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Now showing items 1-20 of 10098
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A biophysical symphony : the interplay of factors determining microRNA-34a activity
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-05-28)microRNAs (miRNAs) play a pivotal role as post-transcriptional regulators in gene expression, adding a layer of complexity to the intricate system of molecular interactions within cells. Despite their short length, miRNAs ... -
Stress in military settings
(Inst för neurovetenskap / Dept of Neuroscience, 2024-05-28)Stress in the military reality is often related to either mental health or performance. When it comes to mental health, most of the literature is concerned with the possible negative effects from exposure to combat-related ... -
Novel biomarkers associated with stress : from normal aging to Alzheimer's disease
(Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2024-05-27)The burden of Alzheimer’s disease (AD) and dementia can be reduced through the elimination of modifiable lifestyle risk factors. Chronic stress is an emerging risk factor which has received significant focus in research ... -
Gaze into literacy : the potential of eye movement analysis for assessing children's word reading skills in ecological contexts
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-05-27)Children's reading proficiency is reflected in their eye movements during reading, a subject predominantly explored in experimental settings. This doctoral project investigates these dynamics within naturalistic environments. ... -
Child health in the Democratic Republic of the Congo : exploring subnational disparities and inequities in illnesses and mortality
(Inst för global folkhälsa / Dept of Global Public Health, 2024-05-24)Background: Today, sub-Saharan Africa accounts for a disproportionally high burden of deaths in children, with the Democratic Republic of the Congo (DRC) being one of the countries with the highest mortality burden. Ample ... -
Network and behavioral correlates of prefrontal neurons
(Inst för neurovetenskap / Dept of Neuroscience, 2024-05-24)The prefrontal cortex is located in the front of the brain. This region is considered crucial for cognitive processes, such as decision-making, attention, and working memory. Neuronal activities in this region are found ... -
Implementing digital interventions for problematic alcohol use in the psychiatric context : visions and reality
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-05-24)The relationship between alcohol use disorder (AUD) and other mental health disorders is complex, with genetic, environmental, and causal factors at play. Comorbid AUD and psychiatric disorders lead to elevated risks of ... -
Tumour-draining lymph nodes in head and neck cancer : immunological signatures and clinical implications
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-05-23)The lymphatic system is responsible for orchestrating immune responses, particularly in cancer. Oral squamous cell carcinoma (OSCC) represents a significant clinical challenge, with lymphatic metastasis being a crucial ... -
Iron deficiency in heart failure
(Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2024-05-23)Background: Iron plays a central role in several vital processes in the human body and is fundamental for organs with high energy demands, like the heart. Iron deficiency (ID) is common in patients with heart failure (HF) ... -
Exploring synbiotic treatment in ADHD, and immune-mediated prenatal risks for neurodevelopmental disorders
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2024-05-22)The etiologies of neurodevelopmental disorders (NDDs) and psychiatric disorders are considered to be multifactorial, with both genetic and environmental factors. NDDs are associated with early atypical brain development ... -
Long-term cardiovascular assessment in women with preeclampsia
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-22)Background: Preeclampsia (PE) is one of the most common medical multi-organ, pregnancy-specific disorder. PE is associated with endothelial dysfunction, elevated blood pressure, and inflammation. In addition to vascular ... -
Lentigo maligna melanoma, a clinicopathological and grenz rays management study
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-22)Lentigo maligna (LM), a neoplastic proliferation of skin melanocytes, is the in situ form of lentigo maligna melanoma (LMM) and it was first described in 1892 by a british surgeon Sir Jonathan Hutchinson. LM and LMM are ... -
Socioeconomic determinants of quality of care and outcomes in multiple sclerosis
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2024-05-22)Background: Multiple sclerosis (MS) is a chronic, inflammatory disease affecting the central nervous system (CNS), leading to varying degrees of neurological disability. While disease-modifying treatment (DMT) can ... -
Testosterone is performance enhancing in women but challenging to detect in doping analyses
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 2024-05-22)BACKGROUND: There is an ongoing debate whether women with testosterone (T) within the male range shall be allowed to compete in the female class in sports. In men, T has an ergogenic effect, but the effect of T in young ... -
Antibiotics in pregnancy : utilization, determinants and safety
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-22)Antibiotics are indispensable in maternal health. Crucial for treating and preventing bacterial infections ranging from common ailments to life-threatening conditions, antibiotics are inevitably prescribed to pregnant women ... -
Local anaesthetics, fluid balance and perioperative outcomes in surgery for advanced ovarian cancer
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-21)The majority of women with ovarian cancer are diagnosed at an advanced stage with extensive dissemination of tumour to the mesothelial lining of the abdomen, the peritoneum. Moreover, large amounts of ascites are often ... -
Unraveling predictive indicators for therapeutic response in HER2-positive breast cancer
(Inst för onkologi-patologi / Dept of Oncology-Pathology, 2024-05-21)Breast cancer is a highly heterogeneous disease, exhibiting significant diversity both in its biological subtypes and clinical manifestations. Biologically directed therapies have revolutionized the treatment landscape for ... -
Fibrotic lung disease : early signs, treatment and outcomes
(Inst för medicin, Solna / Dept of Medicine, Solna, 2024-05-21)Idiopathic pulmonary fibrosis (IPF) has gained a lot of attention by the research community in recent decades. Thanks to enhanced understanding on pathophysiological mechanisms behind the fibrosing process together with ... -
Hantaviruses and SARS-CoV-2 : cell stress and novel antivirals
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-05-21)Hantaviruses and coronaviruses are zoonotic viral pathogens that can cause severe disease in humans. The global spread of SARS-CoV-2 demonstrated the full pandemic potential of viral infections and highlighted our need for ... -
Circulating factors affecting skeletal muscle metabolism
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 2024-05-21)The overall aim of this doctoral thesis was to study the role of circulating factors in modulating skeletal muscle metabolism. To this end, we investigated two different scenarios: Type 2 diabetes, which is characterised ...