Research Interests:
This Review describes the work conducted by the TRANSBIG consortium in the development of the MINDACT (Microarray In Node negative Disease may Avoid ChemoTherapy) trial. The goal of the trial is to provide definitive evidence regarding... more
This Review describes the work conducted by the TRANSBIG consortium in the development of the MINDACT (Microarray In Node negative Disease may Avoid ChemoTherapy) trial. The goal of the trial is to provide definitive evidence regarding the clinical relevance of the 70-gene prognosis signature, and to assess the performance of this signature compared with that of traditional prognostic indicators for assigning adjuvant chemotherapy to patients with node-negative breast cancer. We outline the background work and the key questions in node-negative early-stage breast cancer, and then focus on the MINDACT trial design and statistical considerations. The challenges inherent in this trial in terms of logistics, implementation and interpretation of the results are also discussed. We hope that this article will trigger further discussion about the difficulties of setting up and analyzing trials aimed at establishing the worth of new methods for better selection of patients for cancer treatment.
Research Interests:
Research Interests:
Research Interests: Clinical Trial, Magnetic Resonance Imaging, Treatment Outcome, Literature Review, Humans, and 19 moreEurope, Female, Male, Clinical Sciences, European, Aged, Neoplasms, Retrospective Studies, Simulation Study, Targeted Therapy, Disease Progression, X ray Computed Tomography, Protein Kinase Inhibitors, Non small Cell Lung Cancer, Clinical evaluation, Quinazolines, Evaluation Criteria, Lymph nodes, and Clinical Trials as Topic(Europe, Female, Male, Clinical Sciences, European, Aged, Neoplasms, Retrospective Studies, Simulation Study, Targeted Therapy, Disease Progression, X ray Computed Tomography, Protein Kinase Inhibitors, Non small Cell Lung Cancer, Clinical evaluation, Quinazolines, Evaluation Criteria, Lymph nodes, and Clinical Trials as Topic)
(Europe, Female, Male, Clinical Sciences, European, Aged, Neoplasms, Retrospective Studies, Simulation Study, Targeted Therapy, Disease Progression, X ray Computed Tomography, Protein Kinase Inhibitors, Non small Cell Lung Cancer, Clinical evaluation, Quinazolines, Evaluation Criteria, Lymph nodes, and Clinical Trials as Topic)