Temporary Disabled. :) please Go back Cortisone acetate - WikiProjectMed www.fgks.org » Address: [go: up one dir, main page] Include Form Remove Scripts Accept Cookies Show Images Show Referer Rotate13 Base64 Strip Meta Strip Title Session Cookies Cortisone acetate From WikiProjectMed (Redirected from Cortisone) Jump to navigation Jump to search This article is about the medication. For the natural hormone, see Cortisone (hormone). Cortisone acetateNamesTrade namesAdreson, Cortison, Cortisone, Cortisone Acetate, Cortone, Cortistab, Cortisyl, othersOther namesCortisone 21-acetate; 17α,21-Dihydroxypregn-4-ene-3,11,20-trione 21-acetate IUPAC name [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate Clinical dataDrug classCorticosteroid (glucocorticoid, mineralocorticoid)[1]Main usesAdrenal insufficiency, high blood calcium, autoimmune diseases, COPD, allergic reactions, tuberculosis[2][3]Side effectsOsteoporosis, cataracts, weakness, thrush[2]Typical dose25 to 300 mg/day[2]External linksAHFS/Drugs.comMonographChemical and physical dataFormulaC23H30O6Molar mass402.487 g·mol−13D model (JSmol)Interactive image SMILES CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O InChI InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1Key:ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate, sold under various brand names, is a corticosteroid used for a number of conditions.[2][4] Some of these include adrenal insufficiency, high blood calcium, autoimmune diseases, COPD, allergic reactions, and certain types of tuberculosis.[2][3] It is taken by mouth.[2] Effects generally last for 1 to 2 days.[2] Commonly long term use results in osteoporosis, cataracts, weakness, and thrush.[2] Other side effects may include infection, adrenal insufficiency, swelling, and poor wound healing.[2] While short term use in the later part of pregnancy is safe, long term use may result in harm to the baby.[5] It is a manufactured steroid with both glucocorticoid and mineralocorticoid properties.[1] Cortisone acetate was approved for medical use in the United States in 1950.[2] It is available as a generic medication.[2] In the United States 90 pills of 25 mg costs about 110 USD as of 2022.[6] It is marketed in many countries globally.[7] Contents 1 Medical uses 1.1 Dosage 2 Side effects 3 Mechanism of action 4 Popular culture 5 References 6 External links Medical uses A cortisone injection may provide short-term pain relief and may reduce the swelling from inflammation of a joint, tendon, or bursa in, for example, the joints of the knee, elbow and shoulder[8] and into a broken coccyx.[9] Cortisone is also used by dermatologists to treat keloids,[10] relieve the symptoms of eczema and atopic dermatitis,[11] and stop the development of sarcoidosis. Dosage The typical dose in adults is 25 to 300 mg per day.[2] Side effects Oral use of cortisone has a number of potential systemic adverse effects, including asthma, hyperglycemia, insulin resistance, diabetes mellitus, osteoporosis, anxiety, depression, amenorrhoea, cataracts, glaucoma, Cushing's syndrome, increased risk of infections and impaired growth.[8][12][12] With topical application, it can lead to thinning of the skin, impaired wound healing, increased skin pigmentation, tendon rupture and skin infections (including abscesses).[13] Mechanism of action It is the C21 acetate ester of cortisone,[4][7] and acts as a prodrug of cortisone in the body.[14] Popular culture Addiction to cortisone was the subject of the 1956 motion picture Bigger Than Life, produced by and starring James Mason. John F. Kennedy was regularly administered corticosteroids such as cortisone as a treatment for Addison's disease.[15] References ↑ 1.0 1.1 I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 85–. ISBN 978-94-011-4439-1. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 "Cortisone Acetate Monograph for Professionals". Drugs.com. Archived from the original on 6 December 2021. Retrieved 7 January 2022. ↑ 3.0 3.1 "DailyMed - CORTISONE ACETATE tablet". dailymed.nlm.nih.gov. Archived from the original on 11 January 2022. Retrieved 7 January 2022. ↑ 4.0 4.1 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 317–. ISBN 978-1-4757-2085-3. Archived from the original on 17 October 2021. Retrieved 17 October 2021. ↑ "Cortisone (Cortone Acetate) Use During Pregnancy". Drugs.com. Archived from the original on 6 December 2021. Retrieved 7 January 2022. ↑ "Cortisone Prices, Coupons & Savings Tips - GoodRx". GoodRx. Archived from the original on 27 October 2016. Retrieved 7 January 2022. ↑ 7.0 7.1 Index Nominum 2000: International Drug Directory. Taylor & Francis. 2000. pp. 276–. ISBN 978-3-88763-075-1. ↑ 8.0 8.1 "Cortisone shots". MayoClinic.com. 2010-11-16. Archived from the original on 2013-09-01. Retrieved July 31, 2013. ↑ "injections and needles for coccyx pain". www.coccyx.org. Archived from the original on 2017-07-03. Retrieved 2022-01-07. ↑ Zanon, E; Jungwirth, W; Anderl, H (1992). "Cortisone jet injection as therapy of hypertrophic keloids". Handchirurgie, Mikrochirurgie, Plastische Chirurgie. 24 (2): 100–2. PMID 1582609. ↑ "All About Atopic Dermatitis". National Eczema Association. Archived from the original on 2012-01-30. Retrieved 2022-01-07. ↑ 12.0 12.1 "Prednisone and other corticosteroids: Balance the risks and benefits". MayoClinic.com. 2010-06-05. Archived from the original on 2013-12-13. Retrieved 2017-12-21. Cite error: Invalid <ref> tag; name "mayorisk2" defined multiple times with different content ↑ Cole, BJ; Schumacher (Jan–Feb 2005). "Injectable Corticosteroids in Modern Practice". Journal of the American Academy of Orthopaedic Surgeons. 13 (1): 37–46. CiteSeerX 10.1.1.562.1931. doi:10.5435/00124635-200501000-00006. PMID 15712981. S2CID 18658724. ↑ Løvås K, Husebye ES (2003). "Replacement therapy in Addison's disease". Expert Opin Pharmacother. 4 (12): 2145–9. doi:10.1517/14656566.4.12.2145. PMID 14640913. S2CID 37628998. ↑ Altman, Lawrence (October 6, 1992). "The doctor's world; Disturbing Issue of Kennedy's Secret Illness". The New York Times. Archived from the original on November 8, 2020. Retrieved January 7, 2022. External links Identifiers:CAS Number: 50-04-4PubChem CID: 5745DrugBank: DB01380ChemSpider: 5543UNII: 883WKN7W8XKEGG: D00973ChEBI: CHEBI:3897ChEMBL: ChEMBL1650 vteGlucocorticoids and antiglucocorticoids (D07, H02)GlucocorticoidsNatural Cortisone Cortisone acetate Cortodoxone (cortexolone, 11-deoxycortisol) Desoxycortone (deoxycortone, cortexone, 11-deoxycorticosterone) Desoxycortone esters Hydrocortisone (cortisol)# Hydrocortisone esters Prebediolone acetate Pregnenolone Pregnenolone acetate Pregnenolone succinate Synthetic Cortisol-like and related (16-unsubstituted): Chloroprednisone Cloprednol Difluprednate Fludrocortisone Flugestone acetate (flurogestone acetate) Fluocinolone Fluorometholone Fluorometholone acetate Fluperolone Fluperolone acetate Fluprednisolone Fluprednisolone esters Loteprednol Medrysone Methylprednisolone Methylprednisolone esters Prednicarbate Prednisolone# Prednisone Tixocortol Tixocortol pivalate Methasones and related (16-substituted): Alclometasone Beclometasone Beclometasone esters Betamethasone# Betamethasone esters Clobetasol Clobetasol propionate Clobetasone Clocortolone Clocortolone esters Cortivazol Desoximetasone Dexamethasone Dexamethasone esters Diflorasone Diflucortolone Diflucortolone valerate Fluclorolone Flumetasone Fluocortin Fluocortolone Fluocortolone esters Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halometasone Meprednisone Mometasone Mometasone furoate Paramethasone Prednylidene Rimexolone Triamcinolone Ulobetasol (halobetasol) Cyclic ketals (16,17-cyclized): Amcinonide Budesonide Ciclesonide Deflazacort Desonide Fluclorolone acetonide (flucloronide) Fludroxycortide (flurandrenolone, flurandrenolide) Flunisolide Fluocinolone acetonide Fluocinonide Formocortal (fluoroformylone) Halcinonide Triamcinolone acetonide Triamcinolone acetonide esters Antiglucocorticoids Antagonists: Aglepristone Ketoconazole Mifepristone Ulipristal acetate Synthesis modifiers Acetoxolone Aminoglutethimide Carbenoxolone Enoxolone Ketoconazole Metyrapone Mitotane Trilostane #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III See also Glucocorticoid receptor modulators Mineralocorticoids and antimineralocorticoids List of corticosteroids vteMineralocorticoids and antimineralocorticoids (H02)Mineralocorticoids Desoxycortone (desoxycorticosterone) Desoxycortone esters Hydrocortisone (cortisol) Hydrocortisone esters Fludrocortisone Fludrocortisone acetate Methylprednisolone Methylprednisolone esters Prednisolone Prednisolone esters Prednisone Prednisone esters Antimineralocorticoids Steroidal: Canrenoate potassium (potassium canrenoate) Canrenone Drospirenone Dydrogesterone Eplerenone Gestodene Medrogestone Progesterone Spironolactone Trimegestone Nonsteroidal: Amlodipine Apararenone§ Benidipine Esaxerenone† Felodipine Finerenone† Nifedipine Nimodipine Nitrendipine Synthesis modifiers Acetoxolone Aminoglutethimide Carbenoxolone Enoxolone Ketoconazole Metyrapone Mitotane Trilostane #WHO-EM ‡Withdrawn from market Clinical trials: †Phase III §Never to phase III See also Mineralocorticoid receptor modulators Glucocorticoids and antiglucocorticoids List of corticosteroids vteGlucocorticoid receptor modulatorsGRAgonists Cortisol-like and related (16-unsubstituted): 3α,5α-Tetrahydrocorticosterone 5α-Dihydrocorticosterone 9α-Fluorocortisone (alfluorone) 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone) 11-Dehydrocorticosterone acetate 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone) Desoxycortone esters 11-Deoxycortisol (cortodoxone, cortexolone) Cortifen (cortiphen, kortifen) Cortodoxone acetate 21-Deoxycortisol Δ7-Prednisolone Δ7-Prednisolone 21-acetate Amebucort Chloroprednisone Chloroprednisone acetate Cloprednol Cloprednol acetate Corticosterone Corticosterone acetate Corticosterone benzoate Cortisol (hydrocortisone) Benzodrocortisone (hydrocortisone benzoate) Hydrocortamate (hydrocortisone diethylaminoacetate) Hydrocortisone esters Cortisone Cortisone acetate Deprodone Deprodone propionate Dichlorisone Dichlorisone acetate Dichlorisone diacetate Difluprednate Endrisone (endrysone) Etiprednol Etiprednol dicloacetate (etiprednol dichloroacetate) Fludrocortisone (fludrocortone) Fludrocortisone acetate Fluorometholone Fluorometholone acetate Fluperolone Fluperolone acetate Fluprednisolone Fluprednisolone esters Halopredone Halopredone acetate (halopredone diacetate) Isoflupredone (9α-fluoroprednisolone) Isoflupredone acetate Loteprednol Mazipredone (depersolone) Medrysone Methylprednisolone Methylprednisolone esters Prebediolone Prebediolone acetate Prednisolone Prednazate Prednazoline Prednicarbate (prednisolone ethylcarbonate propionate) Prednimustine Prednisolamate (prednisolone diethylaminoacetate) Prednisolone esters Prednisone Prednisone esters Pregnenolone Pregnenolone acetate Pregnenolone succinate (pregnenolone hemisuccinate) Resocortol Tipredane Tixocortol Butixocort (tixocortol butyrate) Butixocort propionate Tixocortol pivalate Methasones and related (16-substituted): 16α-Methyl-11-oxoprednisolone Alclometasone Alclometasone dipropionate Amelometasone Beclometasone (beclomethasone) Beclometasone esters Betamethasone (betametasone) Betamethasone esters Cortobenzolone (betamethasone salicylate) Ciclometasone (ciclomethasone, cyclomethasone) Clobetasol Clobetasol propionate Clobetasone Clobetasone butyrate Clocortolone Clocortolone esters Cloticasone Cloticasone propionate Cormetasone (cormethasone) Cormetasone acetate Descinolone Desoximetasone (desoxymethasone) Dexamethasone (dexametasone) Dexamethasone esters Diflorasone Diflorasone diacetate Diflucortolone Diflucortolone pivalate Diflucortolone valerate Dimesone Dimesone acetate Doxibetasol (doxybetasol) Fluclorolone Flumetasone (flumethasone) Flumetasone acetate Flumetasone pivalate Fluocinolone Fluocortin Fluocortin butyl (fluocortin butylate) Fluocortolone Fluocortolone esters Fluprednidene (fluprednylidene) Fluprednidene acetate Fluticasone Fluticasone furoate Fluticasone propionate Halocortolone Halometasone Icometasone Icometasone enbutate (icometasone butyrate acetate) Isoprednidene Locicortolone (locicortone) Locicortolone dicibate (locicortone dicibate) Meclorisone Meclorisone dibutyrate Meprednisone (methylprednisone) Meprednisone acetate Meprednisone hydrogen succinate (methylprednisone hemisuccinate) Mometasone Mometasone furoate Paramethasone Paramethasone acetate Paramethasone disodium phosphate Paramethasone phosphate Prednylidene Prednylidene diethylaminoacetate Rimexolone Ticabesone Ticabesone propionate Timobesone Timobesone acetate Triamcinolone Triamcinolone diacetate Ulobetasol (halobetasol) Ulobetasol propionate Vamorolone Cyclic ketals (16,17-cyclized): Acrocinonide (triamcinolone acroleinide) Amcinafal (triamcinolone pentanonide) Amcinafide (triamcinolone acetophenide) Amcinonide (triamcinolone acetate cyclopentanonide) Budesonide Ciclesonide Cicortonide Deflazacort (azacort) Descinolone acetonide Desonide (hydroxyprednisolone acetonide) Desonide disodium phosphate Desonide pivalate Dexbudesonide Drocinonide Drocinonide phosphate Fluazacort Fluclorolone acetonide (flucloronide) Fludroxycortide (flurandrenolone, flurandrenolide) Flumoxonide Flunisolide Flunisolide acetate Fluocinolone acetonide Ciprocinonide (fluocinolone acetonide cyclopropylcarboxylate) Fluocinonide (fluocinolide, fluocinolone acetonide acetate) Procinonide (fluocinolone acetonide propionate) Formocortal Halcinonide Itrocinonide Rofleponide Rofleponide palmitate Tralonide Triamcinolone acetonide Flupamesone (triamcinolone acetonide metembonate) Triamcinolone acetonide esters Triamcinolone aminobenzal benzamidoisobutyrate (TBI-PAB) Triclonide Others/atypical (other expanded steroid ring systems, homosteroids, and non-pregnane steroids): Cortisuzol Cortivazol Domoprednate Naflocort Nicocortonide Nicocortonide acetate Nivacortol (nivazol) Oxisopred RU-26988 RU-28362 Non-corticosteroids with some glucocorticoid activity: 15β-Hydroxycyproterone acetate 17α-Hydroxyprogesterone Bromoketoprogesterone Chlormadinone acetate Cyproterone Cyproterone acetate Danazol Delmadinone acetate Desogestrel DU-41165 Etonogestrel Flugestone Flugestone acetate (flurogestone acetate) Fluoromedroxyprogesterone acetate Fluoxymesterone Gestodene Medrogestone Medroxyprogesterone acetate Megestrol acetate Metribolone Norgestomet Osaterone acetate Progesterone Promegestone RU-2309 Quingestrone Segesterone acetate (nestorone) Tetrahydrogestrinone Nonsteroidal glucocorticoids: AZD-5423 GSK-9027 Mixed(SEGRMs) Dagrocorat Fosdagrocorat Mapracorat Antagonists 7α-Hydroxy-DHEA 17α-Methylprogesterone Aglepristone Asoprisnil Asoprisnil ecamate C108297 C113176 CORT-108297 Cyproterone acetate Exicorilant (CORT-125281) Guggulsterone Ketoconazole Lilopristone LLY-2707 Metapristone (RU-42633) Miconazole Mifepristone (RU-486) Miricorilant (CORT-118335) Onapristone ORG-34116 ORG-34517 (SCH-900636) ORG-34850 Pregnenolone 16α-carbonitrile Relacorilant (CORT-125134) RTI 3021–012 RTI 3021–022 Telapristone Tibolone Toripristone Ulipristal acetate Others Antisense oligonucleotides: IONIS-GCCRRx (ISIS-426115) See also Receptor/signaling modulators Glucocorticoids and antiglucocorticoids Mineralocorticoid receptor modulators List of corticosteroids vteMineralocorticoid receptor modulatorsMRAgonists 11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone) 11-Dehydrocorticosterone acetate 11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone) Desoxycortone esters 11-Deoxycortisol (cortodoxone, cortexolone) Cortifen (cortiphen, kortifen) Cortodoxone acetate 11β-Hydroxyprogesterone 16α,18-Dihydroxy-11-deoxycorticosterone 17α-Hydroxyaldosterone 18-Hydroxy-11-deoxycorticosterone 19-Norprogesterone Aldosterone Corticosterone Corticosterone acetate Corticosterone benzoate Cortisol (hydrocortisone) Benzodrocortisone (hydrocortisone benzoate) Hydrocortamate (hydrocortisone diethylaminoacetate) Hydrocortisone esters Cortisone Cortisone acetate Fludrocortisone (fludrocortone) Fludrocortisone acetate Mometasone Mometasone furoate Prednisolone Prednazate Prednazoline Prednicarbate (prednisolone ethylcarbonate propionate) Prednimustine Prednisolamate (prednisolone diethylaminoacetate) Prednisolone esters Prednisone Prednisone esters Antagonists Steroidal: 6β-Hydroxy-7α-thiomethylspironolactone 7α-Acetylthio-17α-hydroxyprogesterone 7α-Thiomethylspironolactone (SC-26519) 7α-Thioprogesterone (SC-8365) 7α-Thiospironolactone (SC-24813) 16α-Hydroxyprogesterone 17α-Hydroxyprogesterone (hydroxyprogesterone) 18-Deoxyaldosterone 18,19-Dinorprogesterone Canrenoate potassium (potassium canrenoate) Canrenoic acid (canrenoate) Canrenone (canrenoate y-lactone) Dicirenone Dimethisterone Drospirenone Dydrogesterone Eplerenone Gestodene Guggulsterone Hydroxyprogesterone caproate Medrogestone Mespirenone Metribolone Mexrenoate potassium Mexrenoic acid (mexrenoate) Mexrenone Oxprenoic acid (oxprenoate) Oxprenoate potassium (RU-28318) Pregnenolone Progesterone Prorenoate potassium Prorenoic acid (prorenoate) Prorenone RO-14-9012 RU-26752 SC-5233 (spirolactone) SC-8109 SC-11927 (CS-1) SC-19886 SC-27169 Spirorenone Spironolactone Spiroxasone Tibolone Trimegestone ZK-91587 ZK-97894 Nonsteroidal: Amlodipine Apararenone Benidipine BR-4628 Esaxerenone Felodipine Finerenone Miricorilant (CORT-118335) Nifedipine Nimodipine Nitrendipine PF-03882845 SM-368229 See also Receptor/signaling modulators Mineralocorticoids and antimineralocorticoids Glucocorticoid receptor modulators List of corticosteroids This article about a steroid is a stub. 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Cortisone acetate, sold under various brand names, is a corticosteroid used for a number of conditions.[2][4] Some of these include adrenal insufficiency, high blood calcium, autoimmune diseases, COPD, allergic reactions, and certain types of tuberculosis.[2][3] It is taken by mouth.[2] Effects generally last for 1 to 2 days.[2]
Commonly long term use results in osteoporosis, cataracts, weakness, and thrush.[2] Other side effects may include infection, adrenal insufficiency, swelling, and poor wound healing.[2] While short term use in the later part of pregnancy is safe, long term use may result in harm to the baby.[5] It is a manufactured steroid with both glucocorticoid and mineralocorticoid properties.[1]
Cortisone acetate was approved for medical use in the United States in 1950.[2] It is available as a generic medication.[2] In the United States 90 pills of 25 mg costs about 110 USD as of 2022.[6] It is marketed in many countries globally.[7]
A cortisone injection may provide short-term pain relief and may reduce the swelling from inflammation of a joint, tendon, or bursa in, for example, the joints of the knee, elbow and shoulder[8] and into a broken coccyx.[9]
Cortisone is also used by dermatologists to treat keloids,[10] relieve the symptoms of eczema and atopic dermatitis,[11] and stop the development of sarcoidosis.
The typical dose in adults is 25 to 300 mg per day.[2]
Oral use of cortisone has a number of potential systemic adverse effects, including asthma, hyperglycemia, insulin resistance, diabetes mellitus, osteoporosis, anxiety, depression, amenorrhoea, cataracts, glaucoma, Cushing's syndrome, increased risk of infections and impaired growth.[8][12][12] With topical application, it can lead to thinning of the skin, impaired wound healing, increased skin pigmentation, tendon rupture and skin infections (including abscesses).[13]
It is the C21 acetate ester of cortisone,[4][7] and acts as a prodrug of cortisone in the body.[14]
Addiction to cortisone was the subject of the 1956 motion picture Bigger Than Life, produced by and starring James Mason.
John F. Kennedy was regularly administered corticosteroids such as cortisone as a treatment for Addison's disease.[15]
<ref>
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