Jasneet Sandhu

Background and objective: Nephropathy is the major cause of end-stage renal disease (ESRD) in type 2 diabetes mellitus (T2DM). Delay in identification and management of nephropathy in T2DM may cause development of ESRD. An increased level of serum ferritin plays a role in the pathogenesis of chronic kidney disease (CKD) in T2DM. Hence, the present study intended to assess the level of serum ferritin in renal dysfunction in patients with T2DM. Material and methods: This was a retrospective study with 81 T2DM patients with and without nephropathy. They were categorized into two groups. Group-1 consisted of 46 T2DM cases without nephropathy and remaining 35 with nephropathy.The clinical and biochemical parameters such as blood glucose, urea, creatinine, iron, ferritin, transferrin, total iron binding capacity (TIBC), and haemoglobin were measured by standard methods, and estimated glomerular filtration rate (eGFR) by MDRD formula. Results: Significantly (p<0.05) elevated level of se...

Background: In pathology, peripheral blood smear (PBS) interpretation is one of the essential hematological investigations and so is the skill of smear preparation. Among students, this skill seemed to decline with time. Although as syllabus mandatory they had learned to do smear preparation in first year Bachelor of Medicine and Bachelor of Surgery (MBBS), in second year pathology practical assessments their performance for the same was found ineffective. Therefore, the study was taken up to know if there would be skill improvement of their previously acquired ability when reinforced. Aim: The study was taken up to assess if there was skill improvement after a lecture-demonstration sessions using objective structured practical examination (OSPE) as an assessment tool. Materials and Methods: A total of 36 randomly selected second year MBBS students from the Department of Pathology, Mandya Institute of Medical Sciences consented to be study participants. A pre-study assessment follow...

Introduction: Thyroid lesions are a commonly encountered clinical problem in all age groups. Accurate preoperative assessment guides the clinical management and improves the patient outcome. Aim: To describe the cytomorphological features of palpable thyroid nodules using fine needle aspiration cytology (FNAC) along with the assessment of thyroid hormonal status of the patient. The study also tried to assess the sensitivity, specificity and diagnostic accuracy of FNAC as an initial diagnostic modality for thyroid lesions. Materials and Methods: The study was conducted in the Department of Pathology of a teaching hospital during July 2013 to December 2014 and included 350 patients with thyroid lesions. Cytological assessment was done using FNAC along with serological assessment of thyroid hormones and cytohistopathological correlation. Results: A total of 350 patients underwent cytomorphological assessment using FNAC, of which most were females with most patients being in the age gro...

Introduction: Cervical carcinomas are the third leading cause of mortality in women in developing countries. Various clinical, pathological, and molecular-based screening methodologies have been developed for early detection of cervical carcinoma. Aim: The aim of this study was to determine the frequency and pattern of p53 expression in normal, cervical intraepithelial neoplasia (CIN), and invasive carcinoma with clinico-pathological correlation. Methodology: A total of 30 cases of cervical biopsy/hysterectomy specimens of carcinoma cervix and 30 cases of hysterectomy specimens for other gynecologic causes received at the Department of Pathology, from January to December 2012 were examined for gross and microscopic features. Immunohistochemistry was used to study the p53 expression in normal and neoplastic cervical epithelium. The p53 expression was correlated with various clinico-pathological prognostic parameters. Results: Of the 30 cases of carcinoma cervix, 86.7% of the cases sh...