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The recently reported geometrical algorithm to search the conformational space (GASCOS) scans conformational space exhaustively using an internal coordinate tree search. Using only geometrical operations and a set of criteria for... more
Oxidized LDL stimulates the expression of TGF-β and fibronectin in human glomerular epithelial cells. Abnormal lipid accumulation in glomeruli is a recognized early event in the development of glomerulosclerosis. The presence of LDL and... more
Salicylate synthase from Mycobacterium tuberculosis, MbtI, initiates the biosynthesis of siderophores by converting chorismate to salicylate. Nevertheless, three more distinct activities for wild-type MbtI have been detected in vitro:... more
It has been increasingly recognized that cell death phenotypes and their molecular mechanisms are highly diverse. Necrosis is no longer considered a single entity, passively mediated by energy failure. Moreover, caspase-dependent... more
Burkitt’s lymphoma (BL) in Turkish children is commonly associated with Epstein–Barr virus (EBV) infection. The C-terminus of the latent membrane protein 1 (LMP-1) of EBV is essential for transformation and the 30-bp deletion detected in... more
This review is devoted to the problem of regulation of intracellular organelle transport along microtubules. Properties of the system of microtubules as transport tracks are considered. Some motor proteins (kinesins and dyneins) carrying... more
Variable environmental availability of metal ions represents a constant challenge for most organisms, so that during evolution, they have optimised physiological and molecular mechanisms to cope with this particular requirement.... more
1,3-Dinitrobenzene (1,3-DNB) specifically injures Sertoli cells and induces testicular toxicity by disrupting the key function of these cells. To clarify the molecular mechanism underlying 1,3-DNB’s action on Sertoli cells, we analyzed... more