KR102005266B1 - Wet wipes composition comprising laurylpyridinium chloride and organic acid, polyhydric alcohol or mixtures thereof and wet wipes containing the same - Google Patents

Abstract

The present invention relates to a wet tissue composition comprising lauryl pyridinium chloride, organic acid and polyhydric alcohol or a mixture thereof, and wet tissue containing the same. It is found that there is a bacterium called Burkholderia spp. resistant to a wet tissue composition disclosed in a Korean registered patent No. 1798978 filed by the present inventors and unpleasant smell and discoloration take place in the wet tissue containing the wet tissue composition. In order to solve such problems, when organic acid and polyhydric alcohol or a mixture thereof not described in the above registered patent are added along with lauryl pyridinium chloride, it is confirmed that the inventive composition has an anti-bacterial effect on Burkholderia spp. resistant to the prior composition and excellent diffusivity in wet tissue and the unpleasant smell and discoloration do not appear. Therefore, the wet tissue composition comprising lauryl pyridinium chloride, an organic acid and polyhydric alcohol or a mixture thereof according to the present invention is expected to replace a wet tissue composition of the registered patent filed by the present inventors (Korean registered patent No. 1798978) as well as a conventional antiseptic composition comprising cetylpyridinium chloride.

Description

[0001] The present invention relates to a wet tissue composition comprising lauryl pyridinium chloride and an organic acid, a polyhydric alcohol or a mixture thereof, and a wet tissue containing the wet tissue,

The present invention relates to a wet tissue composition comprising lauryl pyridinium chloride and an organic acid, a polyhydric alcohol or a mixture thereof, and a wet tissue containing the same.

Wet wipes refers to nonwoven fabrics containing water used for cleaning the human body and has been used for various purposes in homes and childcare facilities, welfare facilities for the elderly, restaurants, and hospitals since the mid 1950s. Early wet tissue was mainly used for cleaning during travel, but recently it has been used for cleaning infants skin, pads for wiping away makeup or sweat, pain relief, personal hygiene, animal care, health care, (Seo, JH, et al., 2015; Moo, SC, 2016).

The ingredients added to the wet tissue generally include functional ingredients according to purpose such as moisturizers and perfumes in purified water, and sterilization disinfectants and preservatives such as preservatives are added to the tissues so that they can be stored for a long period of time in a wet state. However, since the wet tissue is generally not a product to be washed with water after use, the preservative contained in the product is highly likely to remain on the skin, and the use area of the product is sensitive to chemicals such as mouth and hands. It should have excellent stability and good removability of foreign substances and pathogenic microorganisms that remain on the skin.

Cetylpyridinium chloride (CPC), one of the most widely used preservatives, is a quaternary ammonium cation that has a bactericidal effect against bacteria and microorganisms, prevents plaque formation in the teeth, It is known to have an effect of decreasing the amount of the nasal spray, which is used in oral cleansers, toothpastes, oral sprays, nasal sprays and wet tissues. However, cetylpyridinium chloride has a large amount of bubbles due to its characteristics, so it is necessary to use defoamer together. In this case, contamination and process problems in the manufacturing process occur, and the frequency of popping up phenomenon of slippery and wet tissue increases, There are problems that it is not spread well and is vulnerable to microbial contamination.

In recent years, a wet tissue using cetylpyridinium chloride and benzalkonium chloride (BKC) as a preservative has been used in Burkholderia It has been confirmed that cepacia acquires resistance to a preservative, i.e., a wetting agent preservative, and proliferates in a large amount. Therefore, it is necessary to develop a new wetting agent preservative that can replace cetylpyridinium chloride and benzalkonium chloride preservative.

In order to overcome the limitations and disadvantages of cetylpyridinium chloride and benzalkonium chloride mentioned above, the amount of climbazole, which is often used as a cosmetic preservative ingredient at home and abroad, is increasing. Cream barzol is a white crystalline powder with a grade of 0 in the EWG Skin Deep rating, a non-profit environmental research organization in the United States. It is known to have lower irritancy and lower risk than other ingredients and is an exclusive and persistent ovarian fungal and tricobyte- It is known to have a germicidal effect.

However, it is necessary to develop an antiseptic and harmless preservative which can replace cetylpyridinium chloride, benzalkonium chloride and cream barazole, while being known as a potentially toxic harmful substance that does not dissolve in water. It is a situation.

Laurylpyridinium chloride (LPC, dodecylpyridinium chloride) has excellent antibacterial effect and low skin irritation. As a preservative suitable for application to a wet tissue because of its high water solubility and excellent spreadability in a fabric when applied to a wet tissue, the present inventors have found that a preservative that can replace cetylpyridinium chloride, benzalkonium chloride, (Patent No. 1798978) regarding a wet tissue composition containing pyridinium chloride as a main component and a wet tissue containing the same.

Accordingly, the inventors of the present invention have found that, in a process of continuously studying a wipes composition containing lauryl pyridinium chloride as a main component, the inventors of Burkholderia ( Burkholderia) obtained resistance to the wet tissue composition of Korean Patent No. 1798978, spp.), and found that an unpleasant odor is generated in a wet tissue containing the wet tissue composition and a discoloration phenomenon in which the wet tissue exposed in the air turns yellow. Therefore, in order to solve these problems, it has been found that the use of specific organic acids, polyhydric alcohols or a mixture thereof other than the components described in the registered patents of the present inventors together with laurylpyridinium chloride, The antimicrobial effect and the diffusion property in the wet tissue are increased, and the product is not discolored or discolored. Thus, the present invention can be completed.

Korean Patent No. 1798978, which is a registered trademark of the present inventor, discloses a wet tissue composition comprising lauryl pyridinium chloride as a main component and a wet tissue including the same, which is similar to the present invention, Patent No. 1798978, which is a wipes composition for solving the problem of antibacterial effect and discoloration and the antibacterial effect on bacterium belonging to the genus Bruchhanderia, which is resistant to the wet tissue composition, is more advanced than Korean Patent No. 1798978. Korean Patent Laid-Open Publication No. 2014-0062838 discloses a preservative composition comprising anisic acid, sodium anisate, levulic acid, sodium levulinate, and Japanese Patent Laid-Open No. 2018-154599 includes phenylpropanol and ethylhexyl glycerin European Patent Publication No. 2065025 discloses a preservative composition comprising sodium levulinate and sodium anisate, Korean Patent No. 1472531 discloses a wet tissue composition comprising ethylhexyl glycerin, anisic acid and decylen glycol, However, the composition containing lauryl pyridinium chloride of the present invention is not described, and the composition of the composition is different.

Korean Patent No. 1798978, a wipes composition having increased spreading property in a wet tissue including lauryl pyridinium chloride, and a wet tissue containing the same, 2017. 13. 13. Registration. Korean Utility Model Publication No. 2014-0062838, antiseptic, levulinic acid, and glyceryl caprylate mixtures, 2014. 05. 26. Disclosed. Japanese Laid-Open Patent Application No. 2018-154599, cosmetic materials, disclosed on October 10, European Published Patent No. 2065025, A preservative composition and its use, a method of preparing it and formulations containing it, 2009. 06. 03. Disclosure. Korean Registered Patent No. 1472531, composition for a wet tissue and a wet tissue including the same, 2014. 12. 08. Registration.

Moo, S. C., Bacterial Contamination in Disposable Wet Wipes from General Restaurants, Korean J. Clin. Lab. Sci., 48 (3), 237-241, 2016. Seo, J.H., et al., Studies on the antibacterial activity of wet-tissue saturated aqueous solution of NaCl solution, Journal of Korea TAPPI, 47 (6), 147-153, 2015.

It is an object of the present invention to provide a wet tissue composition having antimicrobial activity against lauryl pyridinium chloride resistant bacteria including lauryl pyridinium chloride and an organic acid, a polyhydric alcohol or a mixture thereof.

It is also an object of the present invention to provide a wet tissue containing the wet tissue composition having antimicrobial activity against the lauryl pyridinium chloride resistant bacteria.

The present invention relates to a process for the preparation of a) laurylpyridinium chloride; And b) anisic acid, sodium anisate, levulinic acid, sodium levulinate, PCA ethyl cocoyl arginate, glyceryl < RTI ID = 0.0 > Glyceryl caprylate, glyceryl monolaurate, sodium cocoPG dimonium chloride phosphate, propylene glycol, dipropylene glycol, methyl (meth) acrylate, But are not limited to, methylpropanediol, pentylene glycol, phenylpropanol, decylene glycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl One or more compounds selected from the group consisting of glyceryl mononucleoside, caproyl glyceryl ether, Water; la, including to us on the wet tissue a composition with antimicrobial effects for pyridinium chloride resistant bacteria.

The wipes composition comprises: a) from 0.01 to 30% by weight of laurylpyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether 0.001 to 40% by weight of the above compound.

Said wipe tissue composition comprising: a) lauryl pyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether The above compound may be mixed in a weight ratio of 1:10 to 10: 1.

The wet tissue composition may further include a moisturizing agent and a pH adjusting agent.

The wet tissue composition may be selected from the group consisting of Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , Aspergillus brasiliensis , Candida albicans , Burkholderia cepacia , It can be sterilized against Burkholderia arboris and Burkholderia lata .

The wipes composition can prevent discoloration or spoilage of the wet tissue.

In another aspect, the present invention relates to a wet tissue containing the wet tissue composition.

Hereinafter, the present invention will be described in detail.

Said wipe tissue composition comprising: a) lauryl pyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether The above compounds may be included.

Said wipes composition comprising: a) from 0.01 to 30% by weight of lauryl pyridinium chloride, based on the total weight of the composition; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether 0.001 to 40% by weight of the above compound. Preferably a) 0.01 to 5% by weight of laurylpyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether 0.005 to 5% by weight of the above compound, more preferably a) 0.02 to 0.5% by weight of laurylpyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether 0.005 to 1% by weight of the above compound.

The laurylpyridinium chloride has excellent antimicrobial effect against bacteria and fungi, and is particularly effective against Staphylococcus aureus , Escherichia coli , Enterobacter hirae , Pseudomonas aeruginosa , It shows excellent antibacterial effect. In addition, it is suitable for the production of wet tissues which are in direct contact with the skin due to low skin irritation, and is excellent in water solubility. Therefore, when applied to a wet tissue, it can be easily applied in the production of wet tissues.

The laurylpyridinium chloride is a compound that can replace cetylpyridinium chloride, which is a widely used preservative, and it is a compound of cetylpyridinium chloride that a large amount of foam is generated, It is possible to overcome the difficulty of spreading of the wet tissue in the wet tissue and the slippery of the wet tissue, the pop-up phenomenon (a phenomenon in which a plurality of wet tissues come out when the wet tissue is pulled) and the wet tissue. In addition, cetylpyridinium chloride can be substituted by showing antibacterial activity against Burkholderia cepacia , which has obtained resistance to cetylpyridinium chloride.

The content of the laurylpyridinium chloride may be 0.01 to 30% by weight based on the total weight of the wet tissue composition. If the content of the laurylpyridinium chloride is less than 0.01% by weight, the disinfecting power of the wet tissue composition does not reach the standard value of the sterilizing power which is a standard in the production of wet tissues. If the laurylpyridinium chloride content exceeds 30% by weight, And it is not economical because additional additives and heating process are required.

The compound of b) may be mixed to increase the antimicrobial effect of the laurylpyridinium chloride and may be mixed for antibacterial effect against bacteria resistant to laurylpyridinium chloride.

The compound may be an organic acid, a polyhydric alcohol, or a mixture thereof.

The organic acids may be anisic acid, sodium anisate, levulinic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, and sodium cocopygidimonium chloride phosphate, But is not limited thereto.

The polyhydric alcohol may be at least one selected from the group consisting of propylene glycol, dipropylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glycerylmonoundecylenate and caprylylglycerylether But is not limited thereto.

The content of the compound may be 0.001 to 40% by weight based on the total weight of the wet tissue composition. If the content of the compound is less than 0.001% by weight, the sterilizing power of the wet tissue composition does not reach the standard value of the sterilizing power, There is no large difference in sterilizing power and it is not preferable because it is economical.

Said wipe tissue composition comprising: a) lauryl pyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether The above compound may be mixed in a weight ratio of 1: 4000 to 10: 1. Preferably in a weight ratio of 1: 100 to 10: 1, more preferably in a weight ratio of 1:10 to 10: 1.

The wipes composition is excellent in bactericidal and fungicidal effects, and is particularly useful as an antimicrobial agent for the treatment of Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , Enterobacter hirae , Aspergillus brasiliensis , , Candida albicans , Mycobacterium terrae and Burkholderia ( Burkholderia < RTI ID = 0.0 > cepacia , Burkholderia arboris , Burkholderia lata , and the like. Preferably, the bactericidal effect against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Burkholderia sephacia, Burkholderia alboris and Burkholderia lata is excellent.

The laurylpyridinium chloride resistant microorganism may be Bruchhorferia homogenate. But are not limited to, Burkholderia cepaia, Burkholderia alboris and Burkholderia lata.

It is important that the bacterium is resistant to antimicrobial agents and preservatives, and that when the bacterium is contaminated with bacteriostatic bacteria due to its rapid growth rate, it is important to control and inhibit the propagation of the bacterium.

The benzoic acid, sodium benzoate, potassium sorbate, dehydroacetic acid, and sodium dehydroacetate used in the wet tissue composition of Korean Patent No. 1798978, which is a registered patent of the present inventors, can induce the product to sweat due to the odor of the raw material itself, The moisture of the wipes may be evaporated and the color of the wet tissue may be changed to deteriorate the value of the product. In order to overcome these limitations and problems, life scents such as cosmetics, shampoos, treatments, and kitchen detergents include various scents to mask the odor of the raw materials themselves, add various pigments to prevent discoloration, It is also said. However, in the case of wet tissues, consumers prefer white fabrics in terms of hygiene and visibility, and therefore, it is difficult to use pigmentation or thick fragrance.

In the present invention, it is important that the color of the wet tissue is changed due to the evaporation of the moisture of the wet tissue, and the discoloration of the wet tissue may damage the value of the product to prevent discoloration. In addition, the wetting of the wet tissue is due to the fact that the raw odor of the raw material such as benzoic acid, sodium benzoate, potassium sorbate, dehydroacetic acid and sodium dehydroacetate contained in the wet tissue composition appears in the wet tissue, It can damage the value of the product.

The wet tissue composition of the present invention can be prevented by using a composition having excellent antimicrobial activity without using benzoic acid, sodium benzoate, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, or the like, which causes discoloration or removal of the wet tissue.

The wipes composition may also have an increased diffusibility in the wet tissue. If the diffusion property is low, the antiseptic composition may not spread evenly on the wet tissue, so that the microorganism may grow on the portion not containing the preservative composition, and the odor, discoloration, Skin troubles may occur due to microbial by-products.

The above wet tissue composition can be used as it is or diluted in purified water.

The dilution of the wet tissue composition may be diluted 1 to 1000 times based on the total weight of the diluted solution, but this may vary depending on the judgment of a person skilled in the art.

The wet tissue composition comprises a) lauryl pyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether The above compounds can be produced in addition to other additives.

The additive may be a moisturizer, a pH regulator, a thickener, a stabilizer, a perfume, a dispersant and a coloring material. Preferably, the additive is a moisturizer and a pH adjusting agent to be.

The humectant may be at least one selected from the group consisting of propylene glycol, diproprylene glycol, hexylene glycol, butylene glycol, glycerin, methylpropanediol methylpropanediol), and the like, preferably propylene glycol, dipropylene glycol, hexylene glycol, and butylene glycol, but are not limited thereto.

The pH adjusting agent may be citric acid, sodium citrate, ethylenediaminetetraacetic acid (EDTA) -2NA, EDTA-4NA or KOH, and is preferably citric acid or EDTA-2NA. .

The present invention also relates to a wet tissue containing the above wet tissue composition.

Wherein the wipes comprise: a) from 0.01 to 30% by weight of laurylpyridinium chloride; And b) an anionic surfactant selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, dipropylene glycol, One kind selected from the group consisting of methyl propanediol, pentylene glycol, phenylpropanol, decylene glycol, propylene glycol, cyclohexyl glycerin, hexyl glycerin, ethylhexyl glycerin, glyceryl mono-undecylenate and caprylyl glyceryl ether And 0.001 to 40% by weight of the above compound. Preferably a) 0.01 to 5% by weight of laurylpyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether 0.005 to 5% by weight of the above compound; and more preferably 0.02 to 0.5% by weight of a) laurylpyridinium chloride; And b) an anhydride selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, propylene glycol, di One kind selected from the group consisting of propylene glycol, methylpropanediol, pentylene glycol, phenylpropanol, decyleneglycol, cyclohexylglycerin, hexylglycerin, ethylhexylglycerin, glyceryl monoundecylenate and caprylyl glyceryl ether And 0.005 to 1% by weight of the above-mentioned compound; however, it may be varied according to the judgment of a person skilled in the art.

The wipes fabric may be fabric, cotton, 100% rayon, mercedes, linens, etc., which are blended with polyester fibers and rayon. However, the present invention is not limited thereto.

The fabric obtained by blending the polyester fiber with rayon is blended with polyester and rayon in a ratio of 3: 7 to 5: 5, excellent in water absorption ability, and soft in touch.

The polyester fabric is a synthetic fiber made from organic materials consisting of linear (chain) or cross-linked (net) molecules made by ester bonding of many small molecules. It is strong against insects in fiber, strong against sunlight and strong against mold. However, since the hygroscopicity is low, 100% polyester fabric is not suitable for wet tissue production.

The rayon fabric is a fabric made of natural materials and has a good absorbing ability of water and a soft feeling, so that it has less irritation when it touches the skin. However, when the water touches the water, it shrinks, the elasticity decreases, and the resistance to microorganisms is weak.

This cotton fabric is 100% natural cotton cellulose fiber extracted from cotton, and it is not only excellent in water absorbency but also has a twist structure of the material itself and good ventilation. However, it has a disadvantage that it is not durable against microorganisms.

The above-mentioned merishi and lanis fabric is a fabric emphasizing softness by increasing the content of rayon, and has advantages of high water absorption ability and high adhesion to the skin to improve foreign matter.

The wet tissue has an excellent germicidal effect due to the presence of the wet tissue composition, and it is possible to prevent the wetting of the wet tissue and the pop-up phenomenon of the wet tissue, and to prevent the wet tissue from being changed or discolored.

The wet tissue includes the wet tissue composition, and may include any wet tissue produced by a known manufacturing method existing in the art.

The present invention relates to a wet tissue composition comprising lauryl pyridinium chloride and an organic acid, a polyhydric alcohol or a mixture thereof, and a wet tissue containing the wet tissue composition, and more particularly, to a wet tissue composition of Korean Patent No. 1798978 Obtained Burkholderia spp., And found an unpleasant smell (change) and discoloration in the wet tissue containing the wet tissue composition. Therefore, in order to solve these problems, the antimicrobial effect of the wet tissue composition containing organic acids, polyhydric alcohols or a mixture thereof, which is not listed in the above patent, on lauryl pyridinium chloride, And it was confirmed that the product was not discolored or discolored.

Thus, a wet tissue composition comprising the lauryl pyridinium chloride of the present invention and an organic acid, a polyhydric alcohol, or a mixture thereof can be used as a preservative composition containing conventional cetylpyridinium chloride as well as a wipes composition of the present invention It is expected to be possible.

Fig. 1 shows the result of discoloration of a fabric according to the wet tissue composition of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in detail. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Rather, the intention is to provide an exhaustive, complete, and complete disclosure of the principles of the invention to those skilled in the art.

EXAMPLE 1 Preparation of a Wet Tissue Composition Comprising One Lauryl Pyridinium Chloride and an Organic Acid or Polyhydric Alcohols [

Laurylpyridinium chloride and one selected from organic acids or polyhydric alcohols was prepared by mixing and mixing the substances of the following Table 1 and purified water in purified water.

Laurylpyridinium chloride Organic acid Polyhydric alcohol
Purified water Anisan
salt Sodium levulinate PCA ethylcocoyl alginate Glyceryl caprylate Sodium coco peji-dimonium chloride phosphate Phenylpropanol Decylene glycol Ethylhexyl glycerin Caprylyl glyceryl ether weight% Example 1-1 0.01 0.001 Remaining amount (To 100) Examples 1-2 0.02 0.02 Remaining amount (To 100) Example 1-3 0.05 0.05 Remaining amount (To 100) Examples 1-4 0.2 0.2 Remaining amount (To 100) Examples 1-5 2 2 Remaining amount (To 100) Examples 1-6 0.05 0.1 Remaining amount (To 100) Examples 1-7 0.1 0.2 Remaining amount (To 100) Examples 1-8 One 2 Remaining amount (To 100) Examples 1-9 0.02 0.02 Remaining amount (To 100) Example 1-10 0.05 0.05 Remaining amount (To 100) Example 1-11 0.2 0.2 Remaining amount (To 100) Examples 1-12 2 2 Remaining amount (To 100) Examples 1-13 0.05 0.1 Remaining amount (To 100) Examples 1-14 0.1 0.2 Remaining amount (To 100) Examples 1-15 One 2 Remaining amount (To 100) Examples 1-16 0.01 0.001 Remaining amount (To 100) Examples 1-17 0.02 0.005 Remaining amount (To 100) Example 1-18 0.2 0.01 Remaining amount (To 100) Example 1-19 0.02 0.2 Remaining amount (To 100) Examples 1-20 0.05 0.5 Remaining amount (To 100) Examples 1-21 0.2 2 Remaining amount (To 100) Examples 1-22 One 10 Remaining amount (To 100) Examples 1-23 0.02 0.04 Remaining amount (To 100) Examples 1-24 0.05 0.1 Remaining amount (To 100) Examples 1-25 0.2 0.4 Remaining amount (To 100) Examples 1-26 0.01 0.001 Remaining amount (To 100) Examples 1-27 0.02 0.04 Remaining amount (To 100) Examples 1-28 0.05 0.1 Remaining amount (To 100) Examples 1-29 0.2 0.2 Remaining amount (To 100) Examples 1-30 0.02 0.04 Remaining amount (To 100) Examples 1-31 0.05 0.1 Remaining amount (To 100) Example 1-32 0.2 0.1 Remaining amount (To 100) Examples 1-33 0.02 0.005 Remaining amount (To 100) Examples 1-34 0.05 0.025 Remaining amount (To 100) Example 1-35 0.2 0.5 Remaining amount (To 100) Example 1-36 0.02 0.04 Remaining amount (To 100) Examples 1-37 0.05 0.1 Remaining amount (To 100) Examples 1-38 0.2 0.4 Remaining amount (To 100)

< Example  2. Laurylpyridinium chloride and  Organic acids and From polyhydric alcohols  Preparation of a Wet Tissue Composition Comprising Two or More of Selected &

The wettable composition of the present invention comprising lauryl pyridinium chloride and two kinds of organic acids and polyhydric alcohols was prepared by mixing and mixing the components and ingredients of the following Table 2 in purified water.

Lauryl
Pyridinium
Chloride Organic acid Polyhydric alcohol
Purified water Sodium anisas Sodium levulinate Phenyl
Propanol Decylene
Glycoll Caprylyl glyceryl ether weight% Example 2-1 0.02 0.02 0.04 Remaining amount (To 100) Example 2-2 0.02 0.02 0.4 Remaining amount (To 100) Example 2-3 0.02 0.02 0.04 Remaining amount (To 100) Examples 2-4 0.02 0.02 0.06 Remaining amount (To 100) Example 2-5 0.02 0.02 0.4 Remaining amount (To 100) Examples 2-6 0.02 0.02 0.04 Remaining amount (To 100) Examples 2-7 0.02 0.02 0.4 Remaining amount (To 100) Examples 2-8 0.02 0.02 0.04 Remaining amount (To 100) Examples 2-9 0.02 0.02 0.4 Remaining amount (To 100) Examples 2-10 0.02 0.02 0.04 Remaining amount (To 100) Examples 2-11 0.02 0.02 0.06 Remaining amount (To 100) Examples 2-12 0.02 0.02 0.4 Remaining amount (To 100) Examples 2-13 0.02 0.02 0.04 Remaining amount (To 100) Examples 2-14 0.02 0.02 0.4 Remaining amount (To 100) Examples 2-15 0.02 0.04 0.04 Remaining amount (To 100) Examples 2-16 0.02 0.04 0.06 Remaining amount (To 100) Examples 2-17 0.02 0.04 0.4 Remaining amount (To 100) Examples 2-18 0.02 0.06 0.04 Remaining amount (To 100) Example 2-19 0.02 0.4 0.04 Remaining amount (To 100) Examples 2-20 0.02 0.04 0.04 Remaining amount (To 100) Examples 2-21 0.02 0.04 0.06 Remaining amount (To 100) Examples 2-22 0.02 0.04 0.4 Remaining amount (To 100) Examples 2-23 0.02 0.06 0.04 Remaining amount (To 100) Examples 2-24 0.02 0.4 0.04 Remaining amount (To 100) Examples 2-25 0.02 0.04 0.04 Remaining amount (To 100) Example 2-26 0.02 0.04 0.06 Remaining amount (To 100) Example 2-27 0.02 0.04 0.4 Remaining amount (To 100) Example 2-28 0.02 0.06 0.04 Remaining amount (To 100) Example 2-29 0.02 0.4 0.04 Remaining amount (To 100)

< Comparative Example  1 to Comparative Example  15. Preparation of Wet Tissue Composition for Comparison>

 The materials and ingredients of the following Table 3 were added to purified water and mixed to prepare a comparative wet tissue composition.

Lauryl
Pyridinium
Chloride Capril
Hydroxamic acid Sodium benzoate Sodium dehydroacetate Organic acid Polyhydric alcohol
Purified water Sodium anisas Sodium levulinate Phenyl
Propanol Decylene
Glycoll weight% Comparative Example 1 0.02 Remaining amount (To 100) Comparative Example 2 One Remaining amount (To 100) Comparative Example 3 One Remaining amount (To 100) Comparative Example 4 One Remaining amount (To 100) Comparative Example 5 One Remaining amount (To 100) Comparative Example 6 One Remaining amount (To 100) Comparative Example 7 One Remaining amount (To 100) Comparative Example 8 0.01 0.0005 Remaining amount (To 100) Comparative Example 9 0.02 0.02 Remaining amount (To 100) Comparative Example 10 0.02 0.02 0.04 Remaining amount (To 100) Comparative Example 11 0.02 0.02 0.04 Remaining amount (To 100) Comparative Example 12 0.02 0.04 0.04 Remaining amount (To 100) Comparative Example 13 0.02 0.04 0.04 Remaining amount (To 100) Comparative Example 14 0.02 0.04 0.04 Remaining amount (To 100) Comparative Example 15 0.02 0.04 0.04 Remaining amount (To 100)

< Experimental Example  1. Identification of Antimicrobial Activity of Wet Tissue Composition &gt;

To confirm the antimicrobial activity of the wet tissue compositions of Examples 1 and 2 and Comparative Examples 1 to 15, the bacterium was selected from the group consisting of Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , fungi mixed with Aspergillus brasiliensis and Candida albicans , Burkholderia cepacia , Burkholderia cepacia , Burkholderia albaris , ( Burkholderia arboris ) and Burkholderia lata ( Burkholderia lata ), respectively.

The antimicrobial activity experiments were performed according to US Pharmacopoeia standards. Specifically, were experimenting with plate culture method to determine the reduction and death rate of the bacteria, the Examples 1 and 2 and Comparative Examples 1 to 10 to 15 wipes compositions of ⁶ ~ 10 ⁷ CFU / ㎖ bacterial mixed bacteria of 10 ⁵ - 10 ⁶ after CFU / ㎖ fungal mixed bacteria, and inoculating each Burkholderia bacteria of 10 ⁶ to 10 ⁷ CFU / ㎖, applied to a plate medium, the bacteria for 24 hours at 30 ~ 35 ℃, fungi For 72 hours at 25 DEG C and for 48 hours at 30 to 35 DEG C. At this time, as a control group, a homogenate solution not treated with a wet tissue composition was used. After each bacterium was cultured, the number of colonies of the bacterium produced on the plate medium was counted, and then the mortality rate of the bacterium was calculated using the following formula 1, and the results are shown in Table 4.

[Formula 1]

(= Number of bacteria in the control group - number of bacteria remaining in the wet tissue composition) / number of bacteria inoculated in the control group) × 100

The criterion of the mortality rate of the microorganism usable as the wet tissue composition is 99.9% or more, and when it is less than 99.9%, it is not suitable for the production of wet tissues.

Composition Germ Fungus Burg
Helderia Sepsisia Burg
Helderia Al Boris Bukur
Helderiarata Composition Germ Fungus Burg
Helderia Sepsisia Burg
Helderia Al Boris Bukur
Helderiarata Death Rate (%) Death Rate (%) Example 1-1 99.9 100 99.9 100 100 Examples 2-4 100 100 100 100 100 Examples 1-2 99.9 99.9 99.9 99.9 99.9 Example 2-5 100 100 100 100 100 Example 1-3 99.9 100 99.9 100 100 Examples 2-6 99.9 100 99.9 99.9 99.9 Examples 1-4 100 100 100 100 100 Examples 2-7 100 100 100 100 100 Examples 1-5 100 100 100 100 100 Examples 2-8 99.9 100 99.9 99.9 99.9 Examples 1-6 100 100 100 100 100 Examples 2-9 99.9 100 100 99.9 100 Examples 1-7 100 100 100 100 100 Examples 2-10 100 99.9 100 100 100 Examples 1-8 100 100 100 100 100 Examples 2-11 100 100 100 100 100 Examples 1-9 99.9 99.9 99.9 99.9 99.9 Examples 2-12 100 100 100 100 100 Example 1-10 99.9 99.9 99.9 99.9 100 Examples 2-13 99.9 99.9 99.9 99.9 99.9 Example 1-11 100 100 100 100 100 Examples 2-14 99.9 100 100 99.9 99.9 Examples 1-12 100 100 100 100 100 Examples 2-15 99.9 100 99.9 99.9 99.9 Examples 1-13 100 100 100 100 100 Examples 2-16 100 99.9 99.9 100 100 Examples 1-14 100 100 100 100 100 Examples 2-17 100 100 100 99.9 99.9 Examples 1-15 100 100 100 100 100 Examples 2-18 100 99.9 100 99.9 100 Examples 1-16 99.9 100 99.9 99.9 100 Example 2-19 99.9 100 99.9 100 100 Examples 1-17 99.9 100 99.9 99.9 99.9 Examples 2-20 100 99.9 99.9 99.9 99.9 Example 1-18 100 100 99.9 100 100 Examples 2-21 100 99.9 100 99.9 100 Example 1-19 99.9 99.9 99.9 99.9 99.9 Examples 2-22 100 100 100 100 100 Examples 1-20 99.9 99.9 99.9 99.9 99.9 Examples 2-23 100 99.9 100 100 100 Examples 1-21 99.9 99.9 99.9 99.9 99.9 Examples 2-24 100 100 100 100 100 Examples 1-22 100 100 99.9 99.9 100 Examples 2-25 99.9 99.9 99.9 99.9 99.9 Examples 1-23 99.9 99.9 99.9 99.9 99.9 Example 2-26 99.9 100 100 100 99.9 Examples 1-24 100 100 99.9 99.9 99.9 Example 2-27 100 99.9 99.9 100 99.9 Examples 1-25 100 100 100 100 100 Example 2-28 99.9 99.9 99.9 99.9 100 Examples 1-26 99.9 100 99.9 99.9 99.9 Example 2-29 99.9 100 99.9 100 100 Examples 1-27 99.9 99.9 99.9 99.9 99.9 Comparative Example 1 98.9 98.4 97.6 96.9 95.9 Examples 1-28 99.9 99.9 99.9 99.9 99.9 Comparative Example 2 100 99.9 99.7 98.9 99.1 Examples 1-29 100 100 99.9 99.9 100 Comparative Example 3 98.9 99.5 98.9 95.7 96.9 Examples 1-30 99.9 100 100 99.9 100 Comparative Example 4 96.8 98.9 97.8 95.9 96.7 Examples 1-31 100 100 100 100 100 Comparative Example 5 96.7 98.3 93.7 94.8 95.2 Example 1-32 100 100 100 100 100 Comparative Example 6 95.8 97.5 95.8 94.9 95.4 Examples 1-33 99.9 99.9 99.9 99.9 99.9 Comparative Example 7 98.3 98.7 97.9 98.6 98.9 Examples 1-34 99.9 100 99.9 99.9 99.9 Comparative Example 8 99.1 98.9 98.9 98.4 98.9 Example 1-35 100 100 100 100 100 Comparative Example 9 99.9 99.9 98.9 98.6 98.1 Example 1-36 99.9 99.9 99.9 99.9 99.9 Comparative Example 10 100 100 99.9 98.9 99.6 Examples 1-37 99.9 100 99.9 99.9 99.9 Comparative Example 11 99.9 100 99.9 99.7 99.8 Examples 1-38 100 100 100 100 100 Comparative Example 12 98.9 99.8 99.7 99.2 99.9 Example 2-1 100 100 100 100 99.9 Comparative Example 13 100 99.8 99.9 99.9 99.8 Example 2-2 100 100 100 99.9 99.9 Comparative Example 14 99.9 100 99.8 99.9 100 Example 2-3 100 100 100 99.9 100 Comparative Example 15 100 99.9 99.9 99.9 99.9

As shown in Table 4, in the case of the wet tissue compositions of Examples 1 and 2, the bactericidal rate of bacteria, fungi, Burkholderia sephacia, Burkholderia alvoris and Burkholderia lata was 99.9% or more , Comparative Examples 1 to 7, and Comparative Examples 9 to 11, as compared with the wet tissue compositions of Comparative Examples 8 and 9 except for the content of the present invention, In the case of a wet tissue composition of Korean Patent No. 1798978, which is a patent, and Comparative Examples 12 to 14, in the case of a wet tissue composition which is different from the composition of the present invention, bacteria, fungus, burgunderia sephacia, burgunderia alboris or burgdelandia It was confirmed that the bactericidal kill rate against rata was less than 99.9%.

Thus, in the case of the wet tissue composition of the present invention, the bactericidal rate is high for bacteria, fungi, Burkholderia sephacia, Burkholderia alvoris and Burkholderia rata, and in particular, Korean Patent No. 1798978 It was also found that the antibacterial effect was excellent also against the bacteria belonging to the genus Bruchholderia sephacia, burgunderia alboris and burgunderia latara, which obtained resistance to the wipes composition of the present invention.

EXPERIMENTAL EXAMPLE 2. Confirmation of Foam Diffusion Property of Wet Tissue Composition [

The wet tissue composition is sprayed onto the central portion of the wet tissue during the production of the wet tissue. If the wet tissue composition is poor in spreadability, the wet tissue composition may not be impregnated at the edge of the raw material. It can cause pollution. Accordingly, in the process of manufacturing the wet tissue using the low-diffusing wet tissue composition, there is a problem that the nozzle is additionally provided on both sides of the wet tissue, thereby increasing the consumption of the wet tissue composition.

As a criterion for determining the spreading power of the wet tissue composition, 0.5 ml or 1 ml of the wet tissue composition was dropped on the fabric of a wet tissue having a diameter of 10 cm, and the size of the diffused diameter was measured after being left for 1 hour. At this time, when the size of the diameter of the spread of the wet tissue composition is 3.0 cm or more when 0.5 ml of the wet tissue composition is dropped, or when the average is 6.0 cm or more when 1 ml is dropped, the wet tissue composition is sufficiently impregnated And it can be judged that the spreading property of the wet tissue composition is excellent on the basis thereof.

Thus, using the wet tissue compositions of Examples 1 and 2 and Comparative Examples 1 to 15, the spreadability of the wet tissue was confirmed.

0.5 mL or 1 mL of each of the wet tissue compositions was dropped on a nonwoven fabric in which rayon and polyethylene were mixed in a ratio of 6: 4, which is mainly used as a wet tissue, and the size of the absorbed diameter was measured. The results are shown in Table 5.

Composition 0.5 ml 1 ml Composition 0.5 ml 1 ml Average value (cm) Average value (cm) Example 1-1 3.0 6.1 Examples 2-4 3.6 7.7 Examples 1-2 3.3 7.5 Example 2-5 3.8 8.1 Example 1-3 3.5 7.3 Examples 2-6 3.5 7.5 Examples 1-4 3.3 6.4 Examples 2-7 3.6 7.4 Examples 1-5 3.1 6.1 Examples 2-8 3.6 7.6 Examples 1-6 3.2 6.3 Examples 2-9 3.7 7.8 Examples 1-7 3.0 6.2 Examples 2-10 3.8 8.2 Examples 1-8 3.1 6.2 Examples 2-11 3.9 8.4 Examples 1-9 3.5 7.1 Examples 2-12 3.8 8.3 Example 1-10 3.3 6.8 Examples 2-13 3.6 7.9 Example 1-11 3.1 6.2 Examples 2-14 3.6 8.1 Examples 1-12 3.0 6.1 Examples 2-15 3.4 7.2 Examples 1-13 3.0 6.3 Examples 2-16 3.6 7.5 Examples 1-14 3.1 6.2 Examples 2-17 3.5 7.4 Examples 1-15 3.3 6.4 Examples 2-18 3.6 7.4 Examples 1-16 3.0 6.0 Example 2-19 3.5 7.3 Examples 1-17 3.2 6.2 Examples 2-20 3.6 7.5 Example 1-18 3.0 6.0 Examples 2-21 3.8 7.8 Example 1-19 3.3 6.8 Examples 2-22 3.9 8.1 Examples 1-20 3.4 7.1 Examples 2-23 3.8 8.1 Examples 1-21 3.0 6.3 Examples 2-24 3.9 8.2 Examples 1-22 3.2 6.2 Examples 2-25 3.6 7.9 Examples 1-23 3.3 6.5 Example 2-26 3.5 7.8 Examples 1-24 3.5 6.8 Example 2-27 3.7 7.9 Examples 1-25 3.3 6.5 Example 2-28 3.6 7.8 Examples 1-26 3.2 6.3 Example 2-29 3.5 7.4 Examples 1-27 3.2 6.6 Comparative Example 1 3.1 6.0 Examples 1-28 3.3 6.5 Comparative Example 2 2.8 5.7 Examples 1-29 3.2 6.5 Comparative Example 3 2.6 5.6 Examples 1-30 3.3 6.7 Comparative Example 4 3.0 5.9 Examples 1-31 3.6 7.2 Comparative Example 5 2.9 5.9 Example 1-32 3.8 7.6 Comparative Example 6 3.1 6.1 Examples 1-33 3.5 7.4 Comparative Example 7 3.3 6.3 Examples 1-34 3.5 7.3 Comparative Example 8 3.2 6.0 Example 1-35 3.4 7.9 Comparative Example 9 3.3 6.2 Example 1-36 3.3 8.0 Comparative Example 10 3.1 6.3 Examples 1-37 3.6 8.3 Comparative Example 11 3.2 6.3 Examples 1-38 3.5 8.1 Comparative Example 12 3.0 6.2 Example 2-1 3.2 7.3 Comparative Example 13 3.3 6.3 Example 2-2 3.3 7.6 Comparative Example 14 3.1 6.0 Example 2-3 3.6 7.7 Comparative Example 15 3.2 6.0

As shown in Table 5, it can be seen that the wet tissue compositions of Examples 1 and 2 have excellent spreading properties in the wet tissue.

PREPARATION EXAMPLE 1 Preparation of a Wet Tissue Containing the Wet Tissue Composition of the Present Invention [

The wet tissue compositions of Examples 1 and 2 and Comparative Examples 1 to 15 were impregnated with 80 wet wipe fabrics mixed with 50% of polyester and 50% of rayon per each wet tissue composition to prepare a wet tissue product.

<Experimental Example 3> Confirmation of discoloration of wet tissue>

The wipes prepared in Preparation Example 1 were used to confirm the discoloration of the wet tissue. The discoloration of the wet tissue is mainly due to the evaporation of moisture at the end of the wet tissue and the change in yellow color during the storage of the wet tissue without sealing.

The wet tissue of Preparation Example 1 was left standing for one week at room temperature and visually observed for discoloration into yellow. The results are shown in Table 6 and FIG.

Composition Discoloration Composition Discoloration Composition Discoloration Example 1-1 X Example 1-32 X Examples 2-23 X Examples 1-2 X Examples 1-34 X Examples 2-25 X Example 1-3 X Example 1-35 X Example 2-26 X Examples 1-6 X Examples 1-37 X Example 2-28 X Examples 1-9 X Examples 1-38 X Comparative Example 1 X Example 1-10 X Example 2-1 X Comparative Example 2 O Examples 1-14 X Example 2-3 X Comparative Example 3 O Examples 1-16 X Examples 2-4 X Comparative Example 4 X Examples 1-17 X Examples 2-6 X Comparative Example 5 X Example 1-18 X Examples 2-8 X Comparative Example 8 X Examples 1-20 X Examples 2-10 X Comparative Example 10 O Examples 1-21 X Examples 2-11 X Comparative Example 11 O Examples 1-24 X Examples 2-13 X Comparative Example 12 O Examples 1-25 X Examples 2-15 X Comparative Example 13 O Examples 1-26 X Examples 2-16 X Comparative Example 14 O Examples 1-28 X Examples 2-18 X Comparative Example 15 O Examples 1-29 X Examples 2-20 X Examples 1-31 X Examples 2-21 X X-not discolored, O-discolored

As shown in FIG. 1 and Table 6, in the case of the wet tissue prepared from the wet tissue compositions of Examples 1 and 2, the wet tissue was not discolored to yellow even when left at room temperature, whereas the wet tissues of Comparative Examples 2, 3, It was confirmed that the wet tissue prepared from the composition discolored to yellow.

Thus, it can be seen that the wet tissue composition of the present invention prevents discoloration of the wet tissue.

EXPERIMENTAL EXAMPLE 4. Confirmation of Change of Wet Tissue [

In the case of a wet tissue made of a wet tissue composition containing ingredients such as benzoic acid, sodium benzoate, potassium sorbate, dehydroacetic acid, sodium dehydroacetate, etc., the odor of the raw material itself appears in the wet tissue, Is damaged.

Therefore, the sensory evaluation of the odor was carried out in order to determine whether or not the raw material itself in the finished wet wipes manufactured in Production Example 1 was deteriorated due to the odor thereof. 15 wipes were subjected to sensory evaluation using the wipes prepared in Preparation Example 1 using the wipes shown in Table 7, and the average value of the wipes was recorded, and the average value was recorded. Weak sensory evaluation was performed in each independent space, and the results are shown in Table 8 below.

score Contents 1 point No offense 2 points Very slightly changed 3 points With 4 points Severe kicking 5 points Extremely severe

Composition Turnover Composition Turnover Composition Turnover Example 1-1 One Example 1-32 One Examples 2-23 One Examples 1-2 One Examples 1-34 One Examples 2-25 One Example 1-3 One Example 1-35 One Example 2-26 One Examples 1-6 One Examples 1-37 One Example 2-28 One Examples 1-9 One Examples 1-38 One Comparative Example 1 One Example 1-10 One Example 2-1 One Comparative Example 2 5 Examples 1-14 One Example 2-3 One Comparative Example 3 5 Examples 1-16 One Examples 2-4 One Comparative Example 4 One Examples 1-17 One Examples 2-6 One Comparative Example 5 One Example 1-18 One Examples 2-8 One Comparative Example 8 One Examples 1-20 One Examples 2-10 One Comparative Example 10 4 Examples 1-21 One Examples 2-11 One Comparative Example 11 3 Examples 1-24 One Examples 2-13 One Comparative Example 12 5 Examples 1-25 One Examples 2-15 One Comparative Example 13 5 Examples 1-26 One Examples 2-16 One Comparative Example 14 4 Examples 1-28 One Examples 2-18 One Comparative Example 15 4 Examples 1-29 One Examples 2-20 One Examples 1-31 One Examples 2-21 One

As shown in Table 8, in the case of the wet tissue prepared from the wet tissue compositions of Examples 1 and 2, there was no change due to the raw material odor contained in the wet tissue composition, while the wet tissue compositions of Comparative Examples 2, 3, The results of this study are as follows.

It can be seen from the results of Experimental Examples 3 and 4 that the wet tissue composition of the present invention is excellent in preventing discoloration of the wet tissue as well as preventing the wet tissue.

Claims (7)

a) from 0.01 to 30% by weight of laurylpyridinium chloride; And
b) anisic acid, sodium anisate, levulinic acid, sodium levulinate, PCA ethyl cocoyl arginate, glyceryl carboxamides, Glyceryl caprylate, glyceryl monolaurate, sodium coco PG dimonium chloride phosphate, dipropylene glycol, methylpropanediol, pentaerythritol, Glyceryl monoundecylenate, glyceryl mononucleoside, glyceryl mononucleoside, glyceryl mononucleoside, glyceryl mononucleoside, glyceryl mononucleoside, glyceryl mononucleoside, glyceryl mononucleoside, 0.001 to 40% by weight of at least one compound selected from the group consisting of caprylic glyceryl ether and caprylic glyceryl ether;
The present invention relates to a wet tissue composition which has antimicrobial effect against lauryl pyridinium chloride resistant bacteria and prevents discoloration or spoilage of a wet tissue. delete The method according to claim 1,
The wet tissue composition
a) laurylpyridinium chloride; And
b) anionic surfactants selected from the group consisting of anisic acid, sodium anisate, levulic acid, sodium levulinate, PCA ethylcocoyl alginate, glyceryl caprylate, glyceryl monolaurate, sodium cocopygidimonium chloride phosphate, dipropylene glycol, methyl At least one compound selected from the group consisting of propanediol, pentylene glycol, phenylpropanol, decylen glycol, cyclohexyl glycerin, hexyl glycerin, ethylhexyl glycerin, glyceryl mono-undecylenate and caprylyl glyceryl ether;
Is mixed in a weight ratio of 1:10 to 10: 1. The wet tissue composition has antimicrobial effect against lauryl pyridinium chloride resistant bacteria and prevents discoloration or spoilage of the wet tissue. The method according to claim 1,
Wherein the wipes composition further comprises a moisturizing agent and a pH adjusting agent. The wipes composition has antimicrobial effect against lauryl pyridinium chloride resistant bacteria and prevents discoloration or spoilage of the wet tissue. The method according to claim 1,
The wet tissue composition may be selected from the group consisting of Staphylococcus aureus , Escherichia coli , Pseudomonas aeruginosa , Aspergillus brasiliensis , Candida albicans , Burkholderia cepacia , The present invention relates to a wet tissue composition having antimicrobial activity against lauryl pyridinium chloride resistant bacteria and preventing discoloration or spoilage of wet tissues, which is characterized by having a bactericidal effect on Burkholderia arboris and Burkholderia lata . delete A wet tissue containing the wet tissue composition of claim 1.

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