Authors: Huie, Emily Z. | Escudero, Anthony | Saito, Naomi | Harvey, Danielle | Nguyen, My-Le | Lucot, Katherine L. | LaGrande, Jayne | Mungas, Dan | DeCarli, Charles | Lamar, Melissa | Schneider, Julie A. | Kapasi, Alifiya | Rissman, Robert A. | Teich, Andrew F. | Dugger, Brittany N.
Article Type:
Research Article
Abstract:
Background: Transactive Response DNA Binding Protein 43 kDa (TDP-43) pathology is frequently found in cases with Alzheimer’s disease (AD). TDP-43 pathology is associated with hippocampal atrophy and greater AD severity denoted by cognition and clinical representation. Current TDP-43 pathology studies are predominantly based on non-Hispanic White cohorts. Objective: We sought to evaluate the presence of TDP-43 pathology across ethnoracial groups utilizing the National Alzheimer’s Coordinating Center; a database containing data from over 29 institutions across the United States. Cases (N = 1135: Hispanics/Latinos = 29, African Americans/Black Americans = 51, Asians/Asian Americans = 10, American Indians/Alaskan Natives = 2, non-Hispanic
…White = 1043) with intermediate/high AD having data on TDP-43 pathology in the amygdala, hippocampus, entorhinal cortex, and neocortex were included. Methods: TDP-43 pathology frequency in each neuroanatomic region among ethnoracial groups were compared using generalized linear mixed effects models with center as a random effect adjusting for age at death, education, and gender. Results: Although groups were imbalanced, there was no significant difference across ethnoracial groups based on TDP-43 pathology (p = 0.84). With respect to neuroanatomical regions evaluated, there were no significant differences across ethnoracial groups (p -values > 0.06). There were also no significant differences for age at death and gender ratios across ethnoracial groups based on TDP-43 pathology. Although not statistically significant, TDP-43 pathology was present less often in Hispanic/Latinos (34%) when compared to non-Hispanic Whites (46%). Conclusion: While this is a preliminary evaluation, it highlights the need for diverse cohorts and on TDP-43 pathology research across ethnoracial groups. This is the first study to our knowledge having a focus on the neuroanatomical distribution of TDP-43 deposits in Hispanic/Latino decedents with AD.
Show more
Keywords: African American, Alzheimer’s disease, Asian, brain, cohort studies, Hispanic, Latino, minoritized groups, neuropathology
DOI: 10.3233/JAD-220558
Citation: Journal of Alzheimer's Disease,
vol. 91, no. 4, pp. 1291-1301, 2023
Price: EUR 27.50