Life Sciences Clinical Data and Analytics (D&A) Platforms PEAK Matrix Assessment 2023

The pandemic accelerated the need to extract value from data due to the substantial increase in data generation from various clinical sources, characterized by high veracity, variety, and volume. As a result, there has been a notable surge in the adoption of clinical data and analytics platforms in clinical development. This prompted considerable interest in assessing their impact on clinical trials, patient care, treatment outcomes, and health system efficiency. The integration of complex clinical data sources including Electronic Health Records (EHR), Electronic Medical Records (EMR), Laboratory Data, Clinical Trial Management Systems (CTMS), connected devices, and Real-world Data (RWD), presents a significant challenge that the industry currently faces.

Clinical D&A platforms provide significant benefits in the realm of clinical development. These platforms enhance data management by facilitating centralized and standardized data collection from various sources, resulting in improved data quality and integrity. Real-time monitoring capabilities enable stakeholders to track trial progress, identify potential issues, and make informed decisions promptly. Advanced analytics tools help uncover patterns, trends, and correlations within the data, resulting in valuable insights for optimizing trial protocols and treatment strategies.

In the full report, we assess the capabilities of 14 platform providers specific to clinical D&A. These platform providers are mapped on the Life Sciences Clinical Data and Analytics (D&A) Platforms PEAK Matrix® Assessment 2023, which is a composite index of a range of distinct metrics related to a provider’s capability and market impact. We focus on:

⚫ The landscape of platform providers for clinical D&A

⚫ Assessment of the platform providers on several capability and market success-related dimensions

Scope of this report

Geography

Providers

Global Life sciences (biopharmaceuticals, medical devices, and Contract Research Organizations (CROs))

Products

Clinical D&A platforms

Life Sciences Clinical D&A PEAK Matrix® characteristics

Leaders

eClinical Solutions, Medidata Solutions, Saama

⚫ Leaders enjoy the highest brand recall among the biopharma enterprises and are perceived as end-to-end clinical D&A platforms for clinical development

⚫ Leaders focus on enhancing the performance of the existing capabilities, and building new products around Artificial Intelligence (AI), Machine Learning (ML), Low-code/No-code (LCNC), visualization, etc., to address the most demanding clinical use case

⚫ Leaders offer robust data integration capabilities connecting various clinical data sources, secured data storage, and management with robust advanced analytics for insights generation

⚫ Leaders have established a wide partnership network consisting of clinical technology platform providers, consulting partners, hyperscalers, System Integrators (SIs), and Clinical Research Organization (CROs), enabling them to broaden their offerings and increase enterprise mindshare

Major Contenders

Cytel, IQVIA, Lokavant, Merative, Oracle, TCS, ThoughtSphere, Veeva

⚫ Major Contenders have an integrated approach in certain areas of the clinical value chain. They offer best-in-class clinical D&A solutions targeting a particular segment such as data management, analytics, reporting, and dashboarding

⚫ A few Major Contenders are augmenting advanced analytics into the platform and enhancing data management capabilities to enter the Leader's market

⚫ The platforms provided by Major Contenders are not fully scalable for larger studies, which require complex integration and management of clinical data sources

⚫ Major Contenders have a robust partnership with SIs and clinical platform providers but lack partnership for change management and consulting

Aspirants

Adaptive Clinical Systems, Datavant, NextTrial AI

⚫ Aspirants offer a point solution in specific segments of clinical D&A

⚫ Aspirants lack the robust partnership for data acquisition and management, clinical analytics, implementation, and change management

Life Sciences Clinical Data and Analytics (D&A) Platforms PEAK Matrix® Assessment 2023

Everest Group PEAK Matrix®

Life Sciences Clinical Data and Analytics (D&A) Platforms PEAK Matrix® Assessment 2023 |

eClinical Solutions is positioned as a Leader

Everest Group Life Sciences Clinical Data and Analytics (D&A) Platforms PEAK Matrix® Assessment 20231,2,3

Vision & capability Measures ability to deliver products successfully

1 Assessments for Adaptive Clinical Systems, Datavant, NextTrial AI, Cytel, and IQVIA excludes platform provider inputs and are based on Everest Group’s proprietary Transaction Intelligence (TI) database, platform providers’ public disclosures, and Everest Group’s interactions with clinical D&A platform buyers

2 Merative is a combined assessment of Merative and Zelta platform

3 Assessment for Veeva is based on partial primary inputs (briefing and demo)

Confidentiality: Everest Group takes its confidentiality pledge very seriously. Any information we collect that is contract specific will only be presented back to the industry in an aggregated fashion

eClinical Solutions profile (page 1 of 6)

Company mission/vision statement for clinical data & analytics platforms

eClinical Solutions assists global life sciences organizations in expediting clinical development initiatives through the utilization of the elluminate Clinical Data Cloud®, which serves as their foundational platform for digital trials. By leveraging elluminate Clinical Data Cloud®, the process of acquiring and analyzing clinical research data becomes more efficient and intelligent, enabling faster availability of new treatments to patients. The platform's automated data pipeline and scalable infrastructure enable organizations to effectively manage the complexities of modern clinical trials, resulting in valuable business outcomes across various development functions.

Overview of the client base

eClinical Solutions has over 100+ clients including software clients and biometric services clients and the majority of the life sciences companies in the United States and Europe rely on the elluminate Clinical Data Cloud®, catering to a wide range of clients across emerging, midsize and large biotech and pharmaceutical sectors, including 15 out of the top 50 life sciences companies.

eClinical Solutions profile (page 2 of 6) Case study

Case study 1 Handling inconsistent reporting from multiple vendors

Business challenge

The client was dealing with multiple vendors providing coding reports with inconsistent formatting and inconsistent feedback of coding reports. There was a need for a technology that could standardize medical coding reports, provide query and issue management, and ensure proper oversight and documentation of oversight for data review completion.

Solution

With elluminate®, the client was able to standardize medical coding report formats, provide verification of data review oversight with the use of audit trail reports, and streamline communication using the issue management functionality, and create enthusiasm for de-risking overall data quality.

Impact

⚫ Developed standardized medical coding reports for MedDRA and WHO Drug across multiple studies and indications

⚫ Developed search strategy criteria for flagging activities

⚫ Created a self-service, centralized location for oversight documentation along with audit trail

Case study 2 Streamlining the data management process

Business challenge

NOT EXHAUSTIVE

The client sponsors numerous clinical trials globally and works with multiple vendors and Contract Research Organizations (CROs). Because multiple sites and various CROs using different data management systems and formats were involved across trials, data management had become complex and they wanted to streamline its clinical trial operations to improve internal resource utilization, reduce trial cycle times, and avoid costly protocol amendments.

Solution

Client connected with eClinical Solutions to leverage the Clinical Data Cloud® for its CDF. The cloud-based SaaS platform had the versatility and power to address all their needs while still being configurable. With the elluminate Clinical Data Cloud platform, they were able to successfully implement the CDF and positively impact the data management, clinical operations, and R&D teams within the organization. The client utilized several products within the elluminate Clinical Data Cloud, including Mapper, Data Central, and Clinical Analytics.

Impact

⚫ Clinical trial cycle time reduction

⚫ Robust data governance, quality, and compliance

⚫ Improved internal resource utilization and collaboration

eClinical Solutions profile (page 3 of 6)

Offerings

Proprietary solutions (representative list)

Solution Details

The elluminate Clinical Data Cloud®

elluminate® serves as a unified platform for all clinical and operational data, which results in a unified source of truth that spans from data ingestion to insights. The platform offers pre-built data connectors, automation capabilities, advanced analytics, and self-service access to data from a single location, enabling faster value recognition and facilitating informed decision making throughout the trial life cycle.

Data Central Data central is a single, integrated application that enables comprehensive data review and management from any data source. Users have self-service access to clinical data and can leverage visualizations and listings to identify and track issues effectively.

Mapper

Clinical Analytics

The Mapper application offers a distinctive drag-and-drop interface, enabling non-programmers to swiftly establish connections with multiple data sources. It facilitates complex data transformations into Study Data Tabulation Model (SDTM) and other standard formats, allowing users to curate and publish data for analytics efficiently.

Transforms clinical trial data into actionable insights with powerful visualizations to optimize data review processes

Risk-Based Quality Management (RBQM) Enables risk management across all trial data sources from a single location for a more focused, data-driven monitoring effort that supports proactive oversight and improves trial compliance.

Operational Insights

Centralizes all operational data to proactively manage trials, risk, and oversight across the entire development portfolio

Statistical Computing Environment (SCE) Provides a validated environment for the production of submission or exploratory analysis outputs in a way that is transparent, auditable, automated, reproducible, and secure.

elluminate IQ (eIQ) elluminate's data-driven products leverage advanced AI and ML capabilities to deliver transformative value and accelerate complex decision making throughout the entire clinical trial life cycle.

eClinical Solutions profile (page 4 of 6)

Features of key offerings

Enterprise clinical data management

Clinical data integration from multiple sources (EHR, EDC, CTMS, LIMS, eCOA/ePRO, devices, etc.)

Metadata management (data lineage, data catalog, metadata discovery, extraction, indexing, etc.)

Data mapping

Data storage and administration

NOT EXHAUSTIVE

Functionality available Functionality not available

Data validation and standardization

Data quality (data profiling, cleansing, enhancement, etc.)

Data model and library management

Data modernization and DataOps

Data blinding and anonymization

Data migration

BI and reporting

Descriptive modeling

KPI monitoring/reporting and intelligent business alerts

Custom visualization

Interactive and mobile BI

Advanced analytics and next-generation technologies

Clinical analytics use cases –predictive and prescriptive

Cognitive capabilities (NLP/NLG, AR/VR, and computer vision)

Recommendation engines AI/ML and deep learning Big data and IoT

eClinical Solutions profile (page 5 of 6)

Recent developments

Key events (representative list)

Event name Type of event Details

New product Initiative In 2022, released the Statistical Computing Environment (SCE) as part of the elluminate Clinical Data Cloud®

New product Initiative In 2022, released elluminate IQ (eIQ) that provides AI-enabled data review capabilities

10-year milestone Initiative In 2022, celebrated 10 years as an independent company

NOT

Partnerships Partnership In 2022, formed a partnership with Medable to support clients with Decentralized Clinical Trial (DCT) technology strategy and implementation. Also established partnerships with large management consulting & global system integrators, such as PwC and Cognizant, to help clients adopt elluminate® and training

Top place to work award Initiative In 2022, earned 2022 Top Workplaces Culture Excellence recognition for Employee Well-Being and Employee Appreciation

New product Initiative In 2021, released Risk-Based Quality Management (RBQM) as part of the elluminate Clinical Data Cloud

Geographic expansion Initiative In 2020, was able to further scale the company and expand international footprint in the European Market

Growth equity investment Investment In 2020, an investment from Summit Partners enabled eClinical Slutions to double down on its digital data vision and drive global brand awareness for the elluminate Clinical Data Cloud.

eClinical Solutions profile (page 6 of 6)

Everest Group assessment – Leader

Strengths

⚫ eClinical Solutions provides a comprehensive, end-to-end platform covering clinical data management, analytics, and Business Intelligence (BI) capabilities. Clients appreciate the platform’s adaptable nature since it allows seamless data upload, standardization, and configurable visualizations in reports

⚫ The platform is highly customizable, offering an abundance of drag-and-drop features and LCNC functionalities. This allows individuals with limited technical expertise to easily navigate and operate the platform

⚫ eClinical Solutions leverages numerous pre-built connectors for data extraction and a multitude of reporting dashboards, enabling robust data insights for clinical decision making

⚫ Clients appreciate the technical and life sciences domain expertise of eClinical Solutions’ team

⚫ eClinical Solutions' support team has a notably short turnaround time, enabling them to deliver value to their clients promptly

Limitations

⚫ eClinical Solutions can work on enhancing clinical data review in a more intuitive way using advanced AI/ML models to suggest the next-best action

⚫ Clients faced challenges in the integration of Clinical Trial Management System (CTMS) data sources and want to see more pre-built connectors and APIs supporting smoother integration

⚫ Clients want eClinical Solutions to build partnerships and tailored functionalities for risk-based quality management use cases

⚫ Clients want to see more custom-developed solutions in the platform and make it off-the-shelf

Products PEAK Matrix® evaluation dimensions

Measures impact created in the market –captured through three subdimensions

Market adoption

Number of clients, revenue base, and YoY growth

Portfolio mix

Diversity of client base across industries, geographies, environments, enterprise size class

Value delivered

Value delivered to the client based on customer feedback and other measures

Market impact

Major Contenders

Leaders

Vision and strategy

Vision for the client and itself; future roadmap and strategy

Aspirants

Technology capability

Technical sophistication and breadth/depth across the technology suite

Vision & capability

Measures ability to deliver products successfully. This is captured through five subdimensions

Flexibility and ease of deployment

Configurability/customize-ability, hosting and tenancy, integration, governance, and security and compliance

Engagement and commercial model

Progressiveness, effectiveness, and flexibility of engagement and commercial models

Support

Training, consulting, maintenance, and other support services

FAQs

Does the PEAK Matrix® assessment incorporate any subjective criteria?

Everest Group’s PEAK Matrix assessment takes an unbiased and fact-based approach that leverages provider / technology vendor RFIs and Everest Group’s proprietary databases containing providers’ deals and operational capability information. In addition, we validate/fine-tune these results based on our market experience, buyer interaction, and provider/vendor briefings.

Is being a Major Contender or Aspirant on the PEAK Matrix, an unfavorable outcome?

No. The PEAK Matrix highlights and positions only the best-in-class providers / technology vendors in a particular space. There are a number of providers from the broader universe that are assessed and do not make it to the PEAK Matrix at all. Therefore, being represented on the PEAK Matrix is itself a favorable recognition.

What other aspects of the PEAK Matrix assessment are relevant to buyers and providers other than the PEAK Matrix positioning?

A PEAK Matrix positioning is only one aspect of Everest Group’s overall assessment. In addition to assigning a Leader, Major Contender, or Aspirant label, Everest Group highlights the distinctive capabilities and unique attributes of all the providers assessed on the PEAK Matrix. The detailed metric-level assessment and associated commentary are helpful for buyers in selecting providers/vendors for their specific requirements. They also help providers/vendors demonstrate their strengths in specific areas.

What are the incentives for buyers and providers to participate/provide input to PEAK Matrix research?

⚫ Enterprise participants receive summary of key findings from the PEAK Matrix assessment

⚫ For providers

– The RFI process is a vital way to help us keep current on capabilities; it forms the basis for our database – without participation, it is difficult to effectively match capabilities to buyer inquiries

– In addition, it helps the provider/vendor organization gain brand visibility through being in included in our research reports

What is the process for a provider / technology vendor to leverage its PEAK Matrix positioning?

⚫ Providers/vendors can use their PEAK Matrix positioning or Star Performer rating in multiple ways including:

– Issue a press release declaring positioning; see our citation policies

– Purchase a customized PEAK Matrix profile for circulation with clients, prospects, etc. The package includes the profile as well as quotes from Everest Group analysts, which can be used in PR

– Use PEAK Matrix badges for branding across communications (e-mail signatures, marketing brochures, credential packs, client presentations, etc.)

⚫ The provider must obtain the requisite licensing and distribution rights for the above activities through an agreement with Everest Group; please contact your CD or contact us

Does the PEAK Matrix evaluation criteria change over a period of time?

PEAK Matrix assessments are designed to serve enterprises’ current and future needs. Given the dynamic nature of the global services market and rampant disruption, the assessment criteria are realigned as and when needed to reflect the current market reality and to serve enterprises’ future expectations.

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