Browsing by Title
Now showing items 1-20 of 10098
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"It's not a quick fix" : consequences of weight loss during life and experiences of weight regain after bariatric surgery
(Inst för medicin, Solna / Dept of Medicine, Solna, 2023-09-18)Maintenance of weight loss is challenging for most people who intentionally lose weight. Complex factors interact with each other and obstruct weight management. This thesis focuses on the consequences of weight loss ... -
"Varför behöver jag ta vätskedrivande?" - Omvårdnad som stödjer framgångsrik egenvård hos personer med kronisk hjärtsvikt.
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2016-05-18)Background: People with congestive heart failure often experience that they are not complicit in self-care. They feel that they do not have sufficient knowledge and understanding of the causes of heart failure. If the ... -
"You have to know why you're doing this" : a mixed methods study of the benefits and burdens of self-tracking in Parkinson's disease
(Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2023-02-17)Background: This study explores opinions and experiences of people with Parkinson's disease (PwP) in Sweden of using self-tracking. Parkinson's disease (PD) is a neurodegenerative condition entailing varied and changing ... -
'Being in the present' : the meaning of the interaction between older persons with Alzheimer's disease and a therapy dog
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2015-03-27)The number of persons with Alzheimer’s disease is increasing world-wide and the disease affects the persons, their families, the health care system and the economy within society worldwide. The symptoms and behaviours ... -
'Hay fever' in children : the real story
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2014-11-14)Rhinitis, allergic (AR) and non-allergic (NAR), and chronic rhinosinusitis (CRS) are different expressions of upper airway inflammation. Chronic upper airway symptoms are common in childhood and adolescence. There is a ... -
'I don't recognize myself' : personality characteristics in subjective cognitive impairment and mild cognitive impairment
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2013-03-14)Background: Personality changes are common in early stages of many neurodegenerative disorders and often precede cognitive deficits. In individuals with cognitive impairment an increase in feelings of distress and worry ... -
'Nobody delivers at home now' : who and why women participate in a conditional cash transfer program to promote institutional delivery in Madhya Pradesh, India
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2015-11-11)Background: One-fifth of global maternal deaths occur in India making this a serious public health challenge. It is well known that skilled birth attendance and access to quality emergency obstetric care reduces maternal ... -
'Not in my backyard' : public attitudes towards mental illness and people with mental illness living in Sweden
(Institutionen för klinisk neurovetenskap / Department of Clinical Neuroscience, 2010-09-10)BACKGROUND: Several studies reveal that inadequate knowledge exist regarding mental illness among the general population as well as stigmatizing attitudes towards persons suffering from a mental illness. The public s ... -
'Striving for motherhood': understanding the socio-cultural context of realizing childbearing among women in Kenya
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2011-04-26)PMTCT allows people living with HIV to actualize childbearing. However, it also complicates motherhood, as the medical consequences and public health implications of non-adherence to PMTCT service recommendations disrupt ... -
'We are deaf, though we hear; we are dumb, though we talk; we are blind, though we see' : understanding Iranian late-in-life immigrants' perceptions and experiences of health, illness and culturally appropriate care
(Institutionen för klinisk neurovetenskap, arbetsterapi och äldrevårdsforskning (NEUROTEC) / Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC), 2000-09-01)Despite the fact that elderly immigrants constitute nearly nine percent of the total population over 65-years of age, they have remained conspicuous by their absence in reports that underlie national welfare- and health ... -
11beta-Hydroxysteroid dehydrogenase type 1 as a pharmacological target in metabolic disease
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2004-04-08)The metabolic syndrome is a collection of associated disorders, affected by lifestyle, genetic predisposition and environment, and emerges as a consequence of the Western society lifestyle. It describes a variety of ... -
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment
(Institutet för miljömedicin (IMM) / Institute of Enviromental Medicine, 2005-11-25)2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased hepatic storage, as well as increased metabolism and excretion of retinoids. ... -
24s-Hydroxycholesterol : studies on regulatory mechanisms behind its formation in the brain and its potential use as a marker for neurodegeneration
(Institutionen för laboratoriemedicin / Department of Laboratory Medicine, 2010-09-10)Cholesterol 24-hydroxylase (CYP46A1) belongs to the cytochrome P450 super family and is responsible for conversion of cholesterol to the oxysterol 24S- hydroxycholesterol (24S-OHC). This structural modification allows 24S-OHC ... -
32P-postlabelling analysis of complex DNA adducts in human tissues
(Biovetenskaper och näringslära / Biosciences and Nutrition, 1998-11-20)Complex DNA adducts in humans originate from exogenous and endogenous sources. Polycyclic aromatic hydrocarbons (PAHs) are a large group of chemicals including many potent carcinogens. PAHs are ubiquitously present in the ... -
3D imaging and quantitative analysis of intact tissues and organs
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2020-04-17)Embryonic development and tumor growth are highly complex and dynamic processes that exist in both time and space. To fully understand the molecular mechanisms that control these processes, it is crucial to study RNA ... -
5-Fluorouracil mediated cell death signaling in colon carcinoma cells
(Institutet för miljömedicin / Institute of Environmental Medicine, 2016-06-07)Colorectal cancer (CRC) is the third most common form of cancer in the world. 5- Fluorouracil (5-FU) belongs to the fluoropyrimidine-type of drugs and is commonly used in the treatment of several solid tumors. It has become ... -
5-HT receptor-mediated modulation of glutamate transmission in the hippocampus and prefrontal cortex and its relation to cognition and depression
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2014-09-24)Depression is a multifaceted disease which is marked by cognitive and emotional memory impairments. It is characterised by an imbalacement of serotonergic and glutamatergic system in brain areas such as hippocampus and ... -
5-HT1A receptor ligands with putative antidepressant activity : pharmacological studies in the rat
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 1996-01-26)Several studies suggest that serotonin (5-hydroxytryptamine, 5-HT)IA receptor agonists possess antidepressant activity. Probably these agents exert their therapeutic effect through stimulation of postsynaptic 5-HT,A ... -
5-Lipoxygenase : studies on the active site iron, and on the stimulatory factors Ca2+ and ATP
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2000-09-13)Human 5-lipoxygenase (5LO) is a monomeric non-heme iron enzyme, which catalyses the first two steps in the biosynthesis of leukotrienes: oxygenation of arachidonic acid to yield 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicos ... -
A 'new public health' perspective on building competence for end-of-life care and communication : how death literacy can be developed and measured
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2022-08-19)Background: Due to aging populations and prolonged dying trajectories in many high-income countries including Sweden, more people will need extended periods of care and support at the end-of-life (EOL). In light of these ...