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Kurdistan Journal of Applied Research
Determination of Acetyl Salicylic Acid in Aspirin tabletsDrug analysis is an important method for determination of active components of any therapeutic drugs. HPLC, Spectrometry, Direct titration and Back-titration are common effective techniques in drug analysis. They were used in this study in a comparative way for the determination of the correct amount of acetyl salicylic acid in aspirin formulations. The aim of this study is to analysis of aspirin and compares both Direct titration and Back-titration techniques to the standard HPLC technique in order to find alternative, the easy and cheaper procedure to assess the quality of active components of medications aspirin in particular in Sulaimani city. Additionally, Spectrophotometric technique were also used and compared with the standard HPLC method. The samples were collected from different local drug stores in which distribute medications to pharmacies and they were from different companies. The analyses were performed after preparing a solution from each of the samples with a standa...
2023 •
Salicylates have been around since the turn of the century. It has the properties of anti-inflammatory, anti pyretic, analgesic, anti-platelet. It belongs to the drug class of NSAIDS. It acts by irreversibly binding to the COX-1 & COX-2 enzymes. In order for clinicians to direct patient care in treating stated conditions as a member of the interprofessional team, this activity describes the indications, mechanism of action, routes of administration, significant adverse effects, contraindications, and monitoring for salicylic acid. used for treating, preventing and managing the disease of multiple system. Which include various disease such as cardiovascular, stroke, pain, headaches, cancer, inflammatory diseases
To overcome the gastric toxicity of aspirin and ketorolac fi ve different N,N-disubstitutedaminoethyl ester derivatives for each were synthesized and evaluated. The intact esters were specially designed to satisfy the structural requirement for possessing the anticholinergic activity before cleavage. Besides blocking the acidic carboxyl group by esterifi cation this activity was incorporated into the synthesized esters with an expected additional benefi t of having reduced gastric acid secretion and thereby abolishing the local irritation by a dual mechanism. This report describes the synthesis, hydrolysis kinetics and the biological activity of these esters. All the ester derivatives were found to be stable in buffers (pH 2.0 and 7.4) for suffi cient time period, assuring them to be absorbed intact and to successfully overcome the local gastric irritation of the parent drug. A fast enzymatic hydrolysis was observed for all the derivatives in 80% pooled human serum. The synthesized ...
Revista de Chimie -Bucharest- Original Edition-
Alternative Synthesis of Paracetamol and Aspirin Under Non-conventional ConditionsÉtudes et Documents Berbères
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