File:IFTcelegans.JPG

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English: Intraflagellar transport in C. elegans. Components of the IFT machinery and ciliary cargo assemble at or near the transition zone (basal body). Two kinesins, heterotrimeric kinesin-II and homodimeric OSM-3-kinesin, separately bind IFT particle subcomplexes A and B, respectively, and transport these together with IFT-dynein and cargo along the middle segment in the anterograde (+) direction. In the distal segment, OSM-3-kinesin alone transports the IFT particles and dynein/cargo. BBS proteins act to stabilize the association between the motors and IFT particle subcomplexes A and B. Components of the IFT machinery and presumably other ciliary molecules are recycled back to the base of the cilium using the IFT-dynein molecular motor. The lengths of the transition zone (1 μm), middle segment (4 μm) and distal segment (2.5 μm) regions are shown (for amphid cilia) along with transverse view schematics of the microtubule arrangements (on top)
Español: Transporte intraflagelar (IFT) en C. elegans Los componentes de la maquinaria IFT y su carga se ensamblan en la zona de transición o en sus proximidades (cuerpo basal). Dos kinesinas (kinesina-II heterotrimérica y kinesina OSM-3 heterodimérica) se unen por separados a los subcomplejos A y B de la partícula IFT y la transportan junto con la dineína Ib y la carga a lo largo del sermento medio en dirección anterógrada (+). En el segmento distal, la kinesina OSM-3 transporta en solitario las partículas IFT junto con la dineína 1b y su carga. Las proteínas BBS (BBSoma) actúan estabilizando la asociación entre los motores y los subcomplejos A y B de la partícula IFT. Los componentes de la maquinaria IFT y posiblemente otras moléculas del cilio son recicladas y enviadas de vuelta a la base del cilio utilizando un motor molecular basado en la dineína 1b. Se muestra las longitudes de la zona de transición (1 μm), segmento medio (4 μm) y segmento distal (2.5 μm) de un cilio de un sensor ánfido del nematodo en un esquema del corte transversal de la disposición de los microtúbulos (parte superior)
Date 5-4-2009
Source Own work
Author Gustavocarra
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