Ingvar Bjelland
University of Bergen, Department of Clinical Medicine, Faculty Member
Background: An association between depression and folate status has been demonstrated in clinical studies, whereas data are sparse on the relationship between de- pression and other components of 1-carbon metabo- lism such as vitamin B12,... more
Background: An association between depression and folate status has been demonstrated in clinical studies, whereas data are sparse on the relationship between de- pression and other components of 1-carbon metabo- lism such as vitamin B12, homocysteine, and the methy- lenetetrahydrofolate reductase677C→T polymorphism. The relationship between anxiety and these compo- nents is less well known. This study examined the asso- ciations
Research Interests: Anxiety Disorders, Polymorphism, Folic acid, Norway, Humans, and 19 morePersonality Assessment Inventory, Male, Population based study, Depressive Disorder, Risk factors, Homocysteine, Aged, Middle Aged, Genotype, Odds ratio, Carbon Metabolism, Clinical Study, Risk Factors, Anxiety Disorder, Cross Sectional Studies, Archives General Psychiatry, Logistic Models, Confidence Interval, and Cohort Studies(Personality Assessment Inventory, Male, Population based study, Depressive Disorder, Risk factors, Homocysteine, Aged, Middle Aged, Genotype, Odds ratio, Carbon Metabolism, Clinical Study, Risk Factors, Anxiety Disorder, Cross Sectional Studies, Archives General Psychiatry, Logistic Models, Confidence Interval, and Cohort Studies)
(Personality Assessment Inventory, Male, Population based study, Depressive Disorder, Risk factors, Homocysteine, Aged, Middle Aged, Genotype, Odds ratio, Carbon Metabolism, Clinical Study, Risk Factors, Anxiety Disorder, Cross Sectional Studies, Archives General Psychiatry, Logistic Models, Confidence Interval, and Cohort Studies)
Background: Cohort Norway (CONOR) containing blood samples and standardised health and exposure variables of about 170,000 subjects, is based on data from health surveys in different parts of Norway. In all participants mental distress is... more
Background: Cohort Norway (CONOR) containing blood samples and standardised health and exposure variables of about 170,000 subjects, is based on data from health surveys in different parts of Norway. In all participants mental distress is measured by seven questions modified after various mental health measure- ment instruments. The purpose of the present study was to examine the agreement between these
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Research Interests: Sociology, Anthropology, Health Behavior, Higher Education, Mental Health, and 25 moreDepression, Anxiety, Social Science & Medicine, Norway, Humans, Longitudinal Analysis, Female, Male, Cohort Study, Risk factors, Aged, Middle Aged, Longitudinal Studies, Adult, Cross Section, Public health systems and services research, Age Factors, Educational Status, Risk Factors, ANXIETY, Long Term Effect, Cross Sectional Studies, Social Science, Age Groups, and Socioeconomic Factors(Depression, Anxiety, Social Science & Medicine, Norway, Humans, Longitudinal Analysis, Female, Male, Cohort Study, Risk factors, Aged, Middle Aged, Longitudinal Studies, Adult, Cross Section, Public health systems and services research, Age Factors, Educational Status, Risk Factors, ANXIETY, Long Term Effect, Cross Sectional Studies, Social Science, Age Groups, and Socioeconomic Factors)
(Depression, Anxiety, Social Science & Medicine, Norway, Humans, Longitudinal Analysis, Female, Male, Cohort Study, Risk factors, Aged, Middle Aged, Longitudinal Studies, Adult, Cross Section, Public health systems and services research, Age Factors, Educational Status, Risk Factors, ANXIETY, Long Term Effect, Cross Sectional Studies, Social Science, Age Groups, and Socioeconomic Factors)
The Hordaland Homocysteine Study (HHS) is a population-based study of more than 18,000 men and women in the county of Hordaland in Western Norway. The first investigation (HHS-I) took place in 1992-93, when the subjects were aged 40-67 y.... more
The Hordaland Homocysteine Study (HHS) is a population-based study of more than 18,000 men and women in the county of Hordaland in Western Norway. The first investigation (HHS-I) took place in 1992-93, when the subjects were aged 40-67 y. In 1997-99, a follow-up study (HHS-II) of 7,053 subjects was carried out. In this large population, plasma levels of total homocysteine (tHcy) are associated with several physiologic and lifestyle factors and common diseases. Increasing age, male sex, smoking, coffee consumption, high blood pressure, unfavorable lipid profile, high creatinine, and the MTHFR 677C > T polymorphism are among the factors associated with increased tHcy levels; physical activity, moderate alcohol consumption, and a good folate or vitamin B-12 status are associated with lower tHcy levels. Subjects with raised tHcy levels have increased risk of cardiovascular morbidity, cardiovascular and noncardiovascular mortality, and are more likely to suffer from depression and fro...
Research Interests: Nutrition and Dietetics, Nutrition, Mental Health, Depression, Polymorphism, and 30 moreAging, Physical Activity, Mortality, Animal Production, Norway, Pregnancy, Osteoporosis, Humans, High Blood Pressure, Female, Disease, Male, Population based study, Follow-up studies, Bone Density, The, Risk factors, Homocysteine, Alcohol Consumption, Aged, Middle Aged, Adult, Bone Mineral Density, Pregnancy Complication, Cardiovascular Diseases, Food Sciences, Risk Factors, Lipid Profile, Pregnancy Outcome, and Cognition disorders(Aging, Physical Activity, Mortality, Animal Production, Norway, Pregnancy, Osteoporosis, Humans, High Blood Pressure, Female, Disease, Male, Population based study, Follow-up studies, Bone Density, The, Risk factors, Homocysteine, Alcohol Consumption, Aged, Middle Aged, Adult, Bone Mineral Density, Pregnancy Complication, Cardiovascular Diseases, Food Sciences, Risk Factors, Lipid Profile, Pregnancy Outcome, and Cognition disorders)
(Aging, Physical Activity, Mortality, Animal Production, Norway, Pregnancy, Osteoporosis, Humans, High Blood Pressure, Female, Disease, Male, Population based study, Follow-up studies, Bone Density, The, Risk factors, Homocysteine, Alcohol Consumption, Aged, Middle Aged, Adult, Bone Mineral Density, Pregnancy Complication, Cardiovascular Diseases, Food Sciences, Risk Factors, Lipid Profile, Pregnancy Outcome, and Cognition disorders)
Research Interests: Primary Care, Anxiety Disorders, Psychometrics, Primary Health Care, Depression, and 12 moreHumans, Depressive Disorder, Hospital Anxiety and Depression Scale, Rating Scale, General Health Questionnaire, Questionnaires, Psychosomatic, Reproducibility of Results, Anxiety Disorder, Sensitivity and Specificity, Factor structure, and General Population
Objective: To review the literature of the validity of the Hospital Anxiety and Depression Scale (HADS). Method: A review of the 747 identified papers that used HADS was performed to address the following questions: (I) How are the factor... more
Objective: To review the literature of the validity of the Hospital Anxiety and Depression Scale (HADS). Method: A review of the 747 identified papers that used HADS was performed to address the following questions: (I) How are the factor structure, discriminant validity and the internal consistency of HADS? (II) How does HADS perform as a case finder for anxiety disorders
Research Interests: Primary Care, Anxiety Disorders, Psychometrics, Primary Health Care, Depression, and 12 moreHumans, Depressive Disorder, Hospital Anxiety and Depression Scale, Rating Scale, General Health Questionnaire, Questionnaires, Psychosomatic, Reproducibility of Results, Anxiety Disorder, Sensitivity and Specificity, Factor structure, and General Population
Research Interests: Nutrition and Dietetics, Aging, Mild Cognitive Impairment, Diet, Animal Production, and 16 moreNorway, Humans, Female, Male, Follow-up studies, Risk factors, Aged, Biological markers, Food Sciences, Geriatric Assessment, Risk Factors, Choline, Cross Sectional Studies, vitamin B deficiency, Cohort Studies, and Betaine
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The aim of this study was to examine the association between haemoglobin levels, anxiety disorder, and depression in cancer patients. Cancer patients attending The Norwegian Radium Hospital (NRH) rated themselves on the Hospital Anxiety... more
The aim of this study was to examine the association between haemoglobin levels, anxiety disorder, and depression in cancer patients. Cancer patients attending The Norwegian Radium Hospital (NRH) rated themselves on the Hospital Anxiety and Depression Scale (HADS). Five hundred thirty-two patients also had valid measurements of haemoglobin at the same time. The associations between tertile haemoglobin levels (7.0-12.3 g/dl, 12.4-13.8 g/dl, 13.9-17.1 g/dl) and HADS-defined anxiety disorder and depression were analysed by logistic regression. HADS-defined depression was identified in 116 cases (22%) and anxiety disorder in 149 (28%). The haemoglobin levels of the lower and middle tertiles were associated with depression (OR=3.85, 95% CI: 2.06-7.21, and OR=2.45, 95% CI: 1.25-4.81, respectively). Adjustment for covariates did not change the association significantly. No association between haemoglobin and anxiety disorder was found. In cancer patients, the risk of depression increases with decreasing haemoglobin levels. This should be taken into account when treatment of anaemic or depressed cancer patients is decided upon.
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Research Interests: Human Geography, Health Promotion, Epidemiology, Anxiety Disorders, Depression, and 21 moreStatistical Analysis, Health Education, Public Health, Medicine, Norway, Humans, Hemodynamics, Blood Pressure, Female, Male, Depressive Disorder, Risk factors, Association, Aged, Middle Aged, Adult, Public health systems and services research, Hypotension, Risk Factors, Cross Sectional Studies, and Logistic Models(Statistical Analysis, Health Education, Public Health, Medicine, Norway, Humans, Hemodynamics, Blood Pressure, Female, Male, Depressive Disorder, Risk factors, Association, Aged, Middle Aged, Adult, Public health systems and services research, Hypotension, Risk Factors, Cross Sectional Studies, and Logistic Models)
(Statistical Analysis, Health Education, Public Health, Medicine, Norway, Humans, Hemodynamics, Blood Pressure, Female, Male, Depressive Disorder, Risk factors, Association, Aged, Middle Aged, Adult, Public health systems and services research, Hypotension, Risk Factors, Cross Sectional Studies, and Logistic Models)
This study aimed to examine whether subjects taking selective serotonin reuptake inhibitors (SSRIs) are more likely to have elements of the metabolic syndrome compared with those taking no psychotropic drugs. For comparison, we also... more
This study aimed to examine whether subjects taking selective serotonin reuptake inhibitors (SSRIs) are more likely to have elements of the metabolic syndrome compared with those taking no psychotropic drugs. For comparison, we also studied subjects taking antipsychotic drugs. We used data from The Hordaland Health Study '97-'99, a general community cross-sectional health survey including 25,315 subjects aged 40 to 49 and 70 to 74 years. For the groups studied, we estimated prevalence and odds ratios (ORs) for obesity, hypercholesterolemia, low high-density lipoprotein cholesterol, hyper-triglyceridemia, and diabetes. We observed an association between use of SSRIs as a group (N = 461) and abdominal obesity (OR = 1.40, 95% CI = 1.08 to 1.81) and hypercholesterolemia (OR = 1.36, 95% CI = 1.07 to 1.73) after adjusting for multiple possible confounders. There was also a trend toward an association between SSRI use and diabetes. In a subgroup analysis of subjects taking SSRIs, the use of paroxetine (N = 187) was markedly associated with both general and abdominal obesity but not with hypercholesterolemia. In contrast, the use of citalopram (N = 142) was not associated with any of the metabolic outcome variables, while the use of any other SSRI (sertraline, fluoxetine, or fluvoxamine) (N = 131) as a mixed subgroup was associated with both abdominal obesity and hypercholesterolemia. We also replicated the previously reported associations between use of antipsychotics and obesity and metabolic disturbances. We have shown that use of at least some SSRIs is associated with clinical and biochemical elements of the metabolic syndrome. Our data indicate differences in the metabolic side effect profile among various SSRI drugs, although treatment bias might have influenced these results. We suggest that patients taking SSRIs be carefully monitored for obesity and dyslipidemia.
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Research Interests: Anxiety Disorders, Polymorphism, Folic acid, Norway, Humans, and 19 morePersonality Assessment Inventory, Male, Population based study, Depressive Disorder, Risk factors, Homocysteine, Aged, Middle Aged, Genotype, Odds ratio, Carbon Metabolism, Clinical Study, Risk Factors, Anxiety Disorder, Cross Sectional Studies, Archives General Psychiatry, Logistic Models, Confidence Interval, and Cohort Studies(Personality Assessment Inventory, Male, Population based study, Depressive Disorder, Risk factors, Homocysteine, Aged, Middle Aged, Genotype, Odds ratio, Carbon Metabolism, Clinical Study, Risk Factors, Anxiety Disorder, Cross Sectional Studies, Archives General Psychiatry, Logistic Models, Confidence Interval, and Cohort Studies)
(Personality Assessment Inventory, Male, Population based study, Depressive Disorder, Risk factors, Homocysteine, Aged, Middle Aged, Genotype, Odds ratio, Carbon Metabolism, Clinical Study, Risk Factors, Anxiety Disorder, Cross Sectional Studies, Archives General Psychiatry, Logistic Models, Confidence Interval, and Cohort Studies)
Research Interests: Engineering, Nutrition, Depression, Health, Public Health, and 12 moreAnxiety, Emotions, Norway, Humans, Female, Male, Aged, Middle Aged, ANXIETY, Choline, Cross Sectional Studies, and Logistic Models(Anxiety, Emotions, Norway, Humans, Female, Male, Aged, Middle Aged, ANXIETY, Choline, Cross Sectional Studies, and Logistic Models)
(Anxiety, Emotions, Norway, Humans, Female, Male, Aged, Middle Aged, ANXIETY, Choline, Cross Sectional Studies, and Logistic Models)