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【Objectives : Depression is a common psychiatric disorder in cancer patients. The Brief Edinburgh Depression Scale(BEDS), which is an abbreviated version of the Edinburgh Depression Scale, may serve as a useful tool in screening for the... more
【Objectives : Depression is a common psychiatric disorder in cancer patients. The Brief Edinburgh Depression Scale(BEDS), which is an abbreviated version of the Edinburgh Depression Scale, may serve as a useful tool in screening for the depression in patients with the medical illnesses. This report investigated the reliability and validity of the Korean Version of the BEDS(K-BEDS) for the depression in cancer patients. Methods : One-hundred cancer patients were enrolled in this study. All subjects completed the K-BEDS, the Hospital Anxiety Depression Scale(HADS), and the Karnofsky Performance Status Scale(KPSS). Reliability, validity and Receiver Operating Characteristic(ROC) curve analysis measures were assessed. Results : The K-BEDS showed good internal consistency(Cronbach ${\alpha}$ =0.77) and 0.77) and test-retest reliability(0.94, p】
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Research Interests: Psychology, Medicine, Prospective studies, Humans, Internal Medicine, and 15 moreMajor Depressive Disorder, Chronic Disease, Female, Male, Quinolones, Clinical Sciences, Rating Scale, Middle Aged, Adult, Akathisia, SECONDARY PREVENTION, Aripiprazole, Clinical Psychopharmacology, Pharmacology and pharmaceutical sciences, and Antidepressive agents
We conducted a case-control association study between the -G308A tumor necrosis factor (TNF)-alpha gene polymorphism and 89 patients with bipolar I disorder (BID). A polymerase chain reaction method was used. We found significant... more
We conducted a case-control association study between the -G308A tumor necrosis factor (TNF)-alpha gene polymorphism and 89 patients with bipolar I disorder (BID). A polymerase chain reaction method was used. We found significant differences in genotype and allele distribution. The -G308A TNF-alpha gene polymorphism may confer a risk for BID in the Korean population.
Research Interests: Psychiatry, Bipolar Disorder, Medicine, Gene expression, Humans, and 15 moreKorea, Female, Male, Polymerase Chain Reaction, Polymorphism (computer Science), Gene, Genotype, Adult, Tumor necrosis factor-alpha, Genetic Polymorphism, Allele, Psychology and Cognitive Sciences, Gene frequency, Medical and Health Sciences, and Population surveillance
The purpose of the present study was to investigate the association between the monocyte chemoattractant protein-1 (MCP-1) promoter -2518 polymorphism and schizophrenia. One hundred and twenty-three schizophrenic inpatients and 114... more
The purpose of the present study was to investigate the association between the monocyte chemoattractant protein-1 (MCP-1) promoter -2518 polymorphism and schizophrenia. One hundred and twenty-three schizophrenic inpatients and 114 healthy controls participated in this study. Genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism. Genotype and allele distributions in patients with schizophrenia were not significantly different from those of the controls. However, distributions of genotypes and alleles were marginally different when considering subjects with positive and negative symptomatology. The present study therefore calls for further studies on the potential role of the MCP-1 promoter -2518 polymorphism in clinical heterogeneity of schizophrenia.
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Background Bipolar Disorder (BPD) is a common and severe mental disorder. The involvement of genetic factors in the pathophysiology of BPD is well known. In the present study we tested the association of several SNPs within three strong... more
Background Bipolar Disorder (BPD) is a common and severe mental disorder. The involvement of genetic factors in the pathophysiology of BPD is well known. In the present study we tested the association of several SNPs within three strong candidate genes, CACNA1C, CHRNA7 and MAPK1, with BPD. These genes are involved in monoamines-related pathways as well as in dendrites development, neuronal survival, synaptic plasticity and memory/learning. Methods One hundred and thirty-two (132) subjects diagnosed with BPD and 326 healthy controls of Korean ancestry were genotyped for 40 SNPs within CACNA1C, CHRNA17 and MAPK1. Distribution of alleles and block of haplotypes within each gene were compared in cases and controls. Interactions between variants in different loci were also tested. Results Significant differences in the distribution of alleles between the cases and controls where detected for rs1016388 within CACNA1C, rs1514250, rs2337980, rs6494223, rs3826029 and rs4779565 within CHRNA7 and rs8136867 within MAPK1. Haplotype analyses also confirmed an involvement of variations within these genes in BPD. Finally, exploratory epistatic analyses demonstrated potential interactive effects, especially regarding variations in CACNA1C and CHRNA7. Discussion Overall, our data suggest a possible role of these three genes in BPD. Alterations of one or more common brain pathways (e.g. neurodevelopment and neuroplasticity, calcium signaling) may explain the obtained results. However, a limited sample size and the consequential risk of false positive findings should be taken into consideration when evaluating this data.
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Available studies indicate that obesity may exert a moderational effect on antidepressant treatment response. The aim of this study was to investigate the relationship between treatment response and metabolic abnormalities amongst... more
Available studies indicate that obesity may exert a moderational effect on antidepressant treatment response. The aim of this study was to investigate the relationship between treatment response and metabolic abnormalities amongst patients with depressive disorders in a large naturalistic clinical setting. A nationwide prospective study was conducted in 18 hospitals in South Korea; 541 depressive patients meeting DSM-IV criteria were recruited. After baseline evaluation, subjects received naturalistic clinician-determined antidepressant interventions. Assessment was performed at baseline and weeks 1, 2, 4, 8, 12, 24 and 52. Treatment response was defined as a ≥50% reduction from baseline on at least one evaluation point. In univariate comparison, the patients who showed insufficient response to antidepressant therapy were more likely to be male, unmarried, unemployed, and obese. After adjusting for baseline variables, male sex (OR=1.82) and obesity (OR=1.55) remained as were signifi...
Research Interests: Depression, Obesity, Treatment Outcome, Medicine, Prospective studies, and 15 moreHumans, Internal Medicine, Affective Disorders, Antidepressant, Female, Male, Risk factors, Republic of Korea, Middle Aged, Adult, Risk Factors, Cohort Studies, Psychology and Cognitive Sciences, Medical and Health Sciences, and Antidepressive agents
We investigated phosphodiesterase 7B (PDE7B), neuromedin B receptor (NMBR) and epilepsy progressive myoclonus type 2A (EPM2A) genes in schizophrenia (SCZ). To the best of our knowledge, these genes have been poorly investigated in studies... more
We investigated phosphodiesterase 7B (PDE7B), neuromedin B receptor (NMBR) and epilepsy progressive myoclonus type 2A (EPM2A) genes in schizophrenia (SCZ). To the best of our knowledge, these genes have been poorly investigated in studies of SCZ. Five hundred and seventy-three SCZ inpatients of Korean ethnicity and 560 healthy controls were genotyped for 2 PDE7B, 3 NMBR and 3 EPM2A polymorphisms. Differences in the allelic and genetic frequencies among healthy subjects and patients were calculated using the x03C7;2 statistics. Repeated-measure ANOVA was used to test possible influences of single-nucleotide polymorphisms on treatment efficacy. In case of positive findings, clinical and demographic variables were added as covariates, in order to investigate possible stratixFB01;cation bias. The rs2717 and rs6926279 within the NMBR gene and rs702304 and rs2235481 within the EPM2A gene were associated with SCZ liability. rs1415744 was also associated with Positive and Negative Symptom S...
Research Interests: Cognitive Science, Schizophrenia, Medicine, Humans, Pharmacogenetics, and 12 moreFemale, Male, Young Adult, Clinical Sciences, Middle Aged, Adult, Neurosciences, Case Control Studies, Antipsychotic agents, Psychology and Cognitive Sciences, Medical and Health Sciences, and Genetic predisposition to disease
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Hoo Rim Song, MD, Young-Hwa Lee, BS, Sujin Yang, PhD, Ji-Young Lee, BS, Jeong-Won Jang, BS, Sona Jeong, PhD, Hyunsuk Jeong, PhD, Sun-Jin Jo, PhD, Hyeon-Woo Yim, MD, PhD, So-Young Lee, MD, PhD and Tae Youn Jun, MD, PhD Department of... more
Hoo Rim Song, MD, Young-Hwa Lee, BS, Sujin Yang, PhD, Ji-Young Lee, BS, Jeong-Won Jang, BS, Sona Jeong, PhD, Hyunsuk Jeong, PhD, Sun-Jin Jo, PhD, Hyeon-Woo Yim, MD, PhD, So-Young Lee, MD, PhD and Tae Youn Jun, MD, PhD Department of Psychiatry, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Clinical Research Center for Depression, Seoul, Medical Library, College of Medicine, The Catholic University of Korea, Seoul, Department of Preventive Medicine, College of Medicine, The Catholic University of Korea, Seoul, Department of Psychiatry, Soonchunhyang University Bucheon Hospital, College of Medicine, Soonchunhyang University, Bucheon, Korea
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Dysbindin gene (DTNBP1) has been consistently reported to be associated with schizophrenia. However data from East Asian population has been sparse and inconsistent till today. This study tried to replicate the genetic association of... more
Dysbindin gene (DTNBP1) has been consistently reported to be associated with schizophrenia. However data from East Asian population has been sparse and inconsistent till today. This study tried to replicate the genetic association of DTNBP1 with schizophrenia in a large Korean sample, as well as analyzing the association of DTNBP1 with clinical variables. Nine hundred and eight (908) patients with schizophrenia and 601 controls were investigated. The high-throughput genotyping method using pyrosequencer (Biotage AB, Sweden) was used for genotyping 4 SNPs (rs3213207, rs1011313, rs760761, and rs2619522). Haplotype analyses revealed a significant association with schizophrenia (P < 0.0001) with the haplotypes A-C-C-C and A-C-T-A having an eminent protective effect toward schizophrenia. The major contribution to the difference in the haplotype distribution between patients and the controls was the rs760761 (C/T) and rs2619522 (A/C) haplotypes (P < 0.0001). No association of DTNBP1 with other clinical variables was found. In conclusion, the present study suggests a possible protective effect of rare DTNBP1 variants in schizophrenia, although subsequent studies in different ethnic groups are warranted.
Research Interests: Cognitive Science, Schizophrenia, Medicine, Korean, Humans, and 15 moreKorea, Haplotypes, Female, Male, Polymerase Chain Reaction, Clinical Sciences, Adult, Ethnic Group, Genotyping, Asian Continental Ancestry Group, Genetic Association, Neurosciences, Haplotype, European Archives, and Gene frequency
OBJECTIVES: Bipolar disorder is known to have a high genetic predisposition. Recently, the main focus of etiologic studies in bipolar disorder has been concentrated on molecular genetic approach including gene polymorphism analysis. The... more
OBJECTIVES: Bipolar disorder is known to have a high genetic predisposition. Recently, the main focus of etiologic studies in bipolar disorder has been concentrated on molecular genetic approach including gene polymorphism analysis. The present study was conducted to ...