Evidence is growing for the long-term effects of environmental factors during early-life on
later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene …

The world's poorest children are likely to be malnourished when receiving their childhood
vaccines. It is uncertain whether this affects vaccine efficacy and whether the …

Although there is extensive evidence that caloric restriction (CR) extends lifespan in several
species the evidence base for humans is weak. We are still at the stage of applying inductive …

In addition to the genetic constitution inherited by an organism, the developmental trajectory
and resulting mature phenotype are also determined by mechanisms acting during critical …

Considerable evidence now exists to suggest that early exposure to nutritional deprivation
can have long term consequences to health, with low birth weight now considered a risk …

It is frequently claimed that weight cycling, or “yo-yo” dieting, causes an inappropriate and
permanent loss of lean body mass (LBM). Data are presented from a rural African population …

Cortical mapping of cognitive function during infancy is poorly understood in low-income
countries due to the lack of transportable neuroimaging methods. We have successfully …

Iron deficiency and malaria have similar global distributions, and frequently co-exist in
pregnant women and young children. Where both conditions are prevalent, iron …

Background The nature of the association between ghrelin, an orexigenic hormone
produced mainly in the stomach, and Helicobacter pylori (H pylori), a bacterium that …

The fat requirements of children can be judged according to 4 criteria: 1) the possible
obligate needs of fat as a metabolic fuel, 2) the provision of a sufficiently energy-dense diet …