Temporary Disabled. :) please Go back DermNet® - Wells syndrome pathology www.fgks.org » Address: [go: up one dir, main page] Include Form Remove Scripts Accept Cookies Show Images Show Referer Rotate13 Base64 Strip Meta Strip Title Session Cookies Search DermNet CtrlK Are you a healthcare professional GO TO DERMNET PRO Home Topics A-Z Images Cases Skin checker Translate Jobs Give feedback Main menu Home Topics A-Z Images Cases Skin checker Translate Jobs Give feedback Common skin conditions Acne Athlete's foot Cellulitis Cold sores Dermatitis/Eczema Heat rash Hives Impetigo Psoriasis Ringworm Rosacea Seborrhoeic dermatitis Shingles Vitiligo NEWS Check out what's new with DermNet Read more Quick links Skin checker Try our skin symptom checker Home Topics A-Z Wells syndrome pathology Wells syndrome pathology — extra information Synonyms: Eosinophilic cellulitis pathology Categories: Diagnosis and testing, Inflammation ICD-10: L98.3 ICD-11: EB30 SNOMED CT: 238931006 ADVERTISEMENT Diagnosis and testing Inflammation Wells syndrome pathology Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2011. Histology Variants Differential diagnoses Histology of Wells syndrome Scanning power view of Wells syndrome reveals a superficial and deep perivascular and interstitial inflammatory pattern (Figures 1 and 2). This can be seen to extend into the subcutaneous tissue (Figure 3) or even the underlying muscle. The inflammatory infiltrate is comprised of lymphocytes, histiocytes and abundant eosinophils (Figures 4,5 and 6). Degranulation of the eosinophils is seen forming flame figures (Figures 4 and 5). In this particular case extensive interstitial mucin is seen (Figures 4 and 5). Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Variants of Wells syndrome pathology Bullous Wells disease: A subepidermal blister can form in the presence of prominent papillary dermal oedema. Differential diagnosis of Wells syndrome pathology Insect bite reaction: Typically here the infiltrate is more localised forming a wedge-shaped pattern possibly with focal overlying epidermal changes. In some cases discrimination is not possible and clinical correlation is required. Bullous pemphigoid: In most circumstances, it is the urticarial phase of bullous pemphigoid which may prove difficult to discriminate. Eosinophils can be seen to tag along with the dermoepidermal junction in conjunction with basal layer vacuolar degeneration Churg Strauss syndrome: While dermal eosinophilia and flame figures can be seen, this condition is characterised by necrotising granuloma formation and variable degrees of vasculitis. References Skin Pathology (2nd edition, 2002). Weedon D Pathology of the Skin (3rd edition, 2005). McKee PH, J. Calonje JE, Granter SR Churg, A. Recent advances in the diagnosis of Churg-Strauss syndrome. Mod Pathol 2001;14(12):1284–93. PubMed On DermNet Wells syndrome Dermatopathology glossary Dermatopathology index Books about skin diseases Books about the skin Dermatology Made Easy - second edition ADVERTISEMENT Other recommended articles TrendMD recommendations failed to load. Please refresh the page. ADVERTISEMENT ADVERTISEMENT ADVERTISEMENT ADVERTISEMENT
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Wells syndrome pathology
Diagnosis and testing Inflammation
Author: Dr Ben Tallon, Dermatologist/Dermatopathologist, Tauranga, New Zealand, 2011.
Histology Variants Differential diagnoses
Scanning power view of Wells syndrome reveals a superficial and deep perivascular and interstitial inflammatory pattern (Figures 1 and 2). This can be seen to extend into the subcutaneous tissue (Figure 3) or even the underlying muscle. The inflammatory infiltrate is comprised of lymphocytes, histiocytes and abundant eosinophils (Figures 4,5 and 6). Degranulation of the eosinophils is seen forming flame figures (Figures 4 and 5). In this particular case extensive interstitial mucin is seen (Figures 4 and 5).
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6
Bullous Wells disease: A subepidermal blister can form in the presence of prominent papillary dermal oedema.
Insect bite reaction: Typically here the infiltrate is more localised forming a wedge-shaped pattern possibly with focal overlying epidermal changes. In some cases discrimination is not possible and clinical correlation is required.
Bullous pemphigoid: In most circumstances, it is the urticarial phase of bullous pemphigoid which may prove difficult to discriminate. Eosinophils can be seen to tag along with the dermoepidermal junction in conjunction with basal layer vacuolar degeneration
Churg Strauss syndrome: While dermal eosinophilia and flame figures can be seen, this condition is characterised by necrotising granuloma formation and variable degrees of vasculitis.
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