C-C motif chemokine ligand 8 (Q5009629)

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mammalian protein found in Homo sapiens

small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2)
small-inducible cytokine A8
C-C motif chemokine 8
MCP-2
CCL8
HC14
monocyte chemoattractant protein 2
chemokine (C-C motif) ligand 8
monocyte chemotactic protein 2

Language	Label	Description	Also known as
English	C-C motif chemokine ligand 8	mammalian protein found in Homo sapiens	small inducible cytokine subfamily A (Cys-Cys), member 8 (monocyte chemotactic protein 2) small-inducible cytokine A8 C-C motif chemokine 8 MCP-2 CCL8 HC14 monocyte chemoattractant protein 2 chemokine (C-C motif) ligand 8 monocyte chemotactic protein 2

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein kinase activity

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

cytokine activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

heparin binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

phospholipase activator activity

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

CCR chemokine receptor binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

chemokine activity

determination method

3 references

8 April 2019

Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

protein binding

determination method

1 reference

8 April 2019

Chemokine interactome mapping enables tailored intervention in acute and chronic inflammation.

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

CCR2 chemokine receptor binding

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P80075&geneProductId=UniProtKB:P80075

determination method

biological process

G protein-coupled receptor signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

monocyte chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

chemokine-mediated signaling pathway

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

cellular response to tumor necrosis factor

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

cell-cell signaling

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

response to virus

determination method

1 reference

8 April 2019

Monocyte chemotactic protein-2 activates CCR5 and blocks CD4/CCR5-mediated HIV-1 entry/replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

cellular calcium ion homeostasis

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

neutrophil chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

positive regulation of GTPase activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

cellular response to interleukin-1

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

immune response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

positive regulation of ERK1 and ERK2 cascade

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

cellular response to interferon-gamma

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

lymphocyte chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

calcium ion transport

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

signal transduction

determination method

1 reference

8 April 2019

The human MCP-2 gene (SCYA8): cloning, sequence analysis, tissue expression, and assignment to the CC chemokine gene contig on chromosome 17q11.2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

determination method

1 reference

8 April 2019

Regulation of the human chemokine receptor CCR1. Cross-regulation by CXCR1 and CXCR2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

protein phosphorylation

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

antimicrobial humoral immune response mediated by antimicrobial peptide

determination method

1 reference

24 April 2018

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P80075&geneProductId=UniProtKB:P80075

determination method

positive regulation of leukocyte migration

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

negative regulation of leukocyte proliferation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

regulation of signaling receptor activity

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

determination method

1 reference

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P80075&geneProductId=UniProtKB:P80075

determination method

eosinophil chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P80075

determination method

http://purl.uniprot.org/uniprot/P80075

1 reference

Identifiers.org

Identifiers

MeSH descriptor ID

subject named as

Chemokine CCL8

0 references

D12.644.276.374.200.110.990.900

0 references

D12.776.467.374.200.110.990.900

0 references

D23.125.300.110.990.900

0 references

D23.469.200.110.990.900

0 references

D23.529.374.200.110.990.875

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000378118

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000378118

0 references

Microsoft Academic ID

0 references

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(7 entries)

bswiki CCL8
dewiki CCL8
enwiki CCL8
shwiki CCL8
srwiki CCL8
ttwiki CCL8
ukwiki CCL8

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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