IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance (Q24309891)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

IQGAP1 protein binds human epidermal growth factor receptor 2 (HER2) and modulates trastuzumab resistance (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

Erb-b2 receptor tyrosine kinase 2

6 February 2020

main subject

cell biology

0 references

1 reference

1 reference

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Colin D White

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Zhigang Li

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

Deborah A Dillon

series ordinal

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

0 references

publication date

1 July 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

6 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

286

1 reference

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6 February 2020

issue

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

29734-29747

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

MAPK scaffold IQGAP1 binds the EGF receptor and modulates its activation

6 February 2020

cites work

1 reference

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IQGAP1 and IQGAP2 are reciprocally altered in hepatocellular carcinoma

19 March 2017

1 reference

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IQGAPs in cancer: a family of scaffold proteins underlying tumorigenesis

7 April 2017

1 reference

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IQGAP1 modulates activation of B-Raf

19 March 2017

1 reference

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IQGAP1 is a scaffold for mitogen-activated protein kinase signaling

19 March 2017

1 reference

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Identification and characterization of the Cdc42-binding site of IQGAP1

19 March 2017

1 reference

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Humanization of an anti-p185HER2 antibody for human cancer therapy

19 March 2017

1 reference

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The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors

19 March 2017

1 reference

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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

19 March 2017

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Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer

19 March 2017

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PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

19 March 2017

1 reference

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

19 March 2017

1 reference

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Untangling the ErbB signalling network

19 March 2017

1 reference

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Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

19 March 2017

1 reference

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IQGAP1 regulation and roles in cancer

19 March 2017

1 reference

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IQGAP1 stimulates proliferation and enhances tumorigenesis of human breast epithelial cells

19 March 2017

1 reference

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IQ-domain GTPase-activating protein 1 regulates beta-catenin at membrane ruffles and its role in macropinocytosis of N-cadherin and adenomatous polyposis coli

19 March 2017

1 reference

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The role of scaffold proteins in MEK/ERK signalling

19 March 2017

2 references

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19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

IQGAP1 binds ERK2 and modulates its activity

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

IQGAP1 is a component of Cdc42 signaling to the cytoskeleton

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

ERBB receptors and cancer: the complexity of targeted inhibitors

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.

7 April 2017

1 reference

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Rac1 contributes to trastuzumab resistance of breast cancer cells: Rac1 as a potential therapeutic target for the treatment of trastuzumab-resistant breast cancer

27 September 2017

1 reference

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ErbB receptors and signaling pathways in cancer

27 September 2017

1 reference

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IQGAP1-dependent signaling pathway regulates endothelial cell proliferation and angiogenesis

27 September 2017

1 reference

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A crucial role for Galphaq/11, but not Galphai/o or Galphas, in gonadotropin-releasing hormone receptor-mediated cell growth inhibition

27 September 2017

1 reference

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Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression.

27 September 2017

1 reference

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Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis

27 September 2017

1 reference

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Trastuzumab: triumphs and tribulations

27 September 2017

1 reference

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The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

HER2 therapy. HER2 (ERBB2): functional diversity from structurally conserved building blocks

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

IQGAP1 regulates cell motility by linking growth factor signaling to actin assembly

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

HER2 therapy: molecular mechanisms of trastuzumab resistance.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

IQGAP1 in cellular signaling: bridging the GAP.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Signaling through ERBB receptors: multiple layers of diversity and control

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Herceptin: mechanisms of action and resistance

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Self-association of IQGAP1: characterization and functional sequelae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Utilizing prognostic and predictive factors in breast cancer

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

The transcriptional activity of estrogen receptor-alpha is dependent on Ca2+/calmodulin.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Characterization of a novel cell line established from a patient with Herceptin-resistant breast cancer.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Identification of differentially expressed genes in human lung squamous cell carcinoma using suppression subtractive hybridization

27 September 2017

1 reference

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P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

The ErbB2/Neu/HER2 receptor is a new calmodulin-binding protein.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

The achilles heel of ErbB-2/HER2: regulation by the Hsp90 chaperone machine and potential for pharmacological intervention.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

In vitro effects of trastuzumab and vinorelbine in trastuzumab-resistant breast cancer cells.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Mechanism of action of trastuzumab and scientific update

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Identification of cadherin-11 down-regulation as a common response of astrocytoma cells to transforming growth factor-alpha

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Effects of oncogenic ErbB2 on G1 cell cycle regulators in breast tumour cells

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin).

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

p27kip1: a multifunctional cyclin-dependent kinase inhibitor with prognostic significance in human cancers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

A discrete three-amino acid segment (LVI) at the C-terminal end of kinase-impaired ErbB3 is required for transactivation of ErbB2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

IQGAP1 promotes cell motility and invasion

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

The role of cyclin-dependent kinase inhibitor p27Kip1 in anti-HER2 antibody-induced G1 cell cycle arrest and tumor growth inhibition

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Gene expression profiles associated with treatment response in oligodendrogliomas.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

28 July 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220939

IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220939

Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220939

Endocytosis and intracellular trafficking of ErbBs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220939

Flavopiridol and trastuzumab synergistically inhibit proliferation of breast cancer cells: association with selective cooperative inhibition of cyclin D1-dependent kinase and Akt signaling pathways.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3191015

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21724847

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IQGAP1 integrates Ca2+/calmodulin and Cdc42 signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21724847

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Combined analysis of Rac1, IQGAP1, Tiam1 and E-cadherin expression in gastric cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21724847

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M111.220939

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

PubMed publication ID

21724847

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21724847%20AND%20SRC:MED&resulttype=core&format=json