JP2764510B2 - Whitening cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic, and more particularly to a whitening cosmetic which is highly safe, has an excellent skin whitening effect, and can prevent and treat spots and freckles caused by sunburn.

[0002]

2. Description of the Related Art In general, skin spots and freckles are activated by melanocytes due to irritation caused by exposure to ultraviolet rays from sunlight, hormonal abnormalities, or genetic factors. Melanin pigments synthesized there are deposited in the skin. It is thought to be caused by abnormal deposition.

Conventionally, various whitening cosmetics have been provided in order to prevent such stains and freckles. Among them, there are many examples of applying a plant extract (extract) to cosmetics. Those that have a whitening effect to treat are reported.

[0004]

However, plant extracts generally have low permeability to the skin, and therefore, there is a problem that cosmetics containing the same do not exhibit a sufficient whitening effect. Therefore, studies have been made on penetration enhancers that improve the skin permeability of such active ingredients.However, those having a penetration promotion effect are so far inferior in safety and are not suitable for application to cosmetics. There are still problems.

[0005] Therefore, there has been a demand for the development of a whitening cosmetic which contains a plant extract, is excellent in safety, has high permeability to the skin, and can prevent and treat spots and freckles.

[0006]

Under such circumstances, the present inventors have conducted intensive studies. As a result, the combined use of a specific plant extract with urea and a urea stabilizer has excellent skin penetration and whitening. The present inventors have found that a whitening cosmetic having good effects and high safety can be obtained, and the present invention has been completed.

That is, the present invention provides the following component (A):
(B) and (C) (A) A plant extract selected from a clove extract, a green tea extract, a radish extract, a mulberry bark extract, a licorice extract, a gougon extract, an aloe extract and an orange peel extract (B) urea (C) A whitening cosmetic characterized by containing a urea stabilizer.

[0008] The plant extract of the component (A) used in the present invention includes butterflies, green tea, kakkon, mulberry bark, licorice, Japanese gourd, aloe or orange peel with water, ethanol, methanol, 1,3-butylene glycol. And an extract obtained by extraction with a hydrophilic organic solvent such as propylene glycol or a mixed solvent thereof, or a dry powder obtained by drying the extract.

For example, in order to obtain an extract of a clove, a bud of a clove is dried and cut into small pieces, a water / ethanol mixture is added thereto, and the mixture is occasionally stirred, immersed at room temperature, and pressed and separated to obtain an extract. After that, it may be filtered.

[0010] As the plant extract of the component (A), commercially available ones can be used.
For example, Falco Rex Clove, Green Tea Liquid, Cuckoo Extract Powder, Falco Rex Sohakuhi, Ougon Extract Powder, Ougon Liquid, Aloe MS, Spruce Extract Powder (all manufactured by Ichimaru Falcos Co., Ltd.), Oil-soluble Licorice Extract (Maruzen Pharmaceutical Co., Ltd.) Manufactured).

The plant extract of the component (A) may be used alone or in combination of two or more, and 0.001 to 20% by weight (hereinafter simply referred to as “% It is particularly preferable to add 0.005 to 10%.

The urea of component (B) used in the present invention is
It is preferable that 0.05 to 10%, particularly 0.2 to 5% is blended in the whole composition. If the amount is less than 0.05%, a sufficient effect cannot be obtained, and if the amount exceeds 10%, a corresponding effect cannot be obtained.

The urea stabilizer of component (C) used in the present invention is not particularly limited as long as it suppresses and stabilizes urea in an aqueous solution. And aliphatic dicarboxylic acids, allantoin, ammonium compounds, aminocarboxylic acids represented by 6-amino-n-caproic acid, amino acids represented by glycine and salts thereof, nicotinic acid and derivatives thereof.

The urea stabilizer of the component (C) can be used alone or in combination of two or more. The effective amount of the urea stabilizer depends on the type of the urea stabilizer. 5 to 200%, especially 1%, based on urea of B)
It is preferable to mix 0 to 100%.

Furthermore, in addition to the above essential components, various optional components used in ordinary cosmetics, quasi-drugs, pharmaceuticals, etc., such as oils, humectants, thickeners, preservatives, etc. Agents, emulsifiers, pigments, powders, pH adjusters, medicinal ingredients, ultraviolet absorbers, antioxidants, fragrances, and the like can be appropriately compounded.

Specifically, examples of oils include liquid paraffin, vaseline, paraffin wax, squalane, beeswax, carnauba wax, olive oil, lanolin, higher alcohols, fatty acids, synthetic ester oils of higher alcohols and fatty acids, silicone oils, and the like. Examples of the humectant include sorbitol, xylitol, glycerin, maltitol, propylene glycol, sodium pyrrolidonecarboxylate, polyoxypropylene fatty acid ester, and polyethylene glycol. And water-soluble polymers such as gelatin, and electrolytes such as sodium chloride and potassium chloride. Examples of preservatives include methyl paraben, ethyl paraben, and propyl paraben. Ben, butylparaben, sodium benzoate, etc., and as the emulsifier, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester And non-ionic surfactants such as polyoxyethylene hydrogenated castor oil and polyoxyethylene sorbitol fatty acid ester. Examples of powders include talc, sericite, mica, kaolin, silica, bentonite, vermiculite, zinc white, mica, and mica Titanium, titanium oxide, magnesium oxide, zirconium oxide, barium sulfate, red iron oxide, iron oxide, ultramarine and the like, and as the pH adjuster, citric acid-sodium citrate and other buffering agents The pharmaceutically active ingredients include arbutin, kojic acid, vitamin C and its derivatives, placenta extract, dipotassium glycyrrhizinate and the like.

The whitening cosmetic of the present invention can be produced according to a conventional method. Further, the whitening cosmetics that are the subject of the present invention are not limited to general skin cosmetics, but include quasi-drugs, external medicines, and the like, and their dosage forms are creams, emulsions, and lotions. , Foundation, pack,
Lotions, gels, solutions, sticks, etc. can be arbitrarily selected according to the purpose.

[0018]

EFFECT OF THE INVENTION The skin-whitening cosmetic composition of the present invention has enhanced skin permeability of the plant extract by using urea and a urea stabilizer in combination with a specific plant extract, and has an excellent whitening effect and sunburn. Has a preventive and therapeutic effect on spots and freckles, and is also highly safe.

[0019]

EXAMPLES The present invention will be described below in more detail with reference to examples, but the present invention is not limited by these examples. In the following examples, evaluation of skin permeability,
The evaluation of the whitening effect was performed by the following method.

Evaluation of skin permeability The back of pig skin is depilated, the surface is washed, and cut into small pieces of 4 cm square. Samples of Examples and Comparative Examples 40 μm shown below
1 is applied to the prepared pigskin and left at room temperature. After removing the unpermeated components remaining on the surface, the permeated components were extracted and collected, and the permeation amount of the plant extract was measured by HPLC. The amount of permeation was expressed as a value per coated area (μg / cm ² ).

Test of Whitening Effect on UV-B-Induced Pigment Spots The inner arm of 20 healthy male subjects was irradiated with ultraviolet rays in the UV-B region twice the minimum erythema dose once a day for 2 days. The whitening effect by continuously applying the sample to the test site twice a day on the pigmented spot thus obtained for one month was examined. The evaluation was performed using a color difference meter (CMS-1200, manufactured by Murakami Color Co., Ltd.), the L ^* value was calculated from the obtained Munsell value, and the ΔΔL ^* value representing the recovery was used. Note that ΔΔL ^*
The values were defined as follows: The sample application test site and the sample uncoated test site of the sample application immediately before the L ^* value, respectively L _0, L ₀ ', the site of the L ^* value of each of the post-continuous coating 1 month L _1, L _1', respectively as ΔΔL ^* was represented by the following equation. ΔΔL ^* = (L ₁ −L ₀ ) − (L ₁ ′ −L ₀ ′) Further, the evaluation was shown by the average value of 20 subjects. Table 1 shows the relationship between the evaluation points and the criteria.

[0022]

[Table 1]

In the following examples, when a liquid plant extract is used, the compounding amount is as follows:
Indicated by

Example 1 A cream having the composition shown in Table 2 was prepared by the following method.
Evaluation of skin permeability and evaluation of whitening effect by continuous application were performed. The amount of skin permeation was the amount of puerarin, the main component of Kakkon extract. The results are shown in Table 2. (Preparation method) After the oil phase components (1) to (6) were dissolved by heating at 80 ° C., the aqueous phase components (7) to (14) heated to 80 ° C. were added with stirring and emulsified (15). )
It was cooled to room temperature with stirring.

[0025]

[Table 2]

As is clear from Table 2, the product of the present invention had significantly higher skin permeability of the plant extract and an excellent whitening effect.

Example 2 Essences (cosmetics) having the compositions shown in Table 3 were prepared by the following method, and the whitening effect by continuous application was evaluated. Table 4 also shows the results. (Preparation method) After stirring and dispersing the components (1) to (5),
To this, 65 parts of purified water (11) was added to give A. on the other hand,
After the components (6), (7), (12) and (13) were stirred and dissolved, the remaining amount of purified water (11) was added to the mixture to give B.
After B was added to A while stirring to make it uniform, (8) to (1)
The component (0) was added and dissolved by stirring.

[0028]

[Table 3]

[0029]

[Table 4]

As is clear from Table 4, the product of the present invention has an excellent whitening effect.

[0031]

Example 3 Emulsion: An emulsion having the following composition was prepared by the following method. (Composition) (% by weight) (1) Polyoxyethylene sorbitan tristearate 1.0 (2) Glyceryl oleate 1.0 (3) Glyceryl monostearate 0.5 (4) Squalane 6.0 (5) Trioctane Glyceryl acid 2.0 (6) Cetyl octoate 2.0 (7) Stearyl alcohol 2.0 (8) Octyl methoxycinnamate 2.0 (9) 1,3-butylene glycol 5.0 (10) Glycerin 3 0.0 (11) Green tea extract ^{* 10} 5.0 (12) Urea 2.0 (13) Nicotinamide 1.0 (14) Remaining purified water (15) Preservatives appropriate amount (16) Flavors appropriate amount * 10: Green tea liquid (solid content: 1.0-2.5% by weight) manufactured by Ichimaru Falcos Co., Ltd.

(Preparation method) The oil phase components (1) to (8)
After the aqueous phase components (9) to (15) heated to 80 ° C. while being stirred and added to the solution heated and dissolved at 0 ° C. and emulsified,
(16) was added and the mixture was cooled to room temperature with stirring.

[0033]

Example 6 Lotion: A lotion having the following composition was prepared by the following method. (Composition) (% by weight) (1) 1,3-butylene glycol 6.0 (2) glycerin 4.0 (3) Sodium hyaluronate 0.1 (4) Ethanol 5.0 (5) Polyoxyethylene-oleyl Ether (20E.O.) 0.3 (6) Disodium edetate 0.1 (7) Sodium citrate 1.0 (8) Clove extract ^{* 11} 0.2 (9) Aloe extract ^{* 12} 2 (10) Urea 1.0 (11) Ammonium chloride 0.5 (12) Magnesium L-ascorbate phosphate 3.0 (13) Purified water Remaining (14) Preservatives proper amount (15) Fragrance proper amount * 11 : Ichimaru Falcos Co., Ltd., Falco Rex Chouzi (solid content: 2.0 to 4.0% by weight) * 12: Ichimaru Falcos Co., Ltd., Aloe MS

(Preparation method) After the components (1) to (3) were stirred and dispersed, 65 parts of purified water (13) was added to prepare A. On the other hand, after the components (4), (5), (14), and (15) were stirred and dissolved, the remaining amount of purified water (13) was added to the mixture to obtain B. After adding B while stirring A to make it uniform, (6)-
The component (12) was added and dissolved by stirring.

[0035]

Example 5 Cream Foundation: A cream foundation having the following composition was prepared by the following method. (Composition) (% by weight) (1) Dimethylpolysiloxane (6cs) 10.0 (2) Methylphenylpolysiloxane 3.0 (3) Octamethylcyclotetrasiloxane 10.0 (4) Polyoxyalkylene-modified silicone 0 (5) Titanium oxide 5.0 (6) Sericite 2.0 (7) Talc 3.0 (8) Bengala 0.4 (9) Iron oxide yellow 0.7 (10) Iron oxide black 0.1 ( 11) Glycerin 5.0 (12) Agon extract ^{* 13} 0.2 (13) Urea 1.0 (14) 6-amino-n-caproic acid 0.5 (15) Purified water Remaining (16) Preservative Appropriate amount (17) Spice Appropriate amount * 13: Ougon extract powder, manufactured by Ichimaru Falcos Co., Ltd.

(Preparation method) The components (1) to (10)
An aqueous phase obtained by heating and dissolving the components (11) to (16) at 80 ° C. was added to the mixture while heating and dissolving at 0 ° C., and the mixture was uniformly emulsified.

[0037]

Example 6 Pack: A pack having the following composition was prepared by the following method. (Composition) (% by weight) (1) Dipropylene glycol 3.0 (2) Polyethylene glycol 3.0 (3) 1,3-butylene glycol 1.0 (4) Glycerin 2.0 (5) Sodium pyrrolidonecarboxylate 1.0 (6) Mulberry bark extract ^{* 14} 1.5 (7) Urea 2.5 (8) Lactic acid 0.5 (9) Sodium lactate 0.5 (10) Polyvinyl alcohol 12.0 (11) Ethanol 3.0 (12) Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.3 (13) Remaining purified water (14) Appropriate amount of preservative (15) Appropriate amount of fragrance * 14: Falco Rex Souhakuhi, manufactured by Ichimaru Falcos Co., Ltd. (Solid content: 0.3-0.8% by weight)

(Preparation method) The components (1) to (9) were dissolved in 50 parts of purified water (13) with stirring to give A. (11), (1
After the components (2), (14) and (15) were stirred and dissolved, the remaining amount of purified water (13) was added to make the mixture uniform and B was obtained. (10) was added while stirring A, and after uniformly dispersing,
Was heated and dissolved. This was cooled to 45 ° C., B was added to make it uniform, and it was cooled to room temperature.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 35/78 A61K 35/78 JKQV ADA ADAC (72) Inventor Yuji Suzuki 3-28-1 Nakashitsu, Sakura City, Chiba Prefecture JP-A-52-79033 (JP, A) JP-A-53-88333 (JP, A) JP-A-3-251514 (JP, A) JP-A-54-2344 (JP, A) JP-A-63-303910 (JP, A) JP-A-60-214721 (JP, A) JP-A-3-90015 (JP, A) JP-A-2-111710 (JP, A) JP-A-4- 282305 (JP, A) JP-A-3-193713 (JP, A) JP-A-4-368315 (JP, A) (58) Fields investigated (Int. Cl. ⁶ , DB name) A61K 7/48 A61K 7 / 00 A61K 35/78

Claims (1)

(57) [Claims] 1. The following components (A), (B) and (C): (A) clove extract, green tea extract, kakkon extract, mulberry bark extract, licorice extract, ogre extract, aloe extract A whitening cosmetic comprising: one or two or more plant extracts selected from an extract and an orange peel extract; (B) urea; and (C) a urea stabilizer.