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Term Information Feedback Accession GO:1990455 Name PTEN phosphatase complex Ontology cellular_component Synonyms phosphatase and tensin homolog, phosphatase and tensin homolog deleted on chromosome ten homodimer, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN homodimer Alternate IDs None Definition A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function. Source: PMID:24766807, GOC:bhm Comment An example of this is PTEN in human (P60484) in PMID:24766807 (inferred from direct assay). History See term history for GO:1990455 at QuickGO Chem. react. None Subset None Related Link to all genes and gene products annotated to PTEN phosphatase complex (including "regulates"). Link to all direct and indirect annotations to PTEN phosphatase complex (including "regulates"). Link to all direct and indirect annotations download (limited to first 10,000) for PTEN phosphatase complex (including "regulates"). Exclude "regulates" For more information, please see the ontology relation documentation. Annotations Graph Views Inferred Tree View Neighborhood Mappings Filter results Loading... pending... View this term in QuickGO. Additional external viewing options OLSVis (interactive) Additional internal viewing options Graphical view (PNG) Graphical view (SVG) GO:0008150 biological_process GO:0003824 catalytic activity GO:0008152 metabolic process GO:0005488 binding CARO:0030000 biological entity GO:0065007 biological regulation GO:0044237 cellular metabolic process GO:0009987 cellular process GO:0016787 hydrolase activity GO:0006793 phosphorus metabolic process GO:0044238 primary metabolic process CARO:0000000 anatomical entity UBERON:0000061 anatomical structure GO:0044255 cellular lipid metabolic process GO:0005575 cellular_component GO:0016788 hydrolase activity, acting on ester bonds GO:0008289 lipid binding GO:0006629 lipid metabolic process GO:0003674 molecular_function GO:0019637 organophosphate metabolic process GO:0006796 phosphate-containing compound metabolic process PR:000050567 protein-containing material entity GO:0050789 regulation of biological process GO:0050896 response to stimulus UBERON:0001062 anatomical entity CL:0000000 cell GO:0007154 cell communication GO:0110165 cellular anatomical entity GO:0051716 cellular response to stimulus GO:0046486 glycerolipid metabolic process CARO:0000006 material anatomical entity GO:0016791 phosphatase activity GO:0052866 phosphatidylinositol phosphate phosphatase activity GO:0005543 phospholipid binding GO:0006644 phospholipid metabolic process GO:0042578 phosphoric ester hydrolase activity GO:0032991 protein-containing complex GO:0050794 regulation of cellular process GO:0023052 signaling GO:0036094 small molecule binding GO:1902494 catalytic complex CARO:0000003 connected anatomical structure GO:0016311 dephosphorylation GO:0006650 glycerophospholipid metabolic process GO:0052745 inositol phosphate phosphatase activity GO:0005622 intracellular anatomical structure GO:0043167 ion binding GO:0030258 lipid modification UBERON:0000465 material anatomical entity GO:0035091 phosphatidylinositol binding GO:0034593 phosphatidylinositol bisphosphate phosphatase activity GO:0007165 signal transduction GO:0043178 alcohol binding GO:0043168 anion binding GO:0052743 inositol tetrakisphosphate phosphatase activity GO:0035556 intracellular signal transduction GO:1903293 phosphatase complex GO:0046488 phosphatidylinositol metabolic process GO:0052744 phosphatidylinositol monophosphate phosphatase activity GO:1901981 phosphatidylinositol phosphate binding GO:0034594 phosphatidylinositol trisphosphate phosphatase activity GO:0106017 phosphatidylinositol-3,4-bisphosphate phosphatase activity GO:0046839 phospholipid dephosphorylation GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0046856 phosphatidylinositol dephosphorylation GO:1904144 phosphatidylinositol phosphate phosphatase complex GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity GO:0043325 phosphatidylinositol-3,4-bisphosphate binding GO:0032266 phosphatidylinositol-3-phosphate binding GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity GO:0048015 phosphatidylinositol-mediated signaling GO:1990455 PTEN phosphatase complex Parents of PTEN phosphatase complex (GO:1990455) subject relation object PTEN phosphatase complex RO:0002215 phosphatidylinositol-3,4-bisphosphate binding (GO:0043325) PTEN phosphatase complex BFO:0000050 cell (CL:0000000) PTEN phosphatase complex RO:0002215 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity (GO:0016314) PTEN phosphatase complex is_a phosphatidylinositol phosphate phosphatase complex (GO:1904144) PTEN phosphatase complex RO:0002162 cellular organisms (NCBITaxon:131567) PTEN phosphatase complex RO:0002215 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity (GO:0051717) PTEN phosphatase complex RO:0002216 phosphatidylinositol-mediated signaling (GO:0048015) PTEN phosphatase complex RO:0002215 phosphatidylinositol-3-phosphate phosphatase activity (GO:0004438) PTEN phosphatase complex RO:0002216 phosphatidylinositol dephosphorylation (GO:0046856) PTEN phosphatase complex RO:0002215 phosphatidylinositol-3,4,5-trisphosphate binding (GO:0005547) PTEN phosphatase complex RO:0002215 phosphatidylinositol-3-phosphate binding (GO:0032266) PTEN phosphatase complex RO:0002215 inositol 1,3,4,5 tetrakisphosphate binding (GO:0043533) PTEN phosphatase complex RO:0002215 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity (GO:0051800) This term has no children. 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