Manufacturing economics of plant‐made biologics: case studies in therapeutic and industrial enzymes

D Tusé, T Tu, KA McDonald - BioMed research international, 2014 - Wiley Online Library
Production of recombinant biologics in plants has received considerable attention as an
alternative platform to traditional microbial and animal cell culture. Industrially relevant …

A simplified techno‐economic model for the molecular pharming of antibodies

P Mir‐Artigues, RM Twyman, D Alvarez… - Biotechnology and …, 2019 - Wiley Online Library
By the end of 2017, the Food and Drug Administration had approved a total of 77 therapeutic
monoclonal antibodies (mAbs), most of which are still manufactured today. Furthermore …

Technoeconomic analysis of semicontinuous bioreactor production of biopharmaceuticals in transgenic rice cell suspension cultures

JM Corbin, MJ McNulty, K Macharoen… - Biotechnology and …, 2020 - Wiley Online Library
Biopharmaceutical protein production using transgenic plant cell bioreactor processes offers
advantages over microbial and mammalian cell culture platforms in its ability to produce …

Economic comparison between conventional and disposables‐based technology for the production of biopharmaceuticals

JL Novais, NJ Titchener‐Hooker… - Biotechnology and …, 2001 - Wiley Online Library
Time to market, cost effectiveness, and flexibility are key issues in today's biopharmaceutical
market. Bioprocessing plants based on fully disposable, presterilized, and prevalidated …

Recombinant proteins for industrial versus pharmaceutical purposes: a review of process and pricing

J Puetz, FM Wurm - Processes, 2019 - mdpi.com
Recombinant proteins have been produced for over 30 years. Applications range from
enzymes used in laundry detergents to antigen-detecting antibodies in cancer therapy …

Techno-economic analysis of the industrial production of a low-cost enzyme using E. coli: the case of recombinant β-glucosidase

RG Ferreira, AR Azzoni, S Freitas - Biotechnology for biofuels, 2018 - Springer
Background The enzymatic conversion of lignocellulosic biomass into fermentable sugars is
a promising approach for producing renewable fuels and chemicals. However, the cost and …

Guidelines and cost analysis for catalyst production in biocatalytic processes

P Tufvesson, J Lima-Ramos, M Nordblad… - … Process Research & …, 2011 - ACS Publications
Biocatalysis is an emerging area of technology, and to date few reports have documented
the economics of such processes. As it is a relatively new technology, many processes do …

[PDF][PDF] Biopharmaceutical Manufacturing: Historical and Future Trends in Titers, Yields, and Efficiency in Commercial-Scale Bioprocessing.

RA Rader, ES Langer - BioProcessing Journal, 2014 - biopharma.com
This article documents the progress, cur-rent state, and projected future trends in titer and
yield as industrial and technological benchmarks for commercial-scale biopharmaceutical …

Cost-effective production of biocatalysts using inexpensive plant biomass: a review

D Sakhuja, H Ghai, RK Rathour, P Kumar, AK Bhatt… - 3 Biotech, 2021 - Springer
Enzymes are the complex protein moieties, catalyze the rate of chemical reactions by
transforming various substrates to specific products and play an integral part in multiple …

[BOOK][B] Biopharmaceutical processing: development, design, and implementation of manufacturing processes

G Jagschies, E Lindskog, K Lacki, PM Galliher - 2018 - books.google.com
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing
Processes covers bioprocessing from cell line development to bulk drug substances. The …