Early-set POMC methylation variability is accompanied by increased risk for obesity and is addressable by MC4R agonist treatment
L Lechner, R Opitz, MJ Silver, PM Krabusch… - Science Translational …, 2023 - science.org
Increasing evidence points toward epigenetic variants as a risk factor for developing obesity.
We analyzed DNA methylation of the POMC (pro-opiomelanocortin) gene, which is pivotal …
We analyzed DNA methylation of the POMC (pro-opiomelanocortin) gene, which is pivotal …
[HTML][HTML] Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic disease
T Candler, P Kühnen, AM Prentice, M Silver - Frontiers in …, 2019 - Elsevier
Proopiomelanocortin (POMC) is a key mediator of satiety. Epigenetic marks such as DNA
methylation may modulate POMC expression and provide a biological link between early life …
methylation may modulate POMC expression and provide a biological link between early life …
An Alu Element–Associated Hypermethylation Variant of the POMC Gene Is Associated with Childhood Obesity
P Kuehnen, M Mischke, S Wiegand, C Sers… - PLoS …, 2012 - journals.plos.org
The individual risk for common diseases not only depends on genetic but also on epigenetic
polymorphisms. To assess the role of epigenetic variations in the individual risk for obesity …
polymorphisms. To assess the role of epigenetic variations in the individual risk for obesity …
DNA CpG Methylation (5-Methylcytosine) and Its Derivative (5-Hydroxymethylcytosine) Alter Histone Posttranslational Modifications at the Pomc Promoter, Affecting …
A maternal high-fat diet (HFD) alters the offspring's feeding regulation, leading to obesity.
This phenomenon is partially mediated by aberrant expression of the hypothalamic …
This phenomenon is partially mediated by aberrant expression of the hypothalamic …
Maternal and post-weaning high-fat, high-sucrose diet modulates glucose homeostasis and hypothalamic POMC promoter methylation in mouse offspring
J Zheng, X Xiao, Q Zhang, M Yu, J Xu, Z Wang… - Metabolic brain …, 2015 - Springer
Substantial evidence demonstrated that maternal dietary nutrients can significantly
determine the susceptibility to developing metabolic disorders in the offspring. Therefore, we …
determine the susceptibility to developing metabolic disorders in the offspring. Therefore, we …
Interindividual variation in DNA methylation at a putative POMC metastable epiallele is associated with obesity
P Kühnen, D Handke, RA Waterland, BJ Hennig… - Cell metabolism, 2016 - cell.com
The estimated heritability of human BMI is close to 75%, but identified genetic variants
explain only a small fraction of interindividual body-weight variation. Inherited epigenetic …
explain only a small fraction of interindividual body-weight variation. Inherited epigenetic …
Leptin resistance and obesity in mice with deletion of methyl-CpG-binding protein 2 (MeCP2) in hypothalamic pro-opiomelanocortin (POMC) neurons
X Wang, Z Lacza, YE Sun, W Han - Diabetologia, 2014 - Springer
Aims/hypothesis Pro-opiomelanocortin (POMC) neurons in the arcuate nucleus (ARC)
regulate energy homeostasis by secreting α-melanocyte-stimulating hormone (α-MSH) …
regulate energy homeostasis by secreting α-melanocyte-stimulating hormone (α-MSH) …
Heterozygous pathogenic variants in POMC are not responsible for monogenic obesity: Implication for MC4R agonist use
L Le Collen, B Delemer, C Poitou, M Vaxillaire… - Genetics in …, 2023 - Elsevier
Purpose Recessive deficiency of proopiomelanocortin (POMC) causes childhood-onset
severe obesity. Cases can now benefit from the melanocortin 4 receptor agonist …
severe obesity. Cases can now benefit from the melanocortin 4 receptor agonist …
Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood
Childhood obesity is a major public health issue. Here we investigated whether differential
DNA methylation was associated with childhood obesity. We studied DNA methylation …
DNA methylation was associated with childhood obesity. We studied DNA methylation …
Hypermethylation of Sp1 Binding Site Suppresses Hypothalamic POMC in Neonates and May Contribute to Metabolic Disorders in Adults: Impact of Maternal Dietary …
Epigenetic regulation of neuropeptide genes associated with central appetite control plays
an important part in the development of nutritional programming. While proopiomelanocortin …
an important part in the development of nutritional programming. While proopiomelanocortin …