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Recommended Screening and Preventive Practices for Long-term Survivors after Hematopoietic Cell Transplantation: Joint Recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood a...more
Advances in hematopoietic cell transplantation (HCT) technology and supportive care techniques have led to improvements in long-term survival after HCT. Emerging indications for transplantation, introduction of newer graft sources (eg,... more
Advances in hematopoietic cell transplantation (HCT) technology and supportive care techniques have led to improvements in long-term survival after HCT. Emerging indications for transplantation, introduction of newer graft sources (eg, umbilical cord blood) and transplantation of older patients using less intense conditioning regimens have also contributed to an increase in the number of HCT survivors. These survivors are at risk for developing late complications secondary to pre-, peri-, and posttransplantation exposures and risk factors. Guidelines for screening and preventive practices for HCT survivors were published in 2006. An international group of transplantation experts was convened in 2011 to review contemporary literature and update the recommendations while considering the changing practice of transplantation and international applicability of these guidelines. This review provides the updated recommendations for screening and preventive practices for pediatric and adult survivors of autologous and allogeneic HCT.
Publication Date: 2006
Publication Name: Biology of Blood and Marrow Transplantation
Research Interests: Risk, Survival Analysis, Community Health, Treatment Outcome, Humans, and 19 moreEurope, Survivors, United States, Female, Male, Follow-up studies, Risk factors, Umbilical Cord Blood, Clinical Sciences, Middle Aged, Bone Marrow Transplantation, Adult, Time Factors, Risk Factors, Hematologic Diseases, Umbilical Cord, SECONDARY PREVENTION, Health Personnel, and Hematopoietic Cell Transplantation(Europe, Survivors, United States, Female, Male, Follow-up studies, Risk factors, Umbilical Cord Blood, Clinical Sciences, Middle Aged, Bone Marrow Transplantation, Adult, Time Factors, Risk Factors, Hematologic Diseases, Umbilical Cord, SECONDARY PREVENTION, Health Personnel, and Hematopoietic Cell Transplantation)
(Europe, Survivors, United States, Female, Male, Follow-up studies, Risk factors, Umbilical Cord Blood, Clinical Sciences, Middle Aged, Bone Marrow Transplantation, Adult, Time Factors, Risk Factors, Hematologic Diseases, Umbilical Cord, SECONDARY PREVENTION, Health Personnel, and Hematopoietic Cell Transplantation)
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Sickle cell disease is a genetic disorder involving a defect in the red blood cells due to its sickled hemoglobin. The main therapeutic interventions include preventive and supportive measures. Hematopoietic stem cell transplantations are... more
Sickle cell disease is a genetic disorder involving a defect in the red blood cells due to its sickled hemoglobin. The main therapeutic interventions include preventive and supportive measures. Hematopoietic stem cell transplantations are carried out with the aim of replacing the defective cells and their progenitors (hematopoietic (i.e. blood forming) stem cells) in order to correct the disorder. To determine whether stem cell transplantation can improve survival and prevent symptoms and complications associated with sickle cell disease. To examine the risks of stem cell transplantation against the potential long-term gain for people with sickle cell disease. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group Group's Haemoglobinopathies Trials Register complied from electronic searches of the Cochrane Central Register of Controlled Trials (CENTRAL) (updated each new issue of The Cochrane Library) and quarterly searches of MEDLINE.Unpublished work was identified by searching the abstract books of major conference proceedings and we conducted a search of the website: www.ClinicalTrials.gov.Date of the most recent search of the Group's Haemoglobinopathies Trials Register: 16 August 2012. Randomized controlled and quasi-randomized studies that compared any method of stem cell transplantation with either each other or with any of the preventive or supportive interventions (e.g. periodic blood transfusion, use of hydroxyurea, antibiotics, pain relievers, supplemental oxygen) in people with sickle cell disease irrespective of the type of sickle cell disease, gender and setting. No relevant trials were identified. Ten trials were identified by the initial search and none for the update. None of these trials were suitable for inclusion in this review. Reports on the use of hematopoietic stem cell transplantation improving survival and preventing symptoms and complications associated with sickle cell disease are currently limited to observational and other less robust studies. No randomized controlled trial assessing the benefit or risk of hematopoietic stem cell transplantations was found. Thus, this systematic review identifies the need for a multicentre randomized controlled trial assessing the benefits and possible risks of hematopoietic stem cell transplantations comparing sickle status and severity of disease in people with sickle cell disease.
Publication Date: 2013
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Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipientsmore
by A. Seber and Lucia Silla
Publication Date: 2007
Publication Name: Bone Marrow Transplantation
Research Interests: Brazil, Adolescent, Multivariate Analysis, Prospective studies, Humans, and 27 moreChild, Escherichia coli, Gram Positive, Female, Male, Infant, Bone marrow, Cephalosporins, Incidence, Risk factors, Pseudomonas aeruginosa, Clinical Sciences, Aged, Middle Aged, Gram-negative bacteria, Anti-Bacterial Agents, Bone Marrow Transplantation, Adult, Carbapenems, Bacteremia, Risk Factors, Pseudomonas Aeruginosa, Multi Drug Resistant Cancer, Predictive value of tests, Confidence Interval, Klebsiella pneumoniae, and Hematopoietic Stem Cell Transplantation(Child, Escherichia coli, Gram Positive, Female, Male, Infant, Bone marrow, Cephalosporins, Incidence, Risk factors, Pseudomonas aeruginosa, Clinical Sciences, Aged, Middle Aged, Gram-negative bacteria, Anti-Bacterial Agents, Bone Marrow Transplantation, Adult, Carbapenems, Bacteremia, Risk Factors, Pseudomonas Aeruginosa, Multi Drug Resistant Cancer, Predictive value of tests, Confidence Interval, Klebsiella pneumoniae, and Hematopoietic Stem Cell Transplantation)
(Child, Escherichia coli, Gram Positive, Female, Male, Infant, Bone marrow, Cephalosporins, Incidence, Risk factors, Pseudomonas aeruginosa, Clinical Sciences, Aged, Middle Aged, Gram-negative bacteria, Anti-Bacterial Agents, Bone Marrow Transplantation, Adult, Carbapenems, Bacteremia, Risk Factors, Pseudomonas Aeruginosa, Multi Drug Resistant Cancer, Predictive value of tests, Confidence Interval, Klebsiella pneumoniae, and Hematopoietic Stem Cell Transplantation)
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Recommended Screening and Preventive Practices for Long-term Survivors after Hematopoietic Cell Transplantation: Joint Recommendations of the European Group for Blood and Marrow Transplantation, the Center for International Blood and Marrow Transplant Research, and the American Society of Blood a...more
by A. Seber
Publication Date: 2006
Publication Name: Biology of Blood and Marrow Transplantation
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High Dose Carboplatin, Etoposide, Melphalan and Autologous Hematopoietic Stem Cell Rescue with for the Treatment of Relapsed Pediatric Germ Cell Tumorsmore
by A. Seber
Publication Date: 2011
Publication Name: Biology of Blood and Marrow Transplantation
Research Interests:
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Publication Date: 2004
Publication Name: Biology of Blood and Marrow Transplantation
Research Interests:
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Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency. The objectives of this study were to analyze the diagnosis, treatment, and prognosis of SCID in Brazil and to document the impact of BCG... more
Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency. The objectives of this study were to analyze the diagnosis, treatment, and prognosis of SCID in Brazil and to document the impact of BCG vaccine. We actively searched for cases by contacting all Brazilian referral centers. We contacted 23 centers and 70 patients from 65 families. Patients were born between 1996 and 2011, and 49 (70%) were male. More than half (39) of the diagnoses were made after 2006. Mean age at diagnosis declined from 9.7 to 6.1 months (P = .058) before and after 2000, respectively, and mean delay in diagnosis decreased from 7.9 to 4.2 months (P = .009). Most patients (60/70) were vaccinated with BCG before the diagnosis, 39 of 60 (65%) had complications related to BCG vaccine, and the complication was disseminated in 29 of 39 (74.3%). Less than half of the patients (30, 42.9%) underwent hematopoietic stem cell transplantation (HSCT). Half of the patients died (35...