KR20020032949A - Compositions of anti-bacterial gel and methods for preparation thereof - Google Patents

Abstract

PURPOSE: A process of preparing a gel composition by dispersing a thickening agent in ethanol, adding water to the dispersion, dissolving an antimicrobial flavor material and humectant in residual ethanol and then adding to the dispersion is provided. Whereby, the gel composition has no problems on residual toxicity and oral toxicity, is excellent in volatile and can be frequently used in disinfecting hands. CONSTITUTION: This antimicrobial gel composition comprises 50 to 60% by weight of ethanol, 0.1 to 0.5% by weight of an antimicrobial flavor material, 1.0 to 3.0% by weight of a humectant such as propylene glycol or ethylene glycol and 0.5 to 1.0% by weight of a thickening agent such as hydroxypropylmethyl cellulose. The antimicrobial flavor material is one or more selected from lemon, lime, eucalyptus, thyme, menthol, methyl salicylate and thymol.

Description

Composition of anti-bacterial gel and methods for preparation thereof

The present invention relates to compositions of antimicrobial gels. More specifically, the present invention can sterilize the bacteria on the skin just by rubbing the gel on the skin, especially the hand, such as applying lotion or cream to the hand, and is made from an edible raw material, which is harmless to the human body. It also relates to a composition of antimicrobial gel that is also protective and easy to use.

In general, the microorganisms found in the hand are Staphylococcus (Staphylococcus), micro Caucus (Micrococcus), Corynebacterium (Corynebacterium), Brevibacterium (Brevibacterium), etc. as easily inhaled into the human body in the process of eating a variety of foods And cause various diseases. Therefore, the removal of the microorganisms from the hand is very important for the prevention of various diseases.

Methods for removing these microorganisms can be divided into sterilization and disinfection. Sterilization is inactivation by killing bacteria by chemical methods, and sterilization is the removal of bacteria by physical methods of washing or wiping. In the case of chemical methods, 100% sterilization is possible, but side effects and toxicity caused by chemical components of the drug are problematic. In the physical methods, there are no toxicity or side effects, but 100% cannot be removed and can be recontaminated. There is this.

The present inventors have concentrated on a method that can completely sterilize the bacteria in the hand while being harmless to the human body. As a result, the composition according to the present invention has excellent antibacterial ability, and even in a small amount, it can almost completely sterilize the bacteria in the hand, and since all the ingredients are food additives, there is no problem in residual toxicity and oral toxicity, and excellent volatility. After confirming that there is no need to wipe off with water or towel to complete the present invention.

Accordingly, it is an object of the present invention to provide an antimicrobial gel composition. The present invention also provides a method for preparing the composition.

The present invention is 50 to 60% by weight of ethanol; Antimicrobial flavors; Humectants; It relates to an antimicrobial gel composition comprising a thickener and water.

Ethanol used in the present invention exhibits maximum bactericidal power when its content is 60 to 70% by weight (see Experimental Example 1). However, when the ethanol content is 60% by weight or more, skin stimulation or destruction of the skin moisturizing ability due to the volatilization characteristics of ethanol may appear, it is preferable to prepare the ethanol content of 50 to 60% by weight.

If you lower the content of ethanol as above, the sterilization power is lowered. Therefore, in order to balance the sterilizing power of the low content of ethanol, antimicrobial antibacterial perfume is added. In this case, the ethanol and the antimicrobial fragrance show synergistic effect, showing nearly 100% bactericidal power (see Experimental Example 3). The antimicrobial flavors used in the present invention are edible, lemon, lime, eucalyptus, thyme, menthol, methyl salicylate, eucalyptol, or thymol, while having good antimicrobial properties. . The amount of the antimicrobial flavoring added may have a desired bactericidal effect even in a small amount, but preferably 0.1 wt% or more, more preferably 0.1 to 0.5 wt%.

The composition of the present invention contains a moisturizer in order to fully utilize the synergistic effect of ethanol and antimicrobial fragrance, so as not to destroy skin irritation or skin moisturizing ability. As the moisturizer used in the present invention, a general moisturizer may be used, for example, edible propylene glycol or ethylene glycol may be used. Preferred humectants are propylene glycol. The amount of the moisturizer to be used may exhibit a desired moisturizing effect even in a small amount, preferably 1.0 wt% or more, more preferably 1.0 to 3.0 wt%.

The composition according to the invention also comprises a thickener. As the thickener used in the present invention, a thickener which may be used as a food additive may be used. For example, hydroxypropylmethyl cellulose may be used. The amount of the thickener to be used may have a desired effect even in a small amount, but is preferably at least 0.5% by weight, more preferably from 0.5 to 1.0% by weight.

The composition according to the present invention can be easily prepared by mixing and stirring the raw materials in a conventional manner, preferably, by the following method:

After weighing each component to the composition ratio, 40% by weight of ethanol was dispersed by adding a thickener, and water was added to the dispersion thus obtained to prepare mixture A. Separately, all other components are added to the remaining amount of ethanol to dissolve it, thereby preparing the mixture B, which can then be added to the above prepared mixture A, followed by stirring and mixing.

As can be seen in the following examples, the composition according to the present invention, by synergistic action of low content of alcohol and antimicrobial perfume, can almost completely sterilize the bacteria on the skin, and since all the ingredients are food additives, residual toxicity and There is no problem with oral toxicity, and it is excellent in volatility so there is no need to wipe it off with water or a towel. The composition according to the present invention can be sterilized by applying a suitable amount to the skin of other parts in addition to the hand.

The invention is illustrated in more detail by the following examples, which however do not limit the scope of the invention.

Experimental Example 1. Test of sterilization by ethanol

Squeeze your finger onto the agar nutrient aga plate (before use), use the composition containing ethanol of the content of Table 1 in your hand, and then use your finger on the new agar nutrient medium plate in the same way After), each plate was incubated at 30 ° C. and incubated. After 3 days, the increase and decrease of the microorganisms in each plate was observed. Water was used as a control.

The experimental results are shown in Table 1 below.

[Table 1]% change of microorganism according to ethanol content

Contact time with ethanol Ethanol concentration (wt%, 25 ° C) 10 20 30 40 50 60 70 80 90 99 Control 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 1 sec 108.3 109.5 80.0 71.4 68.8 59.5 27.1 29.9 68.8 61.9 10 sec 86.7 94.6 65.8 77.6 41.2 34.9 26.6 26.6 37.3 60.7 30 seconds 106.5 92.7 50.2 47.2 35.7 18.4 21.2 34.1 48.2 48.7 1 minute 127.5 91.1 49.8 45.5 22.7 9.3 18.6 14.9 54.4 46.8 5 minutes 108.4 89.9 42.2 14.1 51.5 12.2 21.7 24.4 41.0 26.2 10 minutes 90.4 73.6 24.6 14.7 9.9 13.5 23.4 20.1 46.0 41.8

According to the said result, although it is enough also as a preservative at 15 weight% or more, it is preferable to use to about 20 weight%. As a sterilizing agent, about 60 to 70 weight% is enough, and there is a quick effect which can sterilize within 1 minute. However, when the ethanol content is more than 60% by weight, skin stimulation or destruction of the skin's moisturizing ability due to the volatilization characteristics of ethanol may appear, so it is preferable to use ethanol at 50 to 60% by weight.

Examples 1-3. Preparation of Gel

Each component according to the following Table 2 was weighed to fit the composition ratio, hydroxypropylmethyl cellulose was added to 40% by weight of ethanol and dispersed, and water was added to the dispersion thus obtained to prepare a mixture A. Separately, propylene glycol was added and dissolved in the remaining amount of ethanol to prepare mixture B, which was then added to the mixture A prepared above, followed by stirring and mixing.

As a control, a composition including only ethanol and water in the composition ratio of Table 2 was prepared.

TABLE 2 Composition Components of Each Example and Composition Ratios (Weight%)

ingredient Example Control 1-1 1-2 1-3 2-1 2-2 2-3 3-1 3-2 3-3 One 2 ethanol 50 55 60 60 70 Propylene glycol One 2 3 One 2 3 One 2 3 - - Hydroxypropylmethylcellulose handful - - water Appropriate to be 100 40 30

Experimental Example 2. Moisturizing, stickiness and sterilization test according to the content of the moisturizer

Moisturizing, stickiness and bactericidal powers were tested for each composition prepared in the above examples.

The moisturizing force was 5 g of the composition prepared in the above Example in the hand, and measured 30 minutes later by SKINCON-200.

Stickiness is a sensory evaluation by ten volunteers. The more non-sticky, the better it was evaluated.

The bactericidal power was obtained by pressing the finger on the agar nutrient aga plate (before use), using the composition prepared in the above example in the hand, and then placing the finger on the new agar nutrient medium plate in the same way (after use). Each plate was incubated at 30 ° C. and incubated. After 3 days, microbial sensitization of each plate was observed to determine the bactericidal power of the composition.

The results of each experiment are shown in Table 3 below.

[Table 3] Moisturizing, stickiness and sterilization evaluation

Evaluation item Example Control 1-1 1-2 1-3 2-1 2-2 2-3 3-1 3-2 3-3 One 2 Moisturizing × △ ○ × ○ ◎ × △ △ × × Sticky ◎ ○ △ ◎ ◎ ◎ ○ ○ ○ ○ ○ Bactericidal power × × × △ △ △ ○ ○ ○ ○ ○

Note) ×: Poor

△: normal

○: excellent

◎: very good

As can be seen from the table, the evaluation of the moisturizing power and stickiness is the best in Example 2-3, but the sterilization power is insufficient.

Examples 4-10 Preparation of Gels

According to the above results, the composition according to the present invention was prepared by adding an antimicrobial antimicrobial agent to supplement the bactericidal power in Example 2-3 having the best bactericidal power but the best feeling.

Each component according to Table 4 was weighed according to the composition ratio, hydroxypropylmethyl cellulose was added to 40% by weight of ethanol and dispersed, and water was added to the dispersion thus obtained to prepare a mixture A. Separately, all other ingredients were added to the remaining amount of ethanol to dissolve it, thereby preparing mixture B, which was then added to mixture A prepared above, followed by stirring and mixing.]

TABLE 4 Composition Components of Each Example and Composition Ratio (Weight%)

ingredient Example 4 5 6 7 8 9 10 Antibacterial Flavor 0.1 0.2 0.3 0.4 0.5 0.7 1.0 ethanol 55.0 Propylene glycol 3.0 Hydroxypropylmethylcellulose handful water Appropriate to be 100

On the other hand, the components of the used antimicrobial flavors are shown in Table 5 below.

[Table 5] Ingredients of Antimicrobial Flavors

ingredient Content (% by weight) lemon 30.0 Lime 10.0 Eucalyptus 13.5 time 9.5 menthol 6.0 Methyl salicylate 8.5 Eucalyptol 13.0 Thymol 9.5 Sum 100.0

Experimental Example 3. Test of sterilization according to the content of antibacterial flavor

The bactericidal power of each composition prepared in Examples 4 to 10 was tested in the same manner as the bactericidal test described in Experimental Example 2.

The results are shown in Table 6 below.

Table 6 Evaluation of bactericidal power

division Example Control 2-3 4 5 6 7 8 9 10 One 2 Sterilization (%) 68 73 80 99.5 99.8 100 100 100 98 100

As can be seen from the above results, when the content of the antimicrobial flavor is 0.2% by weight, the bactericidal power is 80% or more, and in Examples 6 to 10, which is 0.3% by weight or more, the bactericidal power is almost 100%.

As can be seen from the above examples and experimental examples, the composition of the present invention maximizes the advantages of ethanol and minimizes the disadvantages. That is, ethanol is about 70% sterilization power at 55% by weight, but by using with antimicrobial fragrance can exhibit a close to 100% sterilization power. Moreover, by using a thickener and a humectant, it prevents skin drying, cloudiness, etc. by ethanol, and it is excellent in the skin moisturizing effect.

On the other hand, since all of the composition components of the composition of the present invention is edible, there is no problem in residual toxicity or oral toxicity, and excellent in volatility, there is no need to wipe off with water or a towel, and thus it is convenient to use.

Claims (7)

50 to 60% by weight of ethanol; Antimicrobial flavors; Humectants; Thickeners; And water comprising an antimicrobial gel composition. The method of claim 1, wherein the antimicrobial perfume is 0.1 to 0.5% by weight; Moisturizer is 1.0-3.0% by weight; A composition wherein the thickener is from 0.5 to 1.0 weight percent. The method of claim 1 or 2, wherein the antimicrobial flavor is at least one selected from the group consisting of lemon, lime, eucalyptus, thyme, menthol, methyl salicylate, eucalyptol and thymol Composition selected. The composition of claim 1 or 2, wherein the moisturizing agent is propylene glycol or ethylene glycol. The composition of claim 1 or 2, wherein the thickener is hydroxypropylmethyl cellulose. The composition of claim 1 or 2, which is used for the hand. a) adding and dispersing a thickener in 40% by weight of ethanol; b) adding water to the dispersion obtained in a); c) antibacterial perfume to the remaining amount of ethanol; And adding a moisturizer to dissolve it; And d) adding the mixture obtained in c) to the mixture obtained in b), followed by stirring and mixing; A process for the preparation of a composition according to claim 1.