Yonathan Freund, Marta Cancella de Abreu, Soufiane Lebal, Alexandra Rousseau, Thomas Lafon, Youri Yordanov, Richard Macrez, Fabien Coisy, Pierrick Le Borgne, Florent Femy, Delphine Douillet, Neus Robert Boter, Xavier Eyer, Jean-Baptiste Bouillon-Minois, Carl Ogereau, Donia Bouzid, Hélène Goulet, Mélanie Roussel, Geoffroy Rousseau, Jeremy Guénézan, Celine Occelli, Tahar Chouihed, Gina Osorio Quispe, Marine Clea Renard, Judith Gorlicki, Ben Bloom, Tabassome Simon, Camille Gerlier
PURPOSE: The efficacy of the 1-h bundle for emergency department (ED) patients with suspected sepsis, which includes lactate measurement, blood culture, broad-spectrum antibiotics administration, administration of 30 mL/kg crystalloid fluid for hypotension or lactate ≥ 4 mmol/L, remains controversial. METHODS: We carried out a pragmatic stepped-wedge cluster-randomized trial in 23 EDs in France and Spain. Adult patients with Sepsis-3 criteria or a quick sequential organ failure assessment (SOFA) score ≥ 2 or a lactate > 2 mmol/L were eligible...
June 24, 2024: Intensive Care Medicine