The impact of glycosylation on the biological function and structure of human immunoglobulins

JN Arnold, MR Wormald, RB Sim, PM Rudd… - Annu. Rev …, 2007 - annualreviews.org
Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …

The production of recombinant pharmaceutical proteins in plants

JKC Ma, PMW Drake, P Christou - Nature reviews genetics, 2003 - nature.com
Imagine a world in which any protein, either naturally occurring or designed by man, could
be produced safely, inexpensively and in almost unlimited quantities using only simple …

Molecular farming in plants: host systems and expression technology

RM Twyman, E Stoger, S Schillberg, P Christou… - TRENDS in …, 2003 - cell.com
Plants provide an inexpensive and convenient system for the large-scale production of
valuable recombinant proteins. This principle has been demonstrated by the commercial …

Plant-based production of biopharmaceuticals

R Fischer, E Stoger, S Schillberg, P Christou… - Current opinion in plant …, 2004 - Elsevier
Plants are now gaining widespread acceptance as a general platform for the large-scale
production of recombinant proteins. The first plant-derived recombinant pharmaceutical …

Role of transgenic plants in agriculture and biopharming

P Ahmad, M Ashraf, M Younis, X Hu, A Kumar… - Biotechnology …, 2012 - Elsevier
At present, environmental degradation and the consistently growing population are two main
problems on the planet earth. Fulfilling the needs of this growing population is quite difficult …

Manufacturing economics of plant‐made biologics: case studies in therapeutic and industrial enzymes

D Tusé, T Tu, KA McDonald - BioMed research international, 2014 - Wiley Online Library
Production of recombinant biologics in plants has received considerable attention as an
alternative platform to traditional microbial and animal cell culture. Industrially relevant …

Sowing the seeds of success: pharmaceutical proteins from plants

E Stoger, JKC Ma, R Fischer, P Christou - Current opinion in biotechnology, 2005 - Elsevier
Among the many plant-based production systems that have been developed for
pharmaceutical proteins, seeds have the useful advantage of accumulating proteins in a …

Plants as bioreactors: recent developments and emerging opportunities

AK Sharma, MK Sharma - Biotechnology advances, 2009 - Elsevier
In recent years, the use of plants as bioreactors has emerged as an exciting area of research
and significant advances have created new opportunities. The driving forces behind the …

Plant molecular farming: systems and products

ME Horn, SL Woodard, JA Howard - Plant cell reports, 2004 - Springer
Plant molecular farming is a new and promising industry involving plant biotechnology. In
this review, we describe several diverse plant systems that have been developed to produce …

High‐level rapid production of full‐size monoclonal antibodies in plants by a single‐vector DNA replicon system

Z Huang, W Phoolcharoen, H Lai… - Biotechnology and …, 2010 - Wiley Online Library
Plant viral vectors have great potential in rapid production of important pharmaceutical
proteins. However, high-yield production of hetero-oligomeric proteins that require the …