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Now showing items 21-40 of 10099
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A 10-year follow-up of people with multiple sclerosis-aspects of disability and health, use of and satisfaction with care, and feasibility of cognitive behavioural therapy
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2014-11-21)Background: Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disease in the central nervous system which affects a number of life areas of the afflicted individual. Detailed knowledge is required on ... -
A 6 month physical activity intervention in university staff : effectiveness and health outcomes : the ASUKI Step Study
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2013-08-20)Physical inactivity is regarded a major public health concern and regular physical activity (PA) has been considered as an important lifestyle modification to improve health and prevent chronic disease. Setting the goal ... -
A balancing act : work life and childcare among parents of children with cancer
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2021-03-24)Aim: The overall aim of this thesis was to investigate the socioeconomic consequences for parents of children with cancer in Sweden. The specific aims were to increase the knowledge of (I) risk of sick leave, (II) division ... -
A battle between host and pathogen : the innate immune response and enterovirus evasion strategies
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2014-09-18)Infections with Coxsackieviruses are common and in most cases the infection is asymptomatic and efficiently cleared. On rare occasions, however, an infection can lead to severe diseases including myocarditis, hepatitis and ... -
A behavioral defense against disease
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2020-01-31)Animals, including humans, have evolved under the continuous selection pressure posed by pathogens. As a result, we have developed a set of physiological mechanisms to combat pathogens – the immune system. However, engaging ... -
A bio-psychological analysis of functional gastrointestinal disorders and a clinical trial of its treatment using psychodrama
(Institutionen för folkhälsovetenskap / Department of Public Health Sciences, 1999-11-17)Functional disorders of the gut are regarded as the result of a complex interaction between factors of biological, social and psychological origin. Psychosocial interventions are expected to play a role in the management ... -
A biophysical symphony : the interplay of factors determining microRNA-34a activity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-28)microRNAs (miRNAs) play a pivotal role as post-transcriptional regulators in gene expression, adding a layer of complexity to the intricate system of molecular interactions within cells. Despite their short length, miRNAs ... -
A clinical and experimental study of basal cell carcinoma : aspects on epidemiology, genetics and microphysiology
(Institutionen Södersjukhuset / Karolinska Institutet, Stockholm Söder Hospital, 2000-01-14)In the present thesis we report on basal cell carcinoma from the points of view of its incidence, risk factors and pathogenesis, with special interest in patients with more than one basal cell carcinoma in life. Incidence ... -
A clinical epidemiological study on end-stage liver disease in Ghana
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2022-06-01)End-stage liver disease (ESLD), including advanced liver cirrhosis and hepatocellular carcinoma (HCC), is the final stage of long-standing injury to the liver due to risk factors such as chronic viral hepatitis and alcoholic ... -
A clinical study of uncemented hip arthroplasty : radiological findings of host-bone reaction to the stem
(Karolinska Institutet, Danderyds Sjukhus / Karolinska Institutet at Danderyds Hospital, 2006-02-24)In total hip arthroplasty (THA), the main reason for failure leading to revision is aseptic loosening. Both mechanical and biological effects act in the loosening process, the factors may be implant design, fixation mode ... -
A community-based child drowning prevention program in Bangladesh : a model for low income countries
(Inst för folkhälsovetenskap / Dept of Public Health Sciences, 2010-11-25)Background: Drowning is a global public health problem of children. Children of low- and middle-income countries are the most susceptible victims. Prevention measures implemented in high-income countries have effectively ... -
A comparative study of estrogen receptors a and b in the female reproductive tract
(Institutionen för kvinnors och barns hälsa / Department of Women's and Children's Health, 2001-11-23)Estrogens have a pronounced influence on the function of the female reproductive system. The regulation of biological processes by estrogens is mediated via specific intracellular receptors (ERs), ERalpha and ERbeta, which ... -
A comparison of self-rated health among Iranians in Teheran, Iranian immigrants and Swedes in Stockholm : a cross-sectional study on self-rated health, mental health and sleep quality among three urban populations, aged 60–75 years
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2011-08-15)Background: Self-rated health (SRH) is one of the most widely used single measures of perceived current health status. It is used across disciplines to explore and explain people’s perceived health. SRH reflects an interaction ... -
A concept for treatment of sports related knee injuries
(Institutionen för kirurgisk vetenskap / Department of Surgical Science, 2004-04-02)The aim of the present thesis was, to evaluate local anaesthesia as ananaesthetic technique when performing knee arthroscopies, from a clinicaland economical point of view, and to describe the total costs for surgeryof ... -
A continuing educational intervention in primary health care using the ConPrim model
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2017-10-17)Background and aim: The overall aim of this thesis was to evaluate an intervention about “Nutritional care for patients cared for at home” developed using an interprofessional continuing educational model adapted for primary ... -
A critic in action? A functional examination of the Striato-Pallido-Habenular circuit
(Inst för neurovetenskap / Dept of Neuroscience, 2022-05-19)The basal ganglia (BG) and the midbrain dopamine (DA) system are considered key loci of reinforcement learning (RL), or learning by "trial and error", in the brain. The BG are implicated in action selection, and thus the ... -
A crystallographic view of egg-sperm interaction
(Inst för biovetenskaper och näringslära / Dept of Biosciences and Nutrition, 2016-08-12)Animal reproduction is a heavily studied biological event, however our knowledge regarding the molecular basis of the recognition between gametes – egg and sperm – still remains very incomplete. In particular, it is currently ... -
A dental perspective on child maltreatment
(Inst för odontologi / Dept of Dental Medicine, 2016-03-22)Children who are exposed to child maltreatment are at risk of developing physical and mental ill-health and of expressing risk-taking behaviors. International studies describe associations of child maltreatment with caries, ... -
A DNA-nanoassembly-based approach to map membrane protein nanoenvironments
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-03-05)Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that enable comprehensive ... -
A family-based study of the association between labor induction and offspring attention-deficit hyperactivity disorder and low academic achievement
(Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)The current study examined associations between labor induction and both (1) offspring attention-deficit hyperactivity disorder (ADHD) diagnosis in a Swedish birth cohort born 1992-2005 (n = 1,085,008) and (2) indices of ...