Mostafa Waly
Sultan Qaboos University, Food Science and Nutrition, Faculty Member
- I received my Ph.D. from the Northeastern University (Boston, USA) in 2003, and currently holds the position of Profe... moreI received my Ph.D. from the Northeastern University (Boston, USA) in 2003, and currently holds the position of Professor in the Department of Food Science and Nutrition at the College of Agricultural and Marine Sciences, Sultan Qaboos University, Oman.
My research expertise is in the field of nutritional biochemistry and the primary prevention of human chronic diseases. My lab has a significant contribution to the cellular metabolites in different in vivo and in vitro experimental models, and my online metrics (SCOPUS, Research gate, and Google scholar) citations indicate the high impact of my research in the international scientific community.
I'm the author/co-author of 90 refereed journal papers, 33 conference papers, 19 book chapters, 4 technical reports, and 2 books published by Springer, New York. Also, I serve as the editor-in-chief for the Canadian Journal of Clinical Nutrition and I'm a professional member in the American Society for Nutrition and Society of Experimental Biology and Medicine.(I received my Ph.D. from the Northeastern University (Boston, USA) in 2003, and currently holds the position of Professor in the Department of Food Science and Nutrition at the College of Agricultural and Marine Sciences, Sultan Qaboos University, Oman. <br /><br />My research expertise is in the field of nutritional biochemistry and the primary prevention of human chronic diseases. My lab has a significant contribution to the cellular metabolites in different in vivo and in vitro experimental models, and my online metrics (SCOPUS, Research gate, and Google scholar) citations indicate the high impact of my research in the international scientific community. <br />I'm the author/co-author of 90 refereed journal papers, 33 conference papers, 19 book chapters, 4 technical reports, and 2 books published by Springer, New York. Also, I serve as the editor-in-chief for the Canadian Journal of Clinical Nutrition and I'm a professional member in the American Society for Nutrition and Society of Experimental Biology and Medicine.)edit - Professor Richard Dethedit
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Būt (Sideroxylon mascatense) is an indigenous wild blueberry found in Oman. It has a very short season and is commonly preserved by drying. The aims of this study were to determine the physico-chemical characteristics and stability of... more
Būt (Sideroxylon mascatense) is an indigenous wild blueberry found in Oman. It has a very short season and is commonly preserved by drying. The aims of this study were to determine the physico-chemical characteristics and stability of phytochemicals (i.e., polyphenols and flavonoids) in the berries during drying (i.e., freeze-drying at −40 °C and air-drying at 60 and 90 °C) and the polyphenol stability of the dried berries as a function of storage temperature (i.e., 90, 70, 60, 40, 20, and −20 °C). The moisture content of fresh berry flesh was 64.5 g/100 g sample (wet basis). The crude protein and fat contents were higher in the seeds than in the flesh. Glucose and fructose were the main sugars and their concentrations were highest in the sample air-dried at 60 °C. The initial total polyphenol content (TPC) and total flavonoid content (TFC) of the flesh were 2.009 mg gallic acid equivalent (GAE)/g dry-solids and 0.199 mg catechin equivalent (CE)/g dry-solids, respectively. The sampl...
Research Interests: Chemistry, Food Science, Flesh, Foods, Gallic acid, and 3 moreFreeze Drying, Flavonoid, and Polyphenol
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Background Among developing countries, there is dearth of information related to sleep problems among children with autism spectrum disorder (ASD) and their sequel on parents health. Objective To e...
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Objective: Study the effect of Omani coffee on the glycemic responses and glycemic index (GI) of commonly consumed snack foods in Oman. Methods: We evaluated 9 Omani snack foods including doughnut, croissant, cheese, chicken and fried egg... more
Objective: Study the effect of Omani coffee on the glycemic responses and glycemic index (GI) of commonly consumed snack foods in Oman. Methods: We evaluated 9 Omani snack foods including doughnut, croissant, cheese, chicken and fried egg sandwiches, sambosa (vegetables), fried and boiled vermicelli, white bread with red beans for their proximate composition and GI. The proximate composition was determined according to AOAC,[1] whereas GI was measured in 12 healthy human volunteers as described by Wolever et al.[2] Results: The proximate composition of snack foods differed significantly (P < 0.05). The moisture, crude protein and fat contents in foods ranged from 21.9 to 67.5%, 4.3 to 17% and 2.7 to 23.4 %, respectively. Almost similar blood glucose responses were observed when snack foods were given with either water or Omani coffee. Significant (P < 0.05) differences were observed in the GI of these foods, which ranged between medium and high GI category. The GI of these foods (with water) ranged between 60 and 75, whereas with Omani coffee the GI values ranged between 64 and 78. Higher GI values were observed for doughnut and cheese sandwich, whereas sambosa (vegetables) showed the lowest value. Overall, no significant (P < 005) differences were observed in the GI of snack foods when served either with water or with Omani coffee. Conclusion: The GI of Omani snack foods differed significantly. However, Omani coffee did not affect the GI of these snack foods.
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This study aimed to assess the status of B-vitamins (folate, vitamin B6, and B12) and homocysteine (HCY) in the sera of Omani coronary artery disease (CAD) patients. Sixteen Omani patients (10 males and 6 females) gave consent for blood... more
This study aimed to assess the status of B-vitamins (folate, vitamin B6, and B12) and homocysteine (HCY) in the sera of Omani coronary artery disease (CAD) patients. Sixteen Omani patients (10 males and 6 females) gave consent for blood sampling and were enrolled in the study on voluntary basis. All patients were evaluated for their anthropometric and biochemical measurements of B-vitamins, glutathione (reduced and oxidized), HCY, and quantification of N-homocysteinylated albumin protein. It was observed that both male and female patients had a comparable age (57.64 ±9.86, 56.5 ±10.04 years, respectively) with no significant difference, P = 0.69 and both genders were obese based on their body mass index (31.22 ± 8.17 kg/m2 for males and 30.26 ± 4.70 kg/m2for females). Serum levels of folate, vitamins B6, and B12 were lower than the normal reference values in all the study participants. There was depletion in glutathione levels (higher level of oxidized glutathione versus lower level of reduced glutathione) in the sera of all study participants. High serum HCY levels in both males and females (75.81±9.21 and 68.66±8.1 μmol/L, respectively) suggest that both males and females had hyperhomocysteinemia. Correlation coefficient analysis revealed that the serum HCY levels were negatively correlated with serum reduced glutathione, folic acid, vitamins B6, and B12 levels in both male and female study participants. The serum HCY level was positively correlated with age, body mass index, and serum oxidized glutathione. Proteomic measurements of N-homocysteinylation in serum albumin revealed that N-homocysteinylated albumin was present in all the assayed serum samples of study participants. The results suggest that low serum status of B-vitamins might act as a metabolic trigger for the observed hyperhomocysteinemia, oxidative stress, and pathological formation of N-homocysteinylated albumin protein, which collectively aggravates the CAD risk in the studied Omani patients.
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Azoxymethane (AOM) is an oxidizing agent that is commonly used to induce cancer in rat colon. Experimental studies strongly suggest an association between glutathione (GSH) depletion and colon cancer. GSH is an essential intracellular... more
Azoxymethane (AOM) is an oxidizing agent that is commonly used to induce cancer in rat colon. Experimental studies strongly suggest an association between glutathione (GSH) depletion and colon cancer. GSH is an essential intracellular antioxidant, where its de novo synthesis requires cyanocobalamin, vitamin B12, yet its role on the prevention of colon cancer pathogenesis was not well studied. This study was undertaken to investigate the dose-dependent effect of cyanocobalamin supplementation in relation to GSH biosynthesis as well as its protective effect against AOM-induced oxidative stress in rat colon. Twenty-eight adult Sprague-Dawley rats were randomly divided into four groups (7 rats/group): Control group that fed standard diet with no AOM injection; and AOMtreated groups which received AOM injection and were fed one of three different diets supplemented with cyanocobalamin as follow: 25 μg, 125 μg, or 250 μg cyanocobalamin/kg of the standard diet. All rats were continuously f...
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... J Ethnopharmacol. 2006; 105(1-2): 39-46. [9] Shirwaikar A, Malini S, Kumari SC. Protective effect of flowers against cisplatin and gentamicin induced nephrotoxicity in rats. Ind J Exp Biol. 2003; 1: 58-62. [10] Punitha R, Vasudevan K,... more
... J Ethnopharmacol. 2006; 105(1-2): 39-46. [9] Shirwaikar A, Malini S, Kumari SC. Protective effect of flowers against cisplatin and gentamicin induced nephrotoxicity in rats. Ind J Exp Biol. 2003; 1: 58-62. [10] Punitha R, Vasudevan K, Manoharan S. Effect of flowers ...
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Environmental toxins and oxidizing agents are the common causes of oxidative stress in different biological systems. Oxidative stress is a common etiological factor of cancer in different human organs, and the oxidative stress-mediated... more
Environmental toxins and oxidizing agents are the common causes of oxidative stress in different biological systems. Oxidative stress is a common etiological factor of cancer in different human organs, and the oxidative stress-mediated carcinogenesis includes activation of oncogenic transcription factors, inhibition of antioxidant enzymes (catalase, glutathione-S-transferase, glutathione peroxidase, and superoxide dismutase), and depletion of glutathione, the major cellular antioxidant. Clinical studies continue to support the notion that different beehive products (honey, pollen, propolis, royal jelly, and venom) supplementation combats cancer development based on their antioxidant and health properties.
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Research Interests: Chemistry, Algae, Antioxidant, Cisplatin, Brown Seaweed, and 2 moreNephrotoxicity and Sargassum(Nephrotoxicity and Sargassum)
(Nephrotoxicity and Sargassum)
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ABSTRACT
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&quot;Let food be the medicine and the medicine be the food&quot; was quoted by Hippocrates more than 2000 years ago. In this context, traditional medicines of different countries have great potential for introducing new natural... more
&quot;Let food be the medicine and the medicine be the food&quot; was quoted by Hippocrates more than 2000 years ago. In this context, traditional medicines of different countries have great potential for introducing new natural remedies for various human diseases. One of these remedies is date palm pollen, which is an edible component of the date palm tree, and has been used in many countries as a therapeutic agent for male infertility. Date palm pollen is rich in bioactive compounds with phytochemicals and nutraceutical properties which might attribute for its therapeutic effects on infertility. However, the therapeutic role of these bioactive compounds in relation to other human chronic diseases was not well understood. The present editorial aims to characterize the therapeutic and nutritional properties of date palm pollen which might enhance its use as a functional food and as a safe additive in food industries.
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Oxalis corniculate and Pteropyrum scoparium are two edible wild Omani plants with known preventive effects on various human diseases, yet their therapeutic role in colon cancer was not studied. Azoxymethane (AOM) is a common oxidizing... more
Oxalis corniculate and Pteropyrum scoparium are two edible wild Omani plants with known preventive effects on various human diseases, yet their therapeutic role in colon cancer was not studied. Azoxymethane (AOM) is a common oxidizing agent that induces colon cancer in experimental animal models. In the current study, we examined the protective effect of Oxalis corniculate and Pteropyrum scoparium leaves extracts against AOM-induced cancer and oxidative stress in rat colon. Sixty Sprague-Dawley rats were randomly divided into 6 groups (10 rats/group). The Control group was fed a standard diet; the AOM-treated group was fed a standard diet and received an intraperitoneal injection of AOM at a dose of 30 mg/kg body weight for each rat. The other four groups received intragastric intubation of Pteropyrum scoparium or Oxalis corniculate leaves extracts (0.1 mg extract/ 1 mL water/day) in the absence or presence of AOM injection. After 8 weeks, all rats were sacrificed and the colon tissues were dissected for Aberrant Crypt Foci (ACF) enumeration of cancer lesions development, and for measurements of glutathione (GSH), total antioxidant capacity (TAC), and DNA oxidative damage. Our results showed that the AOM-injected rats showed a significant increased level of DNA oxidative damage, lower levels of GSH and TAC, and higher ACF as compared to the control group. Oxalis corniculate and Pteropyrum scoparium leaves extracts significantly suppressed the oxidative damage associated with AOM injection and mitigated its carcinogenic effect in rat colon. Both Oxalis corniculate and Pteropyrum scoparium leaves extracts act as potent antioxidants and combat the AOM-associated oxidative stress and colon carcinogenesis. The data from this study suggest that dietary supplementation of these two wild plants might be applied as a therapeutic agent for colon cancer treatment.
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Alzheimer&#39;s disease (AD) is a widespread neurodegenerative disorder of the elderly population. AD was first characterized by Alois Alzheimer in 1907, who reported the remarkable observation that persons diagnosed with AD are... more
Alzheimer&#39;s disease (AD) is a widespread neurodegenerative disorder of the elderly population. AD was first characterized by Alois Alzheimer in 1907, who reported the remarkable observation that persons diagnosed with AD are suffering from loss of their identity, memories, cognitive, and physical functioning. In 1900, the global average life expectancy was 47 years, so few people lived long enough to experience the onset of AD, but now the life expectancy is 75 years. Currently, 4 million people are affected with AD and 250,000 more cases are diagnosed annually worldwide. This steady increase in AD cases is associated with an increase in the medical care and long term rehabilitation services. Amyloid precursor protein is thought to be responsible for the pathology and subsequent cognitive and mental decline in patients with AD.
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ABSTRACT Background : Preschool years are characterized by striking changes in the physical development, language, cognitive and social behavior. Nutritional anthropometry is widely used for the assessment of the nutritional status of... more
ABSTRACT Background : Preschool years are characterized by striking changes in the physical development, language, cognitive and social behavior. Nutritional anthropometry is widely used for the assessment of the nutritional status of preschool children. Subjects : One hundred and twenty eight children (in the age group of 2-6 years) were recruited for this cross sectional study. We evaluated the underweight, wasting and stunting prevalence among this cohort using Z-Scores as compared to reference population. The middle upper arm circumference and body mass index (BMI) percentile were also evaluated. Results: Indicators of under nutrition were as follow; underweight (3.9%), wasting (3.1%), and stunting (2.3%) among the sampled preschool children. Conclusion: Stunting was the lowest among the examined preschool children. Overweight and obesity were not detected among the studied population. Conclusion : A nutrition intervention program should be developed and directed to this vulnerable group, preschool children, to combat these nutritional problems that might predispose children to under nutrition during adulthood.