WO2004112765A1 - Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol - Google Patents
Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol Download PDFInfo
- Publication number
- WO2004112765A1 WO2004112765A1 PCT/SE2004/001001 SE2004001001W WO2004112765A1 WO 2004112765 A1 WO2004112765 A1 WO 2004112765A1 SE 2004001001 W SE2004001001 W SE 2004001001W WO 2004112765 A1 WO2004112765 A1 WO 2004112765A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- diol
- composition
- carrier
- pentane
- weight
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T442/00—Fabric [woven, knitted, or nonwoven textile or cloth, etc.]
- Y10T442/20—Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
- Y10T442/2525—Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]
Definitions
- the present invention relates to a method for inhibiting the growth of multiple-resistant bacteria and a method for the manufacture of a corresponding composition, to such a composition and to uses of the composition.
- multiple-resistant is understood the resistance against at least one antibiotic known to be effective against a corresponding non-resistant strain.
- an antibiotic is an agent which can be administered topically to a person in form of a
- antibiotic thus excludes mere disinfectants which exhibit a non-specific antimicrobial action which are harmful also to the skin and for which the
- 25 skin can be exposed for a short time at best or not at all, such as chlorhexidine and aqueous hypochlorite, respectively.
- nosoco ial resistance problems are caused 35 by methicillin-resistant Staphylococcus aureus, vancomycin- resistant enterococci, and enterobacteriaceae with plasmid- encoded extended-spectrum ⁇ -lactamases.
- the present invention is based on the insight that pentane- 1, 5-diol is effective against multiple-resistant bacteria.
- compositions comprising 15% by weight of more of pentane-1, 5-diol and a suitable carrier that lacks bacteriostatic effect or the bacteriostatic effect of which is less than 5% on a weight basis of the bacteriostatic effect of pentane-1, 5-diol in respect of a particular microorganism provide efficient bacteriostasis against multiple-resistant bacteria. This is entirely unexpected even in view of the known moderate antibacterial effect of pentane- 1, 5-diol and similar diols.
- the bacteriostatic composition of the invention may be used as a pharmaceutical for topical administration but also as a disinfectant which, in contrast to other efficient disinfectants, poses no health risk to persons using it.
- An additional advantage of the composition of the invention is that it does not give rise to resistant strains of bacteria.
- composition of the invention may take the form of a liquid, semi-liquid or solid disinfectant preparation, a bacteriostatic solution, lotion, cream, soap, shampoo, ointment, paste, wet towel, hygiene dish, patch, diaper or similar personal hygiene protection device.
- composition of the invention is combined with antibiotic, antiviral agent, antiseptic, agent for treatment of acne and with other agents used in the treatment of infectious diseases of the skin and the mucous membranes .
- composition of the invention comprises an anionic emulsifier, such as Cetylanum.
- the composition of the invention preferably comprises one or several of tonicity adjustment agent such as sodium chloride, moisturizing agent such as carbamide and lactic acid, UV- absorbing agent, colorant such as calcium carbonate and zinc oxide, and fragrant such as an aetheric oil.
- tonicity adjustment agent such as sodium chloride
- moisturizing agent such as carbamide and lactic acid
- UV- absorbing agent such as carbamide and lactic acid
- colorant such as calcium carbonate and zinc oxide
- fragrant such as an aetheric oil.
- the composition of the invention may also comprise a cationic, neutral, or anionic detergent, in particular a salt of a fatty acid.
- a method for inhibiting the growth of multiple- resistant bacteria by topical administration of a pharmaceutical composition comprising more 15% by weight or more of pentane-1, 5-diol and a pharmaceutical acceptable carrier such as an aqueous carrier, in particular water or saline.
- the pharmaceutical composition preferably consists of pentane-1, 5-diol and a pharmaceutical acceptable carrier.
- Topical administration by a patch of a woven or non-woven material or a combination of these materials provided with the composition is particularly preferrec.
- a method of manufacture of a medicament for topical administration for inhibiting the growth of multiple-resistant bacteria comprising the incorporation of 15% by weight or more of 1, 5-pentanediol in a pharmaceutically acceptable carrier.
- the pharmaceutically acceptable carrier preferably has no bacteriostatic effect of its own or a bacteriostatic effect which is less than 5% on a weight basis of the bacteriostatic effect of pentane-1, 5-diol in respect of a particular microorganism. It is also preferred for the carrier to comprise a patch of a woven or non-woven material or a combination of these materials.
- the carrier is preferably an aqueous carrier.
- a method for inhibiting the growth of multiple- resistant bacteria by application of a bacteriostatic composition comprising 15% by weight or more of pentane-1, 5- diol and a suitable carrier to a non-porous surface (metal, wood, laquer, plastic.) contaminated with said bacteria.
- this bacteriostatic composition essentially consists of pentane-1, 5-diol and a carrier which is essentially free from other bacteriostatic agents.
- the carrier is preferred for the carrier to be an aqueous carrier which advantageously may comprise a thickening agent.
- Preferred thickening agents are agents selected from cellulose derivatives, in particular methyl cellulose, hydroxymethyl cellulose, hydroxymethyl-propyl cellulose.
- the carrier comprises a salt of a fatty acid.
- the bacteriostatic composition is comprised by a patch of a woven or non-woven material or a combination thereof.
- a composition comprising 15% or more by weight of pentane-1, 5- diol and a suitable carrier for inhibiting the growth of multiple-resistant bacteria.
- the carrier is an aqueous carrier, optionally comprising a thickening agent selected from cellulose derivatives, in particular methyl cellulose, hydroxymethyl cellulose, hydroxymethyl-propyl cellulose.
- the carrier may advantageously include a patch of a woven or non-woven material or a combination thereof.
- a method of disinfecting a surface contaminated with multiple resistant bacteria comprising:
- a disinfecting composition comprising 15% or more by weight of pentane-1, 5-diol and a suitable carrier; applying said composition to said surface; - optionally, keeping said composition in contact with said surface for a period of time from 5 min to 24 hrs at ambient temperature, rinsing said surface with water or an aqueous detergent composition.
- MIC minimum inhibitory concentration
- Agar samples with pentane-1, 5-diol concentrations increasing in steps of 2.5 % by weight were prepared by mixing the components at a temperature above the solidifying temperature of the agar prior to solidification.
- the following bacteria were investigated: methicillin-resistant Staphylococcus aureus (MSRA) , fucidic acid-resistant S. aureus, non-resistant S.
- Table. 1 Inhibitory effect of pentane-1 , 5-diol on various bacteria, including multiple-resistant (MR) bacteria; two ⁇ inoculate sizes.
- Bacterial strain MIC (% by weight of pentane-1, 5-diol) MR against
- Inoculate Size 10 Inoculate Size 10" fuc met van dp tri
- Bacterial Strain MIC (% by weight of pentane-1, 5- MR resistant against diol) Inoculate Size 10 fuc met van cip tri .
- Acute toxicity of pentane-1, 5-diol was tested for peroral and topical administration as well as on inhalation.
- Topical administration The penetration of rabbit skin was tested with a cuff model.
- the hair on the back of four male rabbits weighing from 2.5 to 3.5 kg was removed by shaving, the diol applied to the skin with a pipette, and the skin sealed with polyethylene film for 24 hrs.
- the animals were immobilised. After the exposure the animals were observed over a fortnight period. Even at the highest tested dose, 20 ml/kg, the animals survived.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Pest Control & Pesticides (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Detergent Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
Claims
Priority Applications (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200460015597 DE602004015597D1 (en) | 2003-06-26 | 2004-06-23 | PROCESS FOR INHIBITING THE GROWTH OF ANTIBIOTICARESISTENT BACTERIA BY USING PENTANE-1,5-DIOL |
EP04749039A EP1635802B1 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic-resistant bacteria by using pentane-1,5-diol |
PL04749039T PL1635802T3 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic-resistant bacteria by using pentane-1,5-diol |
AU2004249102A AU2004249102A1 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol |
DK04749039T DK1635802T3 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic resistant bacteria using petan-1,5-diol |
BRPI0411749 BRPI0411749A (en) | 2003-06-26 | 2004-06-23 | method for inhibiting the growth of antibiotic resistant bacteria by the use of pentane-1,5-diol |
CA 2529287 CA2529287A1 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol |
CN2004800177928A CN1812775B (en) | 2003-06-26 | 2004-06-23 | Use of pentane-1,5-diol in preparing medicine for inhibiting the growth of antibiotic-resistant of bacteria |
US10/562,608 US7973080B2 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic resistant of bacteria by using pentane-1,5-diol |
JP2006517050A JP4824553B2 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting growth of antibiotic-resistant bacteria by using pentane-1,5-diol |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0301862-9 | 2003-06-26 | ||
SE0301862A SE0301862D0 (en) | 2003-06-26 | 2003-06-26 | Methods to inhibit the growth of antibiotic resistant bacteria |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2004112765A1 true WO2004112765A1 (en) | 2004-12-29 |
Family
ID=27656597
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE2004/001001 WO2004112765A1 (en) | 2003-06-26 | 2004-06-23 | Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol |
Country Status (16)
Country | Link |
---|---|
US (1) | US7973080B2 (en) |
EP (1) | EP1635802B1 (en) |
JP (1) | JP4824553B2 (en) |
KR (1) | KR20060103817A (en) |
CN (1) | CN1812775B (en) |
AT (1) | ATE403421T1 (en) |
AU (1) | AU2004249102A1 (en) |
BR (1) | BRPI0411749A (en) |
CA (1) | CA2529287A1 (en) |
DE (1) | DE602004015597D1 (en) |
DK (1) | DK1635802T3 (en) |
ES (1) | ES2313038T3 (en) |
PL (1) | PL1635802T3 (en) |
RU (1) | RU2355392C9 (en) |
SE (1) | SE0301862D0 (en) |
WO (1) | WO2004112765A1 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007063065A1 (en) * | 2005-11-29 | 2007-06-07 | Ambria Dermatology Ab | Use of a composition comprising pentane-1, 5-diol as deodorant |
WO2010005378A1 (en) | 2008-07-07 | 2010-01-14 | Ambria Dermatology Ab | Antimicrobial composition |
WO2010072738A1 (en) | 2008-12-22 | 2010-07-01 | Pierre Fabre Dermo-Cosmetique | Polyunsaturated fatty acid and diol ester as an anti-acne agent |
US9757596B2 (en) | 2004-11-29 | 2017-09-12 | Ambria Dermatology Ab | Composition comprising at least 3 different diols |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103816165B (en) * | 2014-03-11 | 2019-03-01 | 北京德默高科医药技术有限公司 | A kind of composition for treating acne |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015597A1 (en) * | 1989-06-13 | 1990-12-27 | Gunnar Swanbeck | Preparation for topical treatment of infections caused by virus, bacteria and fungi |
WO1993020812A1 (en) * | 1992-04-14 | 1993-10-28 | Bioglan Ab | Potentiation of antimicrobial effects |
US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
WO2001007003A1 (en) * | 1999-07-22 | 2001-02-01 | Unilever Plc | Silicone elastomer emulsions stabilized with pentylene glycol |
EP1166762B1 (en) * | 2000-06-29 | 2002-10-16 | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | Compositions containing mineral water |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG50568A1 (en) * | 1989-01-31 | 1998-07-20 | Novartis Ag | High salt content rapid disinfection solution for contact lenses |
US5369129A (en) * | 1989-06-13 | 1994-11-29 | Hydro Pharma Ab | Preparation of topical treatment of infections caused by virus, bacteria and fungi |
US5370876A (en) * | 1993-01-08 | 1994-12-06 | Microbarriers | Antimicrobial protective skin composition and method for protecting skin from body fluids |
GB9626513D0 (en) * | 1996-12-20 | 1997-02-05 | Bioglan Ireland R & D Ltd | A pharmaceutical composition |
US20020192273A1 (en) * | 2001-06-15 | 2002-12-19 | Teri Buseman | Therapeutic patch useful for the treatment of hemorrhoids |
-
2003
- 2003-06-26 SE SE0301862A patent/SE0301862D0/en unknown
-
2004
- 2004-06-23 AT AT04749039T patent/ATE403421T1/en not_active IP Right Cessation
- 2004-06-23 US US10/562,608 patent/US7973080B2/en not_active Expired - Fee Related
- 2004-06-23 ES ES04749039T patent/ES2313038T3/en not_active Expired - Lifetime
- 2004-06-23 DE DE200460015597 patent/DE602004015597D1/en not_active Expired - Lifetime
- 2004-06-23 CN CN2004800177928A patent/CN1812775B/en not_active Expired - Fee Related
- 2004-06-23 BR BRPI0411749 patent/BRPI0411749A/en not_active IP Right Cessation
- 2004-06-23 DK DK04749039T patent/DK1635802T3/en active
- 2004-06-23 EP EP04749039A patent/EP1635802B1/en not_active Expired - Lifetime
- 2004-06-23 PL PL04749039T patent/PL1635802T3/en unknown
- 2004-06-23 RU RU2005140049A patent/RU2355392C9/en active
- 2004-06-23 KR KR1020057024973A patent/KR20060103817A/en not_active Application Discontinuation
- 2004-06-23 JP JP2006517050A patent/JP4824553B2/en not_active Expired - Fee Related
- 2004-06-23 AU AU2004249102A patent/AU2004249102A1/en not_active Abandoned
- 2004-06-23 CA CA 2529287 patent/CA2529287A1/en not_active Abandoned
- 2004-06-23 WO PCT/SE2004/001001 patent/WO2004112765A1/en active Search and Examination
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990015597A1 (en) * | 1989-06-13 | 1990-12-27 | Gunnar Swanbeck | Preparation for topical treatment of infections caused by virus, bacteria and fungi |
WO1993020812A1 (en) * | 1992-04-14 | 1993-10-28 | Bioglan Ab | Potentiation of antimicrobial effects |
US5550145A (en) * | 1992-04-14 | 1996-08-27 | Bioglan Ab | Potentiation of antimicrobial effects |
US5879690A (en) * | 1995-09-07 | 1999-03-09 | Perricone; Nicholas V. | Topical administration of catecholamines and related compounds to subcutaneous muscle tissue using percutaneous penetration enhancers |
WO2001007003A1 (en) * | 1999-07-22 | 2001-02-01 | Unilever Plc | Silicone elastomer emulsions stabilized with pentylene glycol |
EP1166762B1 (en) * | 2000-06-29 | 2002-10-16 | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. | Compositions containing mineral water |
Non-Patent Citations (1)
Title |
---|
HOSSEIN SEDGHI ZADEB ET AL.: "Inibitori della crescita microbica", COSMETIC TECHNOLOGY, vol. 4, no. 3, 2001, pages 43 - 48, XP002982292 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9757596B2 (en) | 2004-11-29 | 2017-09-12 | Ambria Dermatology Ab | Composition comprising at least 3 different diols |
WO2007063065A1 (en) * | 2005-11-29 | 2007-06-07 | Ambria Dermatology Ab | Use of a composition comprising pentane-1, 5-diol as deodorant |
JP2014210173A (en) * | 2005-11-29 | 2014-11-13 | アンブリア ダーマトロジーアーベーAmbria Dermatology Ab | Use of composition including pentane-1,5-diol as deodorant |
JP2016073634A (en) * | 2005-11-29 | 2016-05-12 | アンブリア ダーマトロジー アーベーAmbria Dermatology Ab | Use of a composition comprising pentane-1, 5-diol as deodorant |
WO2010005378A1 (en) | 2008-07-07 | 2010-01-14 | Ambria Dermatology Ab | Antimicrobial composition |
US20150105472A1 (en) * | 2008-07-07 | 2015-04-16 | Ambria Dermatology Ab | Antimicrobial composition |
WO2010072738A1 (en) | 2008-12-22 | 2010-07-01 | Pierre Fabre Dermo-Cosmetique | Polyunsaturated fatty acid and diol ester as an anti-acne agent |
Also Published As
Publication number | Publication date |
---|---|
RU2005140049A (en) | 2006-07-27 |
BRPI0411749A (en) | 2006-08-08 |
ATE403421T1 (en) | 2008-08-15 |
PL1635802T3 (en) | 2009-01-30 |
US20070020322A1 (en) | 2007-01-25 |
DE602004015597D1 (en) | 2008-09-18 |
DK1635802T3 (en) | 2008-12-08 |
KR20060103817A (en) | 2006-10-04 |
US7973080B2 (en) | 2011-07-05 |
AU2004249102A1 (en) | 2004-12-29 |
CN1812775B (en) | 2011-07-27 |
RU2355392C2 (en) | 2009-05-20 |
JP4824553B2 (en) | 2011-11-30 |
JP2007521265A (en) | 2007-08-02 |
RU2355392C9 (en) | 2009-07-27 |
CA2529287A1 (en) | 2004-12-29 |
CN1812775A (en) | 2006-08-02 |
EP1635802A1 (en) | 2006-03-22 |
EP1635802B1 (en) | 2008-08-06 |
SE0301862D0 (en) | 2003-06-26 |
ES2313038T3 (en) | 2009-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6956143B2 (en) | Antimicrobial composition and how to use it | |
Hübner et al. | Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds | |
JP3981151B2 (en) | Composition for inactivating stimulants in a liquid | |
CN101489379B (en) | Antimicrobial compositions | |
TWI378796B (en) | Composition and method for pre-surgical skin disinfection | |
KR101555341B1 (en) | Antibiotic wet tissue, and manufacturing method thereof | |
US8193244B1 (en) | Antimicrobial agents | |
JP2010529262A (en) | Long lasting disinfectant cleaner | |
US20190275077A1 (en) | Hypochlorous acid-based hand sanitizer | |
SE1650162A1 (en) | Antimicrobial and cleansing composition comprising a polymeric biguanide, EDTA, and surfactants. | |
JP5535209B2 (en) | Antibacterial composition | |
US7973080B2 (en) | Method for inhibiting the growth of antibiotic resistant of bacteria by using pentane-1,5-diol | |
JPH072615A (en) | Cloth impregnated with antimicrobial disinfectant | |
US10016375B2 (en) | Materials and methods for controlling infections | |
MXPA05013144A (en) | Method for inhibiting the growth of antibiotic-resistant of bacteria by using pentane-1,5-diol | |
RU2714885C1 (en) | Disinfectant composition for hands | |
CN118252760A (en) | Sterilizing wet tissue and preparation method thereof | |
WO2021105956A1 (en) | Disinfectant composition | |
JPH06256104A (en) | Antibacterial action-sustaining disinfectant | |
GB2293765A (en) | Disinfectant composition | |
MXPA06005233A (en) | Disinfecting composition and methods of making and using same | |
BR102014000709A2 (en) | antimicrobial and non-stick composition for cleaning, sanitizing, sanitizing, disinfecting and antiseptic processes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AK | Designated states |
Kind code of ref document: A1 Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A1 Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2004249102 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1353/MUMNP/2005 Country of ref document: IN |
|
WWE | Wipo information: entry into national phase |
Ref document number: PA/a/2005/013144 Country of ref document: MX |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006517050 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2529287 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004749039 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2004249102 Country of ref document: AU Date of ref document: 20040623 Kind code of ref document: A |
|
WWP | Wipo information: published in national office |
Ref document number: 2004249102 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020057024973 Country of ref document: KR Ref document number: 20048177928 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2005140049 Country of ref document: RU |
|
WWP | Wipo information: published in national office |
Ref document number: 2004749039 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007020322 Country of ref document: US Ref document number: 10562608 Country of ref document: US |
|
DPEN | Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed from 20040101) | ||
ENP | Entry into the national phase |
Ref document number: PI0411749 Country of ref document: BR |
|
WWP | Wipo information: published in national office |
Ref document number: 10562608 Country of ref document: US |