The kinetics of the oxidation reaction of hydroxyzine hydrochloride with potassium hydrogen peroxomonosulfate was studied depending on the pH of the medium. It was established for the first time that the kinetics of the reaction of... more
The kinetics of the oxidation reaction of hydroxyzine hydrochloride with potassium hydrogen peroxomonosulfate was studied depending on the pH of the medium. It was established for the first time that the kinetics of the reaction of N-oxidation of hydroxyzine obeyed the general laws of the mechanism of specific acid-base catalysis, proceeded quantitatively and stoichiometrically according to the mechanism of nucleophilic substitution of the β-oxygen atom of the peroxyacid group of peroxomonosulfate ions. It was shown that quantitative oxidation was achieved in 1–1.5 minutes at pH 8.0–8.5. The only reaction product was hydroxyzine N-oxide. A scheme of the oxidation process was proposed. Techniques were developed and the possibility of quantitative determination of hydroxyzine hydrochloride in the substance and tablets of 25 mg by iodometry using Oxone as an analytical reagent was shown. A known excess of reagent was added, and after a predetermined time, the residual reagent was deter...
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Aims.Three different assays for the quantity determination of Cephalexin in pure substance were developed and compared using potassium caroate as analytical reagent. Materials and Methods. Cephalexin pure substance was used and analytical... more
Aims.Three different assays for the quantity determination of Cephalexin in pure substance were developed and compared using potassium caroate as analytical reagent. Materials and Methods. Cephalexin pure substance was used and analytical reaction by means of KHSO5 as an oxidant was studied. Voltammetric, kinetic-spectrophotometric and iodometric methods were developed and validated. Results. The chemical reaction is finished with formation of the S-oxide of Cephalexin in the iodometric and voltammetric methods and the S-oxide hydrolysis product in the kinetic-spectrophotometric method. The reaction finishes in 1 min (observation time). The methods have been validated and good results including precision, accuracy and recovery were obtained. The recovery percent ranged from 98.7 to 101.4%, RSD from 1.42 to 3.0%. The methods proposed are linear in a wide range: voltammetry 2-45 µg mL-1, kinetic-spectrophotometry 1-16 µg mL-1, and iodometry 0.05-0.35 mg mL-1. LOD and LOQ were calculat...
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The book is devoted to the characteristics, purpose and prospects for the use of modern chemical disinfectants and sterilization agents which are based on peroxide compounds. The book examined factors that affect the stability and... more
The book is devoted to the characteristics, purpose and prospects for the use of modern chemical disinfectants and sterilization agents which are based on peroxide compounds. The book examined factors that affect the stability and development efficiency of the specific biological action of peroxide derivatives of carboxylic acids. Presented the results of approbation and using of new disinfection and antiseptics based on higher peroxycarboxylic acids.
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The work presents the obtaining of atropine N-oxide using various peroxyacids (organic monoperoxyacid, diperoxyacids and inorganic peroxyacids). The kinetics of atropine oxidation with various oxidants, for example Oxone,... more
The work presents the obtaining of atropine N-oxide using various peroxyacids (organic monoperoxyacid, diperoxyacids and inorganic peroxyacids). The kinetics of atropine oxidation with various oxidants, for example Oxone, m-chloroperoxybenzoic acid, diperoxysebasic acid and diperoxyazelaic acid, was studied. The optimal conditions for obtaining of atropine N-oxide (oxidation duration, pH) are given in the work. It was established that the best oxidant was potassium peroxymonosulfate, since 100% yield of atropine N-oxide was achieved within 15 min. In this work, we showed that the oxidation reaction of atropine to N-oxide was a second-order reaction. The rate constants of these reactions were established. The electrochemical behavior of atropine N-oxide obtained using potassium peroxymonosulfate and m-chloroperoxybenzoic acid on a mercury dropping electrode was investigated. Atropine N-oxide was reduced forming two peaks. Each reduction peak involved 1 electron and 1 proton.
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A simple procedure for the quantitative determination of the Ceftriaxone pure substance by the spectrophotometric method in its kinetic modification using Caro’s acid has been developed and validated. The scheme of the chemical... more
A simple procedure for the quantitative determination of the Ceftriaxone pure substance by the spectrophotometric method in its kinetic modification using Caro’s acid has been developed and validated. The scheme of the chemical transformation of Ceftriaxone with the reaction of potassium caroate has been proposed. The appearance of a new wave gives the possibility of developing a new procedure for the quantitative determination of Ceftriaxone. The obtained results of accuracy and precision are as follows: RSD = 1.63-2.25 %, δ = 0.33-0.96 %. LOD = 0.1 µg/mL, LOQ = 0.33 µg/mL.
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The electrochemical behaviour of hydrogen peroxide (H2O2) has been studied using the alternating current voltammetry with square wave modulation in the potential range of +1.0…–1.0 V on the carbositall electrode as a working and auxiliary... more
The electrochemical behaviour of hydrogen peroxide (H2O2) has been studied using the alternating current voltammetry with square wave modulation in the potential range of +1.0…–1.0 V on the carbositall electrode as a working and auxiliary electrode (vs Ag,AgCl/KCl(sat)). The peak was obtained at Ep = +0.16 V on the background of 0.1 Mol L–1 Na2SO4 and 0.01 Mol L–1 KHSO4 (pH≈2.4) with its height rising proportionally to the increase of H2O2 concentrations. The linear dependence was observed in the H2O2 concentration range of (1.7-10.2)×10–5 Mol L–1, the calibration curve equation was Ip = (8.6±0.7)×103с (r = 0.998); LOD = 6.16×10–6 Mol L–1, LOQ = 2.05×10–5 Mol L–1. To determine H2O2 in solutions of antiseptic drugs the standard addition method was used.
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The oxidative derivatization method using Diperoxyazelaic acid for the indirect spectrophotometric determination of Levomepromazine hydrochloride is presented. Diperoxyazelaic acid is introduced as a derivatizing agent for... more
The oxidative derivatization method using Diperoxyazelaic acid for the indirect spectrophotometric determination of Levomepromazine hydrochloride is presented. Diperoxyazelaic acid is introduced as a derivatizing agent for Levomepromazine, yielding the sulfoxides. This reaction product was successfully used for the spectrophotometric determination of the Levomepromazine hydrochloride. The UV spectroscopic detection of the sulfoxide proved to be a more robust and sensitive method. The elaborated method allowed the determination of Levomepromazine hydrochloride in the concentration range of 3-150 µg/mL. The limit of quantification, LOQ (10S) is 2.85 µg/mL. A new spectrophotometric technique was developed and the possibility of quantitative determination of Levomepromazine in Tisercin Solution for Injection 25mg/mL was demonstrated. The present method is precise, accurate and other excipients: anhydrous citric acid, monothioglycerol, sodium chloride did not interfere. RSD = 1.24 % (δ =...
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A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the... more
A new the oxidative derivatization method by means of peroxoacid for the indirect spectrophotometric determination of Periciazine is presented. A potassium hydrogenperoxymonosulfateas a derivatizing agent for Periciazine, yielding the absorbative Periciazine sulfoxide at λmaх=362 nm is proposed. This reaction product was successfully employed for spectrophotometric determination of the Periciazine. The UV spectrophotometric determination of the Periciazine as its sulfoxide proved to be the more simple and selective method. Limit of quantification (LOQ=10S) is 2.8 µg·mL-1. The common excipients employed do not interfere in the determination of phenothiazine drug. Results of analysis of the drug dosage forms by the proposed method are in good agreement with those of the official method. RSD=1.76 % (δ
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Objective: The aim of this article was to test the hypothesis about the possibility for extraction of essential oil components from the plant raw material (PRM) by the example of Pimpinella anisum L. fruits with two different perfluoro... more
Objective: The aim of this article was to test the hypothesis about the possibility for extraction of essential oil components from the plant raw material (PRM) by the example of Pimpinella anisum L. fruits with two different perfluoro organic solvents, Novec 1230 and Novec 7100. Methods: For the studies, we used Pimpinella anisum L. fruits ground to obtain particle size between 0.1 and 0.5 mm. The study of qualitative and quantitative content of the extracts was carried out by the following method: simple maceration, PRM: extractant ratio 1:10 w/v; and circulation method for extraction using Soxhlet extractor, PRM: extractant ratio 1:5 w/v. Qualitative analysis of extracts was carried out by gas chromatography-mass spectrometry (GC-MS) method. Quantitative analysis of trans-anethole in the extracts was carried out by reverse phase high-performance liquid chromatography (RP HPLC) method. Results: The largest yield of anethole was observed for n-hexane, 84±4 %, and for Novec 7100, 81...
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The kinetics of cystamine dihydrochloride oxidation by diperoxyadipic acid (DPAA) was studied in aqueous buffer solutions of pH 2.9, 6.9, 8.0, 8.5 and 9.2 under second-order conditions at the temperature 293 K. The second order rate... more
The kinetics of cystamine dihydrochloride oxidation by diperoxyadipic acid (DPAA) was studied in aqueous buffer solutions of pH 2.9, 6.9, 8.0, 8.5 and 9.2 under second-order conditions at the temperature 293 K. The second order rate constants, k (L mol−1 min−1) were calculated from kinetic values. A suitable mechanism scheme based on these observations was proposed. The possibility of application of DPAA as reagent for oxidimetric determination of cystamine dihydrochloride in tabtets was investigated. Cystamine dihydrochloride was determined by indirect titration with DPAA. The required amount of Cystamine dihydrochloride was dissolved in water, pH 8.0 buffer solution and DPAA solution was added. After 7 min, the solution was acidified. The excess DPAA was determined via iodometric titration. The advantages of the applied analytical techniques in the determination of cystamine dihydrochloride in tablets «Cystamine 0.2 g» was presented. The recovery of сystamine dihydrochloride was 9...
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A new polarographic method for the determination of benzocaine and procaine based on the polarographic reduction of their chemically obtained oxidation products with potassium peroxymonosulfate is developed. Experimental conditions... more
A new polarographic method for the determination of benzocaine and procaine based on the polarographic reduction of their chemically obtained oxidation products with potassium peroxymonosulfate is developed. Experimental conditions affecting quantitative yield of benzocaine and procaine oxidation products such as рH, oxidation time, reagents’ concentration, and temperature are explored. It is shown that the reduction current changes in a linear fashion (R=0.999) with increasing concentration of anesthetics over a concentration range of 1·10−6 - 5·10−5 mol L−1. The calculated limits of detection (LOD) for benzocaine and procaine are found to be 5.6·10−6 and 6·10−6 mol L−1, respectively. In the present study, quantitative polarographic determination of benzocaine in Farisil tablets and “Septolete Plus” lozenges and procaine in solution for injections is performed. The results of the analysis are in good agreement with the product specifications described in the quality certificates. T...
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Objetivos: Se ha desarrollado un nuevo método fotométrico cinético sensible para la determinación de la presencia del cloruro de benzalconio. Material y métodos: El método se basa en la capacidad de inhibir la hidrolisis de acetilcolina... more
Objetivos: Se ha desarrollado un nuevo método fotométrico cinético sensible para la determinación de la presencia del cloruro de benzalconio. Material y métodos: El método se basa en la capacidad de inhibir la hidrolisis de acetilcolina en presencia de colinesterasa. La velocidad de reacción se estima mediante el residuo no hidrolizado de acetilcolina, que está determinado por la cantidad de ácido peracetico formado durante la interacción de la acetilcolina con el exceso de peróxido de hidrogeno. La reacción indicativa es la interacción de -etoxianilina con ácido peracetico, que da como resultado la formación de 4,4’-azoxifenetol con λmax = 358 nm ((log10 =4.2). Resultados: Las condiciones óptimas seleccionadas para llevar a cabo el experimento. El experimento se llevó a cabo en el rango de concentraciones (1.4 to 8.4·10-6 mol L-1 de cloruro de benzalconio. el coeficiente de correlación fue 0.999. Los límites de la definición de análisis (20% del grado de inhibición) fueron 1.9·10-6...
Objetivos: Los estudios cinéticos de substancia y medicamento Famotidina (FMT) han sido realizados en las soluciones amortiguadoras en las condiciones de reacción del segundo orden a temperatura de 293 K. Nuevos métodos titrimétricos... more
Objetivos: Los estudios cinéticos de substancia y medicamento Famotidina (FMT) han sido realizados en las soluciones amortiguadoras en las condiciones de reacción del segundo orden a temperatura de 293 K. Nuevos métodos titrimétricos están descritos para determinar FMT. Materiales y métodos: La substancia y los comprimidos FMT han sido usados en la reacción analítica con KHSO5. El comportamiento cinético ha sido estudiado por el método de yodometría en diferentes ambientes de pH. Resultados: La reacción de oxidación de FMT se estudiaba para el producto del óxido S con pH = 2,0-5,0 y de la sulfona con pH = 7,0-8,4. La reacción a estudiar corresponde al segundo orden general. Las constantes de velocidad de la reacción de la formación de sulfona del óxido S FMT se encuentra en el intervalo de 14,49 a 32 l mol-1 min-1. La FMT fue determinada mediante la medición del exceso de solución estándar del caroata de potasio en la solución amortiguadora con pH 7 dentro de 20 minutos desde el ini...