JP5136797B2 - Isopropylmethylphenol-containing liquid oral composition - Google Patents

Description

  The present invention exhibits a high penetrating and bactericidal effect on periodontopathic biofilms, and has good appearance stability over time when stored at low and high temperatures, and when used, has a low stickiness in the oral cavity after use, The present invention relates to an isopropylmethylphenol-containing liquid oral composition characterized by being substantially free from ethanol.

  Conventionally, the causes of caries, gingivitis, periodontitis and bad breath are considered to be caused by various bacteria in plaque. Plaque control, that is, oral bacteria, is an effective means for prevention and improvement of oral diseases. It is said that it is useful to keep the number low.

  As a means for reducing the number of pathogenic bacteria in the oral cavity, it is an effective means to add a nonionic fungicide or a cationic fungicide to the oral care product. In particular, nonionic germicides such as isopropylmethylphenol among the germicides blended in oral care products have characteristics that tend to have a broad antibacterial spectrum compared to cationic germicides. It is blended into products and marketed.

  However, these nonionic disinfectants are oil-soluble compounds and are hardly soluble in water as they are, so they are solubilized by blending various surfactants and solvents such as ethanol. In order to inactivate the activation site of the bactericidal agent, if the blending amount is increased, sufficient bactericidal power is not expressed, and if the blending amount of the surfactant is decreased to improve bactericidal power, the temperature is lowered over time at low and high temperatures. There was a problem that the liquid became cloudy and the appearance stability of the composition was impaired.

  On the other hand, the blending of ethanol used as a solubilizing solvent causes a spicy irritating feeling when using the oral composition, and in recent years, non-alcohol mouthwashes that do not contain ethanol have been widely used. However, the composition for liquid oral cavity containing no ionic disinfectant without ethanol is required to have a solubilizing power with a surfactant than when it is combined with ethanol. It was more difficult to achieve both appearance stability over time.

  Isopropylmethylphenol is a nonionic bactericidal agent that is attracting attention as a bactericidal preparation with a high penetration bactericidal effect on periodontopathic biofilms. Until now, in the technique for preventing oral disease using isopropylmethylphenol, isopropylmethylphenol is solubilized with low-concentration polyoxyethylene hydrogenated castor oil (Japanese Patent Laid-Open Nos. 62-24010 and 1). No.-305021, JP-A-7-482237, JP-A-10-330230: see Patent Documents 1 to 4), and all of these compositions have ethanol, and thus have high irritation.

  In addition, a high-concentration wetting agent is blended so that the moisture content in the preparation is 40% or less (see JP-A-11-322554: Patent Document 5), or the water content is adjusted to half or less of the blended amount of polyols. (See JP 2001-199854 A: Patent Document 6) to secure the aging stability and bactericidal activity of isopropylmethylphenol. However, these techniques have a drawback in that the water content is low and the composition has a high viscosity and is not suitable for mouth washing, or the stickiness in the oral cavity after use is extremely poor.

Japanese Patent Laid-Open No. 62-24010 JP-A-1-305021 JP 7-48237 A Japanese Patent Laid-Open No. 10-330230 JP-A-11-322554 JP 2001-199854 A

  The present invention has been made in view of the above circumstances, exhibits a high penetrating bactericidal effect on periodontopathic biofilms, and has good appearance stability over time during storage at low and high temperatures. An object of the present invention is to provide a liquid oral composition containing isopropylmethylphenol and having substantially no ethanol, which is low in stickiness in the oral cavity and low in irritation.

  As a result of intensive studies to achieve the above object, the present inventors have found that liquid oral compositions containing isopropylmethylphenol as a bactericidal component are at least one selected from sodium alkyl sulfate and sodium N-acyl sarcosine. Anionic surfactants, polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 40 to 100 moles, and a polyoxyethylene having an average added mole number of ethylene oxide of 16 to 18 and ethylene oxide. And at least one nonionic surfactant selected from oxyethylene alkyl ethers, and at least one wetting agent selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 190 to 630. 5-15% by mass of the total composition And by making the water content in the composition 70% by mass or more, a high penetration bactericidal effect on periodontopathic biofilms is exhibited, and appearance stability is good even at high and low temperature storage, and When used, a liquid oral composition that is low in irritation after use and low in irritation and substantially free of ethanol is obtained, and further, by adding triclosan to this liquid oral composition It was found that the bactericidal effect against airborne bacteria is improved.

  According to the present invention, in the liquid oral composition containing isopropylmethylphenol, by blending the specific components in combination, the composition containing substantially no ethanol, the periodontal in the periodontopathic biofilm Combines excellent bactericidal power against oral bacteria such as pathogens, excellent appearance stability over time when stored at low and high temperatures, and excellent usability with low stickiness in mouth after mouthwash and after mouthwash, The present inventors have found that a high-quality liquid composition for oral cavity that is excellent in preventing and improving oral diseases can be obtained.

Therefore, the present invention
[I] A liquid oral composition containing isopropylmethylphenol,
(A) at least one anionic surfactant selected from sodium alkyl sulfate and sodium N-acyl sarcosine,
(B) From polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles and polyoxyethylene alkyl ether having a carbon chain length of 16 to 18 and an average addition mole number of ethylene oxide of 10 to 40 moles At least one nonionic surfactant selected,
(C) At least one wetting agent selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 190 to 630 is 5 to 15% by mass of the total composition.
And a liquid oral composition [II] component (A) characterized in that the amount of water in the composition is 70% by mass or more and the amount of ethanol in the composition is 100 ppm or less , Polyoxyethylene hydrogenated castor having at least one selected from sodium alkyl sulfate having a carbon chain length of 12 to 14 and sodium N-acyl sarcosine, wherein component (B) has an average added mole number of ethylene oxide of 60 to 100 mol Liquid and oral cavity according to [I], which has at least one selected from polyoxyethylene alkyl ethers having an oil and an alkyl chain with a carbon chain length of 16 to 18 and an average addition mole number of ethylene oxide of 20 to 40 moles Composition [III] The liquid oral composition according to [I] or [II], further comprising (D) triclosan That.

  The liquid oral composition of the present invention exhibits an osmotic and bactericidal effect on periodontopathic biofilms, has good appearance stability over time during storage at low and high temperatures, and has a sticky feeling after use during use. It is low and hypoallergenic.

  Hereinafter, the present invention will be described in more detail. The liquid oral composition of the present invention contains isopropylmethylphenol as a bactericidal component, and (A) sodium alkyl sulfate and N-acyl sarcosine sodium as an anionic surfactant. At least one selected as a nonionic surfactant, (B) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles and an average addition mole of ethylene oxide having a carbon chain length of 16 to 18 Composition of at least one selected from polyoxyethylene alkyl ethers having a number of 10 to 40 moles, and (C) glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 190 to 630 as a wetting agent 5-15 quality of the whole thing % Contained, and it is the water content in the composition is 70 mass% or more, characterized in that substantially free of ethanol.

  The anionic surfactant of the component (A) used in the present invention is at least selected from sodium alkyl sulfate and sodium N-acyl sarcosine from the viewpoint of osmotic bactericidal power against periodontal pathogenic biofilm and taste and irritation. Use one. Among these, those selected from sodium alkyl sulfate and sodium N-acyl sarcosine having a carbon chain length of 12 to 14 are preferable in terms of osmotic bactericidal power against periodontal pathogenic biofilms and solubilization of isopropylmethylphenol. Sodium lauryl sulfate and sodium lauroyl sarcosine are preferably used.

  The total amount of component (A) is preferably 0.05 to 1.0% (mass%, the same applies hereinafter) of the whole composition in terms of osmotic sterilization power to periodontopathic biofilm and solubilization of isopropylmethylphenol. ), More preferably 0.05 to 0.5%. If the blending amount is less than 0.05%, it may become cloudy and impair the stability of appearance at high temperatures. If it exceeds 1.0%, it will precipitate over time during storage at low temperatures, cause irritation, and have poor taste. There is a case.

  As the nonionic surfactant of the component (B) used in the present invention, polyene having an average added mole number of ethylene oxide of 40 to 100 moles from the viewpoint of osmotic bactericidal power and taste for periodontopathic biofilms. At least one selected from oxyethylene hydrogenated castor oil and a polyoxyethylene alkyl ether having an alkyl chain having a carbon chain length of 16 to 18 and an average added mole number of ethylene oxide of 10 to 40 mol is used. As the polyoxyethylene alkyl ether, those having an average added mole number of 10 to 40 moles are used from the viewpoint of stimulation. Among these, polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 60 to 100 moles and a carbon chain length of 16 in terms of penetrating bactericidal power against periodontopathic biofilm and solubilization of isopropylmethylphenol. A polyoxyethylene alkyl ether having an alkyl chain of ˜18 and an average addition mole number of ethylene oxide of 20 to 40 mol is preferably used. Furthermore, polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 60 to 100 mol is particularly preferably used from the viewpoint of low irritation. If the average added mole number of ethylene oxide of polyoxyethylene hydrogenated castor oil is less than 40 moles, it will precipitate during low-temperature storage, and those exceeding 100 moles are generally not commercially available. If the average added mole number of polyoxyethylene alkyl ether is less than 10 moles, it will precipitate during low-temperature storage as described above, and will be strongly irritating, and those exceeding 40 moles are generally not commercially available. Moreover, in the said polyoxyethylene alkyl ether, when the alkyl chain length is less than 16, bitterness and irritation | stimulation are strong, and the thing exceeding 18 is inferior to the external appearance stability in low temperature or high temperature.

  The total amount of component (B) is preferably from 0.1 to 1.0% of the total composition, more preferably from the viewpoint of osmotic sterilization power to periodontopathic biofilm and solubilization of isopropylmethylphenol. 2 to 0.7%. If the blending amount is less than 0.1%, it may be difficult to maintain the appearance stability at low and high temperatures, and if it exceeds 1.0%, the sterilizing power may be impaired. When polyoxyethylene alkyl ether is used as the component (B), irritation may occur if the blending amount exceeds 1.0%.

  As the wetting agent of component (C) used in the present invention, at least one selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 190 to 630 is used.

  In addition, the average molecular weight mentioned above shows the average molecular weight described in cosmetic raw material standards (2nd edition comment), and polyethylene glycol 200 (average molecular weight 190-210), polyethylene glycol 300 (average molecular weight 190-630) The average molecular weight 280-320), polyethylene glycol 400 (average molecular weight 380-420), and polyethylene glycol 600 (average molecular weight 570-630) are applicable. Depending on the product, for example, polyethylene glycol # 200, there may be a # between polyethylene glycol and the numerical value.

  Furthermore, it is preferable to use 2 or more types of a component (C) from the point of the external appearance stability in low temperature and the taste at the time of use, and it is more preferable to use 3 or more types from the point of external appearance stability at high temperature. As the two types of combinations, a combination of glycerin and propylene glycol, glycerin and butylene glycol, or glycerin and polyethylene glycol (particularly polyethylene glycol # 400) is preferable. As the three combinations, a combination of glycerin, propylene glycol and polyethylene glycol, or glycerin, propylene glycol and butylene glycol is preferable.

  The total amount of component (C) is 5 to 15% of the entire composition, and is preferably 6 to 13% in terms of appearance stability at low and high temperatures and stickiness in the oral cavity after use at the time of use. . If the blending amount is less than 5%, it is difficult to maintain the appearance stability at high and low temperatures, and it may become cloudy. If it exceeds 15%, an anionic surfactant may precipitate during storage at a low temperature, or stickiness after use may occur during use.

  Furthermore, as a component (C), when blending glycerin, 0.5% or more of the whole composition, when blending propylene glycol, 1% or more of the whole composition, and when blending butylene glycol, 1% or more of polyethylene glycol having an average molecular weight of 190 to 630 is preferably blended in an amount of 1% or more of the entire composition.

  The amount of isopropylmethylphenol used in the present invention is 0.01 to 0.1% of the entire composition, particularly 0.02 to 0.0. Preferably, the content is less than 0.01%. If the blending amount is less than 0.01%, the sterilizing power may not be exerted on the biofilm. If it exceeds 0.1%, the cloudiness and appearance stability may be impaired. .

  In the liquid oral composition of the present invention, the water content is 70% or more of the total amount of the composition from the viewpoint of usability and taste, and is preferably 80% or more from the viewpoint of the feeling of use. In addition, it is preferable that the upper limit of the amount of water is set to an amount at which the sum of the lower limit amounts of the components (A) to (C) and isopropylmethylphenol is 100%, that is, 94.84%.

  Furthermore, (D) triclosan can be mix | blended with the liquid oral cavity composition of this invention in order to improve the bactericidal power to a floating microbe. The blending amount is preferably 0.01 to 0.1%, particularly 0.02 to 0.08% of the entire composition, and if the blending amount is less than 0.01%, it is sterilized against airborne bacteria. In some cases, the strength cannot be exhibited, and when it exceeds 0.1%, cloudiness and appearance stability may be impaired.

The liquid oral composition of the present invention is substantially free of ethanol. Here, "substantially free of ethanol", 100 ppm or less amount of ethanol in the composition is relative to the total composition, preferably 50ppm or less, particularly preferably of 10ppm or less, the lower limit 0ppm It is. The liquid oral composition of the present invention contains no ethanol, but there are cases where a small amount of raw material-derived ethanol is contained in the fragrance compounded in the composition. In addition, it contains no ethanol other than a small amount of ethanol contained in the perfume.

  The liquid oral cavity composition of the present invention can be prepared and applied as a mouthwash, liquid dentifrice, etc., but the liquid oral cavity composition of the present invention is appropriately selected according to its dosage form in addition to the above components. In addition to the above components, for example, wetting agents, thickeners, pH adjusters, preservatives, sweeteners, fragrances, surfactants, active ingredients, coloring agents, and the like can be contained.

  As the wetting agent other than the above component (C), sorbitol, ethylene glycol, xylit, malt, lactit and the like can be contained. In addition, 0-6% of the compounding quantity of wetting agents other than these components (C) is preferable with respect to the whole composition.

  As the thickener, xanthan gum, sodium alginate, polyvinyl alcohol, hydroxyethyl cellulose, carrageenan, sodium carboxymethyl cellulose and the like can be used as long as the effects of the present invention are not hindered.

Examples of pH adjusters include phthalic acid, phosphoric acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid and carbonic acid and their potassium, sodium and ammonium salts, ribonucleic acid and its salts, and sodium hydroxide. At least one of the above can be used, and a combination of phosphoric acid, citric acid and their sodium salts is particularly preferred.
In particular, the liquid oral composition of the present invention preferably adjusts the pH at 25 ° C. to 5.5 to 7.5. As a pH adjuster, sodium dihydrogen phosphate and sodium monohydrogen phosphate or citric acid are used. It is preferable to use a combination of citrate and sodium citrate.

  Examples of the preservative may include sodium benzoate, methyl paraben, ethyl paraben, propyl paraben, butyl paraben, cetyl pyridinium hydrochloride, alkyldiaminoethyl glycine hydrochloride, potassium sorbate, and the like.

  As the sweetener, saccharin sodium, steviosite, sucralose, reduced palatinose, erythritol and the like can be contained.

  Natural flavors such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, etc. Essential oils, and perfume ingredients contained in the above natural essential oils such as l-carvone, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spirantol, etc. Ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol Perfume ingredients such as ethyl maltol, gamma or delta decalactone, gamma or deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate, One or more kinds of blended flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt, etc. Can be used so that ethanol is not substantially contained in the composition as long as the effect of the present invention is not hindered. The blending amount of the fragrance is preferably 0.00001 to 3% of the entire composition.

  As surfactants other than the above components (A) and (B), anionic surfactants such as lauroylmethyl taurine, acylamino acid salts, sodium dodecylbenzenesulfonate, α-sulfo fatty acid alkyl ester / sodium, and alkyl phosphate ester salts Agents, betaine acetate type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine, fatty acid amidopropyldimethylaminoacetic acid betaine, imidazoline type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt, Amino acid surfactants such as N-fatty acid acyl-L-alginate salts can be used alone or in combination as long as the effects of the present invention are not impaired. When a surfactant other than the components (A) and (B) is blended, the blending amount is preferably 0.01 to 5% of the entire composition.

  Active ingredients other than isopropylmethylphenol and triclosan include anti-inflammatory agents such as tranexamic acid and epsilon-aminocaproic acid, enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, lytechenzyme, sodium fluoride , Fluorides such as sodium monofluorophosphate and stannous fluoride, vitamin C such as aluminum chlorohydroxy allantoin, allantoin, azulene, lysozyme chloride, ascorbic acid, dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acid, hydrocholesterol, chlorophyll , Copper chlorophyllin sodium, Thyme, Ogon, Clove, Hamamelis plant extract, Copper gluconate, Caropeptide, Sodium polyphosphate, Water-soluble Phosphoric acid compounds, polyvinylpyrrolidone, anti-tartar agents, anti-plaque agents, potassium nitrate, may be added to aluminum lactate and the like. In addition, the compounding quantity of these active ingredients can be made into an effective quantity in the range which does not prevent the effect of this invention.

  As a colorant, a highly safe water-soluble dye such as Blue No. 1, Green No. 3, Yellow No. 4, Red No. 105 can be added.

  PET (polyethylene terephthalate), glass, polypropylene, and polyethylene can be used as the container for storing the liquid oral cavity composition of the present invention. However, the use of PET and glass is preferred in terms of suppressing adsorption of nonionic fungicides and fragrances. preferable.

EXAMPLES Hereinafter, although this invention is demonstrated in detail based on an experiment example, an Example, and a comparative example, this invention is not restrict | limited by these Examples.
For preparation of these liquid oral compositions, isopropylmethylphenol (manufactured by Osaka Kasei), sodium lauryl sulfate (manufactured by Toho Chemical Industries), sodium myristyl sulfate (manufactured by Nikko Chemicals), sodium cetyl sulfate (manufactured by Nikko Chemicals) ), Sodium lauroyl sarcosine (manufactured by Kawaken Fine Chemicals), sodium myristoyl sarcosine (manufactured by Nikko Chemicals), sodium palmitoyl sarcosine (manufactured by Nikko Chemicals), polyoxyethylene (40) hydrogenated castor oil (manufactured by Nikko Chemicals), poly Oxyethylene (60) hydrogenated castor oil (Nikko Chemicals), polyoxyethylene (100) hydrogenated castor oil (Nikko Chemicals), polyoxyethylene (40) stearyl ether (Nihon Emulsion), polyoxyethylene ( 0) Cetyl ether (manufactured by Nippon Emulsion), polyoxyethylene (20) cetyl ether (manufactured by Nippon Emulsion), polyoxyethylene (10) cetyl ether (manufactured by Nikko Chemicals), glycerin (85%, Sakamoto Yakuhin Kogyo Co., Ltd.) ), Propylene glycol (manufactured by Asahi Glass Co., Ltd.), butylene glycol (manufactured by Daicel Chemical Industries, Ltd.), polyethylene glycol # 200 (macrogor 200, manufactured by Sanyo Chemical Co., Ltd.), polyethylene glycol # 400 (manufactured by Lion Chemical), polyethylene glycol # 600 (Manufactured by Lion Chemical Co., Ltd.), triclosan (manufactured by Ciba Specialty Chemicals Co., Ltd.), citric acid (manufactured by Fuso Chemical Co., Ltd.), and sodium citrate (manufactured by Fuso Chemical Co., Ltd.) were used. Also, sodium lauryl phosphate (manufactured by Nikko Chemicals), polyoxyethylene (2) sodium lauryl ether sulfate (manufactured by Nikko Chemicals), polyoxyethylene (30) hydrogenated castor oil (manufactured by Nikko Chemicals), polyoxyethylene ( 7) Cetyl ether (manufactured by Nippon Emulsion Co., Ltd.) and ethanol (manufactured by Nippon Alcohol Sales Co., Ltd.) were used as comparative examples. In the table, POE represents polyoxyethylene, PEG represents polyethylene glycol, and% shown below means mass% unless otherwise specified.

[Experimental Example 1]
Liquid oral compositions having the compositions shown in Tables 1 to 6 were prepared by a conventional method, and the penetration sterilization effect on the model biofilm was evaluated by the following method. The results are shown in Tables 1-6.
(1) Method for producing model periodontopathic biofilm 4 hours with human unstimulated saliva obtained by filtering a hydroxyapatite (HA) plate (manufactured by Asahi Optical Co., Ltd.) having a diameter of 7 mm and a thickness of 3.5 mm with a 0.45 μm filter. The treated product was used as a carrier for preparing a model biofilm. The culture solution was prepared by adding 5 mg hemin (Sigma) and 0.5 mg menadione (Sigma) to a solution obtained by dissolving 30 g of trypticase soy broth (Difco) in 1 L of purified water. In order to produce a model biofilm, Streptococcus gordonii ATC 51656 strain and Actinomyces naeslandi ATCC 51655 strain were used as oral resident bacteria, and Porphyromonas gingivalis ATCC 33277 strain was used as a pathogenic bacterium. These three bacterial species were inoculated into the above-mentioned culture solution so as to be 2 × 10 ⁷ cfu / mL (cfu: colony forming units), respectively, at 37 ° C. under anaerobic conditions (5% carbon dioxide gas, 95% nitrogen) was continuously cultured for 2 weeks (the replacement rate of the culture medium was set to 10 Vol%) to form a model biofilm mixed with three bacterial species on the HA surface.

(2) Osmotic sterilization effect on model biofilm The formed model biofilm was immersed in 2 mL of the sample shown in Tables 1 to 3 for 3 minutes and washed 6 times with 1 mL of sterile physiological saline. Thereafter, the model biofilm was dispersed by sonication (200 μA, 10 seconds) with 4 mL of sterilized physiological saline, a 10% cotton defibrinated blood-containing trypticase soy agar plate (manufactured by Difco) and kanamycin sulfate (200 mg / L: 50 μL was spread on a tripty case soy blood agar plate containing Sigma) and cultured under anaerobic conditions. The grown colonies were counted, and the number of remaining Porphyromonas gingivalis bacteria (cfu) was determined and determined according to the following criteria.
Penetration bactericidal effect criteria ◎: viable count is less than 10 ⁶ ○: viable count is less than 10 ⁶ or more 10 ⁷ △: viable count is 10 ⁷ to 10 ⁸ less ×: the viable cell count 10 ⁸ or more

[Experimental example 2]
About the liquid oral composition of the composition shown to Tables 1-6, the external appearance stability was evaluated with the following method. The results are shown in Tables 1-6.
(1) Appearance stability 450 mL of the sample shown in Tables 1 to 6 is filled in a 450 mL PET container, and the appearance stability after 1 month storage in a -5 ° C or 50 ° C constant temperature bath is in accordance with the following criteria: Visual judgment was made.

Appearance stability evaluation standard A : No change is observed compared to the initial product.
○: A slight amount of orientation is recognized but there is no problem.
Δ: Slight turbidity is observed.
X: Considerable cloudiness or precipitate is observed.

[Experimental Example 3]
About the liquid oral cavity composition of the composition shown to Tables 1-6, the usability | use_condition was evaluated with the following method. The results are shown in Tables 1-6.
(1) Evaluation of feeling of use 10 mL of the samples shown in Tables 1 to 6 were included in the mouth, rinsed for 30 seconds, and after the mouthwash, no irritation and stickiness were compared with the control product (Comparative Example 6 or 9). Evaluation was made in the following four stages, and the average score of 10 people was shown in the table as ◎, ○, Δ, × according to the following criteria.
Usability Evaluation Criteria ◎: Average point exceeding 3.0 point and 4.0 point or less ○: Average point exceeding 2.0 point and 3.0 point or less Δ: Average point 1.5 point or more and 2.0 point or less ×: Average point 1.0 point or more and less than 1.5 point

No irritation after mouthwash (Control: Comparative Example 6)
4: The irritation was significantly lower than that of the control product.
3: Compared with the stimulus of the control product, the stimulus was slightly lower and there was no problem.
2: Stimulation equivalent to that of the control product was observed.
1: Stimulation was observed in comparison with the control product.
No stickiness after mouthwash (Control: Comparative Example 9)
4: The stickiness was hardly recognized compared with the stickiness of the control product.
3: Compared with the stickiness of the control product, a little stickiness was not recognized, and the level was satisfactory.
2: The stickiness equivalent to the stickiness of the control product was recognized.
1: Stickiness was recognized as compared with the stickiness of the control product.

[Experimental Example 4]
About the composition for liquid oral cavity of the composition shown in Table 6, the bactericidal effect with respect to an airborne microbe was evaluated by the following method. The results are shown in Table 6.
(1) Bactericidal effect against airborne bacteria The bacterial solution used was a solution obtained by dissolving 30 g of Trypticase Soy Broth (Difco) in 1 L of purified water as a culture solution, and using Actinomyces naesrandi ATCC 51655 strain as oral resident bacteria. It was prepared by adding physiological saline so that the permeability at 550 nm of a solution cultured for one day at 37 ° C. under anaerobic conditions (5% carbon dioxide gas, 95% nitrogen) was 20. Add 0.3 mL of the bacterial solution to 2.7 mL of the sample shown in Table 6, and after stirring, react at 37 ° C. for 1 minute. After stirring again, prepare five test tubes containing 2.7 mL of the culture solution in advance. Then, 0.3 mL was added to the first test tube and stirred. 0.3 mL of this solution was collected, added to the second test tube, and stirred. This operation was similarly performed on the third to fifth test tubes in the same manner. After stirring the culture solution in the first, third, and fifth test tubes, 50 μL was smeared on a tripty case soy agar plate (manufactured by Difco) containing 10% cotton defibrinated blood and cultured under anaerobic conditions. The grown colonies were counted, and the number of remaining Actinomyces naeslandi bacteria (cfu) was determined and determined according to the following criteria.
Criteria for determination of bactericidal effect against airborne bacteria ○: Number of viable bacteria is less than 10 ³ Δ: Number of viable bacteria is 10 ³ or more and less than 10 ⁴ ×: Number of viable bacteria is 10 ⁴ or more

  Next, liquid oral compositions of the following examples were prepared by a conventional method and evaluated in the same manner as described above. All of them were excellent in penetrating and bactericidal power to pathogenic biofilms, Only certain Examples 22 and 23 were evaluated), and had appearance stability and usability. In addition, the fragrance | flavor of the composition shown in following Table 7 was used for the fragrance | flavor.

[Example 22] Mouthwash isopropylmethylphenol 0.05%
A Sodium lauryl sulfate 0.1
B polyoxyethylene (60) hydrogenated castor oil 0.3
C Glycerin 2
Propylene glycol 4
PEG # 400 3
D Triclosan 0.05
Tranexamic acid 0.04
Dipotassium glycyrrhizinate 0.06
Citric acid 0.06
Sodium citrate 0.5
Methyl paraoxybenzoate 0.1
Saccharin sodium 0.01
Fragrance A 0.2
Water remaining
Total 100.0%

[Example 23] Mouthwash isopropylmethylphenol 0.05%
A Lauroyl sarcosine sodium 0.1
B polyoxyethylene (60) hydrogenated castor oil 0.3
C Glycerin 2
Propylene glycol 4
PEG # 400 5
D Triclosan 0.02
Xylitol 5
ε-aminocaproic acid 0.03
Sodium benzoate 0.3
Citric acid 0.03
Sodium citrate 0.25
Fragrance B 0.2
Water remaining
Total 100.0%

[Example 24] Mouthwash isopropylmethylphenol 0.05%
A Lauroyl sarcosine sodium 0.1
B Polyoxyethylene (100) hydrogenated castor oil 0.3
C Glycerin 3
Propylene glycol 4
Butylene glycol 5
Xylitol 4
Acetic acid dl-α-tocophenol 0.05
Sodium fluoride 0.1
Citric acid 0.03
Sodium citrate 0.25
Fragrance C 0.3
Water remaining
Total 100.0%

[Example 25] Mouthwash isopropylmethylphenol 0.1%
A Sodium myristyl sulfate 0.2
B Polyoxyethylene (80) hydrogenated castor oil 0.5
C Glycerin 3
Propylene glycol 4
Xylitol 4
Aspartame 0.02
Sodium pyrophosphate 0.17
Sodium polyphosphate 0.02
Citric acid 0.1
Sodium citrate 0.8
Fragrance D 0.4
Water remaining
Total 100.0%

[Example 26] Mouthwashing isopropylmethylphenol 0.06%
A Myristoyl sarcosine sodium 0.2
B polyoxyethylene (20) cetyl ether 0.4
C Glycerin 3
Propylene glycol 4
PEG # 600 5
Saccharin 0.01
Aspartame 0.02
Copper chlorofin sodium 0.01
Dextranase 0.02
Sodium ascorbate 0.03
Citric acid 0.06
Sodium citrate 0.5
Fragrance E 0.2
Water remaining
Total 100.0%

[Example 27] Mouthwash isopropylmethylphenol 0.6%
A Lauroyl sarcosine sodium 0.15
B Polyoxyethylene (40) stearyl ether 0.5
C Glycerin 2
Propylene glycol 4
PEG # 400 3
Xylitol 2
Sorbitol 1
Allantoin 0.01
Citric acid 0.03
Sodium citrate 0.5
Fragrance F 0.2
Water remaining
Total 100.0%

Claims (3)

A liquid oral composition containing isopropylmethylphenol,
(A) at least one anionic surfactant selected from sodium alkyl sulfate and sodium N-acyl sarcosine,
(B) From polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 40 to 100 moles and polyoxyethylene alkyl ether having a carbon chain length of 16 to 18 and an average addition mole number of ethylene oxide of 10 to 40 moles At least one nonionic surfactant selected,
(C) At least one wetting agent selected from glycerin, propylene glycol, butylene glycol, and polyethylene glycol having an average molecular weight of 190 to 630 is 5 to 15% by mass of the total composition.
And an isopropylmethylphenol-containing liquid oral composition, wherein the amount of water in the composition is 70% by mass or more and the amount of ethanol in the composition is 100 ppm or less .   Component (A) is at least one selected from sodium alkyl sulfate having a carbon chain length of 12 to 14 and sodium N-acyl sarcosine, and component (B) has an average added mole number of ethylene oxide of 60 to 100 mol. The polyoxyethylene hydrogenated castor oil is an at least one selected from polyoxyethylene alkyl ethers having an alkyl chain having a carbon chain length of 16 to 18 and an average added mole number of ethylene oxide of 20 to 40 moles. The liquid oral composition according to 1.   The liquid oral composition according to claim 1 or 2, further comprising (D) triclosan.