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Flash poster presentation slide of IUPHAR Guide to PHARMACOLOGY. As presented by Dr. Simon Harding at BPS Pharmacology 2016 @BritPharmSoc @GuidetoPHARM
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Discerning the molecular mechanisms of action (mmoa) for drugs treating human diseases is crucially important. This talk will provide an overview of target numbers in IUPHAR/BPS Guide to PHARMACOLOGY, compare these to other sources and consider the wider implications for drug discovery. We have developed stringent mapping criteria for primary targets (i.e. identifying those direct protein interactions mechanistically causative for therapeutic efficacy). This includes inter-source corroboration by intersecting multiple drug sources inside PubChem to produce consensus structure sets. The analogous approach is used to intersect published target lists and database subsets at the UniProtKB/Swiss-Prot identity level. Our cumulative curation results reveal that structure representation differences, data provenance and variability of assay results, are major issues for experimental pharmacology and global database quality. While our activity mappings encompass some polypharmacology (e.g. dual inhibitors and kinase panel screens) our strategic choice is to annotate minimal rather than maximal target sets. The consequent increased precision gives our database high utility for data mining, linking and cross-referencing. Our small-molecule figures are currently converging to ~200 human protein primary targets for ~1000 consensus chemical structures of approved drugs. Target lists from other sources are typically larger and show a degree of discordance. Comparative analysis of these lists by their UniProt ID content and Gene Ontology distributions suggests differences in curatorial selection are the main cause of divergence. The global target landscape thus shows paradoxical trends. On the one hand, cumulative drug research output and recent expansions (e.g. epigenetic targets and orphan diseases) have pushed bioactive compounds from papers or patents to above 2 million and chemically modulatable human proteins above 1500 (PMID:24204758). On the other hand, reports of Phase II clinical efficacy failure, with implicit target de-validation, are frequent. In addition, our assessment of drug approval data from 2009 to 2013 indicates new targets (i.e. first-in-class mmoas) are so low as to threaten the sustainability of the pharmaceutical industry. Causes and consequences of these paradoxes, along with utilities for minimal and maximal druggable genomes, will be discussed.
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IUPHAR-DB, GRAC and the IUPHAR/BPS Guide to PHARMACOLOGY
IUPHAR-DB, GRAC and the IUPHAR/BPS Guide to PHARMACOLOGY
Prof Anthony Harmar, JR Vane Medal Lecture 2014: A tribute to Anthony Harmar ...
Prof Anthony Harmar, JR Vane Medal Lecture 2014: A tribute to Anthony Harmar ...
More from Guide to PHARMACOLOGY
Guide to Pharmacology Poster - ELIXIR All Hands 2020
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an expert-driven, open database of pharmacological targets and the substances that act on them. It contains information on over 1,800 drug targets and 1,100 related proteins. The database is curated by 500 experts and provides detailed pharmacological data as well as overviews of key properties and ligands. Specialized extensions of GtoPdb include guides to immunopharmacology and malaria pharmacology that connect their fields to drug discovery. The database is continuously updated with new targets, ligands, features and access methods.
Guide to Malaria Pharmacology, GEMM 2019
IUPHAR/MMV Guide to Malaria Pharmacology slide set presented by Dr. Jane Armstrong at GEMM 2019, Edinburgh, UK.
GuideToImmunopharmacology_SIF_Nov2019
Presentation by Dr. Elena Faccenda on the IUPHAR/BPS Guide to Immunopharmacology at the 39° Congresso Nazionale della Società Italiana di Farmacologia in Florence, Nov 2019
GtoPDB_ELIXIR_UK_AllHands_update_Dec2019
This document discusses the IUPHAR/BPS Guide to Pharmacology database and related resources. It provides open access information on pharmacological targets and the substances that act on them. It includes over 1,700 human drug targets, 9,700 ligands including 1,300 approved drugs. Related databases include the Guide to Immunopharmacology and Guide to Malaria Pharmacology. The databases are regularly updated and include links to other resources to enable interoperability.
Harding_ImmunopharmacologyWorkshop_Pharmacology2019
Workshop on Using the Guide to Immunoipharmacology. PDF of slides presented at BPS Pharmacology 2019 by Dr. Simon Harding.
IUPHAR/BPS Guide to Pharmacology
Poster presented at the Elixir All-Hands Meeting in Lisbon, June 2019. Gives a broad summary of Guide to Pharmacology activities in the last year. Emphasising new tools and our extension into malaria pharmacology.
GtoPdb Database Status Report - April 2019
The document provides an overview and progress report on database activities from April 2018 - March 2019. Key points include:
- Publications in peer-reviewed journals on the database and new immunopharmacology guide.
- Engagement through conferences, social media, and interactions with users seeking to improve the database.
- Ongoing development of the database interface and content, including expansion to new therapeutic areas.
- Statistics on usage, file downloads, and web service calls that show increasing interaction over time.
IUPHAR/MMV Guide to Malaria Pharmacology
Poster on IUPHAR/MMV Guide to Malaria Pharmacology presented at BPS Pharmacology 2018 (London, Dec 2018).
IUPHAR/BPS Guide to Pharmacology in 2018
The document summarizes recent updates to the IUPHAR/BPS Guide to PHARMACOLOGY database. It describes new features including expanded target coverage with over 1,700 drug targets and 1,100 related proteins. A new Pharmacology Search Tool allows users to upload protein lists and find associated ligands. The database also now connects immunopharmacology by associating targets with immune processes, cell types, and diseases. Additionally, the guide describes collaborations to include antimalarial compound data and develop an IUPHAR/MMV Guide to Malaria Pharmacology.
IUPHAR Guide to IMMUNOPHARMACOLOGY
Poster on GtoImmuPdb presented at European Congress of Immunology (Amsterdam, Sep 2018). Overview of the main data types and features included in this extension to the IUPHAR/BPS Guide to PHARMACOLOGY
GtoPdb ELIXIR-All Hands 2018
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an open, expert-driven database that contains information on over 1,700 pharmacological targets and the substances that act on them. The database provides overviews and detailed information on targets that is manually curated from literature and reviewed by experts. It aims to cover human drug targets and potential future therapeutic targets. New features of the database include search tools to find targets and ligands, information on diseases associated with targets and ligands, organization of ligand families, and comparison of ligand activity across species. The database content is available to download in various formats and its interoperability has been increased through developing an RDF version and submitting data to other sources
GtoPdb_StatusReport_May2018_Core
The document provides an overview and status report of the Core Guide to PHARMACOLOGY (GtoPdb) database. It discusses recent publications from the team, compliance with new GDPR privacy regulations, website access statistics showing increased usage, new website features, and priorities for further development such as expanding disease and content coverage.
GtoPdb_StatusReport_May2018_GtoImmuPdb
The document provides a status report on the Guide to Immunopharmacology database (GtoImmuPdb). It discusses developments including the addition of disease data, graphical browsing of cell type data, and process data. The database is in beta version 3 and undergoing user testing. Over 500 targets and 1,000 ligands have been curated from the literature. On the curation side, efforts are focused on expanding the literature collection and annotating new targets and ligands. The database is preparing for its official launch in October 2018.
The IUPHAR/BPS Guide to PHARAMCOLOGY in 2018: new features and updates
2018 update poster for the IUPHAR/BPS Guide to PHARMACOLOGY. Giving details of new features and updates. To be presented at Pharmacology Futures, Edinburgh, May 2018; ELIXIR-All Hands, Berlin, June 2018 and World Congress of Pharmacology, Kyoto, Japan, July 2018
IUPHAR Guide to IMMUNOPHARMACOLOGY
Updated poster following beta v3 release. In preparation for Pharmacology Futures, Edinburgh Immunology Symposium and Word Congress of Pharmacology (Kyoto)
IUPHAR/BPS Guide to PHARMACOLOGY in 2017: new features and updates
This document summarizes updates to the IUPHAR/BPS Guide to PHARMACOLOGY database. It provides expert curated data on human drug targets and ligands. Recent additions include new target families, ligands, and links to immunopharmacology data. New features include download options, search tools, and organization of ligand families. The database is maintained by an international team and network of scientists and provides a resource for pharmacology education and research.
Southan BIA 10-2474 Pharmacology 2017
These slides will be presented at the Pharmacology 2017 meeting in London during the following session:
Abstract Number: OB073
Abstract Title: Capturing new BIA 10-2474 molecular data in the IUPHAR/BPS Guide to PHARMACOLOGY
Date: Wednesday, December 13, 2017, 11:30 AM
Oral Session: Oral Communications: Mixed Tracks
GtoPdb generic slides 2017/18
This comprehensive slide deck is provided for use by those who are teaching and presenting on the IUPHAR/BPS Guide to PHARMACOLOGY. Includes:
- Overview of NC-IUPHAR
- Background to GtoPdb
- Screenshots of the website and search tools
- Recent content expansions
- Other features and initiatives including the Guide to IMMUNOPHARMACOLOGY
This slide set updates the previous set from 2014/15 available at https://www.slideshare.net/GuidetoPHARM/iupharbps-guide-to-pharmacology-generic-slideset
Poster on systems pharmacology of the cholesterol biosynthesis pathway
A systems pharmacology study of the cholesterol biosynthesis pathway
Poster presented at the Pharmacology 2017 conference, London, December 2017
Poster PubMed-to-PubChem connectivity between GtoPdb and BJP
Navigating links between structures and papers:
PubMed-to-PubChem connectivity between the IUPHAR/BPS Guide to PHARMACOLOGY and British Journal of Pharmacology
A poster presented at Pharmacology 2017, London, December 2017
More from Guide to PHARMACOLOGY (20)
Guide to Pharmacology Poster - ELIXIR All Hands 2020
Guide to Pharmacology Poster - ELIXIR All Hands 2020
Harding_ImmunopharmacologyWorkshop_Pharmacology2019
Harding_ImmunopharmacologyWorkshop_Pharmacology2019
The IUPHAR/BPS Guide to PHARAMCOLOGY in 2018: new features and updates
The IUPHAR/BPS Guide to PHARAMCOLOGY in 2018: new features and updates
IUPHAR/BPS Guide to PHARMACOLOGY in 2017: new features and updates
IUPHAR/BPS Guide to PHARMACOLOGY in 2017: new features and updates
Poster on systems pharmacology of the cholesterol biosynthesis pathway
Poster on systems pharmacology of the cholesterol biosynthesis pathway
Poster PubMed-to-PubChem connectivity between GtoPdb and BJP
Poster PubMed-to-PubChem connectivity between GtoPdb and BJP
Recently uploaded
Types of Garden (Mughal and Buddhist style)
Garden is the place where, flower blooming on a plant ,aesthetic things are present like Topiary, Hedges, Arches and many more. Whereas, Botanical garden is an educational institution for scientific research as well as gathering information about different culture. Such as, Hindu, Mughal , Buddhist style.
Comparison of Water Bodies in Delhi and Lakshadweep
Comparison of Water Bodies in Delhi and Lakshadweep - Anoop Singh Nagi
Water bodies play a crucial role in shaping the ecology and
lifestyle of regions. This presentation compares the water
bodies in Delhi and Lakshadweep, providing insights into
their types, characteristics, and environmental challenges.
Delhi, a bustling metropolis, features primarily freshwater
bodies such as rivers, lakes, and canals that face significant
pollution issues. In contrast, Lakshadweep, an archipelago in
the Arabian Sea, boasts pristine marine ecosystems including
lagoons and coral reefs known for their rich biodiversity and
clear waters. Understanding these differences highlights the
unique environmental contexts and conservation needs of
each region.
Please Like our PPT for supporting.
ScieNCE grade 08 Lesson 1 and 2 NLC.pptx
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Enhancing non-Perl bioinformatic applications with Perl
Building novel, component-based applications using Object Orientation, PDL, Alien, FFI, Inline and OpenMP
Complement Activation Pathways: Key Mechanisms in Immune Defense
The complement system is a key part of the immune response, made up of proteins that eliminate pathogens. It is activated through three main pathways:
Classical Pathway: Triggered by antibodies bound to antigens on a pathogen's surface.
Lectin Pathway: Initiated by mannose-binding lectin binding to sugars on pathogens.
Alternative Pathway: Activated spontaneously on pathogen surfaces without antibodies.
All pathways converge to form C3 convertase, leading to the destruction of pathogens by marking them for immune attack and creating pores in their membranes. This process enhances the body's ability to fight infections quickly and effectively.
Measuring gravitational attraction with a lattice atom interferometer
Despite being the dominant force of nature on large scales, gravity remains relatively
elusive to precision laboratory experiments. Atom interferometers are powerful tools
for investigating, for example, Earth’s gravity1
, the gravitational constant2
, deviations
from Newtonian gravity3–6
and general relativity7
. However, using atoms in free fall
limits measurement time to a few seconds8
, and much less when measuring
interactions with a small source mass2,5,6,9
. Recently, interferometers with atoms
suspended for 70 s in an optical-lattice mode fltered by an optical cavity have been
demonstrated10–14. However, the optical lattice must balance Earth’s gravity by
applying forces that are a billionfold stronger than the putative signals, so even tiny
imperfections may generate complex systematic efects. Thus, lattice interferometers
have yet to be used for precision tests of gravity. Here we optimize the gravitational
sensitivity of a lattice interferometer and use a system of signal inversions to suppress
and quantify systematic efects. We measure the attraction of a miniature source mass
to be amass = 33.3 ± 5.6stat ± 2.7syst nm s−2, consistent with Newtonian gravity, ruling out
‘screened ffth force’ theories3,15,16 over their natural parameter space. The overall
accuracy of 6.2 nm s−2 surpasses by more than a factor of four the best similar
measurements with atoms in free fall5,6
. Improved atom cooling and tilt-noise
suppression may further increase sensitivity for investigating forces at sub-millimetre
ranges17,18, compact gravimetry19–22, measuring the gravitational Aharonov–Bohm
efect9,23 and the gravitational constant2
, and testing whether the gravitational feld
has quantum properties24.
Introduction, scope objective and history of Ethnobotany.pptx
Introduction, scope objective and history of Ethnobotany
Science-9-Lesson-1 ang lesson 2-NLC-pptx.pptx
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PART 1 The New Natural Principles of Electromagnetism and Electromagnetic Fie...
Document Summary and the History of Perpetual Motion
Every single Faraday Generator coil since 1834 has been and is currently performing Negative Work at infinite efficiency with created Electromagnetic Field Energy during electricity generation and its physical Kinetic Energy reduction or Electromagnetic Resistance of the changing magnetic field which is initially inducing Electric Current in the generator coil according to Faraday's Law of Induction.
The Work-Energy Principle confirms mathematically that the magnitude of the changing magnetic field's Kinetic Energy reduction is equal to the magnitude of Negative Work performed at infinite efficiency, which is equal to the magnitude of Energy (Electromagnetic Field Energy which is created according to Oersted's Law of Creation of Energy of 1820). Created Electromagnetic Field Energy is required in order to perform the Negative Work – because Work cannot be performed in the absence of Energy.
In 2007 Thane Heins of Almonte Ontario, Canada discovered that unlimited amounts of Positive Electromechanical Work could be performed at infinite efficiency with created and TIME DELAYED Electromagnetic Field Energy.
Every single ReGenX Generator coil since 2007 has been and is currently performing Positive Work at infinite efficiency with created Electromagnetic Field Energy during electricity generation and during its physical Kinetic Energy increase or Electromagnetic Assistance of the changing magnetic field which is initially inducing Electric Current in the generator coil according to Heins' Law of Induction.
Faraday Electric Generators all harness internally Created Electromagnetic Field Energy in order to perform Negative Work (system Kinetic Energy reduction) at infinite efficiency and ReGenX Electric Generators harness internally created and Time Delayed Electromagnetic Field Energy in order to perform Positive Work (system Kinetic Energy increase) at infinite efficiency.
Both Faraday Generators and ReGenX Generators operate as Perpetual Motion Machines of the First Kind because they both have the ability to perform both Negative or Positive Work indefinitely and at infinite efficiency without requiring any External Energy input. The unlimited Energy required to perform either the Negative or Positive Work is created at the Sub-Atomic Quantum Electron level inside the generators' Current Bearing Wires according to the Law of Creation of Energy.
Hans Christian Oersted discovered the Law of Creation of Energy in 1820 when he demonstrated the world's first Perpetual Motion Machine of the First Kind at the University of Copenhagen when he also simultaneously violated Newton's 1st, 2nd and 3rd Laws of Motion.
Michael Faraday built and demonstrated the world's second Perpetual Motion Machine of the First Kind in 1822 when he demonstrated his Electric Motor invention which harnessed created Electromagnetic Field Energy in order to perform Positive Electromechanical Work at infinite efficienc
Science grade 09 Lesson1-2 NLC-pptx.pptx
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class 11 physics project on bernoulli's principle
This is a project on class 11 physics made on Bernoulli's principle for CBSE project.
Centrifugation types and its application
Centrifugation is a technique, based upon the behaviour of particles in an applied centrifugal filed.
Centrifugation is a mechanical process which involves the use of the centrifugal force to separate particles from a solution according to their size, shape, density, medium viscosity and rotor speed.
The denser components of the mixture migrate away from the axis of the centrifuge, while the less dense components of the mixture migrate towards the axis.
precipitate (pellet) will travel quickly and fully to the bottom of the tube.
The remaining liquid that lies above the precipitate is called a supernatant.
Chemistry project for class 12 on extracting essential oils from seeds.
This is the class 12th investigatory project on extracting essential oil from aniseed, carum seed etc.
SEMEN PREPARATION TECHNIQUES FOR IVF IN EMBRYOLOGY
SEMEN PREPARATION
SWIM-UP
DENSITY GRADIENT
ADVANCED SEMEN PREPARATION METHODS
ppt on Introduction to Nursing Research 2.ppt
Introduction to Nursing Research
Nursing research is an essential component of the nursing profession, aimed at generating new knowledge and improving patient care through scientific inquiry. It involves systematic investigation, analysis, and application of findings to enhance healthcare practices and outcomes. This introduction provides an overview of the key concepts, methodologies, and significance of nursing research.
What is Nursing Research?
Nursing research is the systematic study of phenomena related to the practice of nursing. It seeks to develop knowledge that can be used to improve patient care, enhance the practice environment, and contribute to the health and well-being of individuals and communities. Nursing research encompasses a broad range of topics, including clinical practice, healthcare systems, education, and policy.
IMPORTANCES OF MICROBIAL TOXINS IN PLANT DISEASES.pptx
In living plant cells several interdependent biochemical reactions are taking place concurrently or in a well defined succession to sustain life. Disturbance of any of these metabolic reactions causes disruption of the physiological processes leading to the development of disease. The harmful substances produced by the pathogenic microorganisms which are responsible for such disturbances are called toxins. Toxins are effective in very low concentrations. Some are unstable or react quickly and are bound tightly to specific sites within the plant cell.
Some toxins act as general protoplasmic poisons and affect many species of plant of different families termed as non specific toxins, other are toxic to only a few plant species or varieties and are harmless to others. Many toxins exists in multiple forms that have different potency.
Recently uploaded (20)
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
GBSN - Microbiology (Unit 2) Susceptibility of Microbial agents
Comparison of Water Bodies in Delhi and Lakshadweep
Comparison of Water Bodies in Delhi and Lakshadweep
Joseph, Gilbert M. & Henderson, Timothy J. - The Mexico Reader. History, Cu...
Joseph, Gilbert M. & Henderson, Timothy J. - The Mexico Reader. History, Cu...
Enhancing non-Perl bioinformatic applications with Perl
Enhancing non-Perl bioinformatic applications with Perl
Complement Activation Pathways: Key Mechanisms in Immune Defense
Complement Activation Pathways: Key Mechanisms in Immune Defense
Measuring gravitational attraction with a lattice atom interferometer
Measuring gravitational attraction with a lattice atom interferometer
Introduction, scope objective and history of Ethnobotany.pptx
Introduction, scope objective and history of Ethnobotany.pptx
PART 1 The New Natural Principles of Electromagnetism and Electromagnetic Fie...
PART 1 The New Natural Principles of Electromagnetism and Electromagnetic Fie...
Chemistry project for class 12 on extracting essential oils from seeds.
Chemistry project for class 12 on extracting essential oils from seeds.
SEMEN PREPARATION TECHNIQUES FOR IVF IN EMBRYOLOGY
SEMEN PREPARATION TECHNIQUES FOR IVF IN EMBRYOLOGY
IMPORTANCES OF MICROBIAL TOXINS IN PLANT DISEASES.pptx
IMPORTANCES OF MICROBIAL TOXINS IN PLANT DISEASES.pptx
GtoImmPdb_flash_poster_presentation
- 1. Dr. Simon D. Harding, University of Edinburgh Poster PB134 ● Improving data exchange between pharmacology and immunology ● Unique portal to immunological data in the GtoPdb ● New ways to search, browse and visualise immunological data ● Public, beta-release, Spring 2017 ● Wellcome Trust-funded extension to the existing GtoPdb ● Richly annotated data on immunological processes, cell types and diseases ● Curated by expert sub-committees at NC-IUPHAR Processes Targets Ligands Cell types Disease