mansur ibrahim

An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Objectives: This study aims to examine the effect of polyherbal erythropoiesis modulatory and stimulatory agent (EMSA) Eritin administration in modulating the activity of erythropoiesis on TER- 119 + VLA-4 + cells and complement regulators TER-119 cells in the irradiated mice was markedly increased with EMSA Eritin from low dose to high dose compared to mice with TBI and mice treated with Epoetin alfa. Results: The highest dose of EMSA Eritin was more effective to promote erythropoiesis than HEMAPO Epoetin alfa and the other dose of EMSA Eritin. Conclusion: Our study findings suggest that EMSA Eritin is a powerful medicinal herbal supplement which may serve as a protective agent to normalize homeostasis and erythropoiesis after irradiation with a dose of 500 rad.

Most people suffer pain at some stage of their lives. Therefore, pain is the most common reason to seeking therapeutic alternative or conventional medicine. Pain management particularly in chronic pain due to postoperative is systematically have been developed by various great recommendations that assist the health care practitioner and patient in making decisions about health care. In recent years, we have developed a better understanding of the pathomechanisms that link inflammation and peripheral sensitization about pain which can be overcome through an alternative treatment. This approach is known as complementary and alternative medicine (CAM). The development of the combined health approach has lately been known as Integrative Medicine, which seeks to restore and maintain health by understanding a series of patients’ unique circumstances and overcoming their various physical, psychological, environmental, and spiritual influences. Through “whole system” treatment will be to el...

Introduction: Recent studies have reported that breast cancer may affect the physiology of other organs, including oxidative stress in the liver. On the other hand, some agents such as white turmeric (Curcuma longa) and Meniran (Phyllanthus niruri) seem to maintain redox stability and immunomodulation. Both of them are combined into Cheral potion. This study was aimed to investigate the Cheral efficacy in modulating oxidative stress based on Nuclear factor erythroid 2-related factor 2 (Nrf2), HEME OXIGenase (HO), and superoxide dismutase (SOD) levels as well as pro-inflammatory cytokines under breast cancer condition in vivo. Methods: Nrf2, HO, and SOD from hepatocytes, and tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) from splenocytes were measured by flow cytometry after 14 days of Cheral administration. Results: The results showed that mice model for breast cancer underwent oxidative stress denoted by high levels of HO, and SOD accompanied by increased levels of TNF-α ...

Hyperglycemia can cause immune system imbalance and lead to the risk of inflammation. Cherry leaves (M. calabura L.) has the property to cure some diseases such as hyperglycemia and inflammation. This study aimed to understand the role of cherry leaf extract for IL-1β and IL-6 production by macrophages, TGFβ production by regulator T cells and NF-κB activity by B lymphocyte and also by natural killer cells in male BALB/c hyperglycemia model mice. Hyperglycemia induction was done by a high-fat diet and 20% fructose. Cherry leaf extract was used as dried decoction for oral treatment at dosages of 420, 700, and 2800 mg/kg body weight. Immunocompetence cells were isolated from axillary and mesenteric lymph nodes and stained for flow cytometric analysis. Data were analyzed by one-way ANOVA and Post Hoc Tukey HSD by 95% significance (p < 0.05) on SPSS 16.0 for Windows. The result showed the production of IL-1β, IL-6, and TGFβ and activity of NF-κB were increased in hyperglycemic mice. Three doses of cherry leaf extract in hyperglycemia mice could decrease the relative number of macrophages which express IL-6 and IL-1β also decreased the number of B lymphocytes as well as Natural Killer cells which expressed NFκB toward the normal condition. Overall, this study showed that cherry leaf extract has a vital role in decreasing IL-6, IL-1β, TGFβ productions and NF-κB activity in hyperglycemic BALB/c mice.

The sharp increase of pro-inflammatory cytokine becomes a severe problem in some degenerative diseases. This study aimed to investigate the effect of cherry leaf extract (CLE) on pro-inflammatory cytokine production in a hyperglycaemic mouse model. In this study, we induced hyperglycemia with high-fat diet and 20% fructose drink. Hyperglycemic mice were orally administered with CLE with the dose of 420, 700, and 28000 mg/kg BW for two weeks. After treatment, the pro-inflammatory molecule was analyzed by flow cytometry by isolating spleen cells. In this study, we show that CLE decreases the production of pro-inflammatory molecules such as IL-6, NF-κB, TNF-α, and IFN γ. In hyperglycemic mice, we found CD68+IL-6+, NK1.1+IL-6+, B220+NFκB+, CD4+TNF-α+, and CD4+IFN γ+ increased significantly (p < 0.05) compared CD4+TNF-α+to control mice without manipulation. After treatment with 420, 700, and 2800 mg/kg BW of CLE the pro-inflammatory molecules decrease significantly (p < 0.05), reac...

ABSTRACT New bis(oxazoline) ligands and their palladium complexes were synthesized and characterized. X-ray crystal structures of the two new complexes showed distorted square planar geometry with the palladium ion bonded to nitrogens of two bidentate heterocycles in addition to two bromides and two acetate ions for Pd-BOX-1 and Pd-BOX-2, respectively. The complexes adopt a chair structure with a rigid curvature inducing an inherent chirality. The complexes were effective catalysts for Suzuki-Miyaura, Mizoroki-Heck, and copper-free Sonogashira coupling reactions in aqueous dimethylformamide and under aerobic conditions. The reaction conditions were optimized for best solvent, base, and temperature. The substrate scope of the new catalytic system was evaluated for coupling reactions of a variety of aryl halides with aryl boronic acids, alkenes, and alkynes.

ABSTRACT An efficient catalytic system based on a new palladium–bis(oxazoline) (Pd-BOX-1) complex has been developed. The complex Pd-BOX-1 adopts a legless chair‐type structure where the distorted square planar [PdN2Cl2] moiety and the benzene ring spacer represent the seat and the chair back, respectively. The catalytic activity of Pd-BOX-1 has been investigated in dimethylformamide–water under aerobic and mild conditions in Suzuki–Miyaura coupling reactions of arylboronic acids with aryl iodides, aryl bromides and aryl chlorides, Mizoroki–Heck coupling reactions of aryl halides with styrene derivatives, and Sonogashira coupling reactions of aryl halides with terminal alkynes. A wide range of functional groups as substituents on the arylboronic acids and aryl halides were considered. Pd-BOX-1 demonstrates exceptional air and moisture stability. Of note, the catalyst system based on Pd-BOX-1 shows high recycling ability in Suzuki–Miyaura coupling reactions in dimethylformamide–water without any loss in catalytic activity. Copyright © 2015 John Wiley & Sons, Ltd. A new bis(oxazoline) (BOX) ligand and a Pd‐BOX complex were synthesized and characterized. Pd‐BOX catalyst gave high isolated yields in Suzuki–Miyaura, Mizoroki–Heck and Sonogashira coupling reactions in DMF–H2O. The new air‐ and moisture‐stable Pd‐BOX catalyst could be recycled for consecutive uses without loss in catalytic activity.

ABSTRACT New bis(oxazoline) ligands and their palladium complexes were synthesized and characterized. X-ray crystal structures of the two new complexes showed distorted square planar geometry with the palladium ion bonded to nitrogens of two bidentate heterocycles in addition to two bromides and two acetate ions for Pd-BOX-1 and Pd-BOX-2, respectively. The complexes adopt a chair structure with a rigid curvature inducing an inherent chirality. The complexes were effective catalysts for Suzuki-Miyaura, Mizoroki-Heck, and copper-free Sonogashira coupling reactions in aqueous dimethylformamide and under aerobic conditions. The reaction conditions were optimized for best solvent, base, and temperature. The substrate scope of the new catalytic system was evaluated for coupling reactions of a variety of aryl halides with aryl boronic acids, alkenes, and alkynes.

The Fulani Jihad (1804-1810) led by Shehu, Uthman Dan Fodio was successfully prosecuted against the established Hausa dynasty in Northern Nigeria. It led to the emergence of a theocratic state, the Sokoto Caliphate, which was administered largely as a federation, due to its wide expanse and diverse composition of its people. The causes, management and impact of the Jihad as well as important lessons for national integration and development in contemporary Nigerian political life form the basic themes of this paper.