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Term Information

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Accession
GO:1990455
Name
PTEN phosphatase complex
Ontology
cellular_component
Synonyms
phosphatase and tensin homolog, phosphatase and tensin homolog deleted on chromosome ten homodimer, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer
Alternate IDs
None
Definition
A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function. Source: PMID:24766807, GOC:bhm
Comment
An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).
History
See term history for GO:1990455 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:1990455 from QuickGO

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Parents of PTEN phosphatase complex (GO:1990455)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  phosphatidylinositol-3-phosphate phosphatase activity (GO:0004438)
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  phosphatidylinositol-3,4-bisphosphate binding (GO:0043325)
PTEN phosphatase complex [RO:0002216 relation] RO:0002216  phosphatidylinositol dephosphorylation (GO:0046856)
PTEN phosphatase complex [RO:0002216 relation] RO:0002216  phosphatidylinositol-mediated signaling (GO:0048015)
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (GO:0016314)
PTEN phosphatase complex [RO:0002162 relation] RO:0002162  cellular organisms (NCBITaxon:131567)
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity (GO:0051800)
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  phosphatidylinositol-3-phosphate binding (GO:0032266)
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547)
PTEN phosphatase complex [BFO:0000050 relation] BFO:0000050  cell (CL:0000000)
PTEN phosphatase complex [is_a relation] is_a  phosphatidylinositol phosphate phosphatase complex (GO:1904144)
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  inositol 1,3,4,5 tetrakisphosphate binding (GO:0043533)
PTEN phosphatase complex [RO:0002215 relation] RO:0002215  inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity (GO:0051717)

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