Temporary Disabled. :) please Go back TGF-beta signalling from cell membrane to nucleus through SMAD proteins - Wikidata www.fgks.org » Address: [go: up one dir, main page] Include Form Remove Scripts Accept Cookies Show Images Show Referer Rotate13 Base64 Strip Meta Strip Title Session Cookies TGF-beta signalling from cell membrane to nucleus through SMAD proteins (Q28131770) From Wikidata Jump to navigation Jump to search scientific article (publication date: 4 December 1997) edit Language Label Description Also known as English TGF-beta signalling from cell membrane to nucleus through SMAD proteins scientific article (publication date: 4 December 1997) Statements instance of scholarly article 0 references review article 1 reference stated in Europe PubMed Central title TGF-beta signalling from cell membrane to nucleus through SMAD proteins (English) 0 references author name string C H Heldin series ordinal 1 0 references K Miyazono series ordinal 2 0 references P ten Dijke series ordinal 3 0 references language of work or name English 0 references publication date 4 December 1997 0 references published in Nature 0 references volume 390 0 references issue 6659 0 references page(s) 465-71 0 references cites work TGF-beta signalling through the Smad pathway 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Mechanism of activation of the TGF-beta receptor 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The types II and III transforming growth factor-beta receptors form homo-oligomers 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Signaling by chimeric erythropoietin-TGF-beta receptors: homodimerization of the cytoplasmic domain of the type I TGF-beta receptor and heterodimerization with the type II receptor are both required for intracellular signal transduction. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Ligand-independent activation of transforming growth factor (TGF) beta signaling pathways by heteromeric cytoplasmic domains of TGF-beta receptors 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Activation of signalling by the activin receptor complex 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Cooperative Binding of Transforming Growth Factor (TGF)-β2 to the Types I and II TGF-β Receptors 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Cloning and characterization of a human type II receptor for bone morphogenetic proteins 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup A kinase subdomain of transforming growth factor-beta (TGF-beta) type I receptor determines the TGF-beta intracellular signaling specificity 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Decreased type II/type I TGF-beta receptor ratio in cells derived from human atherosclerotic lesions. Conversion from an antiproliferative to profibrotic response to TGF-beta1. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Positive and negative regulation of type II TGF-beta receptor signal transduction by autophosphorylation on multiple serine residues 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The type II transforming growth factor-beta receptor autophosphorylates not only on serine and threonine but also on tyrosine residues 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup MADR1, a MAD-related protein that functions in BMP2 signaling pathways 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Xenopus Mad proteins transduce distinct subsets of signals for the TGF beta superfamily 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup A human Mad protein acting as a BMP-regulated transcriptional activator 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Receptor-associated Mad homologues synergize as effectors of the TGF-beta response 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Smad5 induces ventral fates in Xenopus embryo 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Cloning and characterization of a novel member of the human Mad gene family (MADH6) 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Genetic and biochemical analysis of TGF beta signal transduction 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Characterization of functional domains within Smad4/DPC4 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup A structural basis for mutational inactivation of the tumour suppressor Smad4 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Smad6 inhibits signalling by the TGF-beta superfamily 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Daughters against dpp modulates dpp organizing activity in Drosophila wing development 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Antagonistic actions of activin A and BMP-2/4 control dorsal lip-specific activation of the early response gene XFD-1' in Xenopus laevis embryos. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Antagonizing the Spemann organizer: role of the homeobox gene Xvent-1. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Transforming Growth Factor β Activates the Promoter of Cyclin-dependent Kinase Inhibitor p15 through an Sp1 Consensus Site 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup A transcriptional partner for MAD proteins in TGF-beta signalling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Smad4 and FAST-1 in the assembly of activin-responsive factor 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup FKBP-12 recognition is dispensable for signal generation by type I transforming growth factor-beta receptors. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The immunophilin FKBP12 functions as a common inhibitor of the TGF beta family type I receptors. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Mechanism of TGFbeta receptor inhibition by FKBP12 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Cloning of a novel type II serine/threonine kinase receptor through interaction with the type I transforming growth factor-beta receptor 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Interaction of transforming growth factor-beta receptor I with farnesyl-protein transferase-alpha in yeast and mammalian cells 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Interaction of transforming growth factor beta receptors with apolipoprotein J/clusterin 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup A WD-domain protein that is associated with and phosphorylated by the type II TGF-beta receptor 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Altered transforming growth factor signaling in epithelial cells when ras activation is blocked 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Tumor suppressor activity of the TGF-beta pathway in human cancers 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Mad-related genes in the human 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Cdc25 cell-cycle phosphatase as a target of c-myc 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup TGF-beta 1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup STATs: signal transducers and activators of transcription 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1 1 reference stated in Crossref reference URL https://api.crossref.org/works/10.1038%2F37284 retrieved 7 January 2021 based on heuristic inferred from DOI database lookup Identifiers DOI 10.1038/37284 1 reference stated in Consolidated OpenCitations Corpus – April 2017 OpenCitations bibliographic resource ID 147026 Dimensions Publication ID 1001112208 0 references OpenCitations bibliographic resource ID 147026 1 reference stated in Consolidated OpenCitations Corpus – April 2017 OpenCitations bibliographic resource ID 147026 PubMed publication ID 9393997 1 reference stated in Consolidated OpenCitations Corpus – April 2017 OpenCitations bibliographic resource ID 147026 ResearchGate publication ID 13836137 0 references Sitelinks Wikipedia(0 entries) edit Wikibooks(0 entries) edit Wikinews(0 entries) edit Wikiquote(0 entries) edit Wikisource(0 entries) edit Wikiversity(0 entries) edit Wikivoyage(0 entries) edit Wiktionary(0 entries) edit Multilingual sites(0 entries) edit Navigation menu Personal tools EnglishNot logged inTalkContributionsCreate accountLog in Namespaces ItemDiscussion English Views ReadView history More Search Navigation Main pageCommunity portalProject chatCreate a new ItemRecent changesRandom ItemQuery ServiceNearbyHelpDonate Lexicographical data Create a new LexemeRecent changesRandom Lexeme Tools What links hereRelated changesSpecial pagesPermanent linkPage informationConcept URICite this pageGet shortened URLDownload QR code 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