Solute carrier family 19 member 1 (Q21126218)

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mammalian protein found in Homo sapiens

intestinal folate carrier 1
reduced folate carrier 1
folate transporter 1
solute carrier family 19 (folate transporter), member 1
SLC19A1
IFC-1
reduced folate transporter
reduced folate carrier protein
reduced folate transporter 1
RFC
placental folate transporter

Language	Label	Description	Also known as
English	Solute carrier family 19 member 1	mammalian protein found in Homo sapiens	intestinal folate carrier 1 reduced folate carrier 1 folate transporter 1 solute carrier family 19 (folate transporter), member 1 SLC19A1 IFC-1 reduced folate transporter reduced folate carrier protein reduced folate transporter 1 RFC placental folate transporter

Statements

1 reference

13 November 2019

UniProt protein ID

Folate transporter 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41440

MFS transporter superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41440

Major facilitator superfamily domain

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

methotrexate transmembrane transporter activity

determination method

3 references

21 June 2018

A novel cDNA restores reduced folate carrier activity and methotrexate sensitivity to transport deficient cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

vitamin transmembrane transporter activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

folic acid transmembrane transporter activity

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

8 April 2019

Molecular cloning of the human placental folate transporter

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

8 April 2019

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

folate:anion antiporter activity

determination method

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

8 April 2019

Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

basolateral plasma membrane

determination method

1 reference

21 June 2018

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

plasma membrane

determination method

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

apical plasma membrane

determination method

3 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

8 April 2019

Expression and differential polarization of the reduced-folate transporter-1 and the folate receptor alpha in mammalian retinal pigment epithelium

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

biological process

folic acid metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

folate transmembrane transport

determination method

1 reference

24 April 2018

Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

folic acid transport

determination method

4 references

21 June 2018

Molecular cloning of the human placental folate transporter

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

21 June 2018

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P41440&geneProductId=UniProtKB:P41440

determination method

vitamin transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

folate import across plasma membrane

determination method

1 reference

8 April 2019

Regulation of reduced-folate transporter-1 (RFT-1) by homocysteine and identity of transport systems for homocysteine uptake in retinal pigment epithelial (RPE) cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

folic acid transport

determination method

methotrexate transport

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

transmembrane transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

folate transmembrane transport

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41440

determination method

physically interacts with

enzyme inhibitor

2 references

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

major facilitator superfamily domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P41440

Identifiers

MeSH descriptor ID

subject named as

Reduced Folate Carrier Protein

0 references

D12.776.157.530.450.074.500.299.750

0 references

D12.776.157.530.450.162.359

0 references

D12.776.157.530.937.622

0 references

D12.776.543.550.190.608

0 references

D12.776.543.585.450.074.500.224.750

0 references

D12.776.543.585.450.162.359

0 references

D12.776.543.585.937.743

0 references

D23.050.301.500.600.813

0 references

D23.050.705.552.600.663

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000308895

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000308895

ENSP00000369347

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000369347

ENSP00000441772

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000441772

ENSP00000393988

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000393988

ENSP00000401850

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000401850

ENSP00000411345

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000411345

ENSP00000435780

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000435780

ENSP00000457278

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000457278

ENSP00000498221

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498221

0 references

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(5 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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