JP2003212715A - Sheet for cosmetic use - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a cosmetic sheet for keeping juvenescent, healthy and fresh skin and improving the symptom of atopic dermatitis. <P>SOLUTION: A solution containing hyaluronic acid and hydrolyzed silk as active components is impregnated in a nonwoven silk cloth and the obtained cosmetic sheet is applied to the skin to be treated. <P>COPYRIGHT: (C)2003,JPO

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic sheet used in the field of skin care, and more particularly to a cosmetic sheet comprising hyaluronic acid and hydrolyzed silk as active ingredients. And a cosmetic sheet impregnated with a silk non-woven fabric. [0002] Beautiful skin is a common desire of many women. For this reason, many skin care products such as emulsions and lotions are commercially available. In particular, in order to keep the skin fresh, many products containing moisturizing agents such as hyaluronic acid, glycerin, sorbitol, and polyethylene glycol as active ingredients are commercially available. Further, a cosmetic sheet or the like in which a support is impregnated to effectively absorb those active ingredients from the skin and is used for an application site is also commercially available. Further, those containing hyaluronic acid or the like as an active ingredient for preventing and treating atopic dermatitis are also commercially available. [0003] In these skin care products, the effective ingredient penetrates through the skin and exerts its effect. Therefore, the effective ingredient must be efficiently permeated from the skin. In order for the effective ingredient to penetrate efficiently, the skin is sufficiently moistened, and the active ingredient is easily penetrated into the skin.
It must be on the skin for a period of time. Emulsion and lotion have fluidity and may flow after being applied to the application site and may not stop at the application site. In addition, emulsions and lotions dry within a relatively short period of time, and have problems such as difficulty in sufficiently moistening the skin. In addition, due to the fluidity of the milky lotion and the lotion, it is not satisfactory in terms of handling, such as clothes are easily contaminated. Cosmetic sheets, such as face masks, in which a support is impregnated with an active ingredient and used for an application site, allow the active ingredient to remain on the skin for a long period of time and enable efficient absorption. Polyester, cotton, and the like are used as the support. Since these supports are in direct contact with the skin, those with little irritation are desired. For the purpose of preventing and treating atopic dermatitis, it is desired that the support itself be made of a material with less irritation, and a material having a composition close to the skin is required. [0004] The inventors of the present invention have conducted intensive studies and as a result have completed the present invention. That is, the present invention relates to a decorative sheet characterized by comprising hyaluronic acid and hydrolyzed silk as essential active ingredients, dissolving the same in water, and impregnating the silk nonwoven fabric.
By applying this cosmetic sheet to the application site, the skin is kept young and healthy and fresh, and in addition, the prevention of atopic dermatitis and the improvement of symptoms are improved. [0005] Hyaluronic acid, which is the first active ingredient of the cosmetic sheet according to the present invention, comprises D-glucuronic acid and N-acetyl-D-glucosamine alternately with a β-1,3-bond and a β-
It is a polysaccharide with repeated -1,4-bonds and is widely distributed in various animal tissues. In particular, it is abundant in navel cords, skin, and synovial fluid. Usually, it exists as a free acid or a salt, and forms a viscous gel, filling cells and fibers. Hyaluronic acid retains water between cells, retains cells by forming a matrix within the tissue, maintains skin lubricity and flexibility, resists mechanical forces and other external forces, and prevents bacterial infection. With many functions. Hyaluronic acid in the skin decreases with age, resulting in loss of skin moisture and aging, such as fine wrinkles, rough skin, and bulkiness. Thus, hyaluronic acid plays a very important role in vivo. It is necessary for youthful, healthy and fresh skin that this hyaluronic acid be sufficiently present in the skin. The hydrolyzed silk, which is the second active ingredient of the cosmetic sheet according to the present invention, is a peptide obtained by extracting silk fibers obtained from silkworms with dilute sulfuric acid. The silkworms made by silkworms mainly consist of proteins with a huge molecular structure, which are made into fine fibers and have a layered structure that overlaps. This is silk. Its main components are two proteins, sericin and fibroin. Traditionally, silk has been used in human life. Because of its excellent heat retention and touch, it is often used as clothing. The texture of silk is due to fibroin, and the action on the skin is due to sericin. In recent years, the excellent physiological action of sericin has been revealed. For example, it has been found that the action of suppressing the action of active oxygen, the action of inhibiting the activity of tyrokinase, which produces melanin pigment in the skin, the moisturizing action, and the antibacterial action are known. Hydrolyzed silk is a peptide in which two types of proteins have been cut into appropriate lengths, and can be effectively absorbed from the skin. [0007] The silk non-woven fabric, which is a support of the decorative sheet according to the present invention, is formed by shaping silk into Japanese paper, and the excellent functions of silk are efficiently exhibited. Silk is a protein similar to human skin, composed of 18 amino acids, and has excellent water retention and hygroscopicity. Its hygroscopicity is 1.5 times that of cotton.
In addition, since it is a non-woven fabric, a fibrous tissue is present at random and is well adapted to skin. The silk nonwoven fabric has the same composition as the second active ingredient hydrolyzed silk, and does not impair the activity of the hydrolyzed silk. Therefore, when hydrolyzed silk or hyaluronic acid is used as an active ingredient, it can be said that it is an optimal material as a support for a decorative sheet. As described above, the present invention uses two components, hyaluronic acid and hydrolyzed silk, as active ingredients, dissolves them in water, impregnates them into a silk nonwoven fabric, and uses them at the application site. At this time, hyaluronic acid, hydrolyzed silk, and the silk nonwoven fabric as the support work in association with each other, and produce a remarkable effect as compared with the case where they are used alone. The hyaluronic acid that can be used in the present invention may be a free acid, or any of its sodium salt and potassium salt. Examples of the production method include extraction from a chicken cop, fermentation, and the like. The hydrolyzed silk used in the present invention is a liquid obtained by extracting silk fibers obtained from silkworms with diluted sulfuric acid and neutralizing the extraction with a base, but is not limited thereto. . In the present invention, the concentration of hyaluronic acid is 0.1.
Between 1 and 1.0%, the hydrolyzed silk solution is 2 to 10
% Is appropriately selected. In addition to the hydrolyzed silk and hyaluronic acid, optional components such as alkyl p-hydroxybenzoate such as methyl p-hydroxybenzoate, glycerin, glycyrrhizic acid, chitosan, vitamin C,
Vitamin E, seaweed extract, fillet extract, polyoxyethylene sorbite, urea, squalane, fragrance and the like may be added. Examples of optional components include, but are not limited to, these. Hereinafter, preferred embodiments of the present invention will be described to clarify the usefulness of the present invention. It should be noted that this is an example, and it is apparent to those skilled in the art that the present invention is not limited to this example. Example 1 150 ml of water was heated to 80 ° C., and 100 mg of ethyl p-hydroxybenzoate, 24 mg of butyl p-hydroxybenzoate and 280 of methyl p-hydroxybenzoate were added to the water.
mg and propyl p-hydroxybenzoate (80 mg) were added, stirred and dissolved. Then, 1% hyaluronic acid 1
00g, glycerin 600mg, hydrolyzed silk solution 16
In the order of g, addition, stirring and dissolution were repeated. Water was added to this solution so that the total amount became 400 g, and the mixture was stirred until it became uniform. This solution was impregnated into a silk non-woven fabric whose eyes, nose and mouth were cut out, and used as a cosmetic sheet. Example 2 Forty subjects were divided into four groups of ten subjects A, B, C, and D, respectively, and group A was instructed to use the cosmetic sheet of Example 1. Group B was instructed to use a cosmetic sheet obtained by removing hyaluronic acid from the cosmetic sheet of Example 1 (Comparative Example 1), and Group C was a cosmetic sheet obtained by removing the hydrolyzed silk from the cosmetic sheet of Example 1. The use of a decorative sheet (Comparative Example 2) was instructed, and the use of a decorative sheet (Comparative Example 3) in which the support of the decorative sheet of Example 1 was replaced with cotton instead of silk nonwoven fabric was instructed to Group D. 1 for all 4 groups
Used once a day for 10 consecutive minutes for 7 days. The next day after continuous use, the subject reported the moist feeling of the skin. The evaluation was valid when a satisfactory moist feeling was felt, and invalid when not satisfied. As a result, Example 1
Of the makeup sheets of Comparative Example 1, 10 answered that the makeup sheet was effective, 5 of the makeup sheets of Comparative Example 1 answered that it was effective, and 6 of the makeup sheets of Comparative Example 2 answered that it was effective. Six people answered that the sheet was valid. Example 3 Twenty patients with atopic dermatitis were used as subjects and divided into four groups, each group consisting of five persons, and the cosmetic sheets of Example 1, Comparative Example 1, Comparative Example 2, and Comparative Example 3 were respectively obtained. 1
They were used once a day for 7 consecutive days. The next day after continuous use, subjects were asked to report symptoms of atopic dermatitis. As a result, in the cosmetic sheet of Example 1, two persons answered that the symptom was remarkably improved, and three persons answered that it was effective. In the cosmetic sheet of Comparative Example 1, two persons answered that it was valid, in Comparative Example 2, one person answered that it was valid, and in Comparative Example 3, two persons answered that it was valid. As described above, the cosmetic sheet according to the present invention comprises hyaluronic acid and hydrolyzed silk as essential components, and is used at an application site where a silk nonwoven fabric is impregnated. The unique effect is produced by the interaction of the silk non-woven fabric. By using the cosmetic sheet according to the present invention once a day for about 10 minutes, youthful, healthy and fresh skin can be maintained, and the symptoms of atopic dermatitis can be improved. did it. Further, since the present invention has a very high moisturizing effect, it is possible to improve dry skin pruritus. In particular, in winter in Japan, the air is dry, and the number of people suffering from skin pruritus due to dry skin is increasing, and many people have more severe symptoms. In such a case, use of the cosmetic sheet of the present invention can improve symptoms. Therefore, the present invention can be said to be a very useful skin care product.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (Reference) A61K 38/17 A61P 17/00 A61P 17/00 37/08 37/08 A61K 37/12 (72) Inventor Junichi Kumada 725, Kashigo, Oaza, Fukaya-shi, Saitama (72) Inventor Harutoku Ono 3-40-3 Taito, Taito-ku, Tokyo Yu-Hitsu Okachimachi 301 F-term (reference) 4C076 AA77 BB31 CC18 EE41 FF57 4C083 AC122 AC482 AD331 AD332 AD451 AD452 BB51 CC02 DD12 EE12 4C084 AA02 AA03 BA44 CA49 MA02 MA32 MA63 NA12 ZA891 ZB131 4C086 AA01 AA02 EA25 MA02 MA05 MA32 MA63 NA12 ZA89 ZB13

Claims (1)

Claims 1. A decorative sheet comprising hyaluronic acid and hydrolyzed silk as essential active ingredients, dissolved in water, and impregnated in a silk nonwoven fabric.