Kvinapril
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(IUPAC) ime
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(3S)-2-[(2S)-2- {[(2S)-1-etoksi-1-okso-4-fenilbutan-2-il]amino}propanoil]-1,2,3,4-tetrahidroizohinolin-3-karboksilna kiselina
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Klinički podaci
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Robne marke
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Accupril
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AHFS/Drugs.com
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Monografija
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MedlinePlus
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a692026
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Identifikatori
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CAS broj
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85441-61-8
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ATC kod
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C09AA06
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PubChem[1][2]
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54892
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DrugBank
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DB00881
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ChemSpider[3]
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49565
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UNII
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RJ84Y44811 Y
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KEGG[4]
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D03752 Y
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ChEBI
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CHEBI:8713 Y
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ChEMBL[5]
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CHEMBL1592 Y
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Hemijski podaci
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Formula
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C25H30N2O5
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Mol. masa
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438,516 g/mol
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SMILES
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eMolekuli & PubHem
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InChI |
InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1 Y Key: JSDRRTOADPPCHY-HSQYWUDLSA-N Y |
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Farmakokinetički podaci
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Vezivanje za proteine plazme
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97%
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Poluvreme eliminacije
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2 sata
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Farmakoinformacioni podaci
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Trudnoća
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?
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Pravni status
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℞ Prescription only
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Način primene
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Oralno
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Kvinapril (Accupril) je inhibitor angiotenzin konvertujućeg enzima (ACE inhibitor) koji se koristi u tretmanu hipertenzije i zatajenja srca.
Kvinapril je prolek. On se konvertuje u aktivni metabolit, kvinaprilat, u jetri.[6]
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846. edit
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred (2006). Goodman & Gilman's The Pharmacological Basis of Therapeutics (11 izd.). New York: McGraw-Hill. ISBN 0-07-142280-3.