- Philadelphia, United States
Raj Mutharasan
Drexel University, Chemical and Biological Enginering, Faculty Member
- Chemical Engineering, Indian ancient history, Early Indian Insciptions, Engineering, Chemistry, Biotechnology, and 19 moreBiology, Physics, Mathematics, Molecular Biology, Biochemistry, Materials Science, Mechanical Engineering, Microbiology, Environmental Engineering, Renewable Energy, Nanoscience, Nanotechnology, Indian Art, Gene Expression by qRT PCR, Ancient Indian Architecture, Biosensors, Sensors, Polymerase Chain Reaction, and Education(Biology, Physics, Mathematics, Molecular Biology, Biochemistry, Materials Science, Mechanical Engineering, Microbiology, Environmental Engineering, Renewable Energy, Nanoscience, Nanotechnology, Indian Art, Gene Expression by qRT PCR, Ancient Indian Architecture, Biosensors, Sensors, Polymerase Chain Reaction, and Education)edit
There have been extensive heat transfer studies of impinging gas jets on solid surfaces, but few investigations of gas jet/liquid bath interaction. Here we report on the effects of liquid Prandtl number on air-jet induced transport in a... more
There have been extensive heat transfer studies of impinging gas jets on solid surfaces, but few investigations of gas jet/liquid bath interaction. Here we report on the effects of liquid Prandtl number on air-jet induced transport in a bath. Two different liquids having widely different Prandtl numbers (silicone oil and a molten metal alloy, Amalloy-203®) were used. Both numerical calculations and experiments were carried out to characterize the jet induced flow and heat transfer in the liquid. The mixing and thermal behavior of the heated bath were determined as functions of the air jet characteristics (inlet temperature, Reynolds number, diameter and nozzle distance from the bath surface) and bath properties (depth, diameter, and liquid Prandtl number).
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Case 1 61 7 pT2c 11.6 ng/mL-4,314±35 Hz 10±21 Hz Case 2 83 6 pT2a 12.6 ng/mL-269±17 Hz 10±6 Hz Case 3 64 8 pT2c 78.4 ng/mL-977±64 Hz-63±14 Hz Case 4 59 7 pT2b 4.6 ng/mL-600±31 Hz-35±24 Hz Case 5 65 7 PT2c 2.0 ng/mL-801±81 Hz-20±15 Hz
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Piezoelectric-excited millimeter-sized cantilever (PEMC) sensors consisting of a piezoelectric and a borosilicate glass layer with a sensing area of 4mm2 were fabricated. An antibody specific to Escherichia coli (anti-E. coli) O157: H7... more
Piezoelectric-excited millimeter-sized cantilever (PEMC) sensors consisting of a piezoelectric and a borosilicate glass layer with a sensing area of 4mm2 were fabricated. An antibody specific to Escherichia coli (anti-E. coli) O157: H7 was immobilized on PEMC ...
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A novel water-soluble polymer, poly[(chloromethoxytrialanine methyl ester)phosphazene] (poly-Tame), was characterized and evaluated using high-performance size-exclusion chromatography, gradient reversed-phase high-performance liquid... more
A novel water-soluble polymer, poly[(chloromethoxytrialanine methyl ester)phosphazene] (poly-Tame), was characterized and evaluated using high-performance size-exclusion chromatography, gradient reversed-phase high-performance liquid chromatography and ion chromatography. These novel liquid chromatographic methods were validated for application to in vitro biodegradation experiments of poly-Tame in aqueous solutions. Results from method validation experiments are presented.
Research Interests: Engineering, Chemistry, Technology, Chromatography, Ion Chromatography, and 11 moreDrug Delivery System, Polymers, Peptides, Organophosphorus Compounds, High Performance Liquid Chromatography, High Pressure Liquid Chromatography, CHEMICAL SCIENCES, Drug Carriers, Hydrogen-Ion Concentration, Ions, and Methyl Ester
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The behaviour of a non-linear continuous stirred tank reactor (CSTR) with time-delay in the feedback control is determined by expanding the delay factors by means of a series approximation. The resulting system approximates the original... more
The behaviour of a non-linear continuous stirred tank reactor (CSTR) with time-delay in the feedback control is determined by expanding the delay factors by means of a series approximation. The resulting system approximates the original system quite well, and is considerably easier to analyse. The region of stability obtained by this method is substantially larger than that obtained by the application of Liapunov's method.
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ABSTRACT
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Page 31. In: Optical Fibers Research Advances ISBN: 1-60021-866-0 Editor: Jurgen C. Schlesinger, pp. 15-49© 2007 Nova Science Publishers, Inc. Chapter 1 EVANESCENT FIELD TAPERED FIBER OPTIC BIOSENSORS (TFOBS ...
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ABSTRACT We describe a macrocantilever-based method for detecting a prostate cancer biomarker (alpha-methylacyl-CoA racemase; AMACR) directly in patient urine without a sample preparation step and without the use of labeled reagents.... more
ABSTRACT We describe a macrocantilever-based method for detecting a prostate cancer biomarker (alpha-methylacyl-CoA racemase; AMACR) directly in patient urine without a sample preparation step and without the use of labeled reagents. Clean catch voided urine specimens were prospectively collected from five confirmed prostate cancer patients 3 weeks post biopsy. The presence of AMACR was measured in a blinded manner by exposing 3-mL of urine to the anti-AMACR immobilized piezoelectric-excited millimeter-sized (PEMC) sensor. The resonance frequency of PEMC decreases as AMACR from sample binds to the antibody on the sensor. The resonance frequency changes for the five patients tested were 4,314+/-35 (n=2), 269 +/-17 (n=2), 977 +/-64 (n=3), 600 +/-31 (n=2), and 801+/-81 (n=2) Hz, respectively. Positive detection was observed within ~ 15 minutes. The responses to positive, negative, and buffer controls were -9 +/-13, -34+/-18 Hz and -6+/-18 Hz, respectively. Positive verification of AMACR attachment was confirmed by low-pH buffer release. The sensor response was quantitatively related to AMACR concentration in control urine, and the relationship was used in developing an in situ calibration method for quantifying AMACR in patient urine. Estimated concentrations of 42, 2, and 3 fg/mL AMACR were calculated for the three patient urine, while absence of AMACR was confirmed in control urine (n=13). Because of simplicity of measurement is combined with high sensitivity and specificity, the method may be an useful adjunct in a point-of-care setting to identify men at increased risk for prostate cancer.
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We show the detection of 100 cells per ml of Escherichia coli O157:H7 in the presence of spinach, spring lettuce mix, and ground beef washes and particulate matter with piezoelectric-excited millimeter-sized cantilever (PEMC) sensors. The... more
We show the detection of 100 cells per ml of Escherichia coli O157:H7 in the presence of spinach, spring lettuce mix, and ground beef washes and particulate matter with piezoelectric-excited millimeter-sized cantilever (PEMC) sensors. The PEMC sensors (sensing area, 2 mm2) were immobilized with polyclonal antibody specific to E. coli O157:H7 (EC) and were exposed to 10 aqueous washes of locally purchased spinach, spring lettuce mix, and ground beef for testing if EC was present. Absence of resonance frequency shift indicated that EC was not present in the 30 samples tested. Following the last sample in each food matrix, 1,000 cells per ml of EC were spiked into the sample container, and resonance frequency change was monitored. The total resonance frequency change was 880 ± 5, 1,875 ± 8, and 1,417 ± 4 Hz for spinach, spring lettuce mix, and ground beef, respectively. A mixture of the three food matrices spiked with 100 cells per ml of EC gave a sensor response of 260 ± 15 Hz. The re...
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The pH effect on adsorbed antibody-binding protein (protein G) orientation on gold (Au) and its adsorption thermodynamic characteristics were investigated using quartz crystal microbalance (QCM) and X-ray photoelectron spectroscopy (XPS).... more
The pH effect on adsorbed antibody-binding protein (protein G) orientation on gold (Au) and its adsorption thermodynamic characteristics were investigated using quartz crystal microbalance (QCM) and X-ray photoelectron spectroscopy (XPS). The adsorbed protein G orientation was measured by binding response of two antibody-antigen systems: the model bovine serum albumin (BSA) and the foodborne pathogen E. coli O157:H7. Surface coverage was not significantly affected by pH, but its orientation was. The most properly oriented protein G for antibody binding was achieved at near-neutral pH. Adsorption was verified by XPS measurements using nitrogen (N) 1s, oxygen (O) 1s, and Au 4p peak heights. Adsorption energetics were determined by van't Hoff and Langmuir kinetic analyses of adsorption data obtained at 296, 303, and 308 K. Large characteristic entropy change of protein adsorption was observed (ΔS° = 0.52 ± 0.01 kcal/mol·K). The adsorption process was not classical physisorption but exhibited chemisorption characteristics based on significant enthalpy change (ΔH° = -25 ± 6 kcal/mol).
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Page 1. A novel experimental technique for determining node location in resonant mode cantilevers This article has been downloaded from IOPscience. Please scroll down to see the full text article. 2011 J. Micromech. Microeng. 21 065027 ...