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Now showing items 1-20 of 407
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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disrupts vitamin A homeostasis in rodents : quantitative and mechanistic studies to support risk assessment
(Institutet för miljömedicin (IMM) / Institute of Enviromental Medicine, 2005-11-25)2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure is well-known to disrupt Vitamin A (retinoid) homeostasis in rats, resulting in decreased hepatic storage, as well as increased metabolism and excretion of retinoids. ... -
A matter of context : social inequalities in incidence of myocardial infarction
(Institutionen för folkhälsovetenskap / Department of Public Health Sciences, 2005-05-06)Coronary heart disease is the leading cause of death and makes the separate largest contribution to social inequalities in the burden of disease in Sweden. The purpose of this dissertation is to study the potential influences ... -
A study of the transition from premalignancy to clinical prostate cancer
(Institutionen för molekylär medicin / Department of Molecular Medicine, 2005-09-16)Prostate cancer remains the most commonly diagnosed life-threatening malignancy and the second leading cause of death from cancer in men. However, little is known about molecular mechanisms that underline its initiation ... -
A study on the TFIID subunit TAF4
(Centrum för Genomik och Bioinformatik (CGB) / Center for Genomics Research, 2005-01-14)Transcription is a fundamental process in the regulation of gene expression. It has long been generally believed that certain so called basal factors of the transcriptional machinery are ubiquitously expressed. During ... -
Activating proto-oncogene mutations in human cutaneous melanoma
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-05-13)Cutaneous melanoma arises from melanocytes located in the basal layer of the epidermis. The disease is known to progress through well-defined steps: 1) common nevus; 2) dysplastic nevus; 3) radial growth phase (RGP) primary ... -
Adaptive responses during giardia-host interactions
(Mikrobiologiskt och Tumörbiologiskt Centrum (MTC) / Microbiology and Tumor Biology Center (MTC), 2005-01-28)Giardia lamblia is a major cause of water-borne enteric disease. The parasite is a noninvasive, flagellated protozoan that inhabits the upper part of the small intestine of its vertebrate hosts. Differentiation is central ... -
Adult human neural stem cells : properties in vitro and as xenografts in the spinal cord
(Institutionen för klinisk neurovetenskap / Department of Clinical Neuroscience, 2005-05-27)Though the presence of stem cells in the adult human brain has been presented earlier, much has yet to be discovered about these cells. However, the mere potential of these cells has had a significant impact of how we ... -
Adult neurogenesis : from stem cell to functional neuron
(Institutionen för cell- och molekylärbiologi (CMB) / Department of Cell and Molecular Biology, 2005-05-06)The adult mammalian central nervous system harbors a population of neural stem cells with the ability to generate neurons, astrocytes and oligodendrocytes. These pluripotent cells can be enriched in vitro, and by directing ... -
AIDS and endemic Kaposi's sarcoma development : comparison by histopathology, virology (HHV8/KSHV) and cytogenetics
(Institutionen för onkologi-patologi / Department of Oncology-Pathology, 2005-08-30)Kaposi’s sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion with spindle cells (SC) affecting the skin, lymphnodes and viscera which is found in four different clinico-epidemiological forms as Classic KS ... -
Airway responses to NO2 and allergen in asthmatics
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-04-08)Nitrogen dioxide (N02), a gas produced by combustion, is a common environmental air pollutant. Individuals with asthma are more sensitive to N02 exposure than healthy subjects, according to results from controlled ... -
Alterations in activity and specificity of intracellular proteolysis in disease pathogenesis
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-17)The ubiquitin-proteasome pathway (UPP) plays a fundamental role in many basic cellular processes. Virtually all events in cellular physiology include control by the ubiquitin-proteasome pathway. Ubiquitinated substrates ... -
Amino acid and protein turnover in human skeletal muscle
(Centrum för kirurgisk vetenskap CFSS / Center for Surgical Sciences CFSS, 2005-03-25)Critically ill patients are characterised by a severe net protein catabolism. The rate of muscle protein loss is in the magnitude of 10% per week. A consequence of muscle wasting is increased weakness, which is associated ... -
Analysis of HIF-1alpha degradation and function
(Institutionen för cell- och molekylärbiologi (CMB) / Department of Cell and Molecular Biology, 2005-11-18)HIF-1 is a heterodimeric complex of two bHLH/PAS transcription factors, HIF- 1alpha and ANRT. In contrast to the constitutively expressed ARNT, HIF-1alpha protein levels are regulated by oxygen tension. Under normoxic ... -
Ancestral influences on health of grandchildren
(Institutionen för medicinsk näringslära / Department of Medical Nutrition, 2005-03-22)The late effects in adulthood of nutrition during adolescence, childhood, infancy, and the fetal and embryonic stages of development have attracted much attention in research, but less so the time of development of the ... -
Angiogenesis in myeloproliferative disorders
(Institutionen för medicin, Huddinge Sjukhus / Department of Medicine at Huddinge University Hospital, 2005-05-20)The chronic myeloproliferative disorders, comprising polycythemia vera (PV), essential thrombocytosis (ET), chronic myeloid leukaemia (CML) and myelofibrosis (MF), are all characterized by pathological angiogenesis in ... -
Ante partum determination of lactate in amniotic fluid
(Institutionen Södersjukhuset / Karolinska Institutet, Stockholm Söder Hospital, 2005-05-06)Background: The present studies were conducted to investigate whether lactate determination in vaginal fluids, 'Lac-test', could be used as a diagnostic test for prelabour rupture of membranes (PROM). To derive the best ... -
Antibacterial effects of nitrite in urine
(Institutionen för fysiologi och farmakologi / Department of Physiology and Pharmacology, 2005-04-01)Urinary tract infections (UTI`s) are among the most common conditions causing individuals to seek medical care. In addition, catheter-associated infections account for most of the hospital-acquired UTI´s and is also a major ... -
Antimicrobial peptides and pathogenic Neissera : experimental studies in mouse, man and rat
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2005-08-19)Antimicrobial peptides are important effector molecules of innate immunity. In this thesis, the focus is on antimicrobial peptides of the cathelicidin family, i.e. LL-37 in man, CRAMP in mouse and rCRAMP in rat. Expression ... -
Antimicrobial peptides and proteins in innate immunity : emphasis on isolation, characterization and gene regulation
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2005-03-18)Antimicrobial peptides are endogenous antibiotics and effector molecules of Innate immunity. These peptides are mainly localised to epithelial linings and circulating neutrophils. They kill microbes by disruption of their ... -
Antimicrobial polypeptides and lipids as a part of innate defense mechanism of fish and human fetus
(Institutionen för medicinsk biokemi och biofysik (MBB) / Department of Medical Biochemistry and Biophysics, 2005-11-18)Animals are constantly threatened by vast numbers of microbes and have consequently evolved an array of strategies to prevent microbial invasion. In this thesis, I have studied natural antimicrobial lipids and polypeptides ...