The impact of glycosylation on the biological function and structure of human immunoglobulins
Immunoglobulins are the major secretory products of the adaptive immune system. Each is
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …
characterized by a distinctive set of glycoforms that reflects the wide variation in the number …
The production of recombinant pharmaceutical proteins in plants
JKC Ma, PMW Drake, P Christou - Nature reviews genetics, 2003 - nature.com
Imagine a world in which any protein, either naturally occurring or designed by man, could
be produced safely, inexpensively and in almost unlimited quantities using only simple …
be produced safely, inexpensively and in almost unlimited quantities using only simple …
Molecular farming in plants: host systems and expression technology
RM Twyman, E Stoger, S Schillberg, P Christou… - TRENDS in …, 2003 - cell.com
Plants provide an inexpensive and convenient system for the large-scale production of
valuable recombinant proteins. This principle has been demonstrated by the commercial …
valuable recombinant proteins. This principle has been demonstrated by the commercial …
Plant-based production of biopharmaceuticals
R Fischer, E Stoger, S Schillberg, P Christou… - Current opinion in plant …, 2004 - Elsevier
Plants are now gaining widespread acceptance as a general platform for the large-scale
production of recombinant proteins. The first plant-derived recombinant pharmaceutical …
production of recombinant proteins. The first plant-derived recombinant pharmaceutical …
Role of transgenic plants in agriculture and biopharming
At present, environmental degradation and the consistently growing population are two main
problems on the planet earth. Fulfilling the needs of this growing population is quite difficult …
problems on the planet earth. Fulfilling the needs of this growing population is quite difficult …
Manufacturing economics of plant‐made biologics: case studies in therapeutic and industrial enzymes
D Tusé, T Tu, KA McDonald - BioMed research international, 2014 - Wiley Online Library
Production of recombinant biologics in plants has received considerable attention as an
alternative platform to traditional microbial and animal cell culture. Industrially relevant …
alternative platform to traditional microbial and animal cell culture. Industrially relevant …
Sowing the seeds of success: pharmaceutical proteins from plants
E Stoger, JKC Ma, R Fischer, P Christou - Current opinion in biotechnology, 2005 - Elsevier
Among the many plant-based production systems that have been developed for
pharmaceutical proteins, seeds have the useful advantage of accumulating proteins in a …
pharmaceutical proteins, seeds have the useful advantage of accumulating proteins in a …
Plants as bioreactors: recent developments and emerging opportunities
In recent years, the use of plants as bioreactors has emerged as an exciting area of research
and significant advances have created new opportunities. The driving forces behind the …
and significant advances have created new opportunities. The driving forces behind the …
Plant molecular farming: systems and products
ME Horn, SL Woodard, JA Howard - Plant cell reports, 2004 - Springer
Plant molecular farming is a new and promising industry involving plant biotechnology. In
this review, we describe several diverse plant systems that have been developed to produce …
this review, we describe several diverse plant systems that have been developed to produce …
High‐level rapid production of full‐size monoclonal antibodies in plants by a single‐vector DNA replicon system
Z Huang, W Phoolcharoen, H Lai… - Biotechnology and …, 2010 - Wiley Online Library
Plant viral vectors have great potential in rapid production of important pharmaceutical
proteins. However, high-yield production of hetero-oligomeric proteins that require the …
proteins. However, high-yield production of hetero-oligomeric proteins that require the …