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phosphatase and tensin homolog, phosphatase and tensin homolog deleted on chromosome ten homodimer, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer
Alternate IDs
None
Definition
A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function.
Source:PMID:24766807,
GOC:bhm
Comment
An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay).