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Now showing items 1-20 of 371
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Acyl-CoA thioesterases : auxiliary enzymes in peroxisomal lipid metabolism
(Institutionen för laboratoriemedicin / Department of Laboratory Medicine, 2007-05-18)Peroxisomes are small organelles essential for life, which carry out a variety of functions mostly related to lipid metabolism, including α- and β-oxidation as well as the first steps of plasmalogen biosynthesis. Peroxisomal ... -
Adenovirus infection is dependent on regulation and accessibility of the receptor CAR
(Institutionen för cell- och molekylärbiologi (CMB) / Department of Cell and Molecular Biology, 2007-02-23)Coxsackie and Adenovirus Receptor (CAR) displays dual biological functions since it acts both as a viral receptor for the two unrelated viruses, coxsackie and adenovirus (Ad), and as a cell-adhesion molecule in mammalian ... -
Adolescent pregnancy and parenthood in Swaziland : quality of care, community support and health care service needs
(Institutionen för folkhälsovetenskap / Department of Public Health Sciences, 2006-12-25)The aim of this thesis was to study - from different perspectives - adolescent pregnancy and parenthood in Swaziland. The specific objectives were to: i) explore maternity care practices and support for adolescent mothers ... -
Ah receptor mediated toxicity : studies in vitro and in a transgenic mouse model
(Institutet för miljömedicin (IMM) / Institute of Enviromental Medicine, 2007-02-01)The polychlorinated dibenzo-p-dioxins, dibenzofurans and biphenyls are ubiquitously present in the environment. Humans are exposed mainly through diet to continuous low levels which on average are in close proximity to ... -
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-10-26)Although short–term alcohol drinking causes euphoric and stress relieving effects, alcohol abuse is a major risk factor for neurobehavioural, liver and muscle injury as well as reduced host defence with enhanced susceptibility ... -
Analgetic and algetic effects of adenosine in healthy volunteers and patients with coronary disease
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2007-11-23)Background: Adenosine is a bimodal neuromodulator with algesic and analgesic effects. The different effects of adenosine are partly due to the route of administration. Low-dose adenosine infusion induces analgesia at the ... -
Analysis of different forms of locomotor behavior in lamprey
(Institutionen för neurovetenskap / Department of Neuroscience, 2007-05-25)The ability to locomote, that is move actively in space, is characteristic of the animal kingdom. Many species are capable of different forms of locomotion. They include forward and backward locomotion, fast and slow ... -
Analysis of HLA-A2 frequency as prognostic and/or risk factors in ovarian cancer patients
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-03-21)Major histocompatibility complex antigens are mandatory for the immune response, and genetic imbalance may be linked to tumour escape. The HLA-A2 allele in Scandinavia has a high prevalence; it decreases with latitude and ... -
Analysis of kidney glomerular and microvascular transcriptomes
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2007-09-21)Kidney glomeruli play a crucial role in the maintenance of body homeostasis. Many diseases attack the kidney function by primarily affecting glomeruli. However, the transcriptome profiles and the function of the glomerulus ... -
Analytical strategies for identifying relevant phenotypes in microarray data
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2007-11-28)With microarray technology, the transcription thousands of genes can be determined simultaneously. The large number of genes, often assessed in a relatively small number of samples, presents a challenge. The risk of making ... -
Anterior cruciate ligament reconstruction with bone-patellar tendon-bone graft : postoperative intervention and influential factors for patient-relevant long-term outcome
(Institutionen för molekylär medicin och kirurgi / Department of Molecular Medicine and Surgery, 2007-04-13)The overall aim of the present thesis was to assess patient-relevant outcome after anterior cruciate ligament (ACL) reconstruction and to improve the knowledge of which factors that may predict longterm outcome after ... -
Antibiotic resistance and antibiotic consumption with focus on Escherichia coli and Pseudomonas aeruginosa
(Institutionen för medicin / Department of Medicine, 2007-05-04)Aims: The general aims of the present studies were to assess the levels of antibiotic resistance, in relation to antibiotic consumption at the Karolinska University Hospital, Solna (KS) and at 11 other Swedish hospitals, ... -
Aphasia in acute stroke
(Institutionen för kliniska vetenskaper, Danderyds sjukhus / Department of Clinical Sciences, Danderyd Hospital, 2007-04-20)Aphasia is a language impairment due to a brain lesion, usually in the left hemisphere, and is a common symptom in acute stroke. The aims of this thesis were to evaluate aphasia in acute stroke patients, to assess spontaneous ... -
Apoptosis, cellular division or mitotic catastrophe? Effects of kinase inhibition and DNa damage in lung cancer cells
(Institutet för miljömedicin (IMM) / Institute of Enviromental Medicine, 2007-01-07)Non-small cell lung cancer (NSCLC) cells are generally characterized by a low response to conventional anti-cancer agents, such as DNA-damaging drugs. Treatments that induce DNA damage relies on cellular signalling resulting ... -
Apoptotic cell death in neural stem cells exposed to toxic stimuli
(Institutet för miljömedicin (IMM) / Institute of Enviromental Medicine, 2007-09-14)Neural stem cells (NSCs) play an important role in the developing nervous system and in the adult brain, where mitotic regions such as the subventricular zone (SVZ) remain active. In spite of the intense ongoing research ... -
Aspects of immune activation in HIV-1 infection
(Institutionen för laboratoriemedicin / Department of Laboratory Medicine, 2007-05-25)Abnormal immune system activation is central in HIV-1 pathogenesis leading to CD4+ T-cell depletion and inappropriate immune responses. Disease stage and HIV load strongly correlate with the immune activation level which ... -
Aspects of participation in sigmoidoscopy screening for colorectal cancer
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2007-05-25)Colorectal cancer is an important health problem due to a high morbidity and mortality but it is curable at an early stage and is therefore ideal for screening. Population-based screening of the average risk population ... -
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(Institutionen för medicin / Department of Medicine, 2007-02-16)Environmental factors are likely contributing factors in the development of Rheumatoid Arthritis (RA), an autoimmune disease, for which etiologic factors are still poorly known. Mineral oils are efficient adjuvants which ... -
Aspects on chronic stress and glucose metabolism in women with recurrent vulvovaginal candidiasis and in women with localized provoked vulvodynia
(Institutionen för kliniska vetenskaper, Danderyds sjukhus / Department of Clinical Sciences, Danderyd Hospital, 2007-04-06)Objective: To evaluate the degree of stress in women with recurrent vulvovaginal candidiasis (RVVC) and in women with localized provoked vulvodynia (LPV) (former vulvar vestibulitis syndrome) compared with controls. To ... -
Assessment of cognitive function in elderly patients with hip fractures
(Institutionen för klinisk forskning och utbildning, Södersjukhuset / Department of Clinical Science and Education, Södersjukhuset, 2007-03-09)Impaired cognitive function is common among elderly patients. The aim of this thesis was to illuminate the documentation of cognitive function in elderly patients with hip fractures and to study the effect of cognitive ...