JP5233399B2 - Oral spray composition and oral preparation - Google Patents

Description

  The present invention is capable of continuously improving the dry feeling in the mouth due to dry mouth and the like over a long period of time immediately after use, and without giving irritation or stickiness to oral tissues such as oral mucosa. It is related with the composition for oral sprays which was excellent in the storage stability in and excellent in the sprayability by the spray at the time of use, and an oral formulation.

  Dryness in the oral cavity is experienced in daily life and is accompanied by discomfort and bad breath, and may cause caries and periodontal disease. Such dryness in the oral cavity is often caused by a decrease in salivary secretion due to a decrease in oral function.

As a technique for promoting saliva secretion, it is known that saliva secretion is promoted by stimulation of acids such as plum pickles, ume vinegar, and organic acids (Patent Document 1; JP 56-22719 A, Patent Document 2; (See JP-A-7-101856). However, stimulation with acid are merely temporary, not lead to drastic improvements, further case of application of the acid frequently, is feared the influence of the stimulus, such as the oral tissues for dissolution and oral mucosa of the tooth.

  In addition, a method of maintaining a non-dry feeling in the oral cavity and suppressing the dry feeling with a moisturizing component such as hyaluronic acid has been proposed (see Patent Document 3; International Publication No. 00/56344 pamphlet). It did not promote saliva secretion, and it was difficult to say that the sustainability and usability of the effect were sufficient.

  On the other hand, Patent Document 4 (International Publication No. 05/049050 pamphlet) proposes the use of polyglutamic acid (PGA) or a salt thereof as a means for promoting saliva secretion without irritation to oral tissues, Mouthwash solution containing sodium or potassium polyglutamate and mouth refresher, ammonium polyglutamate, citric acid, gargle tablets, polyglutamic acid ethanolamine salt, oral care system solution with water suction function Etc. are disclosed.

  Patent Document 5 (Japanese Patent Laid-Open No. 2005-015347) discloses that poly-γ-glutamic acid or a derivative thereof is effective as an active ingredient of a filaggrin synthesis promoter related to the moisturizing environment of the stratum corneum existing in the outermost layer of the skin. The composition for external use which uses poly-gamma-glutamic acid or its derivative as an active ingredient is prepared for cosmetics of various dosage forms, and the composition of the mouth freshener etc. is specifically disclosed.

  However, the applicant further examined the preparation containing such polyglutamic acid or a salt thereof, and in application to the oral cavity, it cannot be said that the sustainability of the effect over a long period of time immediately after use is sufficient. There was room for improvement in terms of giving a moist feeling.

  Therefore, it is difficult to continuously and effectively improve the dry feeling in the mouth due to dry mouth and the like with such conventional techniques, the above problems are solved, and the dry feeling in the mouth is continued for a long time immediately after use. It is desired to develop an oral composition that can be suppressed over time, has no irritation or stickiness to oral tissues, has a good feeling of use, good storage stability, and is excellent in portability and convenience.

JP-A-56-22719 Japanese Patent Laid-Open No. 7-101856 International Publication No. 00/56344 Pamphlet International Publication No. 05/049050 Pamphlet JP 2005-015347 A

  The present invention has been made in view of the above circumstances, and its purpose is to improve the dry feeling in the mouth due to xerostomia or the like over a long period of time immediately after application, and to the oral mucosa during use. By providing a composition for oral spray that does not give irritation or stickiness to the oral tissues, has excellent storage stability over time, and has excellent sprayability when sprayed in use, and an oral preparation using the composition. is there.

As a result of intensive studies to achieve the above object, the present inventors have found that (A) sodium or potassium salt of polyglutamic acid is 0.05 to 5% (mass%, the same shall apply hereinafter), (B) acid, malic acid, 2-6% of at least one organic acid or its alkali metal salt selected tartaric acid and either et succinic acid in total, and 10-50% blending (C) glycerin, for component (B) ( C) By making the blending ratio of component ((C) / (B)) 3 or more and less than 20, it is accommodated in a spray container and sprayed into the oral cavity at the time of use. Can promote saliva secretion, improve the dryness in the oral cavity and provide an excellent moist feeling. Also, there is almost no irritation to oral tissues such as the oral mucosa of the user, giving a sticky feeling during use Without a feeling of use A good, good storage stability, and excellent portability, found that for oral spray composition that can be easily applied when necessary to obtain, the present invention has been accomplished.

  In the present invention, as apparent from the examples described later, (A) polyglutamate, (B) an organic acid and its salt, and (C) glycerin are combined in a specific amount and proportion. By applying by spraying with a spray, it is possible to obtain a composition for oral spray and a preparation for oral cavity that have the above-mentioned excellent effect of improving the dryness in the oral cavity, and also have good usability and formulation stability. Therefore, such an effect of the present invention cannot be achieved if any of the above essential requirements is lacking.

Therefore, the present invention
A composition for an oral spray applied to the oral cavity by being filled in a spray container having a container main body for storing contents and a spray mechanism, and sprayed from the contents discharge port of the container,
(A) 0.05-5% by mass of sodium salt or potassium salt of polyglutamic acid,
(B) citric acid, malic acid, 2-6 wt% of at least one organic acid or its alkali metal salt selected et or tartaric acid and succinic acid,
(C) 10-50 mass% of glycerol
A composition for oral spraying, wherein the mass ratio (C) / (B) of the component (C) to the component (B) is 3 or more and less than 20, and the composition for oral spray An oral preparation contained in a spray container is provided.

  The composition for oral spray and oral preparation of the present invention are just sprayed into the oral cavity when the user is concerned about dryness in the mouth, and immediately after application without irritation or stickiness to oral tissues such as the oral mucosa. The mouth can be moistened over a long period of time, dry mouth can be effectively suppressed, and the stability over time and the sprayability of the spray during use are excellent.

  Hereinafter, the present invention will be described in more detail. The composition for oral spray of the present invention is selected from (A) sodium or potassium salt of polyglutamic acid, (B) citric acid and its salt, malic acid and its salt, tartaric acid and its salt, succinic acid and its salt Contains an organic acid and its salt, (C) glycerin.

In the present invention, sodium or potassium salt of polyglutamic acid is blended as an active ingredient for promoting salivary secretion.
Examples of the polyglutamate include sodium or potassium salts of α or γ-polyglutamic acid that are chemically synthesized, or natural α or γ-polyglutamic acid sodium or potassium salts obtained as fermentation products from various strains. Although it can be used, natural sodium or potassium salt of polyglutamic acid is preferable because it is used for oral use, and sodium or potassium salt of γ-polyglutamic acid having high productivity as a raw material is more preferable.

  The viscosity of the polyglutamate is not particularly limited, and those having various viscosities can be used depending on the type of product, but the viscosity of a 4% aqueous solution measured by the method described later is 10 to 200 mPa · s, particularly 30 to 120 mPa. -It is preferable that it is the range of s. When the viscosity is less than 10 mPa · s, the salivary secretion promoting action may be insufficient. When it exceeds 200 mPa · s, the viscosity of the preparation increases, and the sprayability of the spray during use may deteriorate.

Viscosity measurement method Take 96 g of water in a 200 mL beaker and add 4.0 g of polyglutamic acid or a salt thereof to the beaker with stirring with a stirrer to completely dissolve it. Next, after leaving still in a 25 degreeC thermostat for 1 hour, the viscosity after 1 minute is measured correctly using the following BL type | mold viscometer.
BL type viscometer: Tokyo Keiki B type viscometer Model BL
Rotor: No. 2 Number of revolutions: 60 rpm Measurement temperature: 25 ° C

  As the polyglutamate, a commercially available product can be used. For example, as γ-polyglutamate sodium, Meiji polyglutamate manufactured by Meiji Food Materials Co., Ltd. can be used.

  The compounding quantity of the sodium salt or potassium salt of polyglutamic acid is 0.05 to 5% of the whole composition, Preferably it is 0.1 to 2%. If it is less than 0.05%, the salivary secretion promoting effect is not sufficiently exhibited, and if it exceeds 5%, the viscosity becomes high and spraying is not possible, or the diffusibility in the mouth is poor and a sticky feeling is generated.

Component (B) is an organic acid and a salt thereof, and according to the present invention, (B) an organic acid, a salt thereof and (C) glycerin are used in combination to stimulate oral tissues such as the oral mucosa. It is possible to moisturize the mouth immediately after application.
As the organic acid and its salt, one or more organic acids selected from citric acid, malic acid, tartaric acid and succinic acid and alkali metal salts thereof (sodium salt, potassium salt, etc.) are used. Contains citric acid and its salt, malic acid and its salt, tartaric acid and its salt, and succinic acid and its salt. Among these, a combination of citric acid and sodium citrate or malic acid and sodium malate is preferable from the viewpoints of irritation during use and moist feeling in the mouth (after 5 minutes).

  The total amount of the organic acid and the organic acid salt is 2 to 6%, preferably 2.5 to 5% of the entire composition. If it is less than 2%, a moist feeling immediately after application of the preparation cannot be obtained satisfactorily, and if it exceeds 6%, no further effect can be obtained, and irritation to the oral mucosa or problems with storage stability over time. Arise.

Furthermore, the compounding amount of the organic acid is 0.005 to 1.5%, particularly preferably 0.05 to 0.5%. If it is less than 0.005%, a sufficient moist feeling in the mouth immediately after application of the preparation cannot be obtained, and if it exceeds 1.5%, dissolution of the teeth and irritation to the oral mucosa are caused.
The amount of the organic acid salt is 1.5 to 5.9%, particularly preferably 1.8 to 5%. If it is less than 1.5%, the effect such as moist feeling in the mouth immediately after the preparation is applied is inferior, and if it exceeds 5.9%, irritation is given to the oral mucosa and the stability over time is inferior.

  Moreover, it is preferable to adjust the compounding quantity of (B) component which combined the organic acid and the organic acid salt in the range from which the pH in 25 degreeC of a formulation will be 5-8. If the pH exceeds 8, the oral mucosa may be stimulated.

  (C) The compounding quantity of glycerol is 10 to 50% of the whole composition, Preferably it is 15 to 40%. If it is less than 10%, the stability of the preparation is reduced or the oral mucosa is irritated. If it exceeds 50%, the feeling of use such as stickiness becomes worse.

  The mass ratio of the component (C) to the component (B) ((C) / (B)) is 3 or more and less than 20, preferably 3 or more and 15 or less, more preferably 3.5 or more and 15 or less. When the ratio of (C) / (B) is less than 3, the formulation is inferior in stability or stimulates the oral mucosa, and when it is 20 or more, it feels moist in the mouth immediately after use or is sticky. Inferior to

  The composition for oral spray of the present invention is prepared in a liquid or liquid form, but in addition to the above components, a moisturizing component, a wetting agent, a water-soluble polymer substance, as long as it does not interfere with the effects of the present invention, if necessary. Surfactants, solvents, antiseptic ingredients, fragrances, active ingredients and the like can be blended.

  Specifically, moisturizing components such as hyaluronic acid salt, and as a wetting agent, sugar alcohols such as xylitol, erythritol, sorbitol, mannitol, reduced lactose, reduced maltose starch syrup, reduced starch syrup, propylene glycol, 1,3-butylene glycol, Polyhydric alcohols other than glycerin, such as polyethylene glycol, and water-soluble polymer substances such as sodium carboxymethylcellulose, polyvinylpyrrolidone, xanthan gum, carrageenan, sodium alginate, and the like can be used in combination.

  When blending the above optional components, the amount of moisturizing component is 0.001 to 1%, the amount of sugar alcohols is 0.1 to 20%, the amount of polyhydric alcohol is 0.1 to 10%, The blending amount of the conductive polymer material is preferably 0.01 to 1%.

  In addition, as an active ingredient, an anti-cariogenic ingredient such as fluoride (such as sodium fluoride), an enzyme such as dextranase or mutanase, an ingredient for preventing or suppressing hypersensitivity such as aluminum lactate, potassium nitrate or piroctone olamine, or cetylpyridinium chloride , Bacterium chloride, benzalkonium chloride, bactericidal and halitosis control ingredients such as isopropylmethylphenol and l-menthol, anti-inflammatory ingredients such as glycyrrhizic acid, dipotassium glycyrrhizinate, ε-aminocaproic acid, others, potassium pyrophosphate, sodium tripolyphosphate An effective amount of a water-soluble polyphosphate such as sodium metaphosphate, ascorbic acid or a salt thereof, herbal extracts such as tocopherol acetate, rosemary, clove, thyme and the like can be blended.

Furthermore, surfactants such as anionic surfactants, nonionic surfactants, and zwitterionic surfactants can be blended for the purpose of solubilizing components insoluble in solvents.
In this case, examples of the anionic surfactant include sodium alkyl sulfates such as sodium lauryl sulfate, sodium myristyl sulfate and sodium cetyl sulfate, sodium N-acyl glutamate such as sodium N-lauroyl glutamate, sodium N-palmitoyl glutamate, and N-lauroyl sarcosine. Sodium, sodium N-acyl sarcosine such as sodium N-myristoyl sarcosine, sodium N-lauroylmethyl taurine, sodium N-methyl-N-acyl taurine such as sodium N-myristoyl methyl taurine, sodium N-methyl-N-acylalanine, Sodium lauryl benzene sulfonate, hydrogenated coconut fatty acid monoglyceride sodium monosulfate, sodium lauryl sulfoacetate, α-ole Sodium Insuruhon acid, lauryl polyoxyethylene (POE) sodium sulfate, sodium lauryl POE acetate, sodium lauryl POE phosphate, sodium stearyl POE phosphate, sodium surfactin or the like is used.

  Nonionic surfactants include glycerin fatty acid esters such as monoglyceryl stearate and decaglyceryl laurate, sugar fatty acid esters such as sucrose fatty acid ester, maltose fatty acid ester, lactose fatty acid ester, maltitol fatty acid ester, lactitol fatty acid ester, etc. Sugar alcohol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate, polyoxyethylene fatty acid ester such as polyoxyethylene hydrogenated castor oil, myristic acid mono or diethanolamide, etc. Fatty acid ethanolamide, sorbitan fatty acid ester, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxy Lopylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester, etc. are used, especially polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100, polyoxyethylene having an average addition mole number of 20 to 50 More preferred are alkyl ethers and polyoxyethylene sorbitan fatty acid esters having an average added mole number of 10 to 30.

  Zwitterionic surfactants include alkyldimethylaminoacetic acid betaines such as lauryldimethylaminoacetic acid betaine, N-alkyldiaminoethylglycine such as N-lauryldiaminoethylglycine, N-myristyldiaminoethylglycine, and N-alkyl-N-carboxyl. Methyl ammonium betaine, 2-alkyl-1-hydroxyethyl imidazoline betaine sodium and the like are used.

  The compounding of these surfactants is arbitrary, but when compounding, the compounding amount of the anionic surfactant and amphoteric surfactant is 0.001 to 3%, and the compounding amount of the nonionic surfactant is 0.1 to 10. % Is preferred. The total amount of the surfactant is preferably 0.001 to 10%.

  Natural flavors such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, etc. Essential oils and flavor components contained in the above natural essential oils such as l-carvone, 1,8-cineol, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spirantol, etc. Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol Perfume ingredients such as ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-1-menthyl carbonate, One or more kinds of blended flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc. Can be blended in the composition in the range of 0.00001 to 3% within a range not impeding the effects of the present invention.

  Furthermore, parabens (paraoxybenzoic acid ester) such as benzoic acid and its sodium salt, methylparaben, ethylparaben, propylparaben, butylparaben, etc., as a preservative component, Red No. 3, Red No. 104, Red No. 106, Yellow No. 4, Blue No. 1, Green No. 3, pigments or colorants such as titanium mica, petiole, xylitol, saccharin and its sodium salt, sweeteners such as sucralose, stevioside, glycyrrhizin, aspartame, and the like can be blended.

In the composition for oral spray of the present invention, a liquid or liquid composition for oral cavity containing the above components is accommodated in a container, and is applied by spraying into the oral cavity at the time of use. In this case, the container is not particularly limited as long as it has a structure capable of spraying a medicine. Specifically, a pressing portion of a spray unit that is provided in close contact with the upper opening of the container main body, including a container main body such as a plastic bottle for storing contents and a spray unit having a spray mechanism such as a pump dispenser. By pressing, the contents contained in the container body can be sprayed and discharged from the contents discharge port (nozzle) by the contents discharge mechanism of the spray section (hereinafter abbreviated as spray container). .
A commercial item may be used for such a spray container, for example, the dispenser part of a spray container is Y-20 (1 push about 0.2mL discharge | emission) and Y-70 (1 push about 0. 07-mL discharge), Y-150 (1 push about 0.15 mL discharge), etc., Mitani Valve Co., Ltd. Z-155 (1 push 0.15 mL discharge), etc., and the bottle part is made by Yoshino Kogyo A polyethylene terephthalate bottle corresponding to a dispenser, a PEI-30 bottle made of Takemoto Container, and the like are commercially available. As for the dispenser part of the spray container, Japanese Utility Model Publication No. 55-373, Japanese Utility Model Publication No. 56-21476, Japanese Patent Application Laid-Open No. 60-32505 are disclosed.

FIG. 1 is a schematic sectional view showing an embodiment of a spray container that can be used in the present invention. The dispenser part of this spray container is marketed as a polyethylene terephthalate bottle (both manufactured by Yoshino Kogyo) corresponding to Y-70 and the bottle part corresponding to Y-70.
The container shown in FIG. 1 includes a container main body 1 for storing contents and a spray unit 2 having a spray mechanism. The spray unit 2 is in close contact with an upper opening of the container main body 1 by a cap 4 having a packing 3. The spray unit 2 is inserted into the container main body 1 with the lower projecting portion of the cylinder 6 serving as the content inflow path of the content discharge mechanism 5 provided with the tube 7 at the tip opening. . This container presses the pressing part 8 of the spray part 2 so that the piston 9 moves up and down in the cylinder 6 along the cylinder guide 10, so that the contents in the container main body 1 become the lower opening of the tube 7. Then, it is sucked up through a ball 11 for adjusting the flow rate in the cylinder 6 and is sprayed and discharged from the nozzle 13 of the content discharge port through the head cylinder 12. In addition, the overcap 14 can be covered on the spray part 2 as needed.

The shape of the spray part constituting the spray container, the content discharge mechanism, the diameter and shape of the nozzle and the like can be freely used as long as they are generally used, and are not particularly limited. The diameter of the nozzle hole through which the object is discharged is preferably 0.1 to 1 mm, particularly 0.3 to 0.8 mm. The spray amount by spraying is preferably 0.01 to 0.5 mL per push. The container body preferably has a height of 40 to 100 mm and a width of 15 to 50 mm, and a capacity of about 5 to 50 mL is suitable.
Use of such a container is effective for exerting more excellent sprayability and moisturizing effect in the mouth.

  The material of the spray container is not particularly limited, but the material of the spray part is preferably polyethylene, polypropylene, polyacetal or the like, and the material of the container body is preferably polyethylene terephthalate or the like.

The material of each part of the spray container of FIG. 1 can be as follows, for example.
Container body 1 (bottle) (polyethylene terephthalate),
Packing 3 (Polyethylene double-sided polypropylene attached)
Cap 4 (polypropylene)
Cylinder 6, cylinder guide 10, head cylinder 12 (polypropylene)
Tube 7 (polyethylene)
Press part 8 (polyethylene)
Piston 9 (polyethylene)
Ball 11 (SUS304 stainless steel)
Nozzle 13 (polyacetal)

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

[Examples 1 to 10, Comparative Examples 1 to 11]
The composition for oral cavity of the composition shown to Tables 1-4 was prepared by the following method, and the following evaluation was performed. The results are also shown in Tables 1-4.
Formulation preparation:
Each component was weighed and prepared by mixing with a stirrer. 30 g of the prepared liquid is filled into a spray container (Y-70 dispenser made by Yoshino Kogyo, nozzle hole 0.55 mm, spray amount of 1 push is about 0.07 mL, capacity 30 mL polyethylene terephthalate bottle), and the test preparation is filled Obtained.
In addition, as γ-polyglutamate sodium in Tables 1 to 4, a natural product (Meiji polyglutamate) manufactured by Meiji Food Materia Co., Ltd. was used.

<Moisture feeling in the mouth during use>
10 panelists who were concerned about dry mouth in daily life used it. The test preparation was sprayed into the mouth of 5 pushes (about 0.35 mL), and after 5 minutes and 30 minutes of use, moist feeling in the mouth, irritation immediately after use, and stickiness were evaluated according to the following criteria.

Moist feeling in the mouth:
7 points: I feel very much 6 points: I feel quite 5 points: I feel a little 4 points: I can't say either 3 points: I don't feel much 2 points: I don't feel almost 1 point: I don't feel at all It evaluated as follows.
◎: 6.0 points or more ○: 5.0 points or more and less than 6.0 points △: 4.0 points or more and less than 5.0 points ×: Less than 4.0 points

<Stimulation immediately after use>
Comparative Example 7 was used as a standard product, and evaluation was performed according to the following criteria.
5 points: Slightly weaker than the standard product 4 points: Slightly weaker than the standard product 3 points: Same level as the standard product 2 points: Slightly stronger than the standard product 1 Point: Remarkably stronger stimulus than the standard product Panel average points were calculated and evaluated as follows.
◎: 4.5 points or more ○: 3.5 points or more and less than 4.5 points △: 2.5 points or more and less than 3.5 points ×: Less than 2.5 points

<Stickness immediately after use>
Evaluation was performed based on the following criteria using Comparative Example 8 as a standard product.
5 points: No obvious stickiness compared to standard products 4 points: No stickiness compared to standard products 3 points: Equivalent to standard products 2 points: Some stickiness compared to standard products 1 point: Remarkable compared to standard products The average score of panelists with stickiness was calculated and evaluated as follows.
◎: 4.5 points or more ○: 3.5 points or more and less than 4.5 points △: 2.5 points or more and less than 3.5 points ×: Less than 2.5 points

<Evaluation of formulation stability and sprayability>
The prepared preparation was filled in a spray container with a capacity of 30 mL and left for one month at −5 ° C. and 50 ° C. The appearance and properties were visually evaluated according to the following criteria to evaluate the stability of the preparation.
○: Colorless and transparent with no precipitates Δ: Slight orientation is observed ×: Significant precipitates or turbidity is observed

In addition, sprayability is measured by measuring a spray pattern when a spray container is placed upright and sprayed on a filter paper (No. 5A) from a distance of 5 cm at a temperature of 20 ° C. Evaluated by criteria.
Evaluation criteria for sprayability ◎: 4.0 cm or more ○: 3.0 cm or more and less than 4.0 cm Δ: 2.0 cm or more and less than 3.0 cm ×: less than 2.0 cm

  According to the results of Tables 1 to 4, the oral spray composition of the present invention can moisturize the mouth for a long time immediately after administration, is safe for oral tissues, has little deterioration over time, and uses sprayability. It was confirmed that it was excellent in properties.

  The preparations of the following Examples 11 to 16 were prepared by the above-described production method, filled in a spray container similar to the above, and evaluated according to the above evaluation method. In addition, as γ-polyglutamate sodium and γ-polyglutamate potassium, natural products manufactured by Meiji Food Materia Co., Ltd. were used.

Example 11
Component A sodium γ-polyglutamate 2.0%
(4% aqueous solution viscosity: 12 mPa · s)
B component Citric acid 0.32
B component Sodium citrate 3.68
Component C Glycerin 20
Polyoxyethylene (60) hydrogenated castor oil 3
Ethanol 15
Xylitol 5
Reduced lactose 5
l-Menthol 0.2
Fragrance B 0.3
Purified water remaining
Total 100%
pH: 6.1 Total amount of component B: 4.0% Mass ratio of component C / component B: 5.0
It was moist feeling (after 5 minutes and after 30 minutes), no irritation, no stickiness:, storage stability (both at -5 ° C and 50 ° C), and sprayability.

Example 12
A component γ-Polyglutamate potassium 0.5%
(4% aqueous solution viscosity: 45 mPa · s)
B component Citric acid 0.5
B component Sodium citrate 3.5
Component C Glycerin 25
Polyoxyethylene (20) sorbitan monooleate 3
Polyvinylpyrrolidone (K90) 0.3
Ethanol 10
Sorbitol 5
Erythritol 5
Sodium fluoride 0.05
Sodium benzoate 0.1
Fragrance C 0.3
Purified water remaining
Total 100%
pH: 5.8 Total amount of component B: 4.0% Mass ratio of component C / component B: 6.25
It was moist feeling (after 5 minutes and after 30 minutes), no irritation, no stickiness:, storage stability (both at -5 ° C and 50 ° C), and sprayability.

Example 13
A component sodium γ-polyglutamate 0.5%
(4% aqueous solution viscosity: 84.5 mPa · s)
B component Citric acid 0.2
B component Sodium citrate 3.8
Component C Glycerin 25
Polyoxyethylene (30) cetyl ether 3
Sodium hyaluronate 0.01
Ethanol 10
Maltitol 5
Xylitol 5
Cetylpyridinium chloride 0.02
Fragrance D 0.3
Purified water remaining
Total 100%
pH: 6.3 B component total blending amount: 4.0% C component / B component mass ratio: 6.25
It was moist feeling (after 5 minutes and after 30 minutes), no irritation, no stickiness:, storage stability (both at -5 ° C and 50 ° C), and sprayability.

Example 14
A component sodium γ-polyglutamate 0.5%
(4% aqueous solution viscosity: 101 mPa · s)
B component Citric acid 0.1
B component sodium citrate 3.9
C component Glycerin 15
Polyoxyethylene (60) hydrogenated castor oil 3
Propylene glycol 2
Polyethylene glycol # 400 3
Sodium carboxymethylcellulose (Ernest gum) 0.1
Ethanol 10
Sorbitol 5
Xylitol 5
Cetylpyridinium chloride 0.02
Fragrance E 0.3
Purified water remaining
Total 100%
pH: 6.7 Total blending amount of component B: 4.0% Mass ratio of component C / component B: 3.75
It was moist feeling (after 5 minutes and after 30 minutes), no irritation, no stickiness:, storage stability (both at -5 ° C and 50 ° C), and sprayability.

Example 15
Component A sodium γ-polyglutamate 0.1%
(4% aqueous solution viscosity: 189 mPa · s)
B component Citric acid 0.32
B component Sodium citrate 3.68
Component C Glycerin 20
Polyoxyethylene (60) hydrogenated castor oil 3
Ethanol 10
Sorbitol 15
Xylitol 1
Sodium carboxymethylcellulose (Ernest gum) 0.2
l-Menthol 0.2
Fragrance F 0.3
Purified water remaining
Total 100%
pH: 6.1 Total amount of component B: 4.0% Mass ratio of component C / component B: 5.0
It was moist feeling (after 5 minutes and after 30 minutes) ◎, no irritation ◎, no stickiness: 、, storage stability (both −5 ° C. and 50 ° C.) ○, sprayability ○.

Example 16
A component sodium γ-polyglutamate 0.5%
(4% aqueous solution viscosity: 84.5 mPa · s)
B component Citric acid 0.32
B component Sodium citrate 3.68
Component C Glycerin 30
Polyoxyethylene (60) hydrogenated castor oil 3
Ethanol 10
Xylitol 5
Sodium carboxymethylcellulose (Ernest gum) 0.1
l-Menthol 0.1
Lemon essential oil 0.1
Fragrance A 0.1
Purified water remaining
Total 100%
pH: 6.1 Total amount of component B: 4.0% Mass ratio of component C / component B: 7.5
It was moist feeling (after 5 minutes and after 30 minutes), no irritation, no stickiness:, storage stability (both at -5 ° C and 50 ° C), and sprayability.
In addition, the fragrance | flavors AF are the compositions as follows.

なお、表中の配合量（部）は質量部である（以下、同様）。

In addition, the compounding quantity (part) in a table | surface is a mass part (hereinafter, the same).

It is a general | schematic fragmentary sectional view which shows one Example of the spray container concerning this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Container body 2 Spray part 3 Packing 4 Cap 5 Contents discharge mechanism 6 Cylinder 7 Tube 8 Press part 9 Piston 10 Cylinder guide 11 Ball 12 Head cylinder 13 Nozzle 14 Overcap

Claims (3)

A composition for an oral spray applied to the oral cavity by being filled in a spray container having a container main body for storing contents and a spray mechanism, and sprayed from the contents discharge port of the container,
(A) 0.05-5% by mass of sodium salt or potassium salt of polyglutamic acid,
(B) citric acid, malic acid, 2-6 wt% of at least one organic acid or its alkali metal salt selected et or tartaric acid and succinic acid,
(C) 10-50 mass% of glycerol
A composition for oral spray, containing, wherein the mass ratio of component (C) to component (B) ((C) / (B)) is 3 or more and less than 20.   An oral preparation comprising the oral spray composition according to claim 1 contained in a spray container. The oral preparation according to claim 2, wherein the diameter of the content discharge port of the spray container is 0.1 to 1 mm, and the spray discharge amount is 0.01 to 0.5 mL per push.

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