ABSTRACT: Allelopathy is the term used to define any process involving secondary metabolites produced by plants and microorganisms that influence growth and development of agrobiological systems. Currently, it is sought to find... more
ABSTRACT: Allelopathy is the term used to define any process involving secondary metabolites produced by plants and microorganisms that influence growth and development of agrobiological systems. Currently, it is sought to find allelochemicals of interest and know how to apply them in bio-herbicides to combat weeds. In this study, the effects of the crude leaf extract and fractions of Machaerium hirtum (Vell.) Stellfeld were analyzed on Euphorbia heterophylla L. (wild poinsettia) and Ipomoea grandifolia (Dammer) O’Donell (morning glory), as well as the occurrence of morphoanatomical changes. For this, 0.04 g of the crude extract and fractions were solubilized and diluted (50 mL) to concentrations of 0.1, 0.2, 0.4, and 0.8 g L-1 (m/v). Initial growth tests were performed on Petri dishes containing two paper sheets and seedlings of weed species with the respective treatments, being maintained in a germination chamber for 48 hours at 25 oC. Distilled water was used as a control. Shoot ...
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Neste trabalho avaliou-se a atividade antibacteriana deextratos de diferentes polaridades de Geophila sp. A atividadeantibacteriana foi medida frente as cepas Bacillus sp, Staphylococcusaureus, Escherichia coli e Pseudomonas aeruginosa. O... more
Neste trabalho avaliou-se a atividade antibacteriana deextratos de diferentes polaridades de Geophila sp. A atividadeantibacteriana foi medida frente as cepas Bacillus sp, Staphylococcusaureus, Escherichia coli e Pseudomonas aeruginosa. O extratocloroformico inibiu o crescimento de S.aureus e Bacillus sp. e o extratometanolico inibiu, em menor grau de crescimento de Bacillus sp. Osextratos bioativos foram submetidos a uma investigacao fitoquimica queresultou no isolamento de β-sitosterol, 3-O-β-glicopiranosilsitosterol e desacarose. As estruturas das substâncias isoladas foram definidas com basena analise de dados espectroscopicos de RMN uni e bi-dimensionais ecomparacao com os da literatura.
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Weeds pose a problem, infesting areas and imposing competition and harvesting difficulties in agricultural systems. Studies that provide the use of alternative methods for weed control, in order to minimize negative impacts on the... more
Weeds pose a problem, infesting areas and imposing competition and harvesting difficulties in agricultural systems. Studies that provide the use of alternative methods for weed control, in order to minimize negative impacts on the environment, have intensified. Native flora represents a source of unexplored metabolites with multiple applications, such as bioherbicides. Therefore, we aimed to carry out a preliminary phytochemical analysis of crude extracts and fractions of Miconia auricoma and M. ligustroides and to evaluate these and the isolated metabolites phytotoxicity on the growth of the target species. The growth bioassays were conducted with Petri dishes with lettuce, morning glory, and sourgrass seeds incubated in germination chambers. Phytochemical analysis revealed the presence of flavonoids, isolated myricetin, and a mixture of quercetin and myricetin. The results showed that seedling growth was affected in a dose-dependent manner, with the root most affected and the seed...
Research Interests: Botany, Organic Chemistry, Biology, Allelopathy, Bioassay, and 5 moreGermination, Weed, Molecules, Seedling, and Phytotoxicity
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The acyl-homoserine lactones (AHL) are compounds used in intercellular chemical signaling processes by Gram-negative bacteria in a phenomenon known as quorum-sensing. This process makes the microorganisms able to sense and respond to... more
The acyl-homoserine lactones (AHL) are compounds used in intercellular chemical signaling processes by Gram-negative bacteria in a phenomenon known as quorum-sensing. This process makes the microorganisms able to sense and respond to stimuli of individuals of the same species, or even cause physiological changes in the surrounding bacterial populations. In recent years, there is a growing interest in the effect that these compounds might have on higher organisms, such as inter-kingdoms communication mechanisms or physiological and morphological changes in host. In this regard, the study of the effects of these metabolites in plants has gained particular attention. Recently, it was shown that N-(3-oxo-octanoyl)-HL is present in the extract obtained from the leaves and stalks of sugarcane cultivated in Brazil, and that this compound can stimulate the growth of roots and shoots of the plant at low concentrations. Interestingly, it was found that both enantiomers (R) and (S) can acceler...
The phytochemical study of <i>Laelia marginata</i> (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid <b>(1)</b>, together with six other known compounds... more
The phytochemical study of <i>Laelia marginata</i> (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid <b>(1)</b>, together with six other known compounds (<b>2</b>–<b>7</b>). The new natural product was identified as a dimer of eucomic acid and was structurally characterised based upon 1D and 2D NMR and HRMS data. Biological assays with plant crude extract, fractions and isolated compounds were performed against two human cancer cell lines (Hela and Siha), and the tropical parasites <i>Trypanosoma cruzi</i> and <i>Leishmania (Leishmania) amazonensis</i>. The phenantrenoid 9,10-dihydro-4-methoxyphenanthren-2,7-diol <b>2</b> was active against Hela and Siha cells (CC<sub>50</sub> 5.86 ± 0.19 and 20.78 ± 2.72 μg/mL, respectively). Sub-lethal concentrations of the flavone rhamnazin <b>4</b> were not able to rescue the viability ...
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The phytochemical study of Laelia marginata (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid (1), together with six other known compounds (2-7). The new natural product was identified... more
The phytochemical study of Laelia marginata (Lindl.) L. O. Williams (Orchidaceae) led to the isolation of a new natural product named crispoic acid (1), together with six other known compounds (2-7). The new natural product was identified as a dimer of eucomic acid and was structurally characterised based upon 1D and 2D NMR and HRMS data. Biological assays with plant crude extract, fractions and isolated compounds were performed against two human cancer cell lines (Hela and Siha), and the tropical parasites Trypanosoma cruzi and Leishmania (Leishmania) amazonensis. The phenantrenoid 9,10-dihydro-4-methoxyphenanthren-2,7-diol 2 was active against Hela and Siha cells (CC50 5.86 ± 0.19 and 20.78 ± 2.72 μg/mL, respectively). Sub-lethal concentrations of the flavone rhamnazin 4 were not able to rescue the viability of the Vero cells infected by Zika virus.
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The phytochemical study of the leaves, roots, and flowers of Palicourea rigida led to the isolation of the triterpenes betulinic acid (1) and lupeol (2), the diterpene phytol (3), and the iridoid glycosides sweroside (4) and secoxyloganin... more
The phytochemical study of the leaves, roots, and flowers of Palicourea rigida led to the isolation of the triterpenes betulinic acid (1) and lupeol (2), the diterpene phytol (3), and the iridoid glycosides sweroside (4) and secoxyloganin (5). These compounds were identified using NMR 1H and 13C and comparing the spectra with published data. We studied the antiedematogenic activity of crude extracts from the organs, and of different fractions, in mice and found that the n-hexane fraction of the leaf extract significantly inhibited the ear edema resulting from croton oil administration. The crude extract from leaves was not acutely toxic to the mice.
Research Interests: Traditional Medicine, Biology, Magnetic Resonance Spectroscopy, Medicine, Phytotherapy, and 15 moreMice, Animals, Phytochemical, Flowers, Rubiaceae, Plant Roots, TERPENE, Plant extracts, Diterpene, Edema, Betulinic Acid, Molecular Structure, Plant Leaves, Lupeol, and Pharmacology and pharmaceutical sciences
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Base de dados : LILACS. Pesquisa : 115647 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Tahin, Quivo S.... more
Base de dados : LILACS. Pesquisa : 115647 [Identificador único]. Referências encontradas : 1 [refinar]. Mostrando: 1 .. 1 no formato [Detalhado]. página 1 de 1, 1 / 1, LILACS, seleciona. para imprimir. Fotocópia. Tahin, Quivo S. experimental, Documentos relacionados. Id: 115647 ...
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RESUMO: O estudo químico de Aloysia gratissima (Gillies & Hook.) Tronc. e Aloysia virgata (Ruiz & Pav.) Pers., Verbenaceae, resultou no isolamento de quatorze substâncias. Suas estruturas foram determinadas com base nos dados de IV, RMN... more
RESUMO: O estudo químico de Aloysia gratissima (Gillies & Hook.) Tronc. e Aloysia virgata (Ruiz & Pav.) Pers., Verbenaceae, resultou no isolamento de quatorze substâncias. Suas estruturas foram determinadas com base nos dados de IV, RMN de 1H e de 13C uni e ...
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Especies nativas do alto do rio Parana, regiao de Porto Rico-PR, tem sido alvo de nossos estudos em conjunto com pesquisadores das areas de botânica e de farmacologia da Universidade Estadual de Maringa. Esta area, denominada planicie... more
Especies nativas do alto do rio Parana, regiao de Porto Rico-PR, tem sido alvo de nossos estudos em conjunto com pesquisadores das areas de botânica e de farmacologia da Universidade Estadual de Maringa. Esta area, denominada planicie alagavel, abrange parte da Area de Protecao Ambiental das Ilhas e Varzeas do Rio Parana (PR e MS) e do Parque Estadual do Ivinhema (MS) – local considerado reserva ecologica pelo Estado. Nossos estudos visam a avaliacao dos potenciais quimico e farmacologico das especies vegetais desta regiao.O genero
Descreve os componentes quimicos de partes aereas da planta pterotade Scleria. De um extrato de ethanolic, o stigmasterol de steroids,campesterol, s-sitosterol, 3-O-s-glycopiranosyl sitosterol e sacaroseisolados. Foram identificadas as... more
Descreve os componentes quimicos de partes aereas da planta pterotade Scleria. De um extrato de ethanolic, o stigmasterol de steroids,campesterol, s-sitosterol, 3-O-s-glycopiranosyl sitosterol e sacaroseisolados. Foram identificadas as estruturas dos produtos naturais embase de dados espectrais, enquanto incluindo 2D experiencias deNMR. Foram investigadas o antibacterial e propriedades de antifungaldas fracoes obtidas dividindo o extrato de ethanolic.
RESUMO: Especies do genero Chomelia sao utilizadas para fins medicinais por apresentarem compostos provenientes do metabolismo secundario das plantas. Pesquisas realizadas com esta especie, no laboratorio de Quimica e produtos naturais da... more
RESUMO: Especies do genero Chomelia sao utilizadas para fins medicinais por apresentarem compostos provenientes do metabolismo secundario das plantas. Pesquisas realizadas com esta especie, no laboratorio de Quimica e produtos naturais da UEM, constataram a presenca de compostos com atividades antiinflamatorias, antioxidante e moderada atividade moluscicida. Contudo nao ha relatos de que tais compostos tenham efeito no desenvolvimento de outras especies vegetais. O presente trabalho teve por objetivo avaliar a influencia do extrato alcoolico de folhas e pequenos ramos de Chomelia obtusa sobre a germinacao e crescimento de plântulas de alface. Para observar o efeito deste extrato sobre a germinacao, as sementes foram expostas ao extrato nas concentracoes de 00; 500; 1000 e 2000µg mL -1 por um periodo de quatro dias, sendo a germinacao acompanhada diariamente. A avaliacao do efeito, do extrato sobre o crescimento, foi feita utilizando-se plântulas de alface, com 3mm, nos mesmos tratam...
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Allelopathy is analyzed as an alternative to herbicides due to the inhibitory or beneficent activities of its compounds with other organisms. Current paper discusses the effects of Aeschynomene fluminensis Vell. fractions on cultivated... more
Allelopathy is analyzed as an alternative to herbicides due to the inhibitory or beneficent activities of its compounds with other organisms. Current paper discusses the effects of Aeschynomene fluminensis Vell. fractions on cultivated plant species, Lactuca sativa L. and Glycine max (L.) Merril, and on weeds, Ipomoea grandifolia (Dammer) O’Donnel and Digitaria insularis (L.) Fedde. Aqueous fractions at 0.80; 0.40; 0.20 and 0.10 mg mL-1 concentrations were employed for initial growth tests. Seeds were pre-germinated in distilled water and transferred to petri plates with separate fractions at different concentrations. Plates were maintained for 48 h in a germination chamber at 25°C for L. sativa and I. grandifolia and at 30°C for G.max and D. insularis. The length of hypocotyl (LH) and root (LR) was measured and LR and foliar length (LF) were taken for D. insularis seedlings. Parameters were employed to calculated inhibition percentage. Plants with morphological changes were fixed a...
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Aspidosperma macrocarpon Mart., popularly known as 'guatambu' or 'peroba', is found from North American (Mexico) to South American (Argentina) continents and in Brazil. Two indole alkaloids were isolated from leaves of A.... more
Aspidosperma macrocarpon Mart., popularly known as 'guatambu' or 'peroba', is found from North American (Mexico) to South American (Argentina) continents and in Brazil. Two indole alkaloids were isolated from leaves of A. macrocarpon, kopsanone (1) and unreported N(4)-oxide-kopsanone (2).
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Abstract Orchidaceae are one of the largest families of flowering plants. In this work, the first phytochemical study of the non-flowering parts of the South American species Stanhopea lietzei (Regel) Schltr. is reported. It led to the... more
Abstract Orchidaceae are one of the largest families of flowering plants. In this work, the first phytochemical study of the non-flowering parts of the South American species Stanhopea lietzei (Regel) Schltr. is reported. It led to the isolation of nine compounds, including the rare dimeric compound 2,2′,7,7′-tetramethoxy-4,4′,6,6′-tetrahydroxy-(1,1′)-biphenanthrene (1). This compound was tested for the first time against HeLa human cancer cells, with IC50 16.9 ± 0.9 μg/mL. Biological assays against neotropical parasites, virus and other human cancer cell lines are also reported. Finally, the relevance of biphenanthrenes, flavonoids, and C-glycosylated phenolic compounds for chemophenetics relationships within neotropical species of the Cymbidieae tribe and Oncidiinae, Maxillariinae, Cyrtopodiinae and Stanhopeinae subtribes was also discussed.
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Abstract The phytochemical study of Gomesa recurva R. Br. (Orchidaceae) allowed the identification of nine compounds, daucosterol (1); the phenanthrenes 3,4,9-trimethoxy-2,5-phenanthrenediol (2); 4-methoxy-2,3,5-phenanthrenetriol (3);... more
Abstract The phytochemical study of Gomesa recurva R. Br. (Orchidaceae) allowed the identification of nine compounds, daucosterol (1); the phenanthrenes 3,4,9-trimethoxy-2,5-phenanthrenediol (2); 4-methoxy-2,3,5-phenanthrenetriol (3); 3,4-dimethoxy-2,5-phenanthrenediol (4); 2,4-dimethoxy-3,5-phenanthrenediol (5); the phenolic compounds 3-(4-hydroxyphenyl)-propanoic acid (6); 2-(E)-propenoic acid, 3-(4-hydroxy-3-methoxyphenyl)-methyl ester (7); 2-(E)-propenoic acid, 3-(4-hydroxyphenyl)-hexadecyl ester (8), and propanoic acid, 3-(4-hydroxyphenyl)-pentadecyl ester (9). Biological assays against fungi, neotropical parasites and human cancer cell lines were also performed. The chemotaxonomic relevance of the presence of phenanthrenoids was discussed.