Maximiliano Sortino

Quiroga, J., Cisneros, C., Insuasty, B., Abonía, R., Nogueras, M., Sortino, M. and Zacchino, S.(2006), Solvent-free microwave multicomponent regiospecific synthesis of pyrimido [4, 5-c] isoquinolines and evaluation In Vitro of their antifungal properties. Journal of Heterocyclic ...

... The MIC was defined as the minimum inhibitory concentration of the extract which resulted in total inhibition of the fungal growth. Jan-Feb 2005 ... Biol., 36, 47 (2002); [e] D. Mares, C. Romagnoli, E. Andreotti, M. Manfrini and CB J. Vicentini, Agric. ... [10a] L. Svetaz, A. Tapia, S. López ...

Multicomponent reactions (MCRs) and microwave-assisted organic synthesis (MAOS) have been used as key methods for the synthesis of fused dihydropyrimidine derivatives. The three-component condensation of 3-amino-5-alkylthio-1,2,4-triazoles with aromatic aldehydes and acetoacetamides under microwave irradiation was developed as a rapid and efficient solution-phase method for the high-yielding preparation of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]pyrimidine-6-carboxamide libraries. In addition, the selective reduction of the formed dihydrotriazolopyrimidines to trans-trans-2-alkylthio-7-aryl-4,5,6,7-tetrahydro-1,2,4-triazolo[1,5-a]pyrimidine-6-carboxamides was established. The described synthetic protocols provide rapid access to novel and diversely substituted dihydroazolopyrimidine libraries.

Abstract: New 2-and 4-methylenedioxyphenyl-8-phenyl-2, 3-dihydropyrazolo [3, 4-b] diazepines 3 were obtained from the reaction of 4, 5-diamino-3-methyl-l-phenylpyrazole 1 with one equivalent of the methylenedioxychalcones 2 in both absolute ethanol and under ...