Research Interests: Biomedical Engineering, Breast Cancer, Optical Spectroscopy, Optical coherence tomography, Biomedical Optics, and 13 moreHumans, Female, Optical physics, Middle Aged, Metabolic rate, Optometry and Ophthalmology, Hybrid Approach, Oxygen, Blood Flow, Biological markers, Neoadjuvant Chemotherapy, Blood Flow Velocity, and Hemoglobins
Research Interests:
Research Interests:
Research Interests: Biomedical Engineering, Nonparametric Statistics, Carbon Dioxide, Magnetic Resonance Imaging, Near Infrared, and 26 moreLinear models, Biomedical Optics, Congenital Heart Defects, Humans, Diffusion, Female, Male, Infant, Optical physics, Repeated Measures, Optometry and Ophthalmology, Blood Flow, Spectrum analysis, Reproducibility of Results, Blood gas analysis, Light Propagation, Cerebral Blood Flow, Human Subjects, Medicine and Science In Sports and Exercise, Aorta, ASL (Arterial Spin Labeling), Electrical And Electronic Engineering, Hypercapnia, Optical Correlator, Laser Doppler Velocimetry, and Child preschool(Linear models, Biomedical Optics, Congenital Heart Defects, Humans, Diffusion, Female, Male, Infant, Optical physics, Repeated Measures, Optometry and Ophthalmology, Blood Flow, Spectrum analysis, Reproducibility of Results, Blood gas analysis, Light Propagation, Cerebral Blood Flow, Human Subjects, Medicine and Science In Sports and Exercise, Aorta, ASL (Arterial Spin Labeling), Electrical And Electronic Engineering, Hypercapnia, Optical Correlator, Laser Doppler Velocimetry, and Child preschool)
(Linear models, Biomedical Optics, Congenital Heart Defects, Humans, Diffusion, Female, Male, Infant, Optical physics, Repeated Measures, Optometry and Ophthalmology, Blood Flow, Spectrum analysis, Reproducibility of Results, Blood gas analysis, Light Propagation, Cerebral Blood Flow, Human Subjects, Medicine and Science In Sports and Exercise, Aorta, ASL (Arterial Spin Labeling), Electrical And Electronic Engineering, Hypercapnia, Optical Correlator, Laser Doppler Velocimetry, and Child preschool)
Research Interests:
Research Interests: Biomedical Engineering, Skeletal muscle biology, Optical Spectroscopy, Near Infrared, Sensors, and 25 moreBiomedical Optics, Humans, Hemodynamics, Near Infrared Spectroscopy, Female, Male, Exercise, Dynamic Light Scattering, Optical physics, Peripheral Vascular Disease, Skeletal Muscle, Optometry and Ophthalmology, Oxygen, Adult, Time Dependent, Time Factors, Blood Flow, Foot, Healthy Subjects, Oxygen Consumption, Hemoglobins, Oxygen saturation, Case Control Studies, Peripheral artery disease, and Diffuse Reflectance Spectroscopy(Biomedical Optics, Humans, Hemodynamics, Near Infrared Spectroscopy, Female, Male, Exercise, Dynamic Light Scattering, Optical physics, Peripheral Vascular Disease, Skeletal Muscle, Optometry and Ophthalmology, Oxygen, Adult, Time Dependent, Time Factors, Blood Flow, Foot, Healthy Subjects, Oxygen Consumption, Hemoglobins, Oxygen saturation, Case Control Studies, Peripheral artery disease, and Diffuse Reflectance Spectroscopy)
(Biomedical Optics, Humans, Hemodynamics, Near Infrared Spectroscopy, Female, Male, Exercise, Dynamic Light Scattering, Optical physics, Peripheral Vascular Disease, Skeletal Muscle, Optometry and Ophthalmology, Oxygen, Adult, Time Dependent, Time Factors, Blood Flow, Foot, Healthy Subjects, Oxygen Consumption, Hemoglobins, Oxygen saturation, Case Control Studies, Peripheral artery disease, and Diffuse Reflectance Spectroscopy)
Research Interests: Kinetics, Prostate Cancer, Photodynamic Therapy, Biological Sciences, Therapeutic drug monitoring, and 13 moreHumans, Lighting, Male, Physical sciences, Light, Real Time, CHEMICAL SCIENCES, Photochemotherapy, Photochemistry and Photobiology, Blood Flow, Oxygen Consumption, Oxygen saturation, and Diffuse Reflectance Spectroscopy
This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO(2)), and total... more
This pilot study explores the potential of noninvasive diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy (DRS) for monitoring early relative blood flow (rBF), tissue oxygen saturation (StO(2)), and total hemoglobin concentration (THC) responses to chemo-radiation therapy in patients with head and neck tumors. rBF, StO(2), and THC in superficial neck tumor nodes of eight patients are measured before and during the chemo-radiation therapy period. The weekly rBF, StO(2), and THC kinetics exhibit different patterns for different individuals, including significant early blood flow changes during the first two weeks. Averaged blood flow increases (52.7+/-9.7)% in the first week and decreases (42.4+/-7.0)% in the second week. Averaged StO(2) increases from (62.9+/-3.4)% baseline value to (70.4+/-3.2)% at the end of the second week, and averaged THC exhibits a continuous decrease from pretreatment value of (80.7+/-7.0) [microM] to (73.3+/-8.3) [microM] at the end of the second week and to (63.0+/-8.1) [microM] at the end of the fourth week of therapy. These preliminary results suggest daily diffuse-optics-based therapy monitoring is feasible during the first two weeks and may have clinical promise.
Research Interests: Physiology, Biomedical Engineering, Radiation, Kinetics, Radiation Therapy, and 24 moreTreatment Outcome, Biomedical, Head and Neck, Biomedical Optics, Humans, Female, Feasibility Studies, Male, Optical physics, Aged, Middle Aged, Pilot study, Optometry and Ophthalmology, Oxygen, Blood Flow, Spectrum analysis, Prognosis, Reproducibility of Results, Sensitivity and Specificity, Pilot Projects, Blood Flow Velocity, Hemoglobins, Oxygen saturation, and Diffuse Reflectance Spectroscopy(Treatment Outcome, Biomedical, Head and Neck, Biomedical Optics, Humans, Female, Feasibility Studies, Male, Optical physics, Aged, Middle Aged, Pilot study, Optometry and Ophthalmology, Oxygen, Blood Flow, Spectrum analysis, Prognosis, Reproducibility of Results, Sensitivity and Specificity, Pilot Projects, Blood Flow Velocity, Hemoglobins, Oxygen saturation, and Diffuse Reflectance Spectroscopy)
(Treatment Outcome, Biomedical, Head and Neck, Biomedical Optics, Humans, Female, Feasibility Studies, Male, Optical physics, Aged, Middle Aged, Pilot study, Optometry and Ophthalmology, Oxygen, Blood Flow, Spectrum analysis, Prognosis, Reproducibility of Results, Sensitivity and Specificity, Pilot Projects, Blood Flow Velocity, Hemoglobins, Oxygen saturation, and Diffuse Reflectance Spectroscopy)