin Romance No. 2
Scott Joplin’s Maple Leaf Rag
5:
Explain in classical terms why a modern character is a hero. Choose from either Luke Skywalker, Indiana Jones, Bilbo Baggins, Harry Potter, Katniss Everdeen, or Ender Wiggins.
.
You will research and prepare a presentation about image. Your rese.docxMargaritoWhitt221
You will research and prepare a presentation about image. Your research / presentation should provide the following information / answers:
What is raster image? List two (2) common types of raster image.
What is a vector image? List two (2) common types of vector image.
Create a table listing pros and cons comparing raster vs. vector images. You should present at list three (3) pros and three (3) cons for each type of image.
Show one (1) good and (1) bad example of raster image. Explain why it is a good and bad example.
Show two (2) examples of vector images.
What is the difference between ppi and dpi?
Which are the common resolution used for: website, plotter, banner and social media. Why do we use different resolution for each type of media?
How you identify the real size of an image using resolution and pixels?
.
You will be asked to respond to five different scenarios. Answer eac.docxMargaritoWhitt221
You will be asked to respond to five different scenarios. Answer each scenario (about 1 page per scenario). You will need to:
Decide what action the responding officer should take and provide an explanation/justification for your response.
In your explanation, explain the role that discretion played in your decision. Choose at least five factors from the list below to include in your explanation.
When considering your response for each scenario, remember that because of the nature of law enforcement work, police officers have always maintained a certain amount of discretion. Due to the amount of interaction that officers have with members of the public, this discretion must be fair, equal, impartial, and legal. As such, the use of discretion by officers is both a foundation of police work and a component of community policing.
Note
: You may make any and all assumptions necessary to answer these scenarios as long as they do not conflict with the details provided.
FACTORS (CHOOSE AT LEAST 5 FOR EACH SCENARIO):
Environmental factors
Nature of the community.
Socio-demographic characteristics.
Level and type of crime in the community.
Police/Community relations.
Organizational factors
Department Rules and Regulations.
Policies and Procedures.
Department bureaucracy.
Officer experience.
Dimensions of policing: philosophical; strategic; tactical; organizational.
Situational factors
Seriousness of crime.
Weapon involvement.
Victim – Desire to prosecute.
Group/gang crime.
Suspect’s demeanor.
Age/gender/race of involved parties.
Suspect’s criminal record.
Ethics
Moral values.
Cultural/Societal norms.
Accountability.
Friends/Family/Coworkers.
Experience/Upbringing.
Legal
Laws.
Past practice.
Evidence.
Victim signatures.
Landmark Supreme Court cases.
Scenario 1:
Officer Merced responds to a call of a Theft in Progress. Upon arrival, he finds that an 18-year-old female has stolen baby formula and diapers by exiting the store without paying. He speaks with her and finds that she has a newborn baby, does not have any source of income, and needed the formula and diapers for the baby. As such, theft is still a crime. What should Officer Merced do?
Do you arrest the woman or not? What factors influenced your decision?
Provide an explanation/justification for your chosen response including the role that discretion played in your decision.
Be sure to consider at least five of the provided factors in your explanation.
Use evidence and details from the scenario as well as supporting information and examples from the text in your response.
Scenario 2:
Dane is in an electronics store where he and a couple of friends are searching for a potential gift to give to a friend. They are happy to find a video game that is on sale but decide to continue looking around the store. They decide to go grab a bite to eat before making a final decision on what to get for their friend. As they are walking .
You might find that using analysis tools to analyze internal .docxMargaritoWhitt221
You might find that using analysis tools to analyze internal
and external environments is an effective way of analyzing the
chosen capstone organization. If you need to learn more
about these types of analysis tools, check out the resources
below.
Internal Analysis Tools
• tutor2u. (2016). PESTLE (PEST) analysis
explained [Video]. YouTube. https://www.youtube.com/
watch?v=sP2sDw5waEU
• SmartDraw. (n.d.). SWOT analysis. https://
www.smartdraw.com/swot-analysis/
• SWOT Framework.
External Analysis Tools
• Applying VRIO and PESTLE.
• PESTLE Analysis. (n.d.). What is PESTLE analysis? A
tool for business analysis. http://pestleanalysis.com/what-
is-pestle-analysis/
• Study.com. (n.d.). What is PESTLE analysis? Definition
and examples. https://study.com/academy/lesson/what-
is-pestle-analysis-definition-examples.html
• Management & Finance1 TU Delft. (2016). The five
competitive forces that shape strategy [Video]. YouTube.
https://www.youtube.com/watch?v=mYF2_FBCvXw
Use these resources as you see appropriate:
• Research Guide – MBA
https://www.youtube.com/watch?v=sP2sDw5waEU
https://www.youtube.com/watch?v=sP2sDw5waEU
https://www.youtube.com/watch?v=sP2sDw5waEU
https://www.smartdraw.com/swot-analysis/
http://media.capella.edu/CourseMedia/MBA5006/GuidedPath/SWOTFramework/wrapper.asp
http://media.capella.edu/CourseMedia/MBA5006/GuidedPath/ApplyVRIOandPESTLE/wrapper.asp
http://pestleanalysis.com/what-is-pestle-analysis/
http://pestleanalysis.com/what-is-pestle-analysis/
https://study.com/academy/lesson/what-is-pestle-analysis-definition-examples.html
https://study.com/academy/lesson/what-is-pestle-analysis-definition-examples.html
https://www.youtube.com/watch?v=mYF2_FBCvXw
https://www.youtube.com/watch?v=mYF2_FBCvXw
https://www.youtube.com/watch?v=mYF2_FBCvXw
https://capellauniversity.libguides.com/MBA
• This research guide was custom created to help
MBA learners. If you are feeling a bit lost on where
to start, this would be a good starting point.
• James, N. (2007). Writing at work: How to write clearly,
effectively and professionally. Crows Nest, Australia:
Allen & Unwin.
• Use this as a general writing handbook. For
example, there are chapters on tone, grammar,
punctuation, style, et cetera.
https://capella.skillport.com/skillportfe/custom/login/saml/login.action?courseaction=launch&assetid=_ss_book:25059
https://capella.skillport.com/skillportfe/custom/login/saml/login.action?courseaction=launch&assetid=_ss_book:25059
1
MBA Capstone Project Description
MBA Capstone Project Description
Throughout your MBA program, you have worked to develop as a business professional and
prepare to meet future challenges as a business leader. Your program culminates in the
capstone project, which forms the primary focus of MBA-FPX5910, the final course you will take
in the program. The capstone project is intended to provide you the opportunity to demonstrate
your MBA program outcomes by:
• Planning and executing .
You will conduct a professional interview with a staff nurse and a s.docxMargaritoWhitt221
You will conduct a professional interview with a staff nurse and a staff nurse leader to discover their intra/inter-professional communications styles. It will be important to incorporate learning objectives regarding therapeutic communication styles including their method of caring, assertive, and responsible communication in your discussion/analysis of the interview.
.
You have chosen the topic of Computer Forensics for your researc.docxMargaritoWhitt221
This document provides instructions for a research project on computer forensics. The research project must include an abstract, introduction, section on computer forensics, and conclusion. It must be 500 words with in-text citations and 4 references.
1.Describe some of the landmark Supreme Court decisions that h.docxMargaritoWhitt221
1.
Describe some of the landmark Supreme Court decisions that have influenced present-day juvenile justice procedures.
2.
How are children processed by the juvenile justice system from arrest to reentry into society?
3.
Discuss the key issues of the preadjudicatory stage of juvenile justice including detention, intake, diversion, pretrial release, plea bargaining and waiver.
Textbook for the class
Siegel, Welsh, and Senna.
(2014).
Juvenile Delinquency: Theory, Practice, and Law
(12). Cengage Learning. [ISBN-978-1-285-45840-3]
Format:
should be thoroughly researched and reported. References and sources should be listed in MLA or APA format. The average length paper is two to three pages. You may interview individuals currently employed or retired from the criminal justice system and use them as a reference. All writing assignments must be original work for this course. Do not submit a paper used in another course. Do not cut and paste paragraphs of information into your paper. All source material should be paraphrased in your own words. Short quotations are allowed.
this paper wil be scanned through turntin
.
Split Shifts From Gantt View in the Odoo 17Celine George
Odoo allows users to split long shifts into multiple segments directly from the Gantt view.Each segment retains details of the original shift, such as employee assignment, start time, end time, and specific tasks or descriptions.
Ardra Nakshatra (आर्द्रा): Understanding its Effects and RemediesAstro Pathshala
Ardra Nakshatra, the sixth Nakshatra in Vedic astrology, spans from 6°40' to 20° in the Gemini zodiac sign. Governed by Rahu, the north lunar node, Ardra translates to "the moist one" or "the star of sorrow." Symbolized by a teardrop, it represents the transformational power of storms, bringing both destruction and renewal.
About Astro Pathshala
Astro Pathshala is a renowned astrology institute offering comprehensive astrology courses and personalized astrological consultations for over 20 years. Founded by Gurudev Sunil Vashist ji, Astro Pathshala has been a beacon of knowledge and guidance in the field of Vedic astrology. With a team of experienced astrologers, the institute provides in-depth courses that cover various aspects of astrology, including Nakshatras, planetary influences, and remedies. Whether you are a beginner seeking to learn astrology or someone looking for expert astrological advice, Astro Pathshala is dedicated to helping you navigate life's challenges and unlock your full potential through the ancient wisdom of Vedic astrology.
For more information about their courses and consultations, visit Astro Pathshala.
Delegation Inheritance in Odoo 17 and Its Use CasesCeline George
There are 3 types of inheritance in odoo Classical, Extension, and Delegation. Delegation inheritance is used to sink other models to our custom model. And there is no change in the views. This slide will discuss delegation inheritance and its use cases in odoo 17.
How to Handle the Separate Discount Account on Invoice in Odoo 17Celine George
In Odoo, separate discount account can be set up to accurately track and manage discounts applied on various transaction and ensure precise financial reporting and analysis
How to Store Data on the Odoo 17 WebsiteCeline George
Here we are going to discuss how to store data in Odoo 17 Website.
It includes defining a model with few fields in it. Add demo data into the model using data directory. Also using a controller, pass the values into the template while rendering it and display the values in the website.
The Jewish Trinity : Sabbath,Shekinah and Sanctuary 4.pdfJackieSparrow3
we may assume that God created the cosmos to be his great temple, in which he rested after his creative work. Nevertheless, his special revelatory presence did not fill the entire earth yet, since it was his intention that his human vice-regent, whom he installed in the garden sanctuary, would extend worldwide the boundaries of that sanctuary and of God’s presence. Adam, of course, disobeyed this mandate, so that humanity no longer enjoyed God’s presence in the little localized garden. Consequently, the entire earth became infected with sin and idolatry in a way it had not been previously before the fall, while yet in its still imperfect newly created state. Therefore, the various expressions about God being unable to inhabit earthly structures are best understood, at least in part, by realizing that the old order and sanctuary have been tainted with sin and must be cleansed and recreated before God’s Shekinah presence, formerly limited to heaven and the holy of holies, can dwell universally throughout creation
Join educators from the US and worldwide at this year’s conference, themed “Strategies for Proficiency & Acquisition,” to learn from top experts in world language teaching.
How to Configure Time Off Types in Odoo 17Celine George
Now we can take look into how to configure time off types in odoo 17 through this slide. Time-off types are used to grant or request different types of leave. Only then the authorities will have a clear view or a clear understanding of what kind of leave the employee is taking.
AI Risk Management: ISO/IEC 42001, the EU AI Act, and ISO/IEC 23894PECB
As artificial intelligence continues to evolve, understanding the complexities and regulations regarding AI risk management is more crucial than ever.
Amongst others, the webinar covers:
• ISO/IEC 42001 standard, which provides guidelines for establishing, implementing, maintaining, and continually improving AI management systems within organizations
• insights into the European Union's landmark legislative proposal aimed at regulating AI
• framework and methodologies prescribed by ISO/IEC 23894 for identifying, assessing, and mitigating risks associated with AI systems
Presenters:
Miriama Podskubova - Attorney at Law
Miriama is a seasoned lawyer with over a decade of experience. She specializes in commercial law, focusing on transactions, venture capital investments, IT, digital law, and cybersecurity, areas she was drawn to through her legal practice. Alongside preparing contract and project documentation, she ensures the correct interpretation and application of European legal regulations in these fields. Beyond client projects, she frequently speaks at conferences on cybersecurity, online privacy protection, and the increasingly pertinent topic of AI regulation. As a registered advocate of Slovak bar, certified data privacy professional in the European Union (CIPP/e) and a member of the international association ELA, she helps both tech-focused startups and entrepreneurs, as well as international chains, to properly set up their business operations.
Callum Wright - Founder and Lead Consultant Founder and Lead Consultant
Callum Wright is a seasoned cybersecurity, privacy and AI governance expert. With over a decade of experience, he has dedicated his career to protecting digital assets, ensuring data privacy, and establishing ethical AI governance frameworks. His diverse background includes significant roles in security architecture, AI governance, risk consulting, and privacy management across various industries, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: June 26, 2024
Tags: ISO/IEC 42001, Artificial Intelligence, EU AI Act, ISO/IEC 23894
-------------------------------------------------------------------------------
Find out more about ISO training and certification services
Training: ISO/IEC 42001 Artificial Intelligence Management System - EN | PECB
Webinars: https://pecb.com/webinars
Article: https://pecb.com/article
-------------------------------------------------------------------------------
CHUYÊN ĐỀ DẠY THÊM TIẾNG ANH LỚP 12 - GLOBAL SUCCESS - FORM MỚI 2025 - HK1 (C...
26 ASBMB TODAY FEBRUARY 2021Discovering an old DoGs’ ne
1. 26 ASBMB TODAY FEBRUARY 2021
Discovering an old DoGs’
new trick
Heterotrimeric G proteins regulate
a variety of signaling pathways that
control cell development and influ-
ence cell morphology via actin/cyto-
skeleton remodeling. There are four
main families of G proteins: Gi/Go,
Gq, Gs and G12/13. Researchers long
have thought that Gs, unlike its family
members, is coupled specifically and
exclusively to adenylyl cyclases.
In a new study published in the
Journal of Biological Chemistry,
Alejandro Castillo–Kauil of the
Center for Research and Advanced
Studies of the National Polytechnic
Institute and collaborators challenge
this dogmatic view by identifying a
new Gs target. Using biochemical,
molecular biological and chemo-
genetic approaches, the researchers
demonstrated that the Gαs subfamily
of G proteins can regulate the activity
of Rho GTPases such as Rho guanine
nucleotide exchange factor, or Rho-
GEF. The interaction identified by the
group activates the small G protein
2. Cdc42 by Gs-coupled GPCRs, stimu-
lating a rearrangement of the cyto-
skeleton and inducing formation of
fingerlike protrusions called filopodia.
These results provide new insight
into G protein activity and define a
new role for RhoGEF coupling in G
protein function.
DOI: 10.1074/jbc.AC120.015204
A pathogen’s proteins target
mitochondria
The tick-borne pathogen Coxiella
burnetii causes Q fever, or query fever,
a rare flulike disease that can spread
to humans who inhale dust particles
contaminated by infected farm or
CONTINUED FROM PAGE 25
Noninvasive tool provides oral cancer prognosis
Oral squamous cell carcinoma, which affects about 34,000
people
in the U.S. each year, is found in the cells lining the lips and
mouth.
Metastasis to the lymph nodes is a sign of disease progression
and may
be accompanied by changes in proteolytic activity. During
proteolysis,
enzymes cut up proteins into short fragments called peptides.
Recent
work suggests that characterizing the sequence and abundance
of these
3. molecules — a method dubbed peptidomics — might provide
new in-
sight on cancer biology and in the clinic. In a recent paper in
the journal
Molecular & Cellular Proteomics, Leandro Xavier Neves of the
Brazil-
ian Biosciences National Laboratory and a team of Brazilian
clinicians
and scientists describe their analysis of oral squamous cell
carcinoma
patient saliva using peptidomics.
After extracting peptides from saliva samples, the research team
ana-
lyzed and compared the peptide content in samples from
patients with
and without metastasis to the lymph nodes. They found more
than 1,000
uniquely expressed peptides in each group and an additional
1,628 pep-
tides expressed by both groups. A series of statistical analyses
identified
77 peptides of particular interest; all of these peptides are
overexpressed
in samples from patients with lymph node metastasis, which
supports the
hypothesis that proteolytic activity increases in metastatic
disease. Ten of
these peptides also correlated with clinical features of
metastatic tumors.
The researchers used a panel measuring the abundance of five
peptides to
classify patients according to metastatic state.
To predict which enzymes generated this distinctive saliva
peptidome,
4. the team compared the sequences of peptides and full-length
proteins to
identify the most common cleavage sites. Many of the predicted
en-
zymes are associated with the lysosome or vacuole, linked to
immunity
or present in the oral microbiome. They then examined the
expression
of these enzymes in
publicly available oral
squamous cell carcinoma
tissue data. This analysis
showed that enhanced
expression of enzymes —
but not the proteins they
target — associates with
metastasis and reduced
survival, further bolster-
ing the link between
proteolytic activity and
disease progression.
Together, these analy-
ses of proteolysis in oral
squamous cell carcinoma may be useful for patient prognosis.
DOI: 10.1074/mcp.RA120.002227
— Nuala Del Piccolo
CDC/UNSPLASH
Peptidomics analyses of saliva samples from oral
squamous cell carcinoma patients correlate with disease
metastasis. The technique may be a useful noninvasive
prognostic tool.
5. JOURNAL NEWS
FEBRUARY 2021 ASBMB TODAY 27
domestic animals. When C. burnetii
infects a human macrophage, it
transfers as many as 150 effector
proteins into the host cell. Research-
ers know these proteins change the
host’s physiology to support the
infection. However, they know little
about the contributions of the indi-
vidual effector proteins, partly due to
their diversity and scarcity.
Laura Fielden and colleagues at
the University of Melbourne hy-
pothesized that C. burnetii effector
proteins target the mitochondria —
known as the powerhouse of the cell
— because that organelle is crucial
in cellular homeostasis. To test this,
the team isolated mitochondria
from human macrophages infected
with C. burnetii and analyzed the
proteins using high-sensitivity mass
spectrometry.
The team’s recent paper in the
journal Molecular & Cellular
Proteomics identified seven C.
burnetii proteins associated with
the mitochondria, including two
6. not previously found in the organ-
elle. They found that one of these
effector proteins, MceC, moves to
the inner mitochondrial membrane
and interacts with mitochondrial
proteins involved in quality control
and metabolic function.
This study presents an adapt-
able method for characterizing the
contributions of a pathogen’s effector
proteins.
DOI: 10.1074/mcp.RA120.002370
Pinpointing therapies
in PAK pathways
The serine/threonine kinase
P21-activated kinase-1, or PAK1,
influences cancer-related biologi-
cal processes such as cell migration,
invasion and angiogenesis. However,
researchers have not completely
delineated the network of signaling
molecules linked to PAK1.
Jae-Hong Kim of Kyungpook
National University and a team of in-
ternational collaborators used genetic
transformation screens, RNAi, phar-
macological inhibition and migration
assays to characterize PAK1-mediated
signal transduction pathways thor-
oughly. The researchers selected 19
candidate PAK1 genetic interactions
7. that had human orthologs and were
expressed in glioma for further ex-
amination in mammalian cells, brain
slice cultures and orthotopic glioma
models. RNAi and pharmacological
inhibition of potential PAK1 interac-
tors confirmed the importance of
several genes related to the mitotic
spindle, proteolysis, autophagy and
metabolism in PAK1-mediated glioma
cell migration, drug resistance and
proliferation.
These results, published in the
Journal of Biological Chemistry,
provide a comprehensive view of
PAK1-mediated signal transduction
pathways and identify new drug
targets for glioma therapy.
DOI: 10.1074/jbc.RA120.014831
Nuala Del Piccolo ([email protected]
ucdavis.edu) is a science writer
in the biomedical engineering
department at the University of
California, Davis. She earned her
Ph.D. in materials science and
engineering at Johns Hopkins
University.
Anand Rao ([email protected])
is an ASBMB science communi-
cator. Follow him on Twitter
@AnandRaoPhD.
Lisa Nicole Learman ([email protected]
8. jhmi.edu) is a Ph.D. candidate
studying molecular neurosci-
ence at Johns Hopkins University
School of Medicine. Follow her on
Twitter @LearmanLisa.
Laurel Oldach ([email protected]
asbmb.org) is a science writer for
the ASBMB. Follow her on Twitter
@LaurelOld.
Wednesdays | 12 p.m. EST
Lipid Research Division Seminar Series
Presentations from researchers highlighti ng
their recent work in the field of lipids.
Hosted by the ASBMB’s Lipid Research Division.
LEARN MORE AT:
asbmb.org/meetings-events/lrd-seminar-series
JOURNAL NEWS
Principles of Business (Level 40)
Name: ___________________________________
1. What are the five types of insurance?
_____________ ______________ ________________
_________________ _______________
2. What is the difference between insurance and assurance?
_____________________________________________________
_____________________________________________________
9. _____________________________________________________
_____________________________________________________
____________________________
3. What are two main types of assurance?
____________________ _____________________
4. Explain the difference between the two types of life
assurance.
_____________________________________________________
_____________________________________________________
_____________________________________________________
_____________________________________________________
_____________________________________________________
_____________________________________________________
__
5. List the four (4) types of Marine Insurance.
__________________ __________________
____________________ _____________________
6. Explain any two (2) types of Marine Insurance.
_____________________________________________________
_____________________________________________________
_____________________________________________________
_____________________________________________________
____________________________
_____________________________________________________
_____________________________________________________
_____________________________________________________
_
7. Distinguish between third party and fully comprehensive
motor insurance.
_____________________________________________________
_____________________________________________________
12. product.
2
A firm employing six sales reps. each of whom drives a
company car.
3
A business employing people handling a large amount of cash.
4
A partner in a firm of lawyers.
5
Mrs. Jones wants a policy that would enable her to benefit from
the proceeds during her lifetime.
6
Edmond wants to insurance his business against possible theft
by public.