Browsing by Publication Year
Now showing items 1-20 of 25
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Allergen-induced late airways reaction in the pig : influence of endogenous and exogenous glucocorticoids
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 1995-11-24)A novel model for studies of the allergen-induced late reaction in the lower airways was developed in the pig. The influence on late bronchial obstruction and granulocyte function of endogenous cortisol levels and treatment ... -
Analysis of ginesenosides
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 1995-11-03)New analytical methods were developed in order to evaluate commercial ginseng preparations and to allow studies on urinary excretion of ginsenosides in humans after consumption of ginseng preparations. An optimized ... -
Beat-to-beat variability of QRS amplitude and heart rate in ischemic heart disease : diagnostic potentials
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 1995-11-03)The diagnostic potential of beat-to-beat QRS amplitude variability in patients with coronary artery disease (CAD) was evaluated with variance ECG and compared to exercise stress test and myocardial scintigraphy (SPECT). ... -
Characterization of Shigella dysenteriae type 1 hybrid vaccine candidates
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 1995-11-16)Shigellae is endemic in many developing countries in the world and a major cause of childhood diarrheal morbidity and mortality. Infections caused by Shigella dysenteriae type 1 are particularly severe. The major virulence ... -
Effects and mechanisms of actions of cyclosporin, FK506 and 15-deoxyspergualin
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 1995-11-17)Immunosuppressive drugs can be used to deal with unwanted or inappropriate immune reactions, such as the rejection of a transplanted organ. However, treatment with these drugs are often associated with serious adverse ... -
Endoscopic diagnosis of reflux-oesophagitis with special regard to computerized image processing
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 1995-11-16)The advent of the video endoscope is an important step in endoscope technology and it is of vital importance in the linkage between endoscopy and computers. The Charge Coupled Device ( CCD ) of an electric video endoscope ... -
Fetal hematopoietic cells in early gestation : aspects in view of fetal transplantation
(Inst för kvinnors och barns hälsa / Dept of Women's and Children's Health, 1995-11-24)The fetus as a patient is a challenge. There are opportunities for early, sometimes life-saving procedures or there may be advantages in prenatal rather than postnatal intervention. This is the case in fetal hematopoietic ... -
Fixation and load in total knee arthroplasty : a clinical, radiographic, radiostereometric and gait study
(Inst för molekylär medicin och kirurgi / Dept of Molecular Medicine and Surgery, 1995-11-24)The treatment of severe gonarthrosis by total knee arthroplasty is generally successful, but tibial component loosening remains a problem. The aim in the present work was to investigate if any association between loading ... -
Function of adenovirus early region 4 proteins in RNA processing and cellular transformation
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 1995-11-17)For almost 30 years, adenovirus has been used as a model system for mechanistic studies of eucaryote gene expression. In this thesis, we have concentrated our efforts to investigate the function of adenovirus early region ... -
Gallstone disease in a Swedish population : an epidemiological investigation
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 1995-11-24)The main objective of the present thesis was to study the prevalence of gallstone disease in a community survey in Danderyd. Symptoms and risk factors for gallstone disease and the changing incidence of cholecystectomy in ... -
Left ventricular filling during coronary artery bypass grafting
(Inst för fysiologi och farmakologi / Dept of Physiology and Pharmacology, 1995-11-17)Left ventricular (LV) filling, determination of preload, right ventricular end-diastolic volumes, volume contributions during early (E) and atrial (A) phases of LV filling and mitral valve opening areas were studied in 75 ... -
Mammalian cell cycle regulation : characterisation of three genes expressed in proliferating cells
(Inst för cell- och molekylärbiologi / Dept of Cell and Molecular Biology, 1995-11-24)Proliferating cells undergo different phases in their life cycle. During interphase the cells grow and duplicate their DNA content, followed by a cell division phase, mitosis, which results in two daughter cells. The ... -
Medium-chain alcohol dehydrogenases : studies of novel class I, II, III and IV forms revealing structural, functional, and evolutionary properties of this enzyme system
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 1995-11-24)Novel forms of alcohol dehydrogenases of classes I, II, III, and IV were characterized. Together with other variants, they give useful information on molecular properties and functions of the alcohol dehydrogenase system. ... -
Molecular mechanisms of nitrogen dioxide induced lung damage
(Institutet för miljömedicin / Institute of Environmental Medicine, 1995-11-17)Nitrogen dioxide (NO2) is an oxidant gas which contaminates ambient air in many urban and industrial locations, and indoor air in homes with combustion appliances. The Environmental Protection Agency (USA) regulates N02 ... -
Neuromuscular adaptations to muscle fatigue during submaximal isometric contractions in man
(Inst för neurovetenskap / Dept of Neuroscience, 1995-11-24)During a sustained contraction, the force producing capacity of a muscle gradually decreases. In order to maintain a constant force output, the neuromuscular system has to adapt to the contractile fatigue process. The aim ... -
Nucleic acid-based detection and characterization of hepatitis C virus
(Inst för laboratoriemedicin / Dept of Laboratory Medicine, 1995-11-24)Nucleic acid-based methods were developed to detect and characterize the HCV genome in immunocompetent and immunodeficient patents of whom some were IFN-a treated. HCV RNA was found in most sera (95%), livers (97%) and ... -
On methods of evaluation of lower extremity eccentric muscle performance and loading
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 1995-11-03)This investigation has developed and evaluated methods for measuring eccentric muscle function and loading of the human lower extremity, including isokinetic tests of knee extensor muscle performance and a comprehensive ... -
On-line vectorcardiography in ischemic heart disease
(Inst för kliniska vetenskaper, Danderyds sjukhus / Dept of Clinical Sciences, Danderyd Hospital, 1995-11-02)The clinical usefulness of continuous on-line vector cardiography (VCG) was assessed in 435 patients, admitted to the coronary care unit. The ability of 24-hour VCG monitoring to differentiate patients with or without ... -
p53 and neoplastic progression in Barrett's esophagus
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 1995-11-03)Barrett's esophagus is a condition in which the normal squamous epithelium is replaced by columnar epithelium as a response to acid reflux. It develops as a complication in 10-20% of patients with gastroesophageal reflux ... -
Population-based analysis of the HLA associated risk for IDDM
(Inst för klinisk neurovetenskap / Dept of Clinical Neuroscience, 1995-11-03)Insulin dependent diabetes (IDDM) is one of the most common chronic illnesses among children and young adults in Sweden. The disease has a complex pattern of inheritance and environmental factors are important. The strongest ...