Skip to main content

antiviral agent

0 Followers
Recent papers in antiviral agent
Design of oseltamivir analogs inhibiting neuraminidase of avian influenza virus H5N1
Assessment of pain in herpes zoster: lessons learned from antiviral trials
Novel antiviral agents: a medicinal plant perspective
Tenofovir and Entecavir Are the Most Effective Antiviral Agents for Chronic Hepatitis B: A Systematic Review and Bayesian Meta-analyses
Functionalized alkyl and aryl diselenides as antimicrobial and antiviral agents: synthesis and properties
Single assay for simultaneous detection and differential identification of human and avian influenza virus types, subtypes, and emergent variants
Aminoglycoside Interactions with RNAs and Nucleases
Economic Analysis of Pandemic Influenza Vaccination Strategies in Singapore
Background: All influenza pandemic plans advocate pandemic vaccination. However, few studies have evaluated the cost-effectiveness of different vaccination strategies. This paper compares the economic outcomes of vaccination compared with... more
Pandemic influenza preparedness in the Asia-Pacific region
Concerns are mounting that the threat of another influenza pandemic will become a reality and that the epicentre of the outbreak could be the Asia-Pacific region. We assessed the documents that some Asia-Pacific countries have published... more
Pyrido [2, 3-d]pyrimidines and Pyrimido[5′, 4′:5, 6]pyrido[2, 3-d]pyrimidines as New Antiviral Agents: Synthesis and Biological Activity
Meeting the Challenge of Influenza Pandemic Preparedness in Developing Countries
Management of Bell's Palsy: A Report of 2 Cases
3-Benzamido, Ureido and Thioureidoimidazo[1,2-a]pyridine Derivatives as Potential Antiviral Agents
Pharmacological actions and potential uses of Momordica charantia: a review
Use of a prenylation inhibitor as a novel antiviral agent
No specific therapy exists for hepatitis delta virus (HDV), which can cause severe liver disease. Molecular genetic studies have implicated the prenylation site of large delta antigen as a critical determinant of HDV particle assembly. We... more
Epidemiology and Clinical Presentation of Pandemic Influenza A (H1N1) among Hospitalized Children in Kuwait
ChemInform Abstract: Synthesis of Novel 3′-Deoxy-3′-C-hydroxymethyl Nucleosides with Conformationally Rigid Sugar Moiety as Potential Antiviral Agents
Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents 1
Small molecules targeting severe acute respiratory syndrome human coronavirus
A comprehensive analysis of the naturally occurring polymorphisms
Modeling targeted layered containment of an influenza pandemic in the United States
C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection
Efficacy of the New Neuraminidase Inhibitor CS-8958 against H5N1 Influenza Viruses
Display of VP1 on the Surface of Baculovirus and Its Immunogenicity against Heterologous Human Enterovirus 71 Strains in Mice
Ribavirin Treatment Up-Regulates Antiviral Gene Expression via the Interferon-Stimulated Response Element in Respiratory Syncytial Virus-Infected Epithelial Cells
Clinical Resistance to Enfuvirtide Does Not Affect Susceptibility of Human Immunodeficiency Virus Type 1 to Other Classes of Entry Inhibitors
The clinical use of the human immunodeficiency virus (HIV) fusion inhibitor enfuvirtide (ENF) can select for drug-resistant HIV-1 strains bearing mutations in the HR1 region of the viral envelope (Env) protein. We analyzed the properties... more
Phase II, Randomized, Double-Blind, Placebo-Controlled Studies of Ruprintrivir Nasal Spray 2-Percent Suspension for Prevention and Treatment of Experimentally Induced Rhinovirus Colds in Healthy Volunteers
Human rhinovirus (HRV) infections are usually self-limited but may be associated with serious consequences, particularly in those with asthma and chronic respiratory disease. Effective antiviral agents are needed for preventing and... more
Determination of rimantadine in pharmaceutical preparations by capillary zone electrophoresis with indirect detection or after derivatization
Summary  Rimantadine is synthetic analog of amantadine; both are antiviral agents used for prophylaxis and treatment of influenza A. A capillary zone electrophoretic (CZE) procedure for the determination of rimantadine has been developed.... more
Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential
A Multicenter Phase I/II Dose Escalation Study of Single-Dose Cidofovir Gel for Treatment of Recurrent Genital Herpes
A randomized, double-blind, clinic-initiated, sequential dose-escalation pilot study was performed to compare the safety and efficacy of single applications of 1, 3, and 5% cidofovir gel with placebo in the treatment of early, lesional,... more
Novel multi-component nanopharmaceuticals derived from poly(ethylene) glycol, retro-inverso-Tat nonapeptide and saquinavir demonstrate combined anti-HIV effects
Current anti-AIDS therapeutic agents and treatment regimens can provide a dramatically improved quality of life for HIV-positive people, many of whom have no detectable viral load for prolonged periods of time. Despite this, curing AIDS... more
Guidelines for laboratory monitoring of treatment of persistent virus infections
Reinfection and reactivation of equine herpesvirus-1 in the mouse
Preclinical Evaluation of Two Human Anti–Hepatitis B Virus(HBV) Monoclonal Antibodies in the HBV-Trimera Mouse Model and in HBV Chronic Carrier Chimpanzees
Two human monoclonal antibodies (mAbs) against hepatitis B surface antigen (HBsAg) generated in the Trimera mouse system are described. Both mAbs 17.1.41 and 19.79.5 are of the IgG1 isotype and have high affinity constants for HBsAg... more
VX-950, a Novel Hepatitis C Virus (HCV) NS3-4A Protease Inhibitor, Exhibits Potent Antiviral Activities in HCV Replicon Cells
The NS3-4A serine protease of hepatitis C virus (HCV) is essential for viral replication and therefore has been one of the most attractive targets for developing specific antiviral agents against HCV. VX-950, a highly selective,... more
Surface structured liposomes for site specific delivery of an antiviral agent-indinavir
Activation by 9-(R)-(2-(Phosphonomethoxy)Propyl)Adenine of Chemokine (RANTES, Macrophage Inflammatory Protein 1) and Cytokine (Tumor Necrosis Factor Alpha, Interleukin-10 (IL-10), IL-1) Production
Silibinin Is a Potent Antiviral Agent in Patients With Chronic Hepatitis C Not Responding to Pegylated Interferon/Ribavirin Therapy
Pharmacology and Pharmacokinetics of the Antiviral Agent -D-2,3-Dideoxy-3-Oxa-5-Fluorocytidine in Cells and Rhesus Monkeys†
New 1-indanone thiosemicarbazone derivatives active against BVDV
Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506
[11C]FMAU and [18F]FHPG as PET tracers for herpes simplex virus thymidine kinase enzyme activity and human cytomegalovirus infections
Acute encephalopathy with a lesion of the splenium of the corpus callosum – A report of two cases
Bleomycin has antiviral properties against drug-resistant HIV strains and sensitises virus to currently used antiviral agents
ChemInform Abstract: Fattiviracin A1, a Novel Antiherpetic Agent Produced by Streptomyces microflavus Strain No. 2445. Part 1. Taxonomy, Fermentation, Isolation, Physico-Chemical Properties and Structure Elucidation
Cystatin C,a HumanProteinase Inhibitor, BlocksReplication ofHerpesSimplex Virus
center, were testedforpossible antiviral activity against herpes simplex virus type1(HSV)andpoliovirus type1.Bothrecombinant cystatin C andZ-LVG-CHN2displayed stronginhibitory effects on HSV replication, whereas no significant effect on... more
A biotechnological product and its potential as a new immunomodulator for treatment of animal phlebovirus infection: Punta Toro virus
Disease Induction by Virus Derived from Molecular Clones of Equine Infectious Anemia Virus
Equine infectious anemia virus (EIAV), a macrophage-tropic lentivirus, causes persistent infections of horses. A number of biologic features, including the rapid development of acute disease, the episodic nature of chronic disease, the... more
Synthesis of C-4′Truncated Phosphonated Carbocyclic 2′-Oxa-3′-azanucleosides as Antiviral Agents