Academia.edu no longer supports Internet Explorer.
To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to upgrade your browser.
2020, Nanomedicine
Free radical research
Physicochemical properties of iron oxide nanoparticles that contribute to cellular ROS-dependent signaling and acellular production of hydroxyl radical2016 •
While nanoparticles (NPs) are increasingly used in a variety of consumer products and medical applications, some of these materials have potential health concerns. Macrophages are the primary responders to particles that initiate oxidative stress and inflammatory reactions. Here, we utilized six flame-synthesized, engineered iron oxide NPs with various physicochemical properties (e.g. Fe oxidation state and crystal size) to study their interactions with RAW 264.7 macrophages, their iron solubilities, and their abilities to produce hydroxyl radical in an acellular assay. Both iron solubility and hydroxyl radical production varied between NPs depending on crystalline diameter and surface area of the particles, but not on iron oxidation state. Macrophage treatment with the iron oxide NPs showed a dose-dependent increase of heme oxygenase 1 (HO-1) and NAD(P)H:quinone oxidoreductase (NQO-1). The nuclear factor (NF)-erythroid-derived 2 (E2)-related factor 2 (Nrf2) modulates the transcript...
Materials Science and Engineering: C
Bio-redox potential of Hyphaene thebaica in bio-fabrication of ultrafine maghemite phase iron oxide nanoparticles (Fe2O3 NPs) for therapeutic applications2020 •
REVIEWS ON ADVANCED MATERIALS SCIENCE
Application of Iron Oxide Nanoparticles in Contemporary Experimental Physiology and Cell Biology ResearchRecent findings have suggested that iron oxide nanoparticles (IONPs) have some exceptional chemical characteristics which make them useful in both experimental physiology and cell biology research. These nanoparticles might be applied as drug delivery systems for anti-cancer and other medications. Also, IONPs might be a valuable part of many novel bioassays in various fundamental medical fields. In recent years, several studies have indicated that IONPs may have certain cytotoxic and genotoxic potential in living systems. During in vitro conditions, IONPs might induce generation of reactive oxygen species and cause oxidative stress in some cell populations. The toxicity of IONPs is not yet fully understood, and additional research is needed to confirm if IONPs have detrimental effects on human health. This short article focuses on the recent developments and trends in the fields of nanomedicine and nanobiology regarding iron oxide nanomaterials and their application in fundamental m...
Human & Experimental Toxicology
Activation of the molecular and functional effects of Nrf2 against chronic iron oxide nanorod overload-induced cardiotoxicity2017 •
Reactive oxygen species have a significant role in the pathogenesis of iron oxide nanorod (IONR) overload-induced organ toxicity in some organs such as the lungs. Green tea induces upregulation of phase II antioxidant enzymes that are transcriptionally organized by the nuclear factor (erythroid-derived 2)-like 2 (Nrf2) that when activated antagonize the oxidative stress induced by IONR overload that causes cardiotoxicity. The aim of the present study was to determine whether treatment of cardiotoxicity with iron chelators (deferiprone (DFP) or deferoxamine (DFO)) alone or in combination with phytochemical activation of Nrf2 (green tea) can protect cardiomyocytes from IONR overload-induced cardiotoxicity. One hundred five rats were distributed into seven groups: two control groups (non-IONR-overloaded and IONR-overloaded) and five IONR-overloaded groups such as a green tea group, DFP group, DFP combined with green tea group, DFO group, and DFO combined with green tea. Blood samples a...
This study centers around diagnostic medicine, and severity staging of inflammatory diseases. Previously, we showed that complexation of PEG and Poly(gallol) on superparamagnetic iron oxide nanoparticles turn OFF the MRI contrasting ability of the nanoparticle. However, in the presence of reactive oxygen species, the contrast agent will turn ON. In this article, for the first time, we provide evidence that our MRI contrast agent is sensitive to physiologically relevant ROS and induces antioxidant activity on immune and endothelial cells. This study provides initial evidence of IPC-SPIOs cellular ROS sensitivity and potential activatable properties in biological conditions.
The use of nanomaterials rationally engineered to treat cancer is a burgeoning field that has reported great medical achievements. Iron-based polymeric nano-formulations with precisely tuned physicochemical properties are an expanding and versatile therapeutic strategy for tumor treatment. Recently, a peculiar type of regulated necrosis named ferroptosis has gained increased attention as a target for cancer therapy. Here, we show for the first time that novel iron oxide nanoparticles coated with gallic acid and polyacrylic acid (IONP–GA/PAA) possess intrinsic cytotoxic activity on various cancer cell lines. Indeed, IONP–GA/PAA treatment efficiently induces ferroptosis in glioblastoma, neuroblastoma, and fibrosarcoma cells. IONP–GA/PAA-induced ferroptosis was blocked by the canonical ferroptosis inhibitors, including deferoxamine and ciclopirox olamine (iron chelators), and ferrostatin-1, the lipophilic radical trap. These ferroptosis inhibitors also prevented the lipid hydroperoxide...
Free Radical Biology and Medicine
Iron and dioxygen chemistry is an important route to initiation of biological free radical oxidations: an electron paramagnetic resonance spin trapping study1999 •
2022 •
A Revista RECAM – MERCOSUL Audiovisual é uma publicação anual composta por uma série de artigos sobre temas relacionados ao audiovisual, dentre os quais quatro são o resultados da presente seleção. A Revista é um espaço de articulação do debate acadêmico e uma janela de visibilidade para as ações da RECAM. Tem como proposta o diálogo Academia – Estado, promovendo a conscientização da identidade regional e colaborando com o projeto de políticas públicas regionais. Nesta edição o tema basal é EDUCAÇÃO, INFÂNCIA, AUDIOVISUAL.
Caderno Espaço Feminino
Disciplinar o corpo e apurar a raça2019 •
Utilizando a concetualização de disciplinamento social, o texto tem como objetivo perceber como se sensibilizam as mulheres para a prática do exercício físico, nas páginas da revista Fémina, ao longo da década de 1930. Procurando captá-las através de um discurso que apelou à vaidade, em muitos artigos o que esteve em causa foi a obtenção de um corpo saudável com vista a gerar crianças robustas, de acordo com os ideais políticos da época. PALAVRAS-CHAVE: Ginástica. Fémina. Raça. Portugal. anos de 1930. ABSTRACT Using the conception of social discipline, the text aims to understand how women are sensitized to the practice of physical exercise, in the pages of Fémina magazine, throughout the decade of 1930. Looking to capture them through a speech that appealed to vanity, in many articles, what was at stake was the attainment of a healthy body in order to generate robust children, according to the political ideals of the time. KEYWORDS: Gymnastics. Fémina. Race. Portugal. 1930s.
Acta Bio Medica : Atenei Parmensis
Spontaneous iliopsoas hematoma in a trasfusion dependent β-thalassemia patient with hypersplenism: a case report2019 •
A 27-year-old married man with transfusion dependent β-thalassemia (TDT) complaining low back pain due to a spontaneous iliopsoas hematoma is reported. A magnetic resonance imaging (MRI) confirmed the diagnosis. The patient was managed conservatively. The mechanism of spontaneous iliopsoas hematoma was unclear, although tearing of muscle fibers, unrecognized minor trauma, low platelet count, secondary to hypersplenism, and severe liver iron overload, associated to abnormalities of clotting factors synthesis, were the suspected etiologies. He showed a good response to treatment and was discharged home 11 days later. A new MRI, performed 7 months later, showed a complete resolution of hematoma. Although iliopsoas haematoma is an uncommon complication in patients with TDT, it should be considered in the differential diagnosis of a patient with back pain. (www.actabiomedica.it)
2013 •
Endocrine Abstracts
Generation of a long acting GCSF for treatment of neutropenia and stem cell harvest2015 •
Social Science Research Network
Should We Trust a Black Box to Safeguard Human Rights? a Comparative Analysis of Ai Governance2021 •
1990 •
E-Amal: Jurnal Pengabdian Kepada Masyarakat
Budi Daya Jamur Tiram Dalam Rangka Meningkatkan Pendapatan Masyarakat Desa Tambakmekar Kecamatan Jalancagak Kabupaten Subang Provinsi Jawa BaratJournal of Biological Chemistry
A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca2+ regulation of Kv4 channels2019 •