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Now showing items 1-20 of 401

    • "You have to know why you're doing this" : a mixed methods study of the benefits and burdens of self-tracking in Parkinson's disease 

      Riggare, Sara; Scott Duncan, Therese; Hvitfeldt, Helena; Hägglund, Maria (Inst för lärande, informatik, management och etik / Dept of Learning, Informatics, Management and Ethics, 2023-02-17)
      Background: This study explores opinions and experiences of people with Parkinson's disease (PwP) in Sweden of using self-tracking. Parkinson's disease (PD) is a neurodegenerative condition entailing varied and changing ...

    • A DNA-nanoassembly-based approach to map membrane protein nanoenvironments 

      Ambrosetti, Elena; Bernardinelli, Giulio; Hoffecker, Ian; Hartmanis, Leonard; Kiriako, Georges; de Marco, Ario; Sandberg, Rickard; Högberg, Björn; Teixeira, Ana I (Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2021-03-05)
      Most proteins at the plasma membrane are not uniformly distributed but localize to dynamic domains of nanoscale dimensions. To investigate their functional relevance, there is a need for methods that enable comprehensive ...

    • A family-based study of the association between labor induction and offspring attention-deficit hyperactivity disorder and low academic achievement 

      Wiggs, Kelsey K; Rickert, Martin E; Hernandez-Diaz, Sonia; Bateman, Brian T; Almqvist, Catarina; Larsson, Henrik; Lichtenstein, Paul; Öberg, Anna Sara; D'Onofrio, Brian M (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-07-07)
      The current study examined associations between labor induction and both (1) offspring attention-deficit hyperactivity disorder (ADHD) diagnosis in a Swedish birth cohort born 1992-2005 (n = 1,085,008) and (2) indices of ...

    • A framework for organ dose estimation in x-ray angiography and interventional radiology based on dose-related data in DICOM structured reports 

      Omar, Artur; Bujila, Robert; Fransson, Annette; Andreo, Pedro; Poludniowski, Gavin (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-03-07)
      Although interventional x-ray angiography (XA) procedures involve relatively high radiation doses that can lead to deterministic tissue reactions in addition to stochastic effects, convenient and accurate estimation of ...

    • A fundamental, national, medical disaster management plan : an education-based model 

      Djalali, Ahmadreza; Hosseinijenab, Vahid; Hasani, Azadeh; Shirmardi, Kianoush; Castrén, Maaret; Öhlén, Gunnar; Panahi, Farzad (Inst för klinisk forskning och utbildning, Södersjukhuset / Dept of Clinical Science and Education, Södersjukhuset, 2012-05-25)
      During disasters, especially earthquakes, health systems are expected to play an essential role in reducing mortality and morbidity. The most significant naturally occurring disaster in Iran is earthquakes; they have killed ...

    • A genetically informed study of the associations between maternal age at childbearing and adverse perinatal outcomes 

      Sujan, Ayesha C; Rickert, Martin E; Class, Quetzal A; Coyne, Claire A; Lichtenstein, Paul; Almqvist, Catarina; Larsson, Henrik; Sjölander, Arvid; Lahey, Benjamin B; Van Hulle, Carol; Waldman, Irwin; Öberg, Anna Sara; D'Onofrio, Brian M (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-03-27)
      We examined associations of maternal age at childbearing (MAC) with gestational age and fetal growth (i.e., birth weight adjusting for gestational age), using two genetically informed designs (cousin and sibling comparisons) ...

    • A global assessment of the male predominance in esophageal adenocarcinoma 

      Xie, Shao-Hua; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-05-09)
      Background: Esophageal adenocarcinoma (EAC) is characterized by a male predominance. However, variations in the sex difference across populations and over time have not previously been thoroughly investigated. Results: ...

    • A longitudinal study of resting heart rate and violent criminality in more than 700 000 men 

      Latvala, Antti; Kuja-Halkola, Ralf; Almqvist, Catarina; Larsson, Henrik; Lichtenstein, Paul (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2016-03-02)
      IMPORTANCE: Low resting heart rate is a well-replicated physiological correlate of aggressive and antisocial behavior in children and adolescents, but whether low resting heart rate increases the risk of violence and other ...

    • A model for predicting individuals' absolute risk of esophageal adenocarcinoma : moving toward tailored screening and prevention 

      Xie, Shao-Hua; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2017-02-15)
      Esophageal adenocarcinoma (EAC) is characterized by rapidly increasing incidence and poor prognosis, stressing the need for preventive and early detection strategies. We used data from a nationwide population-based ...

    • A multimodal brain imaging dataset on sleep deprivation in young and old humans 

      Nilsonne, Gustav; Tamm, Sandra; d'Onofrio, Paolo; Thuné, Hanna Å; Schwarz, Johanna; Lavebratt, Catharina; Liu, Jia Jia; Månsson, Kristoffer N T; Sundelin, Tina; Axelsson, John; Lamm, Claus; Petrovic, Predrag; Fransson, Peter; Kecklund, Göran; Fischer, Håkan; Lekander, Mats; Åkerstedt, Torbjörn (Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 2016-05-26)
      The Stockholm Sleepy Brain Study I is a functional brain imaging study of 48 younger (20-30 years) and 36 older (65-75 years) healthy participants, with magnetic resonance imaging after normal sleep and partial sleep ...

    • A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cells 

      Sarhan, Dhifaf; Wennerberg, Erik; D'Arcy, Pádraig; Gurajada, Deepthy; Linder, Stig; Lundqvist, Andreas (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-05-22)
      The proteasome inhibitor bortezomib simultaneously renders tumor cells sensitive to killing by natural killer (NK) cells and resistant to killing by tumor-specific T cells. Here, we show that b-AP15, a novel inhibitor of ...

    • A possible link between famine exposure in early life and future risk of gastrointestinal cancers : implications from age-period-cohort analysis 

      Xie, Shao-Hua; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2016-10-27)
      The Chinese famine in 1958-1962 was one of the worst in human history, but its potential influence on cancer risks is uncertain. Using cancer incidence data in Shanghai, China, during 1983-2007, we calculated age-specific ...

    • A total-population multigenerational family clustering study of autoimmune diseases in obsessive-compulsive disorder and Tourette’s/chronic tic disorders 

      Mataix-Cols, David; Frans, Emma; Pérez-Vigil, Ana; Kuja-Halkola, Ralf; Gromark, Caroline; Isomura, Kayoko; Fernández de la Cruz, Lorena; Serlachius, Eva; Leckman, James F; Crowley, James J; Rück, Christian; Almqvist, Catarina; Lichtenstein, Paul; Larsson, Henrik (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2017-11-29)
      The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity ...

    • Abandoning native apps to become future friendly 

      Jergefelt, Mikael (Karolinska Institutet Universitetsbiblioteket / Karolinska Institutet University Library, 2015-10-28)
      Native apps have become the norm of mobile interaction with digital services, but it’s an expensive way to reach users. With responsive web design, a more inclusive and accessible experience can be crafted for all mobile ...

    • Abdominal fat and male excess of esophageal adenocarcinoma 

      Lagergren, Katarina; Mattsson, Fredrik; Lagergren, Jesper (Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 2013-04-12)
      The 7-to-1 male-to-female ratio in esophageal and gastroesophageal junctional adenocarcinoma (EAC) might be explained by abdominal adiposity, typical for males. If true, a stronger male predominance in higher BMI categories ...

    • Ability to manage everyday technology : a comparison of persons with dementia or mild cognitive impairment and older adults without cognitive impairment 

      Malinowsky, Camilla; Almkvist, Ove; Kottorp, Anders; Nygård, Louise (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2016-01-18)
      Purpose: The ability to manage technology is important for performance and participation in everyday activities. This study compares the management of technology in everyday activities among people with mild-stage dementia ...

    • Accounting for genetic and environmental confounds in associations between parent and child characteristics : a systematic review of children-of-twins studies 

      McAdams, Tom A; Neiderhiser, Jenae M; Rijsdijk, Fruhling V; Narusyte, Jurgita; Lichtenstein, Paul; Eley, Thalia C (Inst för medicinsk epidemiologi och biostatistik / Dept of Medical Epidemiology and Biostatistics, 2014-06-24)
      Parental psychopathology, parenting style, and the quality of intrafamilial relationships are all associated with child mental health outcomes. However, most research can say little about the causal pathways underlying ...

    • Activated monocytes augment TRAIL-mediated cytotoxicity by human NK cells through release of IFN-gamma 

      Sarhan, Dhifaf; D'Arcy, Pádraig; Wennerberg, Erik; Lindén, Majken; Hu, Jin; Winqvist, Ola; Rolny, Charlotte; Lundqvist, Andreas (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2013-07-25)
      Natural killer (NK) cells are innate lymphocytes that are able to directly kill tumor cells through different mechanisms including ligation of TNF-related apoptosis-inducing ligand (TRAIL) receptors. Zoledronic acid (ZA) ...

    • Active sitting with backrest support : is it feasible? 

      Kuster, Roman P; Bauer, Christoph M; Gossweiler, Lukas; Baumgartner, Daniel (Inst för neurobiologi, vårdvetenskap och samhälle / Dept of Neurobiology, Care Sciences and Society, 2021-05-31)
      Ergonomics science recommends office chairs that promote active sitting to reduce sitting related complaints. Since current office chairs do not fulfil this recommendation, a new chair was developed by inverting an existing ...

    • Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer 

      Kazemi, Mohammad Hossein (Inst för onkologi-patologi / Dept of Oncology-Pathology, 2017-04-24)
      Tumor cells overcome anti-tumor responses in part through immunosuppressive mechanisms. There are several immune modulatory mechanisms. Among them, adenosine is an important factor which is generated by both cancer and ...